Gene: Akr1c3 (aldo-keto reductase family 1, member C3) Rattus norvegicus
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Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Description: ENCODES a protein that exhibits 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; alditol:NADP+ 1-oxidoreductase activity; aldo-keto reductase (NADP) activity; INVOLVED IN cellular response to follicle-stimulating hormone stimulus; cellular response to forskolin; cellular response to gonadotropin-releasing hormone; PARTICIPATES IN isoprenoid metabolic pathway; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; ASSOCIATED WITH polycystic ovary syndrome; pre-eclampsia; Castration-Resistant Prostatic Neoplasms (ortholog); FOUND IN cytoplasm; cytosol; nucleus; INTERACTS WITH (20R)-20-hydroxypregn-4-en-3-one; (20S)-20-hydroxypregn-4-en-3-one; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20alpha-hydroxysteroid dehydrogenase; Akr1c18; aldo-keto reductase family 1 member C18; aldo-keto reductase family 1, member C18; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); HSD1; LOC171516
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01769,761,126 - 69,778,021 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01771,465,942 - 71,482,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,269,626 - 77,286,521 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11777,280,458 - 77,297,354 (+)NCBI
Celera1765,626,116 - 65,643,004 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Akr1c3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 708428
Created: 2003-09-23
Species: Rattus norvegicus
Last Modified: 2018-05-29
Status: ACTIVE