Akr1c3 (aldo-keto reductase family 1, member C3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Akr1c3 (aldo-keto reductase family 1, member C3) Rattus norvegicus
Analyze
Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
RGD ID: 708428
Description: Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and alditol:NADP+ 1-oxidoreductase activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to ketone; and cellular response to transforming growth factor beta stimulus. Acts upstream of or within progesterone metabolic process. Located in cytosol. Biomarker of polycystic ovary syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to human AKR1C3 (aldo-keto reductase family 1 member C3); PARTICIPATES IN isoprenoid metabolic pathway; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (20S)-20-hydroxypregn-4-en-3-one; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20alpha-hydroxysteroid dehydrogenase; Akr1c18; aldo-keto reductase family 1 member C18; aldo-keto reductase family 1, member C18; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); HSD1; LOC171516
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,020,884 - 71,037,779 (+)NCBIGRCr8
mRatBN7.21766,110,970 - 66,127,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,596,139 - 69,613,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,424,984 - 73,441,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,467,962 - 67,484,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,761,126 - 69,778,021 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,761,118 - 69,778,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,465,942 - 71,482,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,269,626 - 77,286,521 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,280,458 - 77,297,354 (+)NCBI
Celera1765,626,116 - 65,643,004 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-20-hydroxypregn-4-en-3-one  (EXP,ISO)
(E)-cinnamyl alcohol  (ISO)
(S)-naringenin  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,8-Dinitropyrene  (ISO)
1-Aminopyrene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
11-deoxycorticosterone  (ISO)
13-dihydrodaunorubicin  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
20-hydroxypregn-4-en-3-one  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4-hydroxybenzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5alpha-Pregnan-20alpha-ol-3-one  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
6-propyl-2-thiouracil  (EXP)
7-hydroxyflavone  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinal  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
androst-4-ene-3,17-dione  (ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
Bandrowski's base  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Bromazepam  (ISO)
bromocriptine  (EXP)
butan-1-ol  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
Clofop  (ISO)
cloxazolam  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
cyclopentanol  (ISO)
cyclopentanone  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (EXP)
desogestrel  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
dutasteride  (ISO)
dydrogesterone  (ISO)
emodin  (ISO)
enasidenib  (ISO)
estazolam  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
eugenol  (ISO)
farnesal  (ISO)
farnesoic acid  (ISO)
farnesol  (ISO)
fenamic acid  (ISO)
flufenamic acid  (ISO)
flunitrazepam  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
Frangulin A  (ISO)
Frangulin B  (ISO)
fructose  (ISO)
furan  (ISO)
geranylgeraniol  (ISO)
gliclazide  (ISO)
glimepiride  (ISO)
glipizide  (ISO)
glucose  (ISO)
glyburide  (ISO)
glycidyl methacrylate  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexane  (ISO)
hexestrol  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoeugenol  (ISO)
Isoxanthohumol  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
levonorgestrel  (ISO)
lithocholic acid  (ISO)
LY294002  (ISO)
meclofenamic acid  (ISO)
Medazepam  (ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methyl salicylate  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
midostaurin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalenes  (ISO)
naproxen  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrazepam  (ISO)
norethisterone  (ISO)
ochratoxin A  (ISO)
octyl gallate  (ISO)
oxaliplatin  (ISO)
oxcarbazepine  (ISO)
oxidopamine  (ISO)
oxycodone  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenolphthalein  (ISO)
phenylmercury acetate  (ISO)
phthalaldehyde  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
