Akr1c3 (aldo-keto reductase family 1, member C3) - Rat Genome Database

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Gene: Akr1c3 (aldo-keto reductase family 1, member C3) Rattus norvegicus
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Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
RGD ID: 708428
Description: Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to ketone; and cellular response to peptide hormone stimulus. Acts upstream of or within progesterone metabolic process. Located in cytosol. Biomarker of polycystic ovary syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; alcohol dependence; and leukemia. Orthologous to human AKR1C3 (aldo-keto reductase family 1 member C3); PARTICIPATES IN isoprenoid metabolic pathway; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (20S)-20-hydroxypregn-4-en-3-one; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20alpha-hydroxysteroid dehydrogenase; Akr1c18; aldo-keto reductase family 1 member C18; aldo-keto reductase family 1, member C18; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); HSD1; LOC171516
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,020,884 - 71,037,779 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1770,970,900 - 71,048,438 (+)EnsemblGRCr8
mRatBN7.21766,110,970 - 66,127,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1769,596,139 - 69,613,038 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,424,984 - 73,441,883 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,467,962 - 67,484,861 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,761,126 - 69,778,021 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,761,118 - 69,778,021 (+)Ensemblrn6Rnor6.0
Rnor_5.01771,465,942 - 71,482,837 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41777,269,626 - 77,286,521 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1765,626,116 - 65,643,004 (+)NCBICelera
RGSC_v3.11777,280,458 - 77,297,354 (+)NCBI
Cytogenetic Map17q12.2NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-20-hydroxypregn-4-en-3-one  (EXP,ISO)
(E)-cinnamyl alcohol  (ISO)
(S)-naringenin  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,8-Dinitropyrene  (ISO)
1-Aminopyrene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
11-deoxycorticosterone  (ISO)
13-dihydrodaunorubicin  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
20-hydroxypregn-4-en-3-one  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxybenzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5alpha-Pregnan-20alpha-ol-3-one  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
6-propyl-2-thiouracil  (EXP)
7-hydroxyflavone  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinal  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
androst-4-ene-3,17-dione  (ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
Azoxymethane  (ISO)
Bandrowski's base  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Bromazepam  (ISO)
bromocriptine  (EXP)
butan-1-ol  (ISO)
butyric acid  (ISO)
cadmium acetate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
Clofop  (ISO)
cloxazolam  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
cyclopentanol  (ISO)
cyclopentanone  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (EXP)
desogestrel  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dinaciclib  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
dutasteride  (ISO)
dydrogesterone  (ISO)
emodin  (ISO)
enasidenib  (ISO)
estazolam  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
eugenol  (ISO)
farnesal  (ISO)
farnesoic acid  (ISO)
farnesol  (ISO)
fenamic acid  (ISO)
flufenamic acid  (ISO)
flunitrazepam  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
Frangulin A  (ISO)
Frangulin B  (ISO)
fructose  (ISO)
furan  (ISO)
geranylgeraniol  (ISO)
gliclazide  (ISO)
glimepiride  (ISO)
glipizide  (ISO)
glucose  (ISO)
glyburide  (ISO)
glycidyl methacrylate  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
hexane  (ISO)
hexestrol  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
idarubicin  (ISO)
Idarubicinol  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoeugenol  (ISO)
isoniazide  (ISO)
Isoxanthohumol  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
levonorgestrel  (ISO)
lithocholic acid  (ISO)
LY294002  (ISO)
meclofenamic acid  (ISO)
Medazepam  (ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methyl salicylate  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
midostaurin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalenes  (ISO)
naproxen  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrazepam  (ISO)
norethisterone  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
octyl gallate  (ISO)
oxaliplatin  (ISO)
oxcarbazepine  (ISO)
oxidopamine  (ISO)
oxycodone  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
Panaxytriol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenolphthalein  (ISO)
