Agtr1a (angiotensin II receptor, type 1a) - Rat Genome Database

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Gene: Agtr1a (angiotensin II receptor, type 1a) Rattus norvegicus
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Symbol: Agtr1a
Name: angiotensin II receptor, type 1a
RGD ID: 2070
Description: Exhibits D1 dopamine receptor binding activity; angiotensin type I receptor activity; and protein kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of cellular metabolic process; and response to glucocorticoid. Localizes to several cellular components, including basolateral plasma membrane; organelle outer membrane; and recycling endosome. Used to study several diseases, including asthma; chronic kidney disease; congestive heart failure; hypertension (multiple); and proteinuria. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); glomerulosclerosis (multiple); hyperinsulinism; and placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; angiotensin III signaling pathway via AT1 receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Agtr1; Angiotensin II receptor type 1 (AT1A); angiotensin II receptor, type 1; Angiotensin II receptor, type 1 (AT1A); angiotensin II type-1A receptor; angiotensin receptor 1a; AT1; AT1A; AT1R; type-1A angiotensin II receptor; vascular type-1 angiotensin II receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Agtr1aem5Mcwi   Agtr1aem1Mcwi  
Genetic Models: SS-Agtr1aem1Mcwi SS-Agtr1aem5Mcwi
Is Marker For: QTLs:   Bp343  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21734,173,446 - 34,226,892 (-)NCBI
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01735,907,102 - 35,958,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01737,217,810 - 37,270,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,629,318 - 40,684,982 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11740,632,160 - 40,687,823 (-)NCBI
Celera1733,705,975 - 33,757,157 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
AIDS-Associated Nephropathy  (ISO)
Allanson Pantzar McLeod Syndrome  (ISO)
Alzheimer's disease  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
asthma  (IMP,ISO)
atrial fibrillation  (ISO)
breast cancer  (ISO)
breast lobular carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IEP,IMP,ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (IEP)
cerebrovascular disease  (ISO)
chronic kidney disease  (IMP,ISO)
congestive heart failure  (IMP,ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (IMP,ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (IEP,IMP)
Ductal Carcinoma  (ISO)
essential hypertension  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fetal Growth Retardation  (IEP)
Fibrosis  (IMP,ISO)
focal segmental glomerulosclerosis  (IEP)
glomerulosclerosis  (IEP)
glucose intolerance  (ISO)
Huntington's disease  (ISO)
hyperinsulinism  (IEP)
hypertension  (IEP,IMP,ISO)
Hypertensive Nephropathy  (IMP)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
Limb Ischemia  (ISO)
lung disease  (ISO)
Mammary Neoplasms, Experimental  (IEP,ISO)
Metabolic Syndrome  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Reperfusion Injury  (IEP)
Neoplasm Metastasis  (ISO)
nephritis  (IMP)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
patent ductus arteriosus  (ISO)
Pituitary Neoplasms  (ISO)
placental insufficiency  (IEP)
Postoperative Cognitive Dysfunction  (IEP)
proteinuria  (IMP,ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries, Experimental  (IMP)
renal cell carcinoma  (ISO)
renal hypertension  (IEP)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (IEP,IMP)
sarcoidosis  (ISO)
Spontaneous Abortions  (ISO)
Vascular System Injuries  (ISO)
Ventricular Remodeling  (IEP)
vesicoureteral reflux  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amlodipine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
aspartame  (ISO)
ATP  (EXP)
benazepril  (EXP,ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
butanal  (ISO)
caffeine  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP)
capsaicin  (EXP)
captopril  (EXP,ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
cilazapril monohydrate  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
corticosterone  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
diisononyl phthalate  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
doxorubicin  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
edaravone  (EXP)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (EXP)
esculetin  (EXP)
estriol  (ISO)
ethanol  (EXP)
flavonoids  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (EXP)
Heptachlor epoxide  (ISO)
hexachlorobenzene  (EXP)
hydrochlorothiazide  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
irbesartan  (ISO)
isoprenaline  (ISO)
isotretinoin  (EXP)
L-ethionine  (EXP)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
losartan  (EXP,ISO)
Magnolol  (EXP)
mangiferin  (EXP)
mechlorethamine  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
mevinphos  (EXP)
mifepristone  (EXP)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
Nandrolone decanoate  (EXP)
nerolidol  (EXP)
nickel atom  (ISO)
nicotinamide  (EXP)
nicotine  (EXP)
nitrendipine  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
olmesartan  (ISO)
omeprazole  (EXP)
ouabain  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
perindopril  (EXP,ISO)
phenylarsine oxide  (EXP)
picrotoxin  (EXP)
pioglitazone  (ISO)
pirfenidone  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregabalin  (EXP)
propanal  (ISO)
Ptaquiloside  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
spironolactone  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP)
superoxide  (EXP)
telmisartan  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
tributylstannane  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triphenylstannane  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vinclozolin  (EXP)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (IMP)
aging  (IEP)
angiotensin-activated signaling pathway  (IMP,ISO)
blood vessel development  (ISO)
brain renin-angiotensin system  (ISO)
calcium-mediated signaling  (ISO)
cell chemotaxis  (ISO)
cellular response to dexamethasone stimulus  (IDA)
dopamine biosynthetic process  (IMP)
drinking behavior  (IMP,ISO)
G protein-coupled receptor signaling pathway  (IBA,IMP,ISO)
heart development  (ISO)
inflammatory response  (IBA,ISO)
kidney development  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
phospholipase C-activating angiotensin-activated signaling pathway  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IDA)
positive regulation of blood pressure  (IMP,ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IMP)
positive regulation of calcium ion import across plasma membrane  (IMP)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of cellular protein metabolic process  (ISO)
positive regulation of cholesterol esterification  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (IBA,ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (ISO)
positive regulation of phospholipase A2 activity  (ISO)
positive regulation of receptor recycling  (IDA)
positive regulation of superoxide anion generation  (IMP)
regulation of pH  (IDA)
regulation of renal output by angiotensin  (ISO)
regulation of smooth muscle cell apoptotic process  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of vasoconstriction  (ISO)
renin secretion into blood stream  (ISO)
renin-angiotensin regulation of aldosterone production  (IMP,ISO)
response to activity  (IEP)
response to angiotensin  (IEP)
response to corticosterone  (IEP)
response to estrogen  (IDA,IEP)
response to salt stress  (IEP)
Rho protein signal transduction  (ISO)
vasoconstriction  (IMP)
viral entry into host cell  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
angiotensin II signaling pathway  (TAS)
angiotensin II signaling pathway via AT1 receptor  (IDA,IMP,TAS)
angiotensin III signaling pathway  (TAS)
angiotensin III signaling pathway via AT1 receptor  (IMP)
atenolol pharmacodynamics pathway  (ISO)
benazepril pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
candesartan pharmacodynamics pathway  (ISO)
captopril pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
cilazapril pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
enalapril pharmacodynamics pathway  (ISO)
eprosartan pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
forasartsn pharmacodynamics pathway  (ISO)
fosinopril pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galpha12/Galpha13 family  (IMP)
G protein mediated signaling pathway via Galphaq family  (IMP)
ibutilide pharmacodynamics pathway  (ISO)
irbesartan pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lisinopril pharmacodynamics pathway  (ISO)
losartan pharmacodynamics pathway  (ISO,TAS)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
moexipril pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
olmesartan pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
perindopril pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinapril pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
ramipril pharmacodynamics pathway  (ISO)
renin-angiotensin cascade pathway  (IEA,TAS)
sotalol pharmacodynamics pathway  (ISO)
spirapril pharmacodynamics pathway  (ISO)
telmisartan pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
trandolapril pharmacodynamics pathway  (ISO)
valsartan pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

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82. Pipeline to import SMPDB annotations from SMPDB into RGD
