GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621422
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh5a1
Name: aldehyde dehydrogenase 5 family, member A1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7352456480464CTDBenzo(a)pyrene results in decreased expression of ALDH5A1 mRNA

PMID:20064835, PMID:21632981
increases expressionISORGD:16238216480464CTDBenzo(a)pyrene results in increased expression of ALDH5A1 mRNA

PMID:20127859, PMID:22228805
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.