phenylmercury acetate  (ISO)
phthalaldehyde  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
progesterone  (EXP,ISO)
propan-2-ol  (ISO)
prostaglandin D2  (ISO)
prostaglandin F2alpha  (ISO)
prostaglandin J2  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
ranirestat  (ISO)
resveratrol  (EXP)
Ro 31-8220  (ISO)
rotenone  (EXP)
salicylic acid  (ISO)
SB 431542  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (EXP,ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulpiride  (EXP)
superoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
tolfenamic acid  (ISO)
trans-isoeugenol  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
umbelliferone  (ISO)
uranium atom  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to calcium ion  (ISO)
cellular response to corticosteroid stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to forskolin  (IEP)
cellular response to gonadotropin-releasing hormone  (IEP)
cellular response to jasmonic acid stimulus  (ISO)
cellular response to prolactin  (IEP)
cellular response to prostaglandin D stimulus  (ISO)
cellular response to prostaglandin stimulus  (ISO)
cellular response to starvation  (ISO)
cellular response to testosterone stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IMP)
daunorubicin metabolic process  (IBA,ISO)
doxorubicin metabolic process  (IBA,ISO)
farnesol catabolic process  (ISO)
female pregnancy  (IEP)
G protein-coupled receptor signaling pathway  (ISO)
keratinocyte differentiation  (ISO)
male gonad development  (ISO)
negative regulation of retinoic acid biosynthetic process  (ISO)
parturition  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
progesterone catabolic process  (IEA,ISO)
progesterone metabolic process  (IBA,IDA,ISO)
prostaglandin metabolic process  (IBA,ISO)
regulation of retinoic acid receptor signaling pathway  (ISO)
regulation of steroid biosynthetic process  (IDA)
regulation of testosterone biosynthetic process  (ISO)
response to nutrient  (ISO)
retinal metabolic process  (ISO)
steroid metabolic process  (ISO)
testosterone biosynthetic process  (ISO)

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,IDA)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of 17beta-hydroxysteroid dehydrogenase type 1 and type 2, P450 aromatase, and 20alpha-hydroxysteroid dehydrogenase enzymes in immature, mature, and pregnant rats. Akinola LA, etal., Endocrinology. 1997 Jul;138(7):2886-92.
2. Identification of a major prolactin-regulated protein as 20 alpha-hydroxysteroid dehydrogenase: coordinate regulation of its activity, protein content, and messenger ribonucleic acid expression. Albarracin CT, etal., Endocrinology 1994 Jun;134(6):2453-60.
3. Paracrine-stimulated gene expression profile favors estradiol production in breast tumors. Amin SA, etal., Mol Cell Endocrinol. 2006 Jul 11;253(1-2):44-55. Epub 2006 Jun 2.
4. Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system. Azzarello J, etal., J Histochem Cytochem. 2008 Sep;56(9):853-61. doi: 10.1369/jhc.2008.951384. Epub 2008 Jun 23.
5. Steroidogenic enzyme activities in rat polycystic ovaries. Cooke GM, etal., Can J Physiol Pharmacol. 1993 Mar-Apr;71(3-4):247-53.
6. Inhibition of 20 alpha-hydroxysteroid dehydrogenase activity by follicle-stimulating hormone and androgens in cultured rat granulosa cells: a search for the mechanism of action. Duleba AJ, etal., Biol Reprod. 1985 Sep;33(2):401-10.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and therapeutic target for castration-resistant prostate cancer. Hamid AR, etal., Mol Med. 2013 Jan 22;18:1449-55. doi: 10.2119/molmed.2012.00296.
9. [Effects of AKR1C3 on kidney damage of preeclamptic rats]. Jin Y, etal., Zhonghua Yi Xue Za Zhi. 2015 Jan 6;95(1):30-3.
10. Direct stimulation of ovarian progesterone-metabolizing enzyme by gonadotropin-releasing hormone in cultured granulosa cells. Jones PB and Hsueh AJ, J Biol Chem. 1981 Feb 10;256(3):1248-54.
11. The roles of pregn-5-ene-3 beta, 20 alpha-diol and 20 alpha-hydroxy steroid dehydrogenase in the control of progesterone synthesis preceding parturition and lactogenesis in the rat. Kuhn NJ and Briley MS, Biochem J. 1970 Apr;117(2):193-201.
12. Maternal and offspring genetic variants of AKR1C3 and the risk of childhood leukemia. Liu CY, etal., Carcinogenesis. 2008 May;29(5):984-90. doi: 10.1093/carcin/bgn071. Epub 2008 Mar 13.
13. Isolation and characterization of a rat luteal cDNA encoding 20 alpha-hydroxysteroid dehydrogenase. Mao J, etal., Biochem Biophys Res Commun 1994 Jun 30;201(3):1289-95.
14. Expression, purification and characterization of the rat luteal 20 alpha-hydroxysteroid dehydrogenase. Mao J, etal., Endocrinology. 1997 Jan;138(1):182-90.
15. 20 alpha-hydroxysteroid dehydrogenase expression in a murine virus-induced myeloproliferative syndrome. Marcovistz R, etal., Biochimie. 1991 Nov;73(11):1351-3.
16. Possible role of transforming growth factor-beta as a mediator of luteotropic action of prolactin in rat luteal cell cultures. Matsuyama S, etal., Endocrinology. 1990 Oct;127(4):1561-7.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Variation in genes encoding the neuroactive steroid synthetic enzymes 5α-reductase type 1 and 3α-reductase type 2 is associated with alcohol dependence. Milivojevic V, etal., Alcohol Clin Exp Res. 2011 May;35(5):946-52. doi: 10.1111/j.1530-0277.2010.01425.x. Epub 2011 Feb 15.
19. Molecular cloning of cDNA for rat ovarian 20 alpha-hydroxysteroid dehydrogenase (HSD1). Miura R, etal., Biochem J 1994 Apr 15;299 ( Pt 2):561-7.
20. AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia. Moradi Manesh D, etal., Blood. 2015 Sep 3;126(10):1193-202. doi: 10.1182/blood-2014-12-618900. Epub 2015 Jun 26.
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Gene expression profiling of maternal blood in early onset severe preeclampsia: identification of novel biomarkers. Sun CJ, etal., J Perinat Med. 2009;37(6):609-16. doi: 10.1515/JPM.2009.103.
26. Involvement of nuclear factor kappa B in the regulation of rat luteal function: potential roles as survival factor and inhibitor of 20alpha-hydroxysteroid dehydrogenase. Telleria CM, etal., J Mol Endocrinol. 2004 Apr;32(2):365-83.
27. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
28. AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression. Tian Y, etal., Diagn Pathol. 2014 Feb 26;9:42. doi: 10.1186/1746-1596-9-42.
29. Prostaglandin F synthase. Watanabe K, Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:401-7.
30. Molecular cloning and characterization of the rat ovarian 20 alpha-hydroxysteroid dehydrogenase gene. Zhong L, etal., Biochem Biophys Res Commun. 1998 Aug 28;249(3):797-803.
Additional References at PubMed
PMID:12477932   PMID:15140254   PMID:15471942   PMID:16983398   PMID:17122075   PMID:18508192   PMID:18641923   PMID:19007764   PMID:19336506   PMID:19429887   PMID:19442656   PMID:19487289  
PMID:19942269   PMID:20036328   PMID:20837989   PMID:21187079   PMID:21232532   PMID:21787718   PMID:21851338   PMID:22170488   PMID:23376485   PMID:23533145   PMID:29627526  


Genomics

Comparative Map Data
Akr1c3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,020,884 - 71,037,779 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1770,970,900 - 71,048,438 (+)EnsemblGRCr8
mRatBN7.21766,110,970 - 66,127,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1769,596,139 - 69,613,038 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,424,984 - 73,441,883 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,467,962 - 67,484,861 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,761,126 - 69,778,021 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,761,118 - 69,778,021 (+)Ensemblrn6Rnor6.0
Rnor_5.01771,465,942 - 71,482,837 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41777,269,626 - 77,286,521 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1765,626,116 - 65,643,004 (+)NCBICelera
RGSC_v3.11777,280,458 - 77,297,354 (+)NCBI
Cytogenetic Map17q12.2NCBI
AKR1C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38105,048,781 - 5,107,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl105,035,354 - 5,107,686 (+)Ensemblhg38GRCh38
GRCh37105,090,973 - 5,149,878 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,126,568 - 5,139,878 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34105,126,567 - 5,139,878NCBI
Celera105,076,549 - 5,089,836 (+)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,024,814 - 5,083,613 (+)NCBIHuRef
CHM1_1105,091,312 - 5,150,193 (+)NCBICHM1_1
T2T-CHM13v2.0105,049,294 - 5,108,188 (+)NCBIT2T-CHM13v2.0
Akr1c18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,182,614 - 4,200,645 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,182,614 - 4,200,653 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38134,132,615 - 4,150,646 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,132,615 - 4,150,654 (-)Ensemblmm10GRCm38
MGSCv37134,131,873 - 4,149,877 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36134,131,873 - 4,149,877 (-)NCBIMGSCv36mm8
Celera134,108,614 - 4,126,601 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.31NCBI
AKR1C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2817,590,820 - 17,668,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11017,660,905 - 17,732,534 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0105,079,580 - 5,157,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1105,061,119 - 5,139,818 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl105,081,214 - 5,139,812 (+)EnsemblpanPan2panpan1.1
AKR1C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1230,661,333 - 30,691,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl230,674,558 - 30,690,043 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha227,694,812 - 27,719,595 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0231,042,072 - 31,071,570 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl231,045,998 - 31,070,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1228,135,405 - 28,160,172 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,972,376 - 28,997,157 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,696,602 - 29,721,383 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
AKR1C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,576,464 - 65,678,248 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11065,650,223 - 65,679,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,902,088 - 71,931,228 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AKR1C3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.195,237,176 - 5,254,772 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605110,405,772 - 10,430,031 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Akr1c3
119 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:114
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000023739
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176364000973951021Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
7 11 39 47 64 65 35 16 35 6 148 80 2 27 18 48 30

Sequence


Ensembl Acc Id: ENSRNOT00000023739   ⟹   ENSRNOP00000023739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1770,970,900 - 71,037,785 (+)Ensembl
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)Ensembl
Rnor_6.0 Ensembl1769,761,118 - 69,778,021 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109545   ⟹   ENSRNOP00000080058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,020,805 - 71,039,715 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117083   ⟹   ENSRNOP00000091104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,020,805 - 71,037,785 (+)Ensembl
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000130492   ⟹   ENSRNOP00000111598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,020,805 - 71,047,158 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000146820   ⟹   ENSRNOP00000098869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,020,805 - 71,048,438 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000168386   ⟹   ENSRNOP00000104189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,020,805 - 71,037,785 (+)Ensembl
RefSeq Acc Id: NM_138510   ⟹   NP_612519
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,020,884 - 71,037,779 (+)NCBI
mRatBN7.21766,110,970 - 66,127,867 (+)NCBI
Rnor_6.01769,761,126 - 69,778,021 (+)NCBI
Rnor_5.01771,465,942 - 71,482,837 (+)NCBI
RGSC_v3.41777,269,626 - 77,286,521 (+)RGD
Celera1765,626,116 - 65,643,004 (+)RGD
Sequence:
RefSeq Acc Id: NP_612519   ⟸   NM_138510
- UniProtKB: Q498E4 (UniProtKB/Swiss-Prot),   P51652 (UniProtKB/Swiss-Prot),   A6JLP6 (UniProtKB/TrEMBL),   Q5RJM6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023739   ⟸   ENSRNOT00000023739
Ensembl Acc Id: ENSRNOP00000091104   ⟸   ENSRNOT00000117083
Ensembl Acc Id: ENSRNOP00000080058   ⟸   ENSRNOT00000109545
Ensembl Acc Id: ENSRNOP00000104189   ⟸   ENSRNOT00000168386
Ensembl Acc Id: ENSRNOP00000111598   ⟸   ENSRNOT00000130492
Ensembl Acc Id: ENSRNOP00000098869   ⟸   ENSRNOT00000146820
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51652-F1-model_v2 AlphaFold P51652 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700547
Promoter ID:EPDNEW_R11070
Type:single initiation site
Name:Akr1c3_1
Description:aldo-keto reductase family 1, member C3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01769,761,115 - 69,761,175EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708428 AgrOrtholog
BioCyc Gene G2FUF-8832 BioCyc
Ensembl Genes ENSRNOG00000017531 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023739.6 UniProtKB/Swiss-Prot
  ENSRNOT00000168386 ENTREZGENE
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7307214 IMAGE-MGC_LOAD
  IMAGE:7307445 IMAGE-MGC_LOAD
InterPro AKR1C UniProtKB/Swiss-Prot
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot
  Aldo/keto_reductase UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:171516 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105325 IMAGE-MGC_LOAD
  MGC:116049 IMAGE-MGC_LOAD
NCBI Gene 171516 ENTREZGENE
PANTHER ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot
Pfam Aldo_ket_red UniProtKB/Swiss-Prot
PharmGKB AKR1C3 RGD
PhenoGen Akr1c3 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/Swiss-Prot
  ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot
  ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017531 RatGTEx
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot
UniProt A0A8I6AD39_RAT UniProtKB/TrEMBL
  A6JLP6 ENTREZGENE, UniProtKB/TrEMBL
  AKC1H_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q498E4 ENTREZGENE
  Q5RJM6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q498E4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Akr1c3  aldo-keto reductase family 1, member C3  Akr1c3  aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-09 Akr1c3  aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)  Akr1c18  aldo-keto reductase family 1, member C18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Akr1c18  aldo-keto reductase family 1, member C18      Symbol and Name updated 1299863 APPROVED
2005-09-30 LOC171516        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in different steroid-producing tissues like ovary, testis, adrenal uterus and placenta 1299435
gene_regulation expression is inhibited by prolactin 1299434