Agtr1a (angiotensin II receptor, type 1a) - Rat Genome Database

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Gene: Agtr1a (angiotensin II receptor, type 1a) Rattus norvegicus
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Symbol: Agtr1a
Name: angiotensin II receptor, type 1a
RGD ID: 2070
Description: Enables D1 dopamine receptor binding activity; angiotensin type I receptor activity; and protein kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of blood pressure; and response to glucocorticoid. Located in several cellular components, including basolateral plasma membrane; organelle outer membrane; and recycling endosome. Used to study several diseases, including asthma; chronic kidney disease; congestive heart failure; hypertension (multiple); and nephritis. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); glomerulosclerosis (multiple); hyperinsulinism; and placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; artery disease (multiple); chronic kidney disease; neurodegenerative disease (multiple); and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Agtr1; Angiotensin II receptor type 1 (AT1A); angiotensin II receptor, type 1; Angiotensin II receptor, type 1 (AT1A); angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1a; AT1; AT1 receptor A; AT1A; AT1R; type-1 angiotensin II receptor A; type-1A angiotensin II receptor; vascular type-1 angiotensin II receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Agtr1aem5Mcwi   Agtr1aem1Mcwi  
Genetic Models: SS-Agtr1aem1Mcwi SS-Agtr1aem5Mcwi
Is Marker For: QTLs:   Bp343  
Candidate Gene For: Bp343
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81734,383,397 - 34,435,523 (-)NCBIGRCr8
mRatBN7.21734,173,446 - 34,226,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1734,174,429 - 34,226,946 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1734,003,015 - 34,054,637 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01735,606,893 - 35,658,508 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01733,998,820 - 34,050,440 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01735,907,102 - 35,958,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01737,217,810 - 37,270,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,629,318 - 40,684,982 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11740,632,160 - 40,687,823 (-)NCBI
Celera1733,705,975 - 33,757,157 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
aceruloplasminemia  (ISO)
AIDS-Associated Nephropathy  (ISO)
Alveolar Bone Loss  (IEP)
Alzheimer's disease  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
asthma  (IMP,ISO)
atrial fibrillation  (ISO)
breast cancer  (ISO)
breast lobular carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IEP,IMP,ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (IEP)
cerebrovascular disease  (ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic kidney disease  (IMP,ISO)
congestive heart failure  (IMP,ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (IMP,ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diffuse cystic renal dysplasia  (ISO)
dilated cardiomyopathy  (IEP,IMP)
Ductal Carcinoma  (ISO)
essential hypertension  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (IEP,ISO)
Experimental Radiation Injuries  (IMP)
Fetal Growth Retardation  (IEP)
Fibrosis  (IMP,ISO)
focal segmental glomerulosclerosis  (IEP)
Friedreich ataxia  (ISO)
genetic disease  (ISO)
glomerulosclerosis  (IEP)
glucose intolerance  (ISO)
glycogen storage disease XV  (ISO)
Huntington's disease  (ISO)
hyperinsulinism  (IEP)
hypertension  (IEP,IMP,ISO)
Hypertensive Nephropathy  (IMP)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
limb ischemia  (ISO)
lung disease  (ISO)
Metabolic Syndrome  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Reperfusion Injury  (IEP)
Neoplasm Metastasis  (ISO)
nephritis  (IMP)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
patent ductus arteriosus  (ISO)
Pituitary Neoplasms  (ISO)
placental insufficiency  (IEP)
Postoperative Cognitive Dysfunction  (IEP)
Prenatal Exposure Delayed Effects  (IEP)
proteinuria  (IMP,ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (IEP)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (IEP,IMP)
sarcoidosis  (ISO)
Spontaneous Abortions  (ISO)
Vascular System Injuries  (ISO)
Ventricular Remodeling  (IEP)
vesicoureteral reflux  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP,ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-dihydroxybenzoic acid  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (ISO)
AM6545  (ISO)
amiodarone  (EXP)
amlodipine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
aspartame  (ISO)
ATP  (EXP)
benazepril  (EXP,ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP)
capsaicin  (EXP)
captopril  (EXP,ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
cilazapril monohydrate  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
corticosterone  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
diuron  (EXP)
doxorubicin  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
edaravone  (EXP)
ellagic acid  (EXP)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (EXP)
esculetin  (EXP)
estriol  (ISO)
ethanol  (EXP)
flavonoids  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycochenodeoxycholic acid  (EXP)
glyoxylic acid  (EXP)
goralatide  (ISO)
Heptachlor epoxide  (ISO)
hexachlorobenzene  (EXP)
hydrochlorothiazide  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
irbesartan  (ISO)
isoprenaline  (ISO)
isotretinoin  (EXP)
L-ethionine  (EXP)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
losartan  (EXP,ISO)
Magnolol  (EXP)
mangiferin  (EXP)
mechlorethamine  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
mevinphos  (EXP)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
Nandrolone decanoate  (EXP)
nerolidol  (EXP)
nickel atom  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP)
nitrendipine  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
olmesartan  (ISO)
omeprazole  (EXP)
ouabain  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
perindopril  (EXP,ISO)
phenylarsine oxide  (EXP)
phosphane  (EXP)
picrotoxin  (EXP)
pioglitazone  (ISO)
pirfenidone  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregabalin  (EXP)
propanal  (ISO)
Ptaquiloside  (ISO)
quercetin  (EXP,ISO)
ramipril  (EXP)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
spironolactone  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP)
superoxide  (EXP)
telmisartan  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
triadimefon  (EXP)
tributylstannane  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triphenylstannane  (EXP)
troglitazone  (ISO)
tryptophan  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vinclozolin  (EXP)
warfarin  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (IMP)
angiotensin-activated signaling pathway  (IMP,ISO)
blood vessel development  (ISO)
brain renin-angiotensin system  (ISO)
calcium-mediated signaling  (ISO)
cell chemotaxis  (ISO)
cellular response to dexamethasone stimulus  (IDA)
dopamine biosynthetic process  (IMP)
drinking behavior  (IMP,ISO)
G protein-coupled receptor signaling pathway  (IBA,IMP,ISO)
gene expression  (ISO)
heart development  (ISO)
inflammatory response  (IBA,ISO)
kidney development  (ISO)
maintenance of blood vessel diameter homeostasis by renin-angiotensin  (ISO,ISS)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
neuron apoptotic process  (ISO)
phospholipase C-activating angiotensin-activated signaling pathway  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IDA,ISO)
positive regulation of angiogenesis  (IMP)
positive regulation of blood pressure  (IMP,ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IMP)
positive regulation of calcium ion import across plasma membrane  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of CoA-transferase activity  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (IBA,ISO)
positive regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of phospholipase A2 activity  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of receptor recycling  (IDA)
positive regulation of superoxide anion generation  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of blood pressure  (ISO)
regulation of pH  (IDA)
regulation of renal output by angiotensin  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
regulation of vasoconstriction  (ISO)
renin secretion into blood stream  (ISO)
renin-angiotensin regulation of aldosterone production  (IMP,ISO)
response to activity  (IEP)
response to angiotensin  (IEP)
response to corticosterone  (IEP)
response to estrogen  (IDA,IEP)
response to salt stress  (IEP)
Rho protein signal transduction  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)
vasoconstriction  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway   (ISO)
angiotensin II signaling pathway   (TAS)
angiotensin II signaling pathway via AT1 receptor  (IDA,IMP,TAS)
angiotensin III signaling pathway  (TAS)
atenolol pharmacodynamics pathway  (ISO)
benazepril pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
candesartan pharmacodynamics pathway  (ISO)
captopril pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
cilazapril pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
enalapril pharmacodynamics pathway  (ISO)
eprosartan pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
forasartsn pharmacodynamics pathway  (ISO)
fosinopril pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galpha12/Galpha13 family  (IMP)
G protein mediated signaling pathway via Galphaq family  (IMP)
ibutilide pharmacodynamics pathway  (ISO)
irbesartan pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lisinopril pharmacodynamics pathway   (ISO)
losartan pharmacodynamics pathway  (ISO,TAS)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
moexipril pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
olmesartan pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
perindopril pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinapril pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
ramipril pharmacodynamics pathway   (ISO)
renin-angiotensin cascade pathway  (IEA,TAS)
sotalol pharmacodynamics pathway  (ISO)
spirapril pharmacodynamics pathway  (ISO)
telmisartan pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
trandolapril pharmacodynamics pathway  (ISO)
valsartan pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits. Abdollahi MR, etal., Hum Mutat. 2007 Jan 8;28(4):365-373.
2. Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor. Ali MS, etal., J Biol Chem. 1997 Sep 12;272(37):23382-8.
3. Genotypic interactions of renin-angiotensin system genes in myocardial infarction. Araujo MA, etal., Int J Cardiol. 2005 Aug 3;103(1):27-32. Epub 2004 Dec 15.
4. Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis. Arumugam S, etal., Toxicology. 2012 Jan 27;291(1-3):139-45. doi: 10.1016/j.tox.2011.11.008. Epub 2011 Nov 23.
5. Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat. Baiardi G, etal., Regul Pept. 2005 Jan 15;124(1-3):7-17.
6. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
7. Differential responses to salt supplementation in adult male and female rat adrenal glands following intrauterine growth restriction. Bibeau K, etal., J Endocrinol. 2011 Apr;209(1):85-94. Epub 2011 Feb 8.
8. Gene polymorphisms of ACE and the angiotensin receptor AT2R1 influence serum ACE levels in sarcoidosis. Biller H, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2009 Jul;26(2):139-46.
9. Renal expression of angiotensin receptors in long-term diabetes and the effects of angiotensin type 1 receptor blockade. Bonnet F, etal., J Hypertens. 2002 Aug;20(8):1615-24.
10. Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution. Bose KS and Sarma RH, Biochem Biophys Res Commun 1975 Oct 27;66(4):1173-9.
11. Effect of celecoxib on the antihypertensive effect of losartan in a rat model of renovascular hypertension. Boshra V, etal., Can J Physiol Pharmacol. 2011 Feb;89(2):103-7.
12. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
13. [Association of the renin-angiotensin system gene polymorphism with nephropathy in type II diabetes]. Buraczynska M, etal., Pol Arch Med Wewn. 2002 Aug;108(2):725-30.
14. Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. Cao Z, etal., J Am Soc Nephrol. 2002 Jul;13(7):1773-87.
15. Mutant animal models of stroke and gene expression: the stroke-prone spontaneously hypertensive rat. Carswell HV, etal., Methods Mol Med 2005;104:49-74.
16. MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension. Castoldi G, etal., J Cell Physiol. 2012 Feb;227(2):850-6. doi: 10.1002/jcp.22939.
17. Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy. Chan LY, etal., J Am Soc Nephrol. 2005 Aug;16(8):2306-17. Epub 2005 Jun 1.
18. Upregulation of angiotensin II receptors in reflux nephropathy. Chertin B, etal., J Pediatr Surg. 2002 Feb;37(2):251-5.
19. Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension. Chung WK, etal., J Heart Lung Transplant. 2009 Apr;28(4):373-9.
20. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
21. Association between the A1166C polymorphism of the angiotensin II receptor type 1 and progression of chronic renal insufficiency. Coll E, etal., J Nephrol. 2003 May-Jun;16(3):357-64.
22. Angiotensin II receptor type 1 is upregulated in atrial tissue of patients with rheumatic valvular disease with atrial fibrillation. Cong H, etal., J Thorac Cardiovasc Surg. 2010 Aug;140(2):298-304. Epub 2010 Jan 18.
23. Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea. da Silva AQ, etal., Brain Res. 2011 Jan 12;1368:231-8. Epub 2010 Oct 30.
24. Involvement of the AT1 receptor in the venoconstriction induced by angiotensin II in both the inferior vena cava and femoral vein. da Silva OG, etal., Peptides. 2011 Jan;32(1):112-7. Epub 2010 Oct 16.
25. International union of pharmacology. XXIII. The angiotensin II receptors. de Gasparo M, etal., Pharmacol Rev. 2000 Sep;52(3):415-72.
26. Expression of cardiac angiotensin II AT1 receptor genes in rat hearts is regulated by steroids but not by angiotensin II. Della Bruna R, etal., J Hypertens. 1995 Jul;13(7):763-9.
27. Angiotensin-2 receptors (AT1-R and AT2-R), new prognostic factors for renal clear-cell carcinoma? Dolley-Hitze T, etal., Br J Cancer. 2010 Nov 23;103(11):1698-705.
28. Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction. Esteban V, etal., J Am Soc Nephrol. 2004 Jun;15(6):1514-29.
29. Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats. Exner EC, etal., PLoS One. 2020 Apr 23;15(4):e0232067. doi: 10.1371/journal.pone.0232067. eCollection 2020.
30. Genetic polymorphisms of the renin-angiotensin system in breast cancer patients. Fishchuk LE and Gorovenko NG, Exp Oncol. 2013 Jun;35(2):101-4.
31. Angiotensin II type 1 receptor A1166C gene polymorphism. Absence of an association with the risk of coronary artery disease and myocardial infarction and of a synergistic effect with angiotensin-converting enzyme gene polymorphism on the risk of these diseases. Gardemann A, etal., Eur Heart J. 1998 Nov;19(11):1657-65.
32. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
33. Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders. Ge J and Barnes NM, Eur J Pharmacol. 1996 Feb 22;297(3):299-306.
34. The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury. Ghosh S, etal., Am J Med Sci. 2002 Dec;324(6):296-304.
35. Angiotensin II AT-1A receptor immunolabeling in rat medial nucleus tractus solitarius neurons: subcellular targeting and relationships with catecholamines. Glass MJ, etal., Neuroscience. 2005;130(3):713-23.
36. Placental gene expression in a rat 'model' of placental insufficiency. Goyal R, etal., Placenta. 2010 Jul;31(7):568-75. Epub 2010 Jun 8.
37. Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis. Granzow M, etal., Hepatology. 2014 Jul;60(1):334-48. doi: 10.1002/hep.27117. Epub 2014 May 6.
38. Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane. Guo DF, etal., Biochem Biophys Res Commun. 2003 Oct 31;310(4):1254-65.
39. Renin and angiotensin II receptor gene expression in kidneys of renal hypertensive rats. Haefliger JA, etal., Hypertension. 1995 Nov;26(5):733-7.
40. Angiotensin II subtype 1 (AT1) receptors contribute to ischemic contracture and regulate chemomechanical energy transduction in isolated transgenic rat (alphaMHC-hAT1)594-17 hearts. Han H, etal., Eur J Heart Fail 2002 Mar;4(2):131-7.
41. Angiotensin receptor subtypes in thin and muscular juxtamedullary efferent arterioles of rat kidney. Helou CM, etal., Am J Physiol Renal Physiol 2003 Sep;285(3):F507-14. Epub 2003 May 6.
42. Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis. Hennenberg M, etal., Eur J Clin Invest. 2009 Oct;39(10):906-13. Epub 2009 Jun 12.
43. Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice. Henriques T, etal., Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1251-6. Epub 2008 May 1.
44. Associations of the angiotensin II type 1 receptor A1166C and the endothelial NO synthase G894T gene polymorphisms with silent subcortical white matter lesions in essential hypertension. Henskens LH, etal., Stroke. 2005 Sep;36(9):1869-73. Epub 2005 Aug 18.
45. Radionuclide imaging of angiotensin II type 1 receptor upregulation after myocardial ischemia-reperfusion injury. Higuchi T, etal., J Nucl Med. 2010 Dec;51(12):1956-61. Epub 2010 Nov 15.
46. Maternal Resveratrol Therapy Protects Male Rat Offspring against Programmed Hypertension Induced by TCDD and Dexamethasone Exposures: Is It Relevant to Aryl Hydrocarbon Receptor? Hsu CN, etal., Int J Mol Sci. 2018 Aug 20;19(8):2459. doi: 10.3390/ijms19082459.
47. Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor. Hsu CN, etal., Int J Mol Sci. 2020 Jun 26;21(12):4552. doi: 10.3390/ijms21124552.
48. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1.
49. Reactive oxygen species-mediated homologous downregulation of angiotensin II type 1 receptor mRNA by angiotensin II. Ichiki T, etal., Hypertension 2001 Feb;37(2 Part 2):535-40.
50. Attenuation of hypertension-mediated glomerulosclerosis in conjunction with increased angiotensin (1-7). Igase M, etal., Ther Adv Cardiovasc Dis. 2011 Dec;5(6):297-304. doi: 10.1177/1753944711429343. Epub 2011 Nov 16.
51. Alterations in sarcoplasmic reticulum and angiotensin II type 1 receptor gene expression after myocardial infarction in rats. Iijima K, etal., Jpn Circ J. 1998 Jun;62(6):449-54.
52. Gene Expression Profiling Distinguishes Between Spontaneous and Radiation-induced Rat Mammary Carcinomas. Imaoka T, etal., J Radiat Res (Tokyo). 2008 Apr 16;.
53. Increased endothelial gene expression of angiotensin AT1A receptor in cyclosporine induced hypertensive rats. Iwai J, etal., Eur J Pharmacol. 1993 Dec 1;248(4):341-4.
54. Rat angiotensin II receptor: cDNA sequence and regulation of the gene expression. Iwai N, etal., Biochem Biophys Res Commun 1991 May 31;177(1):299-304.
55. Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Jaffre F, etal., Circ Res. 2009 Jan 2;104(1):113-23. doi: 10.1161/CIRCRESAHA.108.180976. Epub 2008 Nov 20.
56. Application of angiotensin II to healthy rat sciatic nerve can produce neuropathy without associated vasculopathy. Kasselman LJ and Rutkove SB, Muscle Nerve. 2010 Dec;42(6):959-65. doi: 10.1002/mus.21767. Epub 2010 Sep 30.
57. A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia. Kelly M, etal., J Mol Cell Cardiol. 2011 Nov;51(5):848-54. doi: 10.1016/j.yjmcc.2011.07.001. Epub 2011 Jul 12.
58. Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis. Kim HJ, etal., J Pharmacol Exp Ther. 2011 Feb 25.
59. Mechanism of Ang II involvement in activation of NF-kappaB through phosphorylation of p65 during aging. Kim JM, etal., Age (Dordr). 2011 Feb 12.
60. Angiotensin II receptor type 1 1166 A/C and angiotensin converting enzyme I/D gene polymorphisms in a Dutch sarcoidosis cohort. Kruit A, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2010 Jul;27(2):147-52.
61. Effects of telmisartan on cognition and regional cerebral blood flow in hypertensive patients with Alzheimer's disease. Kume K, etal., Geriatr Gerontol Int. 2012 Apr;12(2):207-14. doi: 10.1111/j.1447-0594.2011.00746.x. Epub 2011 Sep 19.
62. The genomic organization of the rat AT1 angiotensin receptor. Langford K, etal., Biochem Biophys Res Commun 1992 Mar 31;183(3):1025-32.
63. The involvement of angiotensin type 1 and type 2 receptors in estrogen-induced cell proliferation and vascular endothelial growth factor expression in the rat anterior pituitary. Lawnicka H, etal., ScientificWorldJournal. 2012;2012:358102. Epub 2012 Apr 26.
64. Binding of losartan to angiotensin AT1 receptors increases dopamine D1 receptor activation. Li D, etal., J Am Soc Nephrol. 2012 Mar;23(3):421-8. doi: 10.1681/ASN.2011040344. Epub 2011 Dec 22.
65. Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-{beta}1 pathways in cardiac fibroblasts. Li L, etal., Cardiovasc Res. 2011 Mar 2.
66. [Dynamic changes of angiotensin II type-1 receptor mRNA expression in volume-overloaded ventricular hypertrophy]. Li YQ, etal., Sheng Li Xue Bao. 1998 Jun;50(3):303-8.
67. Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction. Li Z, etal., Biochem Biophys Res Commun. 2014 Jun 20;449(1):74-80. doi: 10.1016/j.bbrc.2014.04.153. Epub 2014 May 9.
68. G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes. Macrez-Lepretre N, etal., J Biol Chem. 1997 Apr 11;272(15):10095-102.
69. [ACE and AGTR1 genes polymorphisms in left ventricular hypertrophy pathogenesis in humans]. Makeeva OA, etal., Mol Biol (Mosk). 2004 Nov-Dec;38(6):990-6.
70. Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension. Meng J, etal., Emerg Microbes Infect. 2020 Dec;9(1):757-760. doi: 10.1080/22221751.2020.1746200.
71. Direct angiotensin II type 2 receptor stimulation decreases dopamine synthesis in the rat striatum. Mertens B, etal., Neuropharmacology. 2010 Jun;58(7):1038-44. Epub 2010 Jan 26.
72. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
73. A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists. Michel MC, etal., Pharmacol Rev. 2013 Mar 13;65(2):809-48. doi: 10.1124/pr.112.007278. Print 2013 Apr.
74. TM2-TM7 interaction in coupling movement of transmembrane helices to activation of the angiotensin II type-1 receptor. Miura S, etal., J Biol Chem 2003 Feb 7;278(6):3720-5.
75. Impact of angiotensin II type 2 receptor blockade on experimental radiation nephropathy. Moulder JE, etal., Radiat Res. 2004 Mar;161(3):312-7.
76. Methylglyoxal augments angiotensin II-induced contraction in rat isolated carotid artery. Mukohda M, etal., J Pharmacol Sci. 2010;114(4):390-8. Epub 2010 Nov 9.
77. Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Murphy TJ, etal., Nature. 1991 May 16;351(6323):233-6. doi: 10.1038/351233a0.
78. Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis. Naito T, etal., Am J Physiol Renal Physiol. 2010 Mar;298(3):F683-91. Epub 2009 Dec 30.
79. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
80. Activation of cardiac renin-angiotensin system in unstable angina. Neri Serneri GG, etal., J Am Coll Cardiol. 2001 Jul;38(1):49-55.
81. Adenoviral inhibition of AT1a receptors in the paraventricular nucleus inhibits acute increases in mean arterial blood pressure in the rat. Northcott CA, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1202-11. Epub 2010 Aug 11.
82. The involvement of type 1a angiotensin II receptors in the regulation of airway inflammation in a murine model of allergic asthma. Ohwada K, etal., Clin Exp Allergy. 2007 Nov;37(11):1720-7. Epub 2007 Sep 17.
83. Role of the conserved DRY motif on G protein activation of rat angiotensin II receptor type 1A. Ohyama K, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):362-7.
84. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
85. Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart. Pan J, etal., Circ Res. 1997 Oct;81(4):611-7.
86. Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Paradis P, etal., Proc Natl Acad Sci U S A 2000 Jan 18;97(2):931-6.
87. Reduction of cold-induced hypertension by antisense oligodeoxynucleotides to angiotensinogen mRNA and AT1-receptor mRNA in brain and blood. Peng JF, etal., Hypertension. 1998 Jun;31(6):1317-23.
88. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
89. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
90. The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities. Poumarat JS, etal., Kidney Int. 2002 Aug;62(2):434-45.
91. Renin-angiotensin polymorphisms and QTc interval prolongation in end-stage renal disease. Raizada V, etal., Kidney Int. 2005 Sep;68(3):1186-9.
92. Angiotensin III: a central regulator of vasopressin release and blood pressure. Reaux A, etal., Trends Endocrinol Metab. 2001 May-Jun;12(4):157-62.
93. GOA pipeline RGD automated data pipeline
94. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
95. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
96. AT-1 receptor and phospholipase C are involved in angiotensin III modulation of hypothalamic noradrenergic transmission. Rodriguez-Campos M, etal., Cell Mol Neurobiol. 2000 Dec;20(6):747-62.
97. Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways. Samuelsson AM, etal., Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H787-96. Epub 2006 Mar 24.
98. Evidence for the importance of angiotensin II type 1 receptor in ischemia-induced angiogenesis. Sasaki K, etal., J Clin Invest 2002 Mar;109(5):603-11.
99. Dietary salt intake modulates angiotensin II type 1 receptor gene expression. Schmid C, etal., Hypertension. 1997 Apr;29(4):923-9.
100. [Effects of long-term antihypertensive therapy with losartan on blood pressure and cognitive function in patients with essential hypertension and other cerebrovascular risk factors (AWARE observational study)]. Schrader J, etal., Med Klin (Munich). 2008 Jul 15;103(7):491-9. doi: 10.1007/s00063-008-1073-4.
101. Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy. Shanmugam P, etal., J Mol Cell Cardiol. 2011 Mar 2.
102. Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies. Singh RR, etal., Am J Physiol Renal Physiol. 2007 Aug;293(2):F548-54. Epub 2007 May 30.
103. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
104. Transcriptional suppression of type 1 angiotensin II receptor gene expression by peroxisome proliferator-activated receptor-gamma in vascular smooth muscle cells. Sugawara A, etal., Endocrinology 2001 Jul;142(7):3125-34.
105. Salt-induced renal injury in SHRs is mediated by AT1 receptor activation. Susic D, etal., J Hypertens. 2011 Apr;29(4):716-23.
106. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
107. Angiotensin II type 1 receptor blockade prevents up-regulation of angiotensin II type 1A receptors in rat injured artery. Tazawa S, etal., J Pharmacol Exp Ther. 1999 Feb;288(2):898-904.
108. G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation. Tirupula KC, etal., Biochemistry. 2015 Nov 10;54(44):6673-83. doi: 10.1021/acs.biochem.5b00975. Epub 2015 Nov 2.
109. Renoprotective mechanisms of angiotensin II antagonism in experimental chronic renal failure. Uhlenius N, etal., Kidney Blood Press Res. 2002;25(2):71-9.
110. Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis. Urushihara M, etal., Hypertension. 2011 Mar;57(3):586-93. Epub 2011 Jan 31.
111. Inhibition of corneal neovascularization by blocking the angiotensin II type 1 receptor. Usui T, etal., Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4370-6. doi: 10.1167/iovs.07-0964.
112. Selective silencing of angiotensin receptor subtype 1a (AT1aR) by RNA interference. Vazquez J, etal., Hypertension. 2005 Jan;45(1):115-9. Epub 2004 Nov 29.
113. Positive feedback regulation of angiotensin II-AT1B receptor gene expression in rat adrenal glands. Wagner C and Kurtz A, Pflugers Arch. 1998 Aug;436(3):323-8.
114. Regulation of type 1 angiotensin II receptor and its subtype gene expression in kidney by sodium loading and angiotensin II infusion. Wang DH, etal., J Hypertens. 1996 Dec;14(12):1409-15.
115. [Role of angiotensin II type 1 receptor in activation of nuclear factor-kappaB and activator protein-1 in lung of mice with acute lung injury]. Wang F, etal., Zhonghua Shao Shang Za Zhi. 2010 Apr;26(2):113-6.
116. Effect of valsartan on the expression of angiotensin II receptors in the lung of chronic antigen exposure rats. Wang T, etal., Chin Med J (Engl). 2008 Nov 20;121(22):2312-9.
117. Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice. Waseda Y, etal., Respir Res. 2008 May 23;9:43.
118. Estrogen regulates adrenal angiotensin AT1 receptors by modulating AT1 receptor translation. Wu Z, etal., Endocrinology. 2003 Jul;144(7):3251-61.
119. [The relationship between angiotensin II type 1 receptor gene and coronary heart disease, hypertension and diabetes mellitus in Chinese] Xiang K, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1998 Feb 10;15(1):9-12.
120. Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats. Xu X, etal., Cardiovasc Res. 2008 Jun 1;78(3):523-32. doi: 10.1093/cvr/cvn028. Epub 2008 Feb 5.
121. Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation. Yasuda N, etal., EMBO Rep. 2008 Feb;9(2):179-86. doi: 10.1038/sj.embor.7401157. Epub 2008 Jan 18.
122. Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis. Ye S, etal., Heart. 2003 Oct;89(10):1195-9.
123. Activation of D3 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells. Zeng C, etal., Circ Res. 2006 Sep 1;99(5):494-500. Epub 2006 Aug 10.
124. Effects of RNA interference targeting angiotensin 1a receptor on the blood pressure and cardiac hypertrophy of rats with 2K1C hypertension Zhang JQ, etal., Zhonghua Yi Xue Za Zhi. 2006 Apr 25;86(16):1138-43.
125. Activation of the AT1 angiotensin receptor is dependent on adjacent apolar residues in the carboxyl terminus of the third cytoplasmic loop. Zhang M, etal., J Biol Chem. 2000 May 26;275(21):15782-8. doi: 10.1074/jbc.M000198200.
126. Association of angiotensin II type 1 receptor gene polymorphism with carotid atherosclerosis. Zhu S and Meng QH, Clin Chem Lab Med. 2006;44(3):282-4.
127. Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. Zong WN, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1345-50. doi: 10.1038/aps.2011.96. Epub 2011 Oct 3.
Additional References at PubMed
PMID:1378723   PMID:1544458   PMID:1567413   PMID:1599457   PMID:7622467   PMID:7713098   PMID:9310306   PMID:9466969   PMID:9691085   PMID:10880053   PMID:10993080   PMID:11833541  
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PMID:17496209   PMID:17498700   PMID:17525253   PMID:17540701   PMID:17587757   PMID:17644087   PMID:17646572   PMID:17710629   PMID:17716866   PMID:17761193   PMID:17855497   PMID:17873013  
PMID:17891894   PMID:17903697   PMID:18028779   PMID:18205095   PMID:18208547   PMID:18256274   PMID:18372229   PMID:18398343   PMID:18400212   PMID:18403896   PMID:18408131   PMID:18420589  
PMID:18420994   PMID:18469441   PMID:18497328   PMID:18498681   PMID:18505723   PMID:18515110   PMID:18536757   PMID:18603328   PMID:18609298   PMID:18614617   PMID:18701624   PMID:18711010  
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PMID:19012043   PMID:19017652   PMID:19120129   PMID:19124682   PMID:19126659   PMID:19172459   PMID:19204403   PMID:19211683   PMID:19225144   PMID:19230969   PMID:19254952   PMID:19273745  
PMID:19280879   PMID:19289825   PMID:19298848   PMID:19353416   PMID:19386725   PMID:19399400   PMID:19404405   PMID:19427376   PMID:19451734   PMID:19457762   PMID:19472100   PMID:19501631  
PMID:19508861   PMID:19560439   PMID:19588183   PMID:19639227   PMID:19647773   PMID:19667250   PMID:19692654   PMID:19704104   PMID:19710393   PMID:19733634   PMID:19766149   PMID:19835848  
PMID:19882719   PMID:19887855   PMID:20026366   PMID:20051229   PMID:20056745   PMID:20093128   PMID:20102360   PMID:20360752   PMID:20423855   PMID:20440098   PMID:20448043   PMID:20463030  
PMID:20606474   PMID:20650893   PMID:20663845   PMID:20735984   PMID:20807796   PMID:20807798   PMID:20850747   PMID:20964730   PMID:21056071   PMID:21084406   PMID:21095238   PMID:21123758  
PMID:21135513   PMID:21166237   PMID:21186577   PMID:21285403   PMID:21319377   PMID:21393361   PMID:21540301   PMID:21657802   PMID:21660462   PMID:21720156   PMID:21825224   PMID:21841463  
PMID:21897104   PMID:22020089   PMID:22038231   PMID:22128836   PMID:22146585   PMID:22180636   PMID:22253423   PMID:22464881   PMID:22498426   PMID:22561449   PMID:22579851   PMID:22661470  
PMID:22753221   PMID:22777104   PMID:22860435   PMID:22936038   PMID:22943692   PMID:22957022   PMID:22982071   PMID:23087139   PMID:23087176   PMID:23089979   PMID:23132538   PMID:23139413  
PMID:23376562   PMID:23475749   PMID:23547238   PMID:23576578   PMID:23611777   PMID:23623871   PMID:23754618   PMID:23783021   PMID:23877628   PMID:23934707   PMID:23988741   PMID:24033947  
PMID:24089683   PMID:24218433   PMID:24262995   PMID:24464860   PMID:24465706   PMID:24529758   PMID:24587998   PMID:24719376   PMID:24819472   PMID:24955935   PMID:25003108   PMID:25009217  
PMID:25081544   PMID:25198883   PMID:25350112   PMID:25365520   PMID:25401104   PMID:25481865   PMID:25542758   PMID:25596947   PMID:25658446   PMID:25766467   PMID:25793389   PMID:25850724  
PMID:26034979   PMID:26195268   PMID:26246427   PMID:26310940   PMID:26342563   PMID:26476634   PMID:26575857   PMID:26637556   PMID:26709040   PMID:27085217   PMID:27163380   PMID:27319015  
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Genomics

Comparative Map Data
Agtr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81734,383,397 - 34,435,523 (-)NCBIGRCr8
mRatBN7.21734,173,446 - 34,226,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1734,174,429 - 34,226,946 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1734,003,015 - 34,054,637 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01735,606,893 - 35,658,508 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01733,998,820 - 34,050,440 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01735,907,102 - 35,958,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01737,217,810 - 37,270,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,629,318 - 40,684,982 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11740,632,160 - 40,687,823 (-)NCBI
Celera1733,705,975 - 33,757,157 (-)NCBICelera
Cytogenetic Map17p12NCBI
AGTR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383148,697,903 - 148,743,003 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3148,697,784 - 148,743,008 (+)EnsemblGRCh38hg38GRCh38
GRCh373148,415,690 - 148,460,790 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363149,898,348 - 149,943,480 (+)NCBINCBI36Build 36hg18NCBI36
Build 343149,940,284 - 149,943,486NCBI
Celera3146,826,000 - 146,871,131 (+)NCBICelera
Cytogenetic Map3q24NCBI
HuRef3145,788,031 - 145,833,163 (+)NCBIHuRef
CHM1_13148,378,782 - 148,423,918 (+)NCBICHM1_1
T2T-CHM13v2.03151,448,936 - 151,494,033 (+)NCBIT2T-CHM13v2.0
Agtr1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391330,520,339 - 30,566,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1330,520,424 - 30,566,850 (+)EnsemblGRCm39 Ensembl
GRCm381330,336,356 - 30,382,867 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,336,441 - 30,382,867 (+)EnsemblGRCm38mm10GRCm38
MGSCv371330,428,225 - 30,474,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361330,343,922 - 30,390,332 (+)NCBIMGSCv36mm8
Celera1330,550,710 - 30,597,281 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.19NCBI
Agtr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554748,733,942 - 8,781,255 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554748,733,942 - 8,781,305 (-)NCBIChiLan1.0ChiLan1.0
AGTR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22146,594,053 - 146,639,172 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13146,599,078 - 146,643,902 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03145,722,475 - 145,767,550 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13153,301,331 - 153,346,268 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3153,341,947 - 153,345,380 (+)Ensemblpanpan1.1panPan2
AGTR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12343,569,658 - 43,617,113 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2343,614,035 - 43,616,238 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2343,434,074 - 43,481,582 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02344,190,631 - 44,238,133 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12343,779,664 - 43,827,179 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02343,832,799 - 43,880,312 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02344,086,806 - 44,134,323 (+)NCBIUU_Cfam_GSD_1.0
Agtr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560282,859,961 - 82,902,941 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365196,831,096 - 6,873,985 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365196,831,096 - 6,873,977 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGTR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1388,934,868 - 88,983,105 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11388,934,873 - 88,980,317 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21396,933,114 - 96,978,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGTR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11541,957,826 - 42,002,776 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604114,800,710 - 14,845,597 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agtr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473025,964,811 - 26,006,463 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473025,964,848 - 26,006,468 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Agtr1a
308 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:89
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000038532
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat

Markers in Region
D17Arb4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,225,566 - 34,225,727 (+)MAPPERmRatBN7.2
mRatBN7.21734,225,481 - 34,225,727 (+)MAPPERmRatBN7.2
mRatBN7.21734,225,481 - 34,225,872 (+)MAPPERmRatBN7.2
Rnor_6.01735,956,457 - 35,957,000NCBIRnor6.0
Rnor_6.01735,956,457 - 35,956,698NCBIRnor6.0
Rnor_5.01737,268,920 - 37,269,463UniSTSRnor5.0
Rnor_5.01737,268,920 - 37,269,161UniSTSRnor5.0
RGSC_v3.41740,683,664 - 40,683,905UniSTSRGSC3.4
RGSC_v3.41740,683,663 - 40,683,905RGDRGSC3.4
RGSC_v3.11740,686,504 - 40,686,746RGD
SHRSP x BN Map1726.9699RGD
SHRSP x BN Map1726.9699UniSTS
Cytogenetic Map17q12UniSTS
D17Mco9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,227,036 - 34,227,298 (+)MAPPERmRatBN7.2
Rnor_6.01735,958,310 - 35,958,571NCBIRnor6.0
Rnor_5.01737,270,773 - 37,271,034UniSTSRnor5.0
RGSC_v3.41740,685,215 - 40,685,476UniSTSRGSC3.4
Celera1733,757,390 - 33,757,651UniSTS
Cytogenetic Map17q12UniSTS
D17Mco8  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01737,271,013 - 37,271,345UniSTSRnor5.0
Celera1733,757,630 - 33,757,962UniSTS
Cytogenetic Map17q12UniSTS
D17Wox34  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,227,276 - 34,227,609 (+)MAPPERmRatBN7.2
Rnor_6.01735,958,550 - 35,958,882NCBIRnor6.0
Rnor_5.01737,271,013 - 37,271,345UniSTSRnor5.0
RGSC_v3.41740,685,455 - 40,685,787UniSTSRGSC3.4
Celera1733,757,630 - 33,757,962UniSTS
Cytogenetic Map17q12UniSTS
RH94717  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,174,927 - 34,175,204 (+)MAPPERmRatBN7.2
Rnor_6.01735,907,271 - 35,907,547NCBIRnor6.0
Rnor_5.01737,218,997 - 37,219,273UniSTSRnor5.0
RGSC_v3.41740,629,483 - 40,629,759UniSTSRGSC3.4
Celera1733,706,140 - 33,706,416UniSTS
Cytogenetic Map17q12UniSTS
Agtr1a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,846,542 - 102,846,612 (+)MAPPERmRatBN7.2
Rnor_6.02105,150,594 - 105,150,663NCBIRnor6.0
Rnor_5.02124,880,836 - 124,880,905UniSTSRnor5.0
RGSC_v3.42105,504,843 - 105,504,912UniSTSRGSC3.4
Celera298,216,100 - 98,216,169UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map17q12UniSTS
RH130649  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,174,980 - 34,175,163 (+)MAPPERmRatBN7.2
Rnor_6.01735,907,324 - 35,907,506NCBIRnor6.0
Rnor_5.01737,219,050 - 37,219,232UniSTSRnor5.0
RGSC_v3.41740,629,536 - 40,629,718UniSTSRGSC3.4
Celera1733,706,193 - 33,706,375UniSTS
Cytogenetic Map17q12UniSTS
UniSTS:256385  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,175,936 - 34,176,577 (+)MAPPERmRatBN7.2
mRatBN7.22102,846,237 - 102,846,878 (+)MAPPERmRatBN7.2
Rnor_6.02105,150,289 - 105,150,929NCBIRnor6.0
Rnor_6.01735,908,280 - 35,908,920NCBIRnor6.0
Rnor_5.01737,220,006 - 37,220,646UniSTSRnor5.0
Rnor_5.02124,880,531 - 124,881,171UniSTSRnor5.0
RGSC_v3.41740,630,492 - 40,631,132UniSTSRGSC3.4
RGSC_v3.42105,504,538 - 105,505,178UniSTSRGSC3.4
Celera298,215,795 - 98,216,435UniSTS
Celera1733,707,149 - 33,707,789UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map17q12UniSTS
Agtr1a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,175,886 - 34,176,577 (+)MAPPERmRatBN7.2
Rnor_6.01735,908,230 - 35,908,920NCBIRnor6.0
Rnor_5.01737,219,956 - 37,220,646UniSTSRnor5.0
RGSC_v3.41740,630,442 - 40,631,132UniSTSRGSC3.4
Celera1733,707,099 - 33,707,789UniSTS
Cytogenetic Map17q12UniSTS


Genetic Models
This gene Agtr1a is modified in the following models/strains:
SS-Agtr1aem1Mcwi     SS-Agtr1aem5Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000038532   ⟹   ENSRNOP00000034687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1734,174,429 - 34,226,946 (-)Ensembl
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102465   ⟹   ENSRNOP00000091615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1734,174,444 - 34,226,675 (-)Ensembl
RefSeq Acc Id: NM_030985   ⟹   NP_112247
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,383,401 - 34,435,432 (-)NCBI
mRatBN7.21734,174,763 - 34,226,804 (-)NCBI
Rnor_6.01735,907,106 - 35,958,077 (-)NCBI
Rnor_5.01737,217,810 - 37,270,540 (-)NCBI
RGSC_v3.41740,629,318 - 40,684,982 (-)RGD
Celera1733,705,975 - 33,757,157 (-)RGD
Sequence:
RefSeq Acc Id: XM_008771594   ⟹   XP_008769816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,383,397 - 34,435,523 (-)NCBI
mRatBN7.21734,173,446 - 34,226,892 (-)NCBI
Rnor_6.01735,907,102 - 35,958,136 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095335   ⟹   XP_038951263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81734,383,397 - 34,435,523 (-)NCBI
mRatBN7.21734,173,446 - 34,226,892 (-)NCBI
RefSeq Acc Id: NP_112247   ⟸   NM_030985
- UniProtKB: Q9QVS5 (UniProtKB/Swiss-Prot),   P25095 (UniProtKB/Swiss-Prot),   A6J7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769816   ⟸   XM_008771594
- Peptide Label: isoform X1
- UniProtKB: Q9QVS5 (UniProtKB/Swiss-Prot),   P25095 (UniProtKB/Swiss-Prot),   A6J7M4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034687   ⟸   ENSRNOT00000038532
RefSeq Acc Id: XP_038951263   ⟸   XM_039095335
- Peptide Label: isoform X1
- UniProtKB: P25095 (UniProtKB/Swiss-Prot),   Q9QVS5 (UniProtKB/Swiss-Prot),   A6J7M4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091615   ⟸   ENSRNOT00000102465
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AT1a I-TASSER model P25095 1-359 view protein structure
AF-P25095-F1-model_v2 AlphaFold P25095 1-359 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700428
Promoter ID:EPDNEW_R10952
Type:multiple initiation site
Name:Agtr1a_1
Description:angiotensin II receptor, type 1a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01735,958,089 - 35,958,149EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2070 AgrOrtholog
BioCyc Gene G2FUF-9530 BioCyc
Ensembl Genes ENSRNOG00000018346 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055013980 UniProtKB/Swiss-Prot
  ENSRNOG00060019076 UniProtKB/Swiss-Prot
  ENSRNOG00065023214 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038532.4 UniProtKB/Swiss-Prot
  ENSRNOT00000102465.1 UniProtKB/Swiss-Prot
  ENSRNOT00055024035 UniProtKB/Swiss-Prot
  ENSRNOT00055024048 UniProtKB/Swiss-Prot
  ENSRNOT00060032958 UniProtKB/Swiss-Prot
  ENSRNOT00060033009 UniProtKB/Swiss-Prot
  ENSRNOT00065039637 UniProtKB/Swiss-Prot
  ENSRNOT00065039660 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126918 IMAGE-MGC_LOAD
InterPro ATII_AT1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATII_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93396 IMAGE-MGC_LOAD
NCBI Gene 24180 ENTREZGENE
PANTHER APELIN RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AGTR1 RGD
PhenoGen Agtr1a PhenoGen
PRINTS ANGIOTENSINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANGIOTENSN1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018346 RatGTEx
  ENSRNOG00055013980 RatGTEx
  ENSRNOG00060019076 RatGTEx
  ENSRNOG00065023214 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6J7M4 ENTREZGENE, UniProtKB/TrEMBL
  AGTRA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QVS5 ENTREZGENE
UniProt Secondary Q9QVS5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-04-03 Agtr1a  angiotensin II receptor, type 1a  Agtr1  angiotensin II receptor, type 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Agtr1  angiotensin II receptor, type 1  Agtr1a  angiotensin II receptor, type 1a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Agtr1a  angiotensin II receptor, type 1a  Agtr1a  angiotensin II receptor, type 1 (AT1A)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Agtr1a  angiotensin receptor 1a      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in adrenal gland, liver and kidney 1298647
gene_expression expression is increased in brain microvessels in SHRSP strain compared with WKY rat strain 1553895
gene_function receptor for angiotensin II 68888
gene_function receptor for angiotensin II 69670
gene_process activation induces cell contraction, proliferation and migration in vascular smooth muscle cells (VSMCs) 68888
gene_process activation induces cell contraction, proliferation and migration in vascular smooth muscle cells (VSMCs) 69670
gene_process functions to regulate aldosterone secretion and to control blood pressure and cardiac volume 68888
gene_process functions to regulate aldosterone secretion and to control blood pressure and cardiac volume 69670
gene_process may be involved in regulating myocardial efficiency and ischemic contracture 1298607
gene_process couples to intracellular Ca2+ signaling with vasoconstricting effects on glomerular arterioles 1298648
gene_regulation repressed by peroxisome proliferator activated receptor gamma (Pparg) through inhibition of Sp1 via a protein-protein interaction 69670
gene_regulation activation in vascular smooth muscle cells (VSMCs) is mainly through several signaling transduction pathways, including tyrosine kinases and mitogen activated protein kinase 69670
gene_regulation transcription may be regulated by sodium in adrenal tissue 1298647
gene_regulation expression may be developmentally regulated 1298647