ALDH5A1 (aldehyde dehydrogenase 5 family member A1) - Rat Genome Database
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Gene: ALDH5A1 (aldehyde dehydrogenase 5 family member A1) Canis lupus familiaris
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Symbol: ALDH5A1
Name: aldehyde dehydrogenase 5 family member A1
RGD ID: 12358831
Description: ENCODES a protein that exhibits carboxylic acid binding (ortholog); NAD binding (ortholog); succinate-semialdehyde dehydrogenase (NAD+) activity (ortholog); INVOLVED IN gamma-aminobutyric acid catabolic process (ortholog); gamma-aminobutyric acid metabolic process (ortholog); glutamate metabolic process (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; ASSOCIATED WITH Animal Disease Models (ortholog); dystonia (ortholog); epilepsy (ortholog); FOUND IN mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase); succinate-semialdehyde dehydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3522,560,008 - 22,587,875 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13522,560,005 - 22,590,996 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrion  (IEA,ISO)

Molecular Function

References

Genomics

Comparative Map Data
ALDH5A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3522,560,008 - 22,587,875 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13522,560,005 - 22,590,996 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ALDH5A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl624,494,867 - 24,537,207 (+)EnsemblGRCh38hg38GRCh38
GRCh38624,494,969 - 24,537,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37624,495,197 - 24,537,435 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36624,603,176 - 24,645,414 (+)NCBINCBI36hg18NCBI36
Build 34624,603,175 - 24,645,414NCBI
Celera625,728,607 - 25,770,806 (+)NCBI
Cytogenetic Map6p22.3NCBI
HuRef624,444,647 - 24,486,850 (+)NCBIHuRef
CHM1_1624,499,400 - 24,541,589 (+)NCBICHM1_1
Aldh5a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391325,091,562 - 25,121,740 (-)NCBIGRCm39mm39
GRCm381324,907,579 - 24,937,661 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1324,907,579 - 24,937,661 (-)EnsemblGRCm38mm10GRCm38
MGSCv371324,999,448 - 25,029,530 (-)NCBIGRCm37mm9NCBIm37
MGSCv361324,918,497 - 24,945,126 (-)NCBImm8
Celera1325,138,248 - 25,168,330 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1310.77NCBI
Aldh5a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21740,132,339 - 40,158,677 (+)NCBI
Rnor_6.0 Ensembl1742,133,076 - 42,159,413 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01742,133,076 - 42,159,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01744,000,875 - 44,027,212 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41747,193,407 - 47,216,499 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11747,196,722 - 47,219,340 (+)NCBI
Celera1739,769,869 - 39,796,199 (+)NCBICelera
Cytogenetic Map17p11NCBI
Aldh5a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554832,467,425 - 2,494,416 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554832,467,425 - 2,494,416 (-)NCBIChiLan1.0ChiLan1.0
ALDH5A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1624,665,026 - 24,703,242 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl624,665,026 - 24,705,151 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0624,332,093 - 24,370,764 (+)NCBIMhudiblu_PPA_v0panPan3
Aldh5a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936671843,577 - 865,798 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH5A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl719,351,361 - 19,379,100 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1719,351,485 - 19,375,515 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2720,501,722 - 20,526,975 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH5A1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11747,712,785 - 47,746,198 (-)NCBI
ChlSab1.1 Ensembl1747,709,888 - 47,745,830 (-)Ensembl
Aldh5a1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247562,464,912 - 2,500,773 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 21 6 6 5 6 12 10 6
Low 1 6 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000016493   ⟹   ENSCAFP00000015258
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3522,560,008 - 22,587,875 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000059785   ⟹   ENSCAFP00000062405
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3522,560,763 - 22,582,172 (+)Ensembl
RefSeq Acc Id: XM_014110599   ⟹   XP_013966074
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13522,560,005 - 22,590,996 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014110600   ⟹   XP_013966075
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13522,560,005 - 22,586,260 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013966074   ⟸   XM_014110599
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013966075   ⟸   XM_014110600
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000062405   ⟸   ENSCAFT00000059785
RefSeq Acc Id: ENSCAFP00000015258   ⟸   ENSCAFT00000016493
Protein Domains
Aldedh


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010366 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000015258 UniProtKB/TrEMBL
  ENSCAFP00000062405 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016493 UniProtKB/TrEMBL
  ENSCAFT00000059785 UniProtKB/TrEMBL
Gene3D-CATH 3.40.309.10 UniProtKB/TrEMBL
  3.40.605.10 UniProtKB/TrEMBL
InterPro Ald_DH/histidinol_DH UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/TrEMBL
  Succ_semiAld_DH UniProtKB/TrEMBL
NCBI Gene ALDH5A1 ENTREZGENE
Pfam Aldedh UniProtKB/TrEMBL
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/TrEMBL
Superfamily-SCOP SSF53720 UniProtKB/TrEMBL
TIGRFAMs SSADH UniProtKB/TrEMBL
UniProt A0A5F4DC41_CANLF UniProtKB/TrEMBL
  F1PP35_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:37787 ENTREZGENE