progesterone  (EXP,ISO)
propan-2-ol  (ISO)
prostaglandin D2  (ISO)
prostaglandin F2alpha  (ISO)
prostaglandin J2  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
salicylic acid  (ISO)
SB 431542  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (EXP,ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulpiride  (EXP)
superoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
tolfenamic acid  (ISO)
trans-isoeugenol  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
umbelliferone  (ISO)
uranium atom  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to calcium ion  (ISO)
cellular response to corticosteroid stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to forskolin  (IEP)
cellular response to gonadotropin-releasing hormone  (IEP)
cellular response to jasmonic acid stimulus  (ISO)
cellular response to prolactin  (IEP)
cellular response to prostaglandin D stimulus  (ISO)
cellular response to prostaglandin stimulus  (ISO)
cellular response to starvation  (ISO)
cellular response to testosterone stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IMP)
daunorubicin metabolic process  (IBA,ISO)
doxorubicin metabolic process  (IBA,ISO)
farnesol catabolic process  (ISO)
female pregnancy  (IEP)
G protein-coupled receptor signaling pathway  (ISO)
keratinocyte differentiation  (ISO)
male gonad development  (ISO)
negative regulation of retinoic acid biosynthetic process  (ISO)
parturition  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
progesterone catabolic process  (ISO)
progesterone metabolic process  (IBA,IDA,ISO)
prostaglandin metabolic process  (IBA,ISO)
regulation of retinoic acid receptor signaling pathway  (ISO)
regulation of steroid biosynthetic process  (IDA)
regulation of testosterone biosynthetic process  (ISO)
response to nutrient  (ISO)
retinal metabolic process  (ISO)
steroid metabolic process  (IEA,ISO)
testosterone biosynthetic process  (ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA,IDA,IEA)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of 17beta-hydroxysteroid dehydrogenase type 1 and type 2, P450 aromatase, and 20alpha-hydroxysteroid dehydrogenase enzymes in immature, mature, and pregnant rats. Akinola LA, etal., Endocrinology. 1997 Jul;138(7):2886-92.
2. Identification of a major prolactin-regulated protein as 20 alpha-hydroxysteroid dehydrogenase: coordinate regulation of its activity, protein content, and messenger ribonucleic acid expression. Albarracin CT, etal., Endocrinology 1994 Jun;134(6):2453-60.
3. Paracrine-stimulated gene expression profile favors estradiol production in breast tumors. Amin SA, etal., Mol Cell Endocrinol. 2006 Jul 11;253(1-2):44-55. Epub 2006 Jun 2.
4. Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system. Azzarello J, etal., J Histochem Cytochem. 2008 Sep;56(9):853-61. doi: 10.1369/jhc.2008.951384. Epub 2008 Jun 23.
5. Steroidogenic enzyme activities in rat polycystic ovaries. Cooke GM, etal., Can J Physiol Pharmacol. 1993 Mar-Apr;71(3-4):247-53.
6. Inhibition of 20 alpha-hydroxysteroid dehydrogenase activity by follicle-stimulating hormone and androgens in cultured rat granulosa cells: a search for the mechanism of action. Duleba AJ, etal., Biol Reprod. 1985 Sep;33(2):401-10.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and therapeutic target for castration-resistant prostate cancer. Hamid AR, etal., Mol Med. 2013 Jan 22;18:1449-55. doi: 10.2119/molmed.2012.00296.
9. [Effects of AKR1C3 on kidney damage of preeclamptic rats]. Jin Y, etal., Zhonghua Yi Xue Za Zhi. 2015 Jan 6;95(1):30-3.
10. Direct stimulation of ovarian progesterone-metabolizing enzyme by gonadotropin-releasing hormone in cultured granulosa cells. Jones PB and Hsueh AJ, J Biol Chem. 1981 Feb 10;256(3):1248-54.
11. The roles of pregn-5-ene-3 beta, 20 alpha-diol and 20 alpha-hydroxy steroid dehydrogenase in the control of progesterone synthesis preceding parturition and lactogenesis in the rat. Kuhn NJ and Briley MS, Biochem J. 1970 Apr;117(2):193-201.
12. Maternal and offspring genetic variants of AKR1C3 and the risk of childhood leukemia. Liu CY, etal., Carcinogenesis. 2008 May;29(5):984-90. doi: 10.1093/carcin/bgn071. Epub 2008 Mar 13.
13. Isolation and characterization of a rat luteal cDNA encoding 20 alpha-hydroxysteroid dehydrogenase. Mao J, etal., Biochem Biophys Res Commun 1994 Jun 30;201(3):1289-95.
14. Expression, purification and characterization of the rat luteal 20 alpha-hydroxysteroid dehydrogenase. Mao J, etal., Endocrinology. 1997 Jan;138(1):182-90.
15. 20 alpha-hydroxysteroid dehydrogenase expression in a murine virus-induced myeloproliferative syndrome. Marcovistz R, etal., Biochimie. 1991 Nov;73(11):1351-3.
16. Possible role of transforming growth factor-beta as a mediator of luteotropic action of prolactin in rat luteal cell cultures. Matsuyama S, etal., Endocrinology. 1990 Oct;127(4):1561-7.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Molecular cloning of cDNA for rat ovarian 20 alpha-hydroxysteroid dehydrogenase (HSD1). Miura R, etal., Biochem J 1994 Apr 15;299 ( Pt 2):561-7.
19. AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia. Moradi Manesh D, etal., Blood. 2015 Sep 3;126(10):1193-202. doi: 10.1182/blood-2014-12-618900. Epub 2015 Jun 26.
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Gene expression profiling of maternal blood in early onset severe preeclampsia: identification of novel biomarkers. Sun CJ, etal., J Perinat Med. 2009;37(6):609-16. doi: 10.1515/JPM.2009.103.
25. Involvement of nuclear factor kappa B in the regulation of rat luteal function: potential roles as survival factor and inhibitor of 20alpha-hydroxysteroid dehydrogenase. Telleria CM, etal., J Mol Endocrinol. 2004 Apr;32(2):365-83.
26. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
27. AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression. Tian Y, etal., Diagn Pathol. 2014 Feb 26;9:42. doi: 10.1186/1746-1596-9-42.
28. Prostaglandin F synthase. Watanabe K, Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:401-7.
29. Molecular cloning and characterization of the rat ovarian 20 alpha-hydroxysteroid dehydrogenase gene. Zhong L, etal., Biochem Biophys Res Commun. 1998 Aug 28;249(3):797-803.
Additional References at PubMed
PMID:12477932   PMID:15140254   PMID:15471942   PMID:16983398   PMID:17122075   PMID:18508192   PMID:18641923   PMID:19007764   PMID:19336506   PMID:19429887   PMID:19442656   PMID:19487289  
PMID:19942269   PMID:20036328   PMID:20837989   PMID:21187079   PMID:21232532   PMID:21787718   PMID:21851338   PMID:22170488   PMID:23376485   PMID:23533145   PMID:29627526  


Genomics

Comparative Map Data
Akr1c3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,020,884 - 71,037,779 (+)NCBIGRCr8
mRatBN7.21766,110,970 - 66,127,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,596,139 - 69,613,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,424,984 - 73,441,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,467,962 - 67,484,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,761,126 - 69,778,021 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,761,118 - 69,778,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,465,942 - 71,482,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,269,626 - 77,286,521 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,280,458 - 77,297,354 (+)NCBI
Celera1765,626,116 - 65,643,004 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
AKR1C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38105,048,781 - 5,107,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl105,035,354 - 5,107,686 (+)EnsemblGRCh38hg38GRCh38
GRCh37105,090,973 - 5,149,878 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,126,568 - 5,139,878 (+)NCBINCBI36Build 36hg18NCBI36
Build 34105,126,567 - 5,139,878NCBI
Celera105,076,549 - 5,089,836 (+)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,024,814 - 5,083,613 (+)NCBIHuRef
CHM1_1105,091,312 - 5,150,193 (+)NCBICHM1_1
T2T-CHM13v2.0105,049,294 - 5,108,188 (+)NCBIT2T-CHM13v2.0
Akr1c18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,182,614 - 4,200,645 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,182,614 - 4,200,653 (-)EnsemblGRCm39 Ensembl
GRCm38134,132,615 - 4,150,646 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,132,615 - 4,150,654 (-)EnsemblGRCm38mm10GRCm38
MGSCv37134,131,873 - 4,149,877 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,131,873 - 4,149,877 (-)NCBIMGSCv36mm8
Celera134,108,614 - 4,126,601 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.31NCBI
AKR1C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2817,590,820 - 17,668,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11017,660,905 - 17,732,534 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0105,079,580 - 5,157,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1105,061,119 - 5,139,818 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl105,081,214 - 5,139,812 (+)Ensemblpanpan1.1panPan2
AKR1C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1230,661,333 - 30,691,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl230,674,558 - 30,690,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha227,694,812 - 27,719,595 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0231,042,072 - 31,071,570 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl231,045,998 - 31,070,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1228,135,405 - 28,160,172 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,972,376 - 28,997,157 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,696,602 - 29,721,383 (+)NCBIUU_Cfam_GSD_1.0
AKR1C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,576,464 - 65,678,248 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11065,650,223 - 65,679,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,902,088 - 71,931,228 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Akr1c3
106 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:114
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000023739
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176364000973951021Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 2
Medium 4 3 3 1
Low 10 21 10 8 10 8 10 8 1 13 7 8
Below cutoff 2 11 11 8 6 8 1 12 12 9 3

Sequence


RefSeq Acc Id: ENSRNOT00000023739   ⟹   ENSRNOP00000023739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)Ensembl
Rnor_6.0 Ensembl1769,761,118 - 69,778,021 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117083   ⟹   ENSRNOP00000091104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)Ensembl
RefSeq Acc Id: NM_138510   ⟹   NP_612519
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,020,884 - 71,037,779 (+)NCBI
mRatBN7.21766,110,970 - 66,127,867 (+)NCBI
Rnor_6.01769,761,126 - 69,778,021 (+)NCBI
Rnor_5.01771,465,942 - 71,482,837 (+)NCBI
RGSC_v3.41777,269,626 - 77,286,521 (+)RGD
Celera1765,626,116 - 65,643,004 (+)RGD
Sequence:
RefSeq Acc Id: NP_612519   ⟸   NM_138510
- UniProtKB: Q498E4 (UniProtKB/Swiss-Prot),   P51652 (UniProtKB/Swiss-Prot),   A6JLP6 (UniProtKB/TrEMBL),   Q5RJM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023739   ⟸   ENSRNOT00000023739
RefSeq Acc Id: ENSRNOP00000091104   ⟸   ENSRNOT00000117083
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51652-F1-model_v2 AlphaFold P51652 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700547
Promoter ID:EPDNEW_R11070
Type:single initiation site
Name:Akr1c3_1
Description:aldo-keto reductase family 1, member C3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01769,761,115 - 69,761,175EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708428 AgrOrtholog
BioCyc Gene G2FUF-8832 BioCyc
Ensembl Genes ENSRNOG00000017531 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018391 UniProtKB/Swiss-Prot
  ENSRNOG00060015960 UniProtKB/Swiss-Prot
  ENSRNOG00065003624 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023739 ENTREZGENE
  ENSRNOT00000023739.6 UniProtKB/Swiss-Prot
  ENSRNOT00000117083.1 UniProtKB/TrEMBL
  ENSRNOT00055031228 UniProtKB/Swiss-Prot
  ENSRNOT00060027345 UniProtKB/Swiss-Prot
  ENSRNOT00065005257 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7307214 IMAGE-MGC_LOAD
  IMAGE:7307445 IMAGE-MGC_LOAD
InterPro AKR UniProtKB/TrEMBL
  AKR1C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171516 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105325 IMAGE-MGC_LOAD
  MGC:116049 IMAGE-MGC_LOAD
NCBI Gene 171516 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER C18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AKR1C3 RGD
PhenoGen Akr1c3 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017531 RatGTEx
  ENSRNOG00055018391 RatGTEx
  ENSRNOG00060015960 RatGTEx
  ENSRNOG00065003624 RatGTEx
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AD39_RAT UniProtKB/TrEMBL
  A6JLP6 ENTREZGENE, UniProtKB/TrEMBL
  AKC1H_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q498E4 ENTREZGENE
  Q5RJM6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q498E4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Akr1c3  aldo-keto reductase family 1, member C3  Akr1c3  aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-09 Akr1c3  aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)  Akr1c18  aldo-keto reductase family 1, member C18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Akr1c18  aldo-keto reductase family 1, member C18      Symbol and Name updated 1299863 APPROVED
2005-09-30 LOC171516        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in different steroid-producing tissues like ovary, testis, adrenal uterus and placenta 1299435
gene_regulation expression is inhibited by prolactin 1299434