Dhtkd1 (dehydrogenase E1 and transketolase domain containing 1) - Rat Genome Database

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Gene: Dhtkd1 (dehydrogenase E1 and transketolase domain containing 1) Rattus norvegicus
Analyze
Symbol: Dhtkd1
Name: dehydrogenase E1 and transketolase domain containing 1
RGD ID: 1308092
Description: Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity and thiamine pyrophosphate binding activity. Predicted to be involved in generation of precursor metabolites and energy. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth disease axonal type 2Q. Orthologous to human DHTKD1 (dehydrogenase E1 and transketolase domain containing 1); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; glutaric aciduria type I pathway; hyperlysinemia pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2-oxoadipate dehydrogenase complex component E1; 2-oxoadipate dehydrogenase, mitochondrial; alpha-KADH-E1; alpha-ketoadipate dehydrogenase; dehydrogenase E1 and transketolase domain-containing protein 1; E1a; LOC103694860; LOC361272; MGC116097; OADC-E1; OADH-E1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81777,242,512 - 77,316,074 (+)NCBIGRCr8
mRatBN7.21772,355,201 - 72,406,725 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1772,355,201 - 72,406,723 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1775,862,147 - 75,912,680 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01779,683,597 - 79,734,126 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01773,733,852 - 73,784,395 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01776,306,585 - 76,358,058 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1776,306,585 - 76,358,058 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01777,943,860 - 78,003,052 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01778,007,307 - 78,014,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41783,461,479 - 83,463,086 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11783,407,566 - 83,477,143 (+)NCBI
Celera1771,810,969 - 71,857,821 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dinophysistoxin 1  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
indometacin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
methapyrilene  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:23141294   PMID:24029230   PMID:28601082   PMID:32024885  


Genomics

Comparative Map Data
Dhtkd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81777,242,512 - 77,316,074 (+)NCBIGRCr8
mRatBN7.21772,355,201 - 72,406,725 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1772,355,201 - 72,406,723 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1775,862,147 - 75,912,680 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01779,683,597 - 79,734,126 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01773,733,852 - 73,784,395 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01776,306,585 - 76,358,058 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1776,306,585 - 76,358,058 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01777,943,860 - 78,003,052 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01778,007,307 - 78,014,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41783,461,479 - 83,463,086 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11783,407,566 - 83,477,143 (+)NCBI
Celera1771,810,969 - 71,857,821 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
DHTKD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381012,068,954 - 12,123,221 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1012,068,954 - 12,123,221 (+)EnsemblGRCh38hg38GRCh38
GRCh371012,110,953 - 12,165,220 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361012,150,940 - 12,205,230 (+)NCBINCBI36Build 36hg18NCBI36
Build 341012,150,976 - 12,205,229NCBI
Celera1012,040,496 - 12,094,736 (+)NCBICelera
Cytogenetic Map10p14NCBI
HuRef1012,028,394 - 12,082,077 (+)NCBIHuRef
CHM1_11012,110,884 - 12,165,186 (+)NCBICHM1_1
T2T-CHM13v2.01012,080,265 - 12,134,492 (+)NCBIT2T-CHM13v2.0
Dhtkd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3925,901,030 - 5,947,648 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl25,900,926 - 5,947,603 (-)EnsemblGRCm39 Ensembl
GRCm3825,896,219 - 5,942,829 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl25,896,115 - 5,942,792 (-)EnsemblGRCm38mm10GRCm38
MGSCv3725,819,106 - 5,863,838 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3625,813,366 - 5,860,064 (-)NCBIMGSCv36mm8
Celera25,851,991 - 5,882,783 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map23.62NCBI
Dhtkd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955462103,598 - 162,344 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955462103,501 - 163,472 (+)NCBIChiLan1.0ChiLan1.0
DHTKD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2824,592,829 - 24,658,832 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11024,599,491 - 24,659,548 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01012,073,324 - 12,130,589 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11012,053,943 - 12,110,691 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1012,054,060 - 12,108,387 (+)Ensemblpanpan1.1panPan2
DHTKD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1224,298,323 - 24,349,848 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl224,299,789 - 24,349,899 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha221,322,088 - 21,373,860 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0224,668,644 - 24,720,216 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl224,668,726 - 24,720,383 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1221,795,337 - 21,846,631 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0222,638,206 - 22,689,654 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0223,353,134 - 23,404,876 (-)NCBIUU_Cfam_GSD_1.0
Dhtkd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934427,043,369 - 27,100,551 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364843,208,198 - 3,251,896 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364843,207,650 - 3,251,661 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHTKD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1059,820,423 - 59,875,290 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11059,820,418 - 59,875,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21065,608,721 - 65,613,359 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DHTKD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1912,117,927 - 12,169,217 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605117,620,513 - 17,674,270 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhtkd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248054,814,546 - 4,869,359 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248054,814,444 - 4,871,097 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dhtkd1
396 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:219
Count of miRNA genes:153
Interacting mature miRNAs:183
Transcripts:ENSRNOT00000065978
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176364000973951021Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)177100332581153923Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)177177462182479847Rat