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Additional References at PubMed
PMID:1378723   PMID:1544458   PMID:1567413   PMID:1599457   PMID:2041570   PMID:7622467   PMID:7713098   PMID:9310306   PMID:9466969   PMID:9691085   PMID:10880053   PMID:10993080  
PMID:11833541   PMID:12167595   PMID:12203396   PMID:12486173   PMID:12657564   PMID:12887132   PMID:12931036   PMID:14517903   PMID:14596846   PMID:14687660   PMID:14718562   PMID:14985364  
PMID:15007027   PMID:15117835   PMID:15126250   PMID:15161553   PMID:15213263   PMID:15252015   PMID:15489334   PMID:15499027   PMID:15509535   PMID:15539403   PMID:15539634   PMID:15578192  
PMID:15582714   PMID:15611106   PMID:15613739   PMID:15635042   PMID:15680918   PMID:15692220   PMID:15705782   PMID:15879490   PMID:15944340   PMID:16116425   PMID:16213531   PMID:16343550  
PMID:16516913   PMID:16556732   PMID:16566904   PMID:16580689   PMID:16585392   PMID:16618838   PMID:16728497   PMID:16774988   PMID:16780972   PMID:16822558   PMID:16919293   PMID:16934905  
PMID:16962210   PMID:16980435   PMID:17010318   PMID:17033091   PMID:17069818   PMID:17082724   PMID:17177883   PMID:17206447   PMID:17218415   PMID:17237618   PMID:17278880   PMID:17440033  
PMID:17449550   PMID:17496209   PMID:17498700   PMID:17525253   PMID:17540701   PMID:17587757   PMID:17644087   PMID:17646572   PMID:17710629   PMID:17716866   PMID:17761193   PMID:17855497  
PMID:17873013   PMID:17891894   PMID:17903697   PMID:18028779   PMID:18205095   PMID:18208547   PMID:18256274   PMID:18372229   PMID:18398343   PMID:18400212   PMID:18403896   PMID:18408131  
PMID:18420589   PMID:18420994   PMID:18469441   PMID:18497328   PMID:18498681   PMID:18505723   PMID:18515110   PMID:18536757   PMID:18603328   PMID:18609298   PMID:18614617   PMID:18701624  
PMID:18711010   PMID:18725581   PMID:18768402   PMID:18779436   PMID:18789946   PMID:18793415   PMID:18852381   PMID:18927221   PMID:18931023   PMID:18957383   PMID:18957817   PMID:18971559  
PMID:18976642   PMID:19012043   PMID:19017652   PMID:19120129   PMID:19124682   PMID:19126659   PMID:19172459   PMID:19204403   PMID:19211683   PMID:19225144   PMID:19230969   PMID:19254952  
PMID:19273745   PMID:19280879   PMID:19289825   PMID:19298848   PMID:19353416   PMID:19386725   PMID:19399400   PMID:19404405   PMID:19427376   PMID:19451734   PMID:19457762   PMID:19472100  
PMID:19501631   PMID:19508861   PMID:19560439   PMID:19588183   PMID:19639227   PMID:19647773   PMID:19667250   PMID:19692654   PMID:19704104   PMID:19710393   PMID:19733634   PMID:19766149  
PMID:19835848   PMID:19882719   PMID:19887855   PMID:20026366   PMID:20051229   PMID:20056745   PMID:20093128   PMID:20102360   PMID:20360752   PMID:20423855   PMID:20440098   PMID:20448043  
PMID:20463030   PMID:20606474   PMID:20650893   PMID:20663845   PMID:20735984   PMID:20807796   PMID:20807798   PMID:20850747   PMID:20964730   PMID:21056071   PMID:21084406   PMID:21095238  
PMID:21123758   PMID:21135513   PMID:21166237   PMID:21186577   PMID:21285403   PMID:21319377   PMID:21393361   PMID:21540301   PMID:21657802   PMID:21660462   PMID:21720156   PMID:21825224  
PMID:21841463   PMID:21897104   PMID:22020089   PMID:22038231   PMID:22128836   PMID:22146585   PMID:22180636   PMID:22253423   PMID:22464881   PMID:22498426   PMID:22561449   PMID:22579851  
PMID:22661470   PMID:22753221   PMID:22777104   PMID:22860435   PMID:22936038   PMID:22943692   PMID:22957022   PMID:22982071   PMID:23087139   PMID:23087176   PMID:23089979   PMID:23132538  
PMID:23139413   PMID:23376562   PMID:23475749   PMID:23547238   PMID:23576578   PMID:23611777   PMID:23623871   PMID:23754618   PMID:23783021   PMID:23877628   PMID:23934707   PMID:23988741  
PMID:24033947   PMID:24089683   PMID:24218433   PMID:24262995   PMID:24464860   PMID:24465706   PMID:24529758   PMID:24587998   PMID:24719376   PMID:24819472   PMID:24955935   PMID:25003108  
PMID:25009217   PMID:25081544   PMID:25198883   PMID:25350112   PMID:25365520   PMID:25401104   PMID:25481865   PMID:25542758   PMID:25596947   PMID:25658446   PMID:25766467   PMID:25793389  
PMID:25850724   PMID:26034979   PMID:26195268   PMID:26246427   PMID:26310940   PMID:26342563   PMID:26476634   PMID:26575857   PMID:26637556   PMID:26709040   PMID:27085217   PMID:27163380  
PMID:27319015   PMID:27330080   PMID:27400779   PMID:27531064   PMID:27693081   PMID:27763643   PMID:27818235   PMID:27903510   PMID:27923787   PMID:28161727   PMID:28656283   PMID:28695320  
PMID:28887229   PMID:29061726   PMID:29179208   PMID:29407760   PMID:29923351   PMID:30227249   PMID:30316779   PMID:30803087   PMID:30892911   PMID:31346990   PMID:31433522   PMID:31473996  
PMID:32324784   PMID:32446297   PMID:32674346  


