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Gene: Aldh5a1 (aldehyde dehydrogenase 5 family, member A1) Rattus norvegicus

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Symbol:

Aldh5a1

Name:

aldehyde dehydrogenase 5 family, member A1

RGD ID:

621422

Description:

Enables NAD binding activity; carboxylic acid binding activity; and succinate-semialdehyde dehydrogenase (NAD+) activity. Involved in succinate metabolic process. Predicted to be located in synapse. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; acetaldehyde.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase); aldehyde dehydrogenase family 5 member A1; aldehyde dehydrogenase family 5, subfamily A1; NAD(+)-dependent succinic semialdehyde dehydrogenase; Ssadh; succinate-semialdehyde dehydrogenase, mitochondrial; succinic semialdehyde dehydrogenase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	40,560,373 - 40,586,711 (+)	NCBI		GRCr8
mRatBN7.2	17	40,132,339 - 40,158,677 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	40,130,883 - 40,158,677 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	40,200,441 - 40,226,804 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	41,804,498 - 41,830,863 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	40,087,826 - 40,114,061 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	42,133,076 - 42,159,413 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	42,133,076 - 42,159,413 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	44,000,875 - 44,027,212 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	47,193,407 - 47,216,499 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	47,196,722 - 47,219,340 (+)	NCBI
Celera	17	39,769,869 - 39,796,199 (+)	NCBI		Celera
Cytogenetic Map	17	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

autism spectrum disorder (ISO)

dystonia (ISO)

epilepsy (ISO,ISS)

fetal akinesia deformation sequence syndrome 1 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Metabolic Brain Diseases (ISO)

Neurologic Manifestations (ISO)

prostate cancer (ISO)

succinic semialdehyde dehydrogenase deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

4-hydroxybutyric acid (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetaldehyde (EXP)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amitrole (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

ATP (ISO)

atrazine (ISO)

beauvericin (ISO)

benomyl (EXP)

benzo[a]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bortezomib (ISO)

Brodifacoum (EXP)

butanal (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clofibrate (EXP)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

cypermethrin (EXP)

decabromodiphenyl ether (EXP)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diiodine (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

enniatin (ISO)

ethanol (ISO)

folic acid (ISO)

gamma-aminobutyric acid (EXP)

genistein (EXP)

glafenine (EXP)

Heliotrine (ISO)

indometacin (EXP)

lead(0) (ISO)

leflunomide (ISO)

mancozeb (EXP)

maneb (EXP,ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

melatonin (ISO)

mercury atom (ISO)

mercury(0) (ISO)

methimazole (EXP)

methylmercury chloride (ISO)

motexafin gadolinium (ISO)

NAD zwitterion (EXP)

NAD(+) (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

Nonylphenol (EXP)

paracetamol (ISO)

paraquat (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

pirinixic acid (EXP)

quercetin (ISO)

rac-lactic acid (ISO)

reactive oxygen species (ISO)

rotenone (EXP)

SB 431542 (ISO)

Senkirkine (ISO)

silicon dioxide (ISO)

sodium arsenite (EXP,ISO)

sodium perchlorate (EXP)

succinic semialdehyde (EXP)

sulfadimethoxine (EXP)

sunitinib (ISO)

superoxide (ISO)

Tesaglitazar (EXP)

tetrachloromethane (EXP,ISO)

tetrahydropalmatine (ISO)

thapsigargin (ISO)

thimerosal (ISO)

thioacetamide (EXP)

triphenyl phosphate (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vancomycin (ISO)

vorinostat (ISO)

XL765 (ISO)

zinc acetate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

central nervous system development (ISO,ISS,TAS)

gamma-aminobutyric acid catabolic process (IBA,IEA,ISO,ISS,TAS)

gamma-aminobutyric acid metabolic process (ISO)

glutamate metabolic process (ISO)

post-embryonic development (ISO)

succinate metabolic process (IDA,ISO)

synaptic transmission, GABAergic (ISO)

Cellular Component

mitochondrion (IBA,IEA,ISO,ISS)

synapse (IEA)

Molecular Function

carboxylic acid binding (IPI)

identical protein binding (ISO)

NAD binding (IDA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (IEA)

succinate-semialdehyde dehydrogenase (NAD+) activity (IBA,IDA,IEA,ISO,ISS)

succinate-semialdehyde dehydrogenase [NAD(P)+] activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

2-hydroxyglutaric aciduria pathway (ISO)

alanine, aspartate and glutamate metabolic pathway (IEA)

butanoate metabolic pathway (IEA)

glutamic acid/glutamate metabolic pathway (ISO)

homocarnosinosis pathway (ISO)

succinic semialdehyde dehydrogenase deficiency pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular cloning of the mature NAD(+)-dependent succinic semialdehyde dehydrogenase from rat and human. cDNA isolation, evolutionary homology, and tissue expression.	Chambliss KL, etal., J Biol Chem 1995 Jan 6;270(1):461-7.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A).	Murphy TC, etal., J Neurochem 2003 Jul;86(2):298-305.
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation.	Nguyen E and Picklo MJ Sr, Biochim Biophys Acta. 2003 Jan 20;1637(1):107-12.
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Kinetic studies with rat-brain succinic-semialdehyde dehydrogenase.	Rivett AJ and Tipton KF, Eur J Biochem. 1981 Jun;117(1):187-93.

Additional References at PubMed

PMID:9683595	PMID:11544478	PMID:12065715	PMID:12067239	PMID:14651853	PMID:15037717	PMID:15262267	PMID:16199352	PMID:16504488	PMID:16647690	PMID:17300923	PMID:17303287
PMID:17854388	PMID:18614015	PMID:18926807	PMID:20833797

Genomics

Comparative Map Data

Aldh5a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	40,560,373 - 40,586,711 (+)	NCBI		GRCr8
mRatBN7.2	17	40,132,339 - 40,158,677 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	40,130,883 - 40,158,677 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	40,200,441 - 40,226,804 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	41,804,498 - 41,830,863 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	40,087,826 - 40,114,061 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	42,133,076 - 42,159,413 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	42,133,076 - 42,159,413 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	44,000,875 - 44,027,212 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	47,193,407 - 47,216,499 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	47,196,722 - 47,219,340 (+)	NCBI
Celera	17	39,769,869 - 39,796,199 (+)	NCBI		Celera
Cytogenetic Map	17	p11	NCBI

ALDH5A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	24,494,969 - 24,537,207 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	24,494,867 - 24,537,207 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	24,495,197 - 24,537,435 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	24,603,176 - 24,645,414 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	24,603,175 - 24,645,414	NCBI
Celera	6	25,728,607 - 25,770,806 (+)	NCBI		Celera
Cytogenetic Map	6	p22.3	NCBI
HuRef	6	24,444,647 - 24,486,850 (+)	NCBI		HuRef
CHM1_1	6	24,499,400 - 24,541,589 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	24,364,950 - 24,407,166 (+)	NCBI		T2T-CHM13v2.0

Aldh5a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	25,091,562 - 25,121,740 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	25,091,562 - 25,121,644 (-)	Ensembl		GRCm39 Ensembl
GRCm39 Ensembl	13	25,089,560 - 25,119,021 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	24,907,579 - 24,937,661 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	24,907,579 - 24,937,661 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	24,999,448 - 25,029,530 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	24,918,497 - 24,945,126 (-)	NCBI		MGSCv36	mm8
Celera	13	25,138,248 - 25,168,330 (-)	NCBI		Celera
Cytogenetic Map	13	A3.1	NCBI
cM Map	13	10.77	NCBI

Aldh5a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955483	2,467,425 - 2,494,416 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955483	2,467,425 - 2,494,416 (-)	NCBI	ChiLan1.0	ChiLan1.0

ALDH5A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	39,145,143 - 39,187,630 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	35,144,631 - 35,187,096 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	24,332,093 - 24,370,764 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	24,665,026 - 24,703,242 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	24,665,026 - 24,705,151 (+)	Ensembl	panpan1.1		panPan2

ALDH5A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	22,560,005 - 22,590,996 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	22,560,008 - 22,587,875 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	22,524,175 - 22,552,036 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	22,678,366 - 22,704,116 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	22,678,366 - 22,713,142 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	22,483,861 - 22,512,841 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	22,532,027 - 22,557,461 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	23,968,214 - 23,996,095 (+)	NCBI		UU_Cfam_GSD_1.0

Aldh5a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	2,755,755 - 2,777,970 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936671	843,577 - 865,881 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936671	843,577 - 865,798 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALDH5A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	19,351,361 - 19,379,098 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	19,351,485 - 19,375,515 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	20,501,722 - 20,526,975 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALDH5A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	47,712,785 - 47,746,198 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	47,709,888 - 47,745,830 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	24,427,783 - 24,464,046 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aldh5a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	2,464,899 - 2,501,130 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624756	2,464,912 - 2,500,773 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Aldh5a1
65 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	239
Count of miRNA genes:	124
Interacting mature miRNAs:	139
Transcripts:	ENSRNOT00000031384, ENSRNOT00000050919
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9991286	40540197	Rat
1354640	Scl32	Serum cholesterol level QTL 32	5.4		blood HDL cholesterol amount (VT:0000184)	blood high density lipoprotein cholesterol level (CMO:0000052)	17	15781592	60781592	Rat
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	23930421	79524188	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	37479847	82479847	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	27389946	53481766	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22454924	50909196	Rat
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	31990784	76990784	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21293039	60781592	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27027949	56836890	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23080567	59555013	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	31368391	62109574	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24184890	79524188	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
2313854	Bp343	Blood pressure QTL 343	3.9		life span trait (VT:0005372)	age at time of death (CMO:0001193)	17	31990784	50909196	Rat
2317054	Aia12	Adjuvant induced arthritis QTL 12	4.24		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	38281509	83281509	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15330613	55836425	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	34550843	73951021	Rat
2317060	Aia26	Adjuvant induced arthritis QTL 26	3.22		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	38281509	83281509	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
4889955	Bss93	Bone structure and strength QTL 93	4.4		tibia size trait (VT:0100001)	tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)	17	27027949	60463643	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	31368391	73951021	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	23930421	79524188	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	31990784	81292925	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	57246843	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			23930421	79524188	Rat
1354659	Scl68	Serum cholesterol level QTL 68	3.9		blood VLDL cholesterol amount (VT:0005144)	blood very low density lipoprotein cholesterol level (CMO:0000648)	17	15781592	60781592	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	23930421	79524188	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	35837085	69599340	Rat

Markers in Region

RH142226

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	40,154,857 - 40,155,011 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	42,155,594 - 42,155,747	NCBI	Rnor6.0
Rnor_5.0	17	44,023,393 - 44,023,546	UniSTS	Rnor5.0
RGSC_v3.4	17	47,216,263 - 47,216,416	UniSTS	RGSC3.4
Celera	17	39,792,380 - 39,792,533	UniSTS
Cytogenetic Map	17	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022851	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM032642	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L34821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000031384 ⟹ ENSRNOP00000035601

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	40,132,355 - 40,158,677 (+)	Ensembl
Rnor_6.0 Ensembl	17	42,133,076 - 42,159,413 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096987 ⟹ ENSRNOP00000078818

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	40,130,883 - 40,158,677 (+)	Ensembl

RefSeq Acc Id:

NM_022851 ⟹ NP_074042

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	40,560,373 - 40,586,711 (+)	NCBI
mRatBN7.2	17	40,132,339 - 40,158,677 (+)	NCBI
Rnor_6.0	17	42,133,076 - 42,159,413 (+)	NCBI
Rnor_5.0	17	44,000,875 - 44,027,212 (+)	NCBI
Celera	17	39,769,869 - 39,796,199 (+)	NCBI

Sequence:

show sequence

CCGCTGCTGCCGGGCCATGGCGACCTGCTTTCTGCTGCGGAACTTCTGCGCCGCGCGTCCCGCG
CTGCGGCCTCCGGGCCGACTCCTCCGGGAGCCCGCAGGGGCCCAGCGGCGCAGCTACGTCGGCG
GCCCGGCTGACCTCCACGCCGACCTGCTCCGCGGGGACAGCTTTGTGGGCGGCCGCTGGCTTCC
AACCCCTGCCACCTTCCCTGTGTATGACCCGGCCAGCGGCGCCAAGCTGGGCACCGTGGCCGAC
TGCGGGGTACCGGAGGCCCGCGCTGCTGTGCGCGCCGCCTACGATGCCTTCAGCAGCTGGAAAG
AGATCTCGGTCAAGGAGAGGAGCTCATTGCTCCGTAAATGGTACGACTTAATGATACAAAACAA
GGACGAGCTTGCCAAGATCATAACAGCTGAGAGTGGAAAGCCACTGAAAGAGGCCCAGGGAGAG
ATCCTGTATTCAGCGTTTTTCCTGGAGTGGTTCTCAGAGGAAGCTCGCCGTGTTTATGGAGACA
TCATCTATACCTCTGCCAAAGATAAGCGAGGACTGGTCCTCAAGCAGCCCGTTGGTGTGGCGTC
CATCATCACACCGTGGAATTTTCCCAGTGCCATGATCACCCGGAAAGTGGGGGCTGCCCTGGCA
GCTGGCTGCACTGTGGTGGTAAAACCTGCTGAAGATACACCCTATTCTGCCCTGGCCCTGGCTC
AGCTTGCAAACCAGGCAGGAATCCCTCCAGGTGTCTATAATGTCATTCCCTGCTCTAGAACCAA
GGCCAAGGAAGTGGGAGAGGTGCTGTGTACTGATCCCCTCGTGTCCAAAATCTCCTTTACTGGC
TCAACGGCAACGGGAAAGATCCTGCTGCATCATGCAGCAAATTCTGTGAAGCGTGTCTCCATGG
AGCTGGGTGGCCTCGCCCCATTCATTGTCTTTGACAGTGCCAACGTGGACCAGGCTGTCGCAGG
AGCAATGGCATCTAAATTTAGGAATGCTGGGCAGACTTGCGTTTGCTCAAACAGATTCTTGGTA
CAACGGGGTATCCACGATTCCTTTGTAACGAAGTTTGCAGAAGCGATGAAGAAAAGCCTGCGTG
TAGGTAACGGATTTGAGGAAGGAACAACTCAAGGGCCATTAATTAATGAGAAAGCTGTAGAAAA
GGTAGAGAAGCATGTGAATGACGCAGTTGCCAAAGGGGCCACGGTTGTGACAGGCGGGAAGCGA
CACCAGAGCGGAGGGAATTTCTTCGAACCCACCCTGCTCAGCAACGTCACCAGGGACATGCTCT
GCATCACCGAGGAGACCTTTGGGCCGCTGGCGCCAGTCATCAAGTTCGATAAAGAGGAAGAGGC
TGTCGCCATCGCAAATGCAGCTGATGTTGGATTGGCAGGTTACTTTTACTCTCAAGACCCAGCC
CAGATCTGGAGAGTGGCGGAGCAGCTGGAGGTGGGCATGGTTGGCGTGAACGAAGGACTGATCT
CTTCAGTGGAGTGCCCTTTTGGTGGGGTGAAACAGTCCGGCCTTGGGCGAGAAGGGTCCAAGTA
TGGCATTGACGAATATCTAGAGGTCAAATATGTGTGTTATGGAGGCTTGTAGGGTTCTCACTTC
TTTAATAAATTACCTAGATCCATAGGGACATTCCATCCATTTTTTTACAATGAACAAGTAGGTT
ATCAGAGTTATGAATTTTTAAAAATTCAGCCGGTCCTGTCTTAGATGTACACCCTAACCCTTCC
CTTATCTAACTAGGGACCAATGGACACCATATACCTGTGGCTGTGGGTCCCAGCCAGTGCTGAG
ACCCCAGCACAACCCCACTGCCTCCAGACAAAGTACAGTGTGAGTGTTCACATGCCCTCTGGCA
CCTCACGAAGTGTAGTCACTGTGTGGGCAGTGGGTCCGCCCAGGCCTGTCAGCTTTGAGGAACA
GCTGGCTGCCTGTCCGGGGGTTGGGGTGGGGATGGAGGTGGGGGCGTTGGTTGGCAAAGGCTTT
GGTTTCCTAAGACTTCTTTCTAAACCTCACAGATTGCCTGCACTATATGGAATGAAGGGGTGTT
TCTCCTTGTTTCTGGGCTGCTGTTTATTACTGGGAGCAGGGTTATTTTGGGTTTTTTGTTTTGT
TTTTGCTTTCTTTGGTTCATCCTGGTTTGGTTTGACTTTATCCGACAGGGTCTTGCTAAGTAGC
CTACCTGGCTTCAGACTCACAGGTCTCCTGTTTCAGCCTCCGAAGGGTTAGGGTCACAGGCATG
CTCTCCTACAGCTGGGTAAAGGAAGTCTCTATTGCCCTAAACTTACAGCTCATGTTTAATTTTG
TTCCTCTTAGAAAATCAACCCAAACTGGGGGCAAAAATCAGCAGAGTCGGGTTGGTAGGACAGA
CAACATGGCTTTTGTGTCTTTTCCAGTGCTTGGTGTTGGATCCATGGCCTTGTCATACCAGCAT
GTGTTCTACCACCGAACTATCCCTAGCTTTTTTTCTTTCTTTCCTTTTAATTTTTGAGACAGAG
TCTTGATAAGTTGCACTGGCTGGCCTTGAGCTGCTTGGTCTCAGTAGCCTACGTAGCTGGGGAG
ACAGGCCTGCATTGCTGGCCAGGCCAGTGGAGAGTCTCAACTGCCGCCTGCTGTCTTGGGCATG
CTCTTTAGGGCACCATGGTCCCACTTACAGAGATTCATGCTTGGCTTAAAGGACAGTGTGGGCC
TGGAAGAAAAAATTGCTTTACAAAATGGTGGAAATGCAGCTCAAGTACAGGAACCATTTTCGAT
GACCACCCTGCCCCTCCTTGAGCTCAGGAGGTGACTTCGTGGAGGAAAGAAACCAGGCACCTAG
TTGCTCACCTGCCTAAGTCTGACCCAGGTTTTCTGTATCTGGGTGTGGCTGCTGCTAAACTTGC
AGAAGAGCAAATACACTTTACTGCTATGAAAAAAGTTATTCCCACCATGGCCAGTCTGCTGTGG
AAGAGAGCTGAAGCCATGAATCTCAGGCACCTTTGCCCTAAGTAAAGCGTTTATGGTTCATGAT
TCAAAAACAAAGCACCACACAGGGACCTGCAAGATAACTTGGGTAAGGCTTTGCTGGACAAGCC
TGGTGACCTGAGACCTGAGTTCTATCCCTGGAACCTACAGAAAGACAGAGAACCAACATGACAG
TGTTGACCTCTGACCTCCACAAATGCATCAGAGCATTCACCACACACACACACACCCCAAAATT
CCCTGCAACTGGTGTTGGTCTTGCTTTGAAACAGTTTAAGTGAGGGAGAGCCTATGTTCTTGTA
GGCATGCCTCCCATCTACCTAGAAGCTATTTATTCCCAACAGGCAACGATGAAGCTCCCTGCTC
CCTCCCCCTCTCTGTGCAGAGAGCCCACTGGCACACTCTGTGGATGCTCTGTAACACATCAACG
GGAATGACAGTAGCACTAGCTGCAGTGGTTCCTAAACACTAAGCCCCATGCCACTGGGAATGTT
GAATGAGGAAGTCATGATTCTTAAAATCTCTGTGCACAAGAAGAAAGTAGAAATCTGCCTCCTA
GGGACCCCGCCCAAATGGCAAGGGTCACAACTCAGGATGCTCATAGTCTGTTTATGCCATTCTT
TTGTATAGTGTGTATAGTCGGTTTCTATTACATTTTCTAATTTAAATTTTAATTTTTTTATGGA
CGTGGGTGTTTTGCCTACATGTATATCTGTGCACCACATGTATGCTGGTGCCCTCAAGAGGCCA
GAAAGGGGCATCAGAACACCTAGAAATAGAGTTACAGATGATTGTAAGCCGCCTTGTGGGTTCT
GGGAATCGACCCCTGGCCCTCTGAAAATAAGCATTTTTCTGAAAATAAGCATTTTTCTGAAAAT
AAGCATTTTTCTGAAAATGAGCCTTCTTGACAGCCCGACATTTCTAATTTCTTAATAATTGTGC
CATCTTTTTTTTTTAATTAAAAATACAAAATGTTCTGCTGGTTATTTTGTAGAAAATGAATACA
CCCACTGAGATGTGAATTCCTTTCAAATATACTTTAAACTGTGTCAACCAGTGGGTTCCCGGAC
TGTGTGGCAAGTTTGTACTTTTTGTGTGTGCATGTTTGATTCACTGGGTAGATCGCCGGCCCAT
ACATTTGTTACAATAAGTGTAATCAATTTCTGTAATTAAAACAAGGTGGGGGGCTATTGGTGGT
GAAGTATATACTTAGCACACTGGAGACCATGGAATTAATCATCACCAAAGAGTGAACATTGGGA
TTTTATATTGTTTTTAAACACGATCTCCTGTTGGCCTTAAATTCTGGGCTCAAATGATCCTTAG
TTCGCCAAATATCTATAACTATAGGCATGTTGTCACCAAGTCAACTAAGTAGATTTATTATTTT
TAGGGGTTTTTGAGTCTGGGTCTCATGTAGTTGGGGCTCACCTTGGAACTCTCCTGCCCCTACT
TCCTGTACTGGAACTACCACACCTAACTAAGGAGTGTTTGCTGGTGAATCTCTGTTGCTGTTCC
TTAAGATATGTGACAGATGGGAGTTTTGAAGCTGTCTATACAGGCATGCAAGGACAAGGGCTAA
TGACCCACAACCTGTGAGTCAGATCTGACCTGCCACCTGATTTTGTCTAACTTGGGACTTTAGT
TTGTTTTTTTTTTAATCTATTCAAATGGATTGGGGTGGGTGACAACTGTTATTTCATGAAACCT
GTGGATGACCACAGCCACAGTGCCCTGTGCCTGAGTGGCTGTGGTGTGACAGTATGGCCTGCAG
AGCCTAAAGGATTAACTGCAAAGCTGCTAAAAAAAAGGTTTACAGCCCCTCACCTAGATCAAGC
CGGAGACACTGGCCTTCTCCCGGCCCCCACCCCACCCCACCCCCGTGTTTATGAGTCATCATTT
TATCCTATTAAACACCCTCTGTGAAAACTGCACATTTTCTGGGCATTGGTTAGCAGGACTTCTT
GGCAGTAATTATCAACTCAAATGACATAAGCCTGATAGTCATGTCTCCCAGGTAGTGGGGCTCA
CTGAAGTACCAGAGTTCGTCTGTTTTTCCATCTGAGGGACCTTGAAGCAGGGCCTCGTAGCAAG
TGATTCTTCTTTCTCTATCTTTGTTCTTCAGGACTGGGGGGGAGGGGTGTAGGAGAATAAAGAT
CAGACGCACAATGTAAGCAAGCCTATTCTGTGATGTAACAACCTTCAAATGGGGTCCCATGGGT
TGTCCTCTCTGAAGGCCAGATCCCAGTGTTTATTACCCCTGTGCACCTATTTTAACACACAACT
TTACTTGAATACTTAATACTGTGACTGTTCTATGCCATACTTTGTGAGACAAATTTCATGAGTT
GTTGAGAAATATATTTTGCTCTATCAACATGTATTGCTTCGTTTTTCTAGTGTTTGACATTGTG
TGATCAACAGAGTTGAATCTCAATAAATGTTTAACAGGATTTCTTATTCCTGTGTGAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_074042	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA67058	(Get FASTA)	NCBI Sequence Viewer
	EDL86492	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000035601.4
	ENSRNOP00000078818.1
	ENSRNOP00000108778
GenBank Protein	P51650	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_074042 ⟸ NM_022851
- Peptide Label:	precursor
- UniProtKB:	P51650 (UniProtKB/Swiss-Prot), A6KLE7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MATCFLLRNFCAARPALRPPGRLLREPAGAQRRSYVGGPADLHADLLRGDSFVGGRWLPTPATF PVYDPASGAKLGTVADCGVPEARAAVRAAYDAFSSWKEISVKERSSLLRKWYDLMIQNKDELAK IITAESGKPLKEAQGEILYSAFFLEWFSEEARRVYGDIIYTSAKDKRGLVLKQPVGVASIITPW NFPSAMITRKVGAALAAGCTVVVKPAEDTPYSALALAQLANQAGIPPGVYNVIPCSRTKAKEVG EVLCTDPLVSKISFTGSTATGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASK FRNAGQTCVCSNRFLVQRGIHDSFVTKFAEAMKKSLRVGNGFEEGTTQGPLINEKAVEKVEKHV NDAVAKGATVVTGGKRHQSGGNFFEPTLLSNVTRDMLCITEETFGPLAPVIKFDKEEEAVAIAN AADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEY LEVKYVCYGGL hide sequence

Ensembl Acc Id:

ENSRNOP00000035601 ⟸ ENSRNOT00000031384

Ensembl Acc Id:

ENSRNOP00000078818 ⟸ ENSRNOT00000096987

Protein Domains

Aldehyde dehydrogenase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P51650-F1-model_v2	AlphaFold	P51650	1-523	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700441

Promoter ID:

EPDNEW_R10964

Type:

initiation region

Name:

Aldh5a1_1

Description:

aldehyde dehydrogenase 5 family, member A1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	42,133,066 - 42,133,126	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621422	AgrOrtholog
BioCyc Gene	G2FUF-9426	BioCyc
BioCyc Pathway	GLUDEG-I-PWY [GABA shunt]	BioCyc
	PWY-6535 [4-aminobutanoate degradation I]	BioCyc
BioCyc Pathway Image	GLUDEG-I-PWY	BioCyc
	PWY-6535	BioCyc
Ensembl Genes	ENSRNOG00000023538	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000031384.6	UniProtKB/TrEMBL
	ENSRNOT00000096987.1	UniProtKB/TrEMBL
	ENSRNOT00000134364	ENTREZGENE
Gene3D-CATH	Aldehyde Dehydrogenase, Chain A, domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldehyde Dehydrogenase, Chain A, domain 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Ald_DH/histidinol_DH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_CS_CYS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_CS_GLU	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldehyde_DH_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldehyde_DH_Superfamily	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Succ_semiAld_DH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:291133	UniProtKB/TrEMBL
NCBI Gene	Aldh5a1	ENTREZGENE
PANTHER	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL	UniProtKB/Swiss-Prot
	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL	UniProtKB/Swiss-Prot
	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL	UniProtKB/TrEMBL
	SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	Aldedh	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Aldh5a1	PhenoGen
PROSITE	ALDEHYDE_DEHYDR_CYS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALDEHYDE_DEHYDR_GLU	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000023538	RatGTEx
Superfamily-SCOP	SSF53720	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZLJ2_RAT	UniProtKB/TrEMBL
	A6KLE7	ENTREZGENE, UniProtKB/TrEMBL
	G3V945_RAT	UniProtKB/TrEMBL
	P51650	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-26	Aldh5a1	aldehyde dehydrogenase 5 family, member A1	Aldh5a1	aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-19	Aldh5a1	aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)	Aldh5a1	aldehyde dehydrogenase family 5, subfamily A1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Aldh5a1	aldehyde dehydrogenase family 5, subfamily A1			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Aldh5a1				Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_function	oxidizing enzyme for 4-hydroxy-trans-2-nonenal (HNE), a neurotoxic aldehyde in the CNS creating a non-toxic metabolite	1304407
gene_homology	shares 83 and 91% identity to human in nucleotide and protein sequence, respectively	632258
gene_product	belongs to the aldehyde dehydrogenase superfamily	632258
gene_protein	488 amino acids	632258

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways