Aldh5a1 (aldehyde dehydrogenase 5 family, member A1) - Rat Genome Database

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Gene: Aldh5a1 (aldehyde dehydrogenase 5 family, member A1) Rattus norvegicus
Analyze
Symbol: Aldh5a1
Name: aldehyde dehydrogenase 5 family, member A1
RGD ID: 621422
Description: Enables NAD binding activity; carboxylic acid binding activity; and succinate-semialdehyde dehydrogenase (NAD+) activity. Involved in succinate metabolic process. Predicted to be located in synapse. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; acetaldehyde.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase); aldehyde dehydrogenase family 5 member A1; aldehyde dehydrogenase family 5, subfamily A1; NAD(+)-dependent succinic semialdehyde dehydrogenase; Ssadh; succinate-semialdehyde dehydrogenase, mitochondrial; succinic semialdehyde dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,560,373 - 40,586,711 (+)NCBIGRCr8
mRatBN7.21740,132,339 - 40,158,677 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1740,130,883 - 40,158,677 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1740,200,441 - 40,226,804 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,804,498 - 41,830,863 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01740,087,826 - 40,114,061 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01742,133,076 - 42,159,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,133,076 - 42,159,413 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01744,000,875 - 44,027,212 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41747,193,407 - 47,216,499 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11747,196,722 - 47,219,340 (+)NCBI
Celera1739,769,869 - 39,796,199 (+)NCBICelera
Cytogenetic Map17p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
4-hydroxybutyric acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
ATP  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benomyl  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (ISO)
diiodine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
gamma-aminobutyric acid  (EXP)
genistein  (EXP)
glafenine  (EXP)
Heliotrine  (ISO)
indometacin  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
mancozeb  (EXP)
maneb  (EXP,ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
motexafin gadolinium  (ISO)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
Nonylphenol  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sodium perchlorate  (EXP)
succinic semialdehyde  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
superoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
XL765  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
mitochondrion  (IBA,IEA,ISO,ISS)
synapse  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of the mature NAD(+)-dependent succinic semialdehyde dehydrogenase from rat and human. cDNA isolation, evolutionary homology, and tissue expression. Chambliss KL, etal., J Biol Chem 1995 Jan 6;270(1):461-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A). Murphy TC, etal., J Neurochem 2003 Jul;86(2):298-305.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation. Nguyen E and Picklo MJ Sr, Biochim Biophys Acta. 2003 Jan 20;1637(1):107-12.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Kinetic studies with rat-brain succinic-semialdehyde dehydrogenase. Rivett AJ and Tipton KF, Eur J Biochem. 1981 Jun;117(1):187-93.
Additional References at PubMed
PMID:9683595   PMID:11544478   PMID:12065715   PMID:12067239   PMID:14651853   PMID:15037717   PMID:15262267   PMID:16199352   PMID:16504488   PMID:16647690   PMID:17300923   PMID:17303287  
PMID:17854388   PMID:18614015   PMID:18926807   PMID:20833797  


Genomics

Comparative Map Data
Aldh5a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,560,373 - 40,586,711 (+)NCBIGRCr8
mRatBN7.21740,132,339 - 40,158,677 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1740,130,883 - 40,158,677 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1740,200,441 - 40,226,804 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,804,498 - 41,830,863 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01740,087,826 - 40,114,061 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01742,133,076 - 42,159,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,133,076 - 42,159,413 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01744,000,875 - 44,027,212 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41747,193,407 - 47,216,499 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11747,196,722 - 47,219,340 (+)NCBI
Celera1739,769,869 - 39,796,199 (+)NCBICelera
Cytogenetic Map17p11NCBI
ALDH5A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38624,494,969 - 24,537,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl624,494,867 - 24,537,207 (+)EnsemblGRCh38hg38GRCh38
GRCh37624,495,197 - 24,537,435 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36624,603,176 - 24,645,414 (+)NCBINCBI36Build 36hg18NCBI36
Build 34624,603,175 - 24,645,414NCBI
Celera625,728,607 - 25,770,806 (+)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef624,444,647 - 24,486,850 (+)NCBIHuRef
CHM1_1624,499,400 - 24,541,589 (+)NCBICHM1_1
T2T-CHM13v2.0624,364,950 - 24,407,166 (+)NCBIT2T-CHM13v2.0
Aldh5a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391325,091,562 - 25,121,740 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1325,091,562 - 25,121,644 (-)EnsemblGRCm39 Ensembl
GRCm381324,907,579 - 24,937,661 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1324,907,579 - 24,937,661 (-)EnsemblGRCm38mm10GRCm38
MGSCv371324,999,448 - 25,029,530 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361324,918,497 - 24,945,126 (-)NCBIMGSCv36mm8
Celera1325,138,248 - 25,168,330 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1310.77NCBI
Aldh5a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554832,467,425 - 2,494,416 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554832,467,425 - 2,494,416 (-)NCBIChiLan1.0ChiLan1.0
ALDH5A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2539,145,143 - 39,187,630 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1635,144,631 - 35,187,096 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0624,332,093 - 24,370,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1624,665,026 - 24,703,242 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl624,665,026 - 24,705,151 (+)Ensemblpanpan1.1panPan2
ALDH5A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13522,560,005 - 22,590,996 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3522,560,008 - 22,587,875 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3522,524,175 - 22,552,036 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03522,678,366 - 22,704,116 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3522,678,366 - 22,713,142 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13522,483,861 - 22,512,841 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03522,532,027 - 22,557,461 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03523,968,214 - 23,996,095 (+)NCBIUU_Cfam_GSD_1.0
Aldh5a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049462,755,755 - 2,777,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936671843,577 - 865,881 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936671843,577 - 865,798 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH5A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl719,351,361 - 19,379,098 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1719,351,485 - 19,375,515 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2720,501,722 - 20,526,975 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH5A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11747,712,785 - 47,746,198 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1747,709,888 - 47,745,830 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604424,427,783 - 24,464,046 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh5a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247562,464,899 - 2,501,130 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247562,464,912 - 2,500,773 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldh5a1
65 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:239
Count of miRNA genes:124
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000031384, ENSRNOT00000050919
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat

Markers in Region
RH142226  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21740,154,857 - 40,155,011 (+)MAPPERmRatBN7.2
Rnor_6.01742,155,594 - 42,155,747NCBIRnor6.0
Rnor_5.01744,023,393 - 44,023,546UniSTSRnor5.0
RGSC_v3.41747,216,263 - 47,216,416UniSTSRGSC3.4
Celera1739,792,380 - 39,792,533UniSTS
Cytogenetic Map17p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 39 26 21 3 21 5 8 74 20 22 4 5
Low 3 4 31 20 16 20 3 3 15 19 7 3
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000031384   ⟹   ENSRNOP00000035601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1740,132,355 - 40,158,677 (+)Ensembl
Rnor_6.0 Ensembl1742,133,076 - 42,159,413 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096987   ⟹   ENSRNOP00000078818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1740,130,883 - 40,158,677 (+)Ensembl
RefSeq Acc Id: NM_022851   ⟹   NP_074042
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,560,373 - 40,586,711 (+)NCBI
mRatBN7.21740,132,339 - 40,158,677 (+)NCBI
Rnor_6.01742,133,076 - 42,159,413 (+)NCBI
Rnor_5.01744,000,875 - 44,027,212 (+)NCBI
Celera1739,769,869 - 39,796,199 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_074042 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA67058 (Get FASTA)   NCBI Sequence Viewer  
  EDL86492 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035601.4
  ENSRNOP00000078818
  ENSRNOP00000078818.1
GenBank Protein P51650 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_074042   ⟸   NM_022851
- Peptide Label: precursor
- UniProtKB: P51650 (UniProtKB/Swiss-Prot),   A6KLE7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000035601   ⟸   ENSRNOT00000031384
RefSeq Acc Id: ENSRNOP00000078818   ⟸   ENSRNOT00000096987
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51650-F1-model_v2 AlphaFold P51650 1-523 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700441
Promoter ID:EPDNEW_R10964
Type:initiation region
Name:Aldh5a1_1
Description:aldehyde dehydrogenase 5 family, member A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01742,133,066 - 42,133,126EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621422 AgrOrtholog
BioCyc Gene G2FUF-9426 BioCyc
BioCyc Pathway GLUDEG-I-PWY [GABA shunt] BioCyc
  PWY-6535 [4-aminobutanoate degradation I] BioCyc
BioCyc Pathway Image GLUDEG-I-PWY BioCyc
  PWY-6535 BioCyc
Ensembl Genes ENSRNOG00000023538 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031384.6 UniProtKB/TrEMBL
  ENSRNOT00000096987 ENTREZGENE
  ENSRNOT00000096987.1 UniProtKB/TrEMBL
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Succ_semiAld_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:291133 UniProtKB/TrEMBL
NCBI Gene Aldh5a1 ENTREZGENE
PANTHER SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/TrEMBL
  SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Aldedh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aldh5a1 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023538 RatGTEx
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZLJ2_RAT UniProtKB/TrEMBL
  A6KLE7 ENTREZGENE, UniProtKB/TrEMBL
  G3V945_RAT UniProtKB/TrEMBL
  P51650 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Aldh5a1  aldehyde dehydrogenase 5 family, member A1  Aldh5a1  aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-19 Aldh5a1  aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)  Aldh5a1  aldehyde dehydrogenase family 5, subfamily A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Aldh5a1  aldehyde dehydrogenase family 5, subfamily A1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Aldh5a1        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function oxidizing enzyme for 4-hydroxy-trans-2-nonenal (HNE), a neurotoxic aldehyde in the CNS creating a non-toxic metabolite 1304407
gene_homology shares 83 and 91% identity to human in nucleotide and protein sequence, respectively 632258
gene_product belongs to the aldehyde dehydrogenase superfamily 632258
gene_protein 488 amino acids 632258