Genomics

Candidate Gene Status
Agtr1a is a candidate Gene for QTL Bp343
Comparative Map Data
Agtr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21734,173,446 - 34,226,892 (-)NCBI
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01735,907,102 - 35,958,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01737,217,810 - 37,270,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,629,318 - 40,684,982 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11740,632,160 - 40,687,823 (-)NCBI
Celera1733,705,975 - 33,757,157 (-)NCBICelera
Cytogenetic Map17p12NCBI
AGTR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3148,697,784 - 148,743,008 (+)EnsemblGRCh38hg38GRCh38
GRCh383148,697,903 - 148,743,003 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373148,415,690 - 148,460,790 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363149,898,348 - 149,943,480 (+)NCBINCBI36hg18NCBI36
Build 343149,940,284 - 149,943,486NCBI
Celera3146,826,000 - 146,871,131 (+)NCBI
Cytogenetic Map3q24NCBI
HuRef3145,788,031 - 145,833,163 (+)NCBIHuRef
CHM1_13148,378,782 - 148,423,918 (+)NCBICHM1_1
Agtr1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391330,520,339 - 30,566,850 (+)NCBIGRCm39mm39
GRCm39 Ensembl1330,520,424 - 30,566,850 (+)Ensembl
GRCm381330,336,356 - 30,382,867 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,336,441 - 30,382,867 (+)EnsemblGRCm38mm10GRCm38
MGSCv371330,428,225 - 30,474,736 (+)NCBIGRCm37mm9NCBIm37
MGSCv361330,343,922 - 30,390,332 (+)NCBImm8
Celera1330,550,710 - 30,597,281 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.19NCBI
Agtr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554748,733,942 - 8,781,255 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554748,733,942 - 8,781,305 (-)NCBIChiLan1.0ChiLan1.0
AGTR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13153,301,331 - 153,346,268 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3153,341,947 - 153,345,380 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03145,722,475 - 145,767,550 (+)NCBIMhudiblu_PPA_v0panPan3
AGTR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12343,569,658 - 43,617,113 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2343,614,035 - 43,616,238 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2343,434,074 - 43,481,582 (+)NCBI
ROS_Cfam_1.02344,190,631 - 44,238,133 (+)NCBI
UMICH_Zoey_3.12343,779,664 - 43,827,179 (+)NCBI
UNSW_CanFamBas_1.02343,832,799 - 43,880,312 (+)NCBI
UU_Cfam_GSD_1.02344,086,806 - 44,134,323 (+)NCBI
Agtr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560282,859,961 - 82,902,941 (+)NCBI
SpeTri2.0NW_0049365196,831,096 - 6,873,977 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGTR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1388,934,868 - 88,983,131 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11388,934,873 - 88,980,317 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21396,933,114 - 96,978,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGTR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11541,957,826 - 42,002,776 (-)NCBI
Vero_WHO_p1.0NW_02366604114,800,710 - 14,845,597 (-)NCBI
Agtr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473025,964,848 - 26,006,468 (+)NCBI

Position Markers
D17Arb4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,225,566 - 34,225,727 (+)MAPPER
mRatBN7.21734,225,481 - 34,225,727 (+)MAPPER
mRatBN7.21734,225,481 - 34,225,872 (+)MAPPER
Rnor_6.01735,956,457 - 35,957,000NCBIRnor6.0
Rnor_6.01735,956,457 - 35,956,698NCBIRnor6.0
Rnor_5.01737,268,920 - 37,269,463UniSTSRnor5.0
Rnor_5.01737,268,920 - 37,269,161UniSTSRnor5.0
RGSC_v3.41740,683,664 - 40,683,905UniSTSRGSC3.4
RGSC_v3.41740,683,663 - 40,683,905RGDRGSC3.4
RGSC_v3.11740,686,504 - 40,686,746RGD
SHRSP x BN Map1726.9699RGD
SHRSP x BN Map1726.9699UniSTS
Cytogenetic Map17q12UniSTS
D17Mco9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,227,036 - 34,227,298 (+)MAPPER
Rnor_6.01735,958,310 - 35,958,571NCBIRnor6.0
Rnor_5.01737,270,773 - 37,271,034UniSTSRnor5.0
RGSC_v3.41740,685,215 - 40,685,476UniSTSRGSC3.4
Celera1733,757,390 - 33,757,651UniSTS
Cytogenetic Map17q12UniSTS
D17Mco8  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01737,271,013 - 37,271,345UniSTSRnor5.0
Celera1733,757,630 - 33,757,962UniSTS
Cytogenetic Map17q12UniSTS
D17Wox34  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,227,276 - 34,227,609 (+)MAPPER
Rnor_6.01735,958,550 - 35,958,882NCBIRnor6.0
Rnor_5.01737,271,013 - 37,271,345UniSTSRnor5.0
RGSC_v3.41740,685,455 - 40,685,787UniSTSRGSC3.4
Celera1733,757,630 - 33,757,962UniSTS
Cytogenetic Map17q12UniSTS
RH94717  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,174,927 - 34,175,204 (+)MAPPER
Rnor_6.01735,907,271 - 35,907,547NCBIRnor6.0
Rnor_5.01737,218,997 - 37,219,273UniSTSRnor5.0
RGSC_v3.41740,629,483 - 40,629,759UniSTSRGSC3.4
Celera1733,706,140 - 33,706,416UniSTS
Cytogenetic Map17q12UniSTS
Agtr1a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,846,542 - 102,846,612 (+)MAPPER
Rnor_6.02105,150,594 - 105,150,663NCBIRnor6.0
Rnor_5.02124,880,836 - 124,880,905UniSTSRnor5.0
RGSC_v3.42105,504,843 - 105,504,912UniSTSRGSC3.4
Celera298,216,100 - 98,216,169UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map17q12UniSTS
RH130649  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,174,980 - 34,175,163 (+)MAPPER
Rnor_6.01735,907,324 - 35,907,506NCBIRnor6.0
Rnor_5.01737,219,050 - 37,219,232UniSTSRnor5.0
RGSC_v3.41740,629,536 - 40,629,718UniSTSRGSC3.4
Celera1733,706,193 - 33,706,375UniSTS
Cytogenetic Map17q12UniSTS
UniSTS:256385  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,175,936 - 34,176,577 (+)MAPPER
mRatBN7.22102,846,237 - 102,846,878 (+)MAPPER
Rnor_6.02105,150,289 - 105,150,929NCBIRnor6.0
Rnor_6.01735,908,280 - 35,908,920NCBIRnor6.0
Rnor_5.01737,220,006 - 37,220,646UniSTSRnor5.0
Rnor_5.02124,880,531 - 124,881,171UniSTSRnor5.0
RGSC_v3.41740,630,492 - 40,631,132UniSTSRGSC3.4
RGSC_v3.42105,504,538 - 105,505,178UniSTSRGSC3.4
Celera298,215,795 - 98,216,435UniSTS
Celera1733,707,149 - 33,707,789UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map17q12UniSTS
Agtr1a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,175,886 - 34,176,577 (+)MAPPER
Rnor_6.01735,908,230 - 35,908,920NCBIRnor6.0
Rnor_5.01737,219,956 - 37,220,646UniSTSRnor5.0
RGSC_v3.41740,630,442 - 40,631,132UniSTSRGSC3.4
Celera1733,707,099 - 33,707,789UniSTS
Cytogenetic Map17q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138243814Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17163676140Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17173413148Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17173413148Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1751977036283402Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17333697237790462Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17333697263676140Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17333697273413148Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17333697273413148Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17333697273413148Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17519104750191047Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17519104750191047Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17982730454827304Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)171052970942542027Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171574375561036897Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171867614063676140Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171867614063676140Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172149095062195822Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172149095066490950Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172149095066490950Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172149095066490950Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172149095066490950Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172149095066490950Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172149095074823273Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172213681453475276Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172277506564946194Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172403061863676140Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172769095938110914Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172769095961794615Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172769095963994435Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172807358956207236Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172841314873413148Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173097522875975228Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173097522875975228Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173205588258468016Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173205588277922655Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173330362753475276Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173330362778303627Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173330362785321557Rat


Genetic Models
This gene Agtr1a is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:89
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000038532
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 47 39 5 39 1 1 35 18 11 1
Low 2 37 10 2 14 2 7 10 70 20 7
Below cutoff 6 4 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000038532   ⟹   ENSRNOP00000034687
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)Ensembl
RefSeq Acc Id: NM_030985   ⟹   NP_112247
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21734,174,763 - 34,226,804 (-)NCBI
Rnor_6.01735,907,106 - 35,958,077 (-)NCBI
Rnor_5.01737,217,810 - 37,270,540 (-)NCBI
RGSC_v3.41740,629,318 - 40,684,982 (-)RGD
Celera1733,705,975 - 33,757,157 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253882   ⟹   XP_006253944
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21734,173,446 - 34,226,647 (-)NCBI
Rnor_6.01735,907,102 - 35,957,940 (-)NCBI
Rnor_5.01737,217,810 - 37,270,540 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771593   ⟹   XP_008769815
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01735,907,102 - 35,957,940 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771594   ⟹   XP_008769816
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21734,173,446 - 34,226,892 (-)NCBI
Rnor_6.01735,907,102 - 35,958,136 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095335   ⟹   XP_038951263
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21734,173,446 - 34,226,892 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_112247   ⟸   NM_030985
- UniProtKB: P25095 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253944   ⟸   XM_006253882
- Peptide Label: isoform X1
- UniProtKB: P25095 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008769816   ⟸   XM_008771594
- Peptide Label: isoform X1
- UniProtKB: P25095 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008769815   ⟸   XM_008771593
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000034687   ⟸   ENSRNOT00000038532
RefSeq Acc Id: XP_038951263   ⟸   XM_039095335
- Peptide Label: isoform X1

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
AT1a I-TASSER model P25095 1-359 view protein structure  

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700428
Promoter ID:EPDNEW_R10952
Type:multiple initiation site
Name:Agtr1a_1
Description:angiotensin II receptor, type 1a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01735,958,089 - 35,958,149EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2070 AgrOrtholog
Ensembl Genes ENSRNOG00000018346 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000034687 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038532 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7126918 IMAGE-MGC_LOAD
InterPro ATII_AT1_rcpt UniProtKB/Swiss-Prot
  ATII_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:24180 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93396 IMAGE-MGC_LOAD
NCBI Gene 24180 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB AGTR1 RGD
PhenoGen Agtr1a PhenoGen
PRINTS ANGIOTENSINR UniProtKB/Swiss-Prot
  ANGIOTENSN1R UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt AGTRA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9QVS5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-04-03 Agtr1a  angiotensin II receptor, type 1a  Agtr1  angiotensin II receptor, type 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Agtr1  angiotensin II receptor, type 1  Agtr1a  angiotensin II receptor, type 1a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Agtr1a  angiotensin II receptor, type 1a  Agtr1a  angiotensin II receptor, type 1 (AT1A)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Agtr1a  angiotensin receptor 1a      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is increased in brain microvessels in SHRSP strain compared with WKY rat strain 1553895
gene_expression expressed in adrenal gland, liver and kidney 1298647
gene_function receptor for angiotensin II 68888
gene_function receptor for angiotensin II 69670
gene_process activation induces cell contraction, proliferation and migration in vascular smooth muscle cells (VSMCs) 68888
gene_process activation induces cell contraction, proliferation and migration in vascular smooth muscle cells (VSMCs) 69670
gene_process functions to regulate aldosterone secretion and to control blood pressure and cardiac volume 68888
gene_process functions to regulate aldosterone secretion and to control blood pressure and cardiac volume 69670
gene_process may be involved in regulating myocardial efficiency and ischemic contracture 1298607
gene_process couples to intracellular Ca2+ signaling with vasoconstricting effects on glomerular arterioles 1298648
gene_regulation repressed by peroxisome proliferator activated receptor gamma (Pparg) through inhibition of Sp1 via a protein-protein interaction 69670
gene_regulation activation in vascular smooth muscle cells (VSMCs) is mainly through several signaling transduction pathways, including tyrosine kinases and mitogen activated protein kinase 69670
gene_regulation transcription may be regulated by sodium in adrenal tissue 1298647
gene_regulation expression may be developmentally regulated 1298647