(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1352888 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AKR1C3 mRNA CTD PMID:22079256 (20S)-20-hydroxypregn-4-en-3-one multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone, [AKR1C3 protein results in increased reduction of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone CTD PMID:19010312 , PMID:20036328 (20S)-20-hydroxypregn-4-en-3-one increases chemical synthesis EXP 6480464 AKR1C18 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone CTD PMID:8172618 (20S)-20-hydroxypregn-4-en-3-one increases chemical synthesis ISO RGD:1352888 6480464 AKR1C3 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone CTD PMID:25463305 (E)-cinnamyl alcohol increases expression ISO RGD:1352888 6480464 cinnamyl alcohol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 (S)-naringenin decreases activity ISO RGD:1352888 6480464 naringenin results in decreased activity of AKR1C3 protein CTD PMID:19007764 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactions EXP 6480464 2 more ... CTD PMID:19414516 1,10-phenanthroline decreases activity ISO RGD:1352888 6480464 1, 10-phenanthroline results in decreased activity of AKR1C3 protein CTD PMID:12604236 1,2-dichloroethane increases expression ISO RGD:733290 6480464 ethylene dichloride results in increased expression of AKR1C18 mRNA CTD PMID:28960355 1,2-dimethylhydrazine decreases expression ISO RGD:733290 6480464 1, 2-Dimethylhydrazine results in decreased expression of AKR1C18 mRNA CTD PMID:22206623 1,8-Dinitropyrene multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased degradation of 1, 8-dinitropyrene] which results in increased abundance of 1-amino-8-nitropyrene CTD PMID:36399404 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:1352888 6480464 Dinitrochlorobenzene results in increased expression of AKR1C3 mRNA CTD PMID:20566472 1-chloro-2,4-dinitrobenzene affects expression ISO RGD:733290 6480464 Dinitrochlorobenzene affects the expression of AKR1C18 mRNA CTD PMID:22302311 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of AKR1C3 mRNA CTD PMID:25380136 , PMID:30723492 1-nitropyrene multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased degradation of 1-nitropyrene] which results in increased abundance of 1-aminopyrene CTD PMID:36399404 11-deoxycorticosterone increases metabolic processing ISO RGD:733290 6480464 AKR1C18 protein results in increased metabolism of Desoxycorticosterone CTD PMID:17122075 13-dihydrodaunorubicin multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased metabolism of Daunorubicin] which results in increased abundance of daunorubicinol more ... CTD PMID:30703376 more ... 13-dihydrodaunorubicin increases chemical synthesis ISO RGD:1352888 6480464 AKR1C3 protein results in increased chemical synthesis of daunorubicinol CTD PMID:33025066 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions ISO RGD:1352888 6480464 [Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12, 14)-prostaglandin J2 CTD PMID:19997560 17beta-estradiol multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased metabolism of Estrone] which results in increased chemical synthesis of Estradiol more ... CTD PMID:19010312 more ... 17beta-estradiol increases expression ISO RGD:733290 6480464 Estradiol results in increased expression of AKR1C18 mRNA CTD PMID:19484750 17beta-estradiol decreases expression ISO RGD:1352888 6480464 Estradiol results in decreased expression of AKR1C3 mRNA CTD PMID:19619570 more ... 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased metabolism of Androstenedione] which results in increased chemical synthesis of Dihydrotestosterone, Flufenamic Acid inhibits the reaction [AKR1C3 protein results in increased metabolism of Dihydrotestosterone] CTD PMID:14672942 , PMID:19010312 17beta-hydroxy-5alpha-androstan-3-one increases metabolic processing ISO RGD:1352888 6480464 AKR1C3 protein results in increased metabolism of Dihydrotestosterone CTD PMID:14672942 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1352888 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of AKR1C3 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:733290 6480464 Tetrachlorodibenzodioxin results in increased expression of AKR1C18 mRNA CTD PMID:28922406 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:733290 6480464 Tetrachlorodibenzodioxin affects the expression of AKR1C18 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1C3 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of AKR1C3 mRNA] CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1352888 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1C3 mRNA CTD PMID:19619570 2-amino-14,16-dimethyloctadecan-3-ol decreases expression ISO RGD:1352888 6480464 2-amino-14, 16-dimethyloctadecan-3-ol results in decreased expression of AKR1C3 protein CTD PMID:32044396 2-hydroxyethyl methacrylate increases expression ISO RGD:1352888 6480464 hydroxyethyl methacrylate results in increased expression of AKR1C3 mRNA CTD PMID:30497689 2-hydroxypropanoic acid increases expression ISO RGD:1352888 6480464 Lactic Acid results in increased expression of AKR1C3 mRNA CTD PMID:20566472 2-methoxyethanol multiple interactions EXP 6480464 methyl cellosolve inhibits the reaction [Bromocriptine results in increased expression of AKR1C3 mRNA] CTD PMID:21427058 2-methoxyethanol decreases expression EXP 6480464 methyl cellosolve results in decreased expression of AKR1C3 mRNA CTD PMID:21427058 20-hydroxypregn-4-en-3-one increases chemical synthesis ISO RGD:1352888 6480464 AKR1C3 protein results in increased chemical synthesis of 3-hydroxypregn-4-en-20-one CTD PMID:25463305 3,3',5-triiodo-L-thyronine increases expression ISO RGD:1352888 6480464 Triiodothyronine results in increased expression of AKR1C3 mRNA CTD PMID:15507505 3,4-dichloroaniline increases expression ISO RGD:1352888 6480464 3, 4-dichloroaniline results in increased expression of AKR1C3 mRNA CTD PMID:24172598 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:733290 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of AKR1C18 mRNA CTD PMID:20188158 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of AKR1C3 protein CTD PMID:34915118 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1352888 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C3 mRNA CTD PMID:28628672 3-Nitrobenzanthrone increases reduction ISO RGD:1352888 6480464 AKR1C3 protein results in increased reduction of 3-nitrobenzanthrone CTD PMID:30406992 3-Nitrobenzanthrone multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone, [AKR1C3 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone CTD PMID:30406992 3alpha-hydroxy-5beta-pregnan-20-one increases chemical synthesis ISO RGD:1352888 6480464 AKR1C3 protein results in increased chemical synthesis of Pregnanolone CTD PMID:25463305 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of AKR1C3 mRNA CTD PMID:25380136 4,4'-diaminodiphenylmethane increases expression ISO RGD:733290 6480464 4, 4'-diaminodiphenylmethane results in increased expression of AKR1C18 mRNA CTD PMID:18648102 4-hydroxybenzoic acid decreases activity ISO RGD:1352888 6480464 4-hydroxybenzoic acid analog results in decreased activity of AKR1C3 protein CTD PMID:27163852 4-hydroxynon-2-enal multiple interactions ISO RGD:1352888 6480464 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal] CTD PMID:22964423 4-hydroxynon-2-enal increases expression ISO RGD:1352888 6480464 4-hydroxy-2-nonenal results in increased expression of AKR1C3 mRNA, 4-hydroxy-2-nonenal results in increased expression of AKR1C3 protein CTD PMID:22964423 , PMID:30849339 4-hydroxynon-2-enal increases response to substance ISO RGD:1352888 6480464 AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal CTD PMID:22964423 4-hydroxyphenyl retinamide decreases expression ISO RGD:733290 6480464 Fenretinide results in decreased expression of AKR1C3 mRNA CTD PMID:28973697 5-fluorouracil affects expression ISO RGD:1352888 6480464 Fluorouracil affects the expression of AKR1C3 mRNA CTD PMID:16584549 5-fluorouracil affects response to substance ISO RGD:1352888 6480464 AKR1C3 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 5alpha-Pregnan-20alpha-ol-3-one increases chemical synthesis ISO RGD:1352888 6480464 AKR1C3 protein results in increased chemical synthesis of allopregnan-20 alpha-ol-3-one CTD PMID:25463305 5alpha-pregnane-3,20-dione increases chemical synthesis ISO RGD:1352888 6480464 AKR1C3 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone CTD PMID:25463305 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of AKR1C18 mRNA CTD PMID:24780913 7-hydroxyflavone decreases activity ISO RGD:1352888 6480464 7-hydroxyflavone results in decreased activity of AKR1C3