Markers in Region
D17Uwm2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21772,365,907 - 72,366,191 (+)MAPPERmRatBN7.2
Rnor_6.01776,317,291 - 76,317,574NCBIRnor6.0
Rnor_5.01777,954,566 - 77,954,849UniSTSRnor5.0
RGSC_v3.41783,407,439 - 83,407,722UniSTSRGSC3.4
Cytogenetic Map17q12.3UniSTS
RH130992  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21772,406,213 - 72,406,396 (+)MAPPERmRatBN7.2
Rnor_6.01776,357,547 - 76,357,729NCBIRnor6.0
Rnor_5.01778,014,245 - 78,014,427UniSTSRnor5.0
RGSC_v3.41783,465,799 - 83,465,981UniSTSRGSC3.4
Celera1771,857,310 - 71,857,492UniSTS
RH 3.4 Map17719.9UniSTS
Cytogenetic Map17q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 29 27 27 3 23 4
Low 3 43 28 14 19 14 8 11 71 12 37 11 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000065978   ⟹   ENSRNOP00000059952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1772,355,201 - 72,406,723 (+)Ensembl
Rnor_6.0 Ensembl1776,306,585 - 76,358,058 (+)Ensembl
RefSeq Acc Id: NM_001025720   ⟹   NP_001020891
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81777,264,558 - 77,316,074 (+)NCBI
mRatBN7.21772,355,201 - 72,406,725 (+)NCBI
Rnor_6.01776,306,585 - 76,358,058 (+)NCBI
Rnor_5.01777,943,860 - 78,003,052 (+)NCBI
Rnor_5.01778,007,307 - 78,014,756 (+)NCBI
RGSC_v3.41783,461,479 - 83,463,086 (-)RGD
Celera1771,810,969 - 71,857,821 (+)RGD
Sequence:
RefSeq Acc Id: XM_063276635   ⟹   XP_063132705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81777,242,512 - 77,316,069 (+)NCBI
RefSeq Acc Id: XM_063276636   ⟹   XP_063132706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81777,264,424 - 77,300,887 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001020891 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132705 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132706 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99075 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059952
  ENSRNOP00000059952.4
GenBank Protein Q4KLP0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020891   ⟸   NM_001025720
- UniProtKB: Q4KLP0 (UniProtKB/Swiss-Prot),   A0A8L2UN65 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059952   ⟸   ENSRNOT00000065978
RefSeq Acc Id: XP_063132705   ⟸   XM_063276635
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063132706   ⟸   XM_063276636
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KLP0-F1-model_v2 AlphaFold Q4KLP0 1-920 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700567
Promoter ID:EPDNEW_R11091
Type:initiation region
Name:Dhtkd1_1
Description:dehydrogenase E1 and transketolase domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01776,306,579 - 76,306,639EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308092 AgrOrtholog
BioCyc Gene G2FUF-8708 BioCyc
BioCyc Pathway LYSINE-DEG1-PWY [L-lysine degradation XI (mammalian)] BioCyc
  PWY-5652 [2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA] BioCyc
BioCyc Pathway Image LYSINE-DEG1-PWY BioCyc
  PWY-5652 BioCyc
Ensembl Genes ENSRNOG00000023587 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065978 ENTREZGENE
  ENSRNOT00000065978.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.11610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.12470 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP helical domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7441857 IMAGE-MGC_LOAD
InterPro 2oxoglutarate_DH_E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KGD_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KGD_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THDP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase-like_Pyr-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361272 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116097 IMAGE-MGC_LOAD
NCBI Gene 361272 ENTREZGENE
PANTHER 2-OXOGLUTARATE DEHYDROGENASE E1 COMPONENT DHKTD1, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23152 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam E1_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxoGdeHyase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transket_pyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dhtkd1 PhenoGen
PIRSF Oxoglu_dh_E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023587 RatGTEx
SMART Transket_pyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2UN65 ENTREZGENE, UniProtKB/TrEMBL
  DHTK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Dhtkd1  dehydrogenase E1 and transketolase domain containing 1  LOC103694860  probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial  Data merged from RGD:9237776 737654 PROVISIONAL
2014-08-25 LOC103694860  probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-05-24 Dhtkd1  dehydrogenase E1 and transketolase domain containing 1  LOC100362392  probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial-like  Data merged from RGD:2318295 1643240 APPROVED
2010-05-05 LOC100362392  probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Dhtkd1  dehydrogenase E1 and transketolase domain containing 1  Dhtkd1_predicted  dehydrogenase E1 and transketolase domain containing 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dhtkd1_predicted  dehydrogenase E1 and transketolase domain containing 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED