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Gene: Agtr1a (angiotensin II receptor, type 1a) Rattus norvegicus
Symbol: Agtr1a
Name: angiotensin II receptor, type 1a
Description: Exhibits D1 dopamine receptor binding activity; angiotensin type I receptor activity; and protein kinase binding activity. Involved in several processes, including positive regulation of cellular metabolic process; regulation of blood pressure; and response to glucocorticoid. Localizes to several cellular components, including basolateral plasma membrane; organelle outer membrane; and recycling endosome. Used to study several diseases, including asthma; chronic kidney disease; congestive heart failure; hypertension (multiple); and proteinuria. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); glomerulosclerosis (multiple); hyperinsulinism; and placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; angiotensin III signaling pathway via AT1 receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; INTERACTS WITH (R)-lipoic acid; (S)-nicotine; 1-naphthyl isothiocyanate.
Type: protein-coding
Also known as: Agtr1; Angiotensin II receptor type 1 (AT1A); angiotensin II receptor, type 1; Angiotensin II receptor, type 1 (AT1A); angiotensin II type-1A receptor; angiotensin receptor 1a; AT1; AT1A; AT1R; type-1A angiotensin II receptor; vascular type-1 angiotensin II receptor
Homo sapiens (human) : AGTR1 (angiotensin II receptor type 1)  HGNC  Alliance
Mus musculus (house mouse) : Agtr1a (angiotensin II receptor, type 1a)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Agtr1 (angiotensin II receptor type 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AGTR1 (angiotensin II receptor type 1)
Canis lupus familiaris (dog) : AGTR1 (angiotensin II receptor type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Agtr1 (angiotensin II receptor type 1)
Sus scrofa (pig) : AGTR1 (angiotensin II receptor type 1)
Chlorocebus sabaeus (African green monkey) : AGTR1 (angiotensin II receptor type 1)
Heterocephalus glaber (naked mole-rat) : Agtr1 (angiotensin II receptor type 1)
more info ...
Allele / Splice: Agtr1aem5Mcwi   Agtr1aem1Mcwi  
Genetic Models: SS-Agtr1aem1Mcwi SS-Agtr1aem5Mcwi
Is Marker For: QTLs:   Bp343  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01735,907,102 - 35,958,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01737,217,810 - 37,270,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,629,318 - 40,684,982 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11740,632,160 - 40,687,823 (-)NCBI
Celera1733,705,975 - 33,757,157 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Protein Structures

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Agtr1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2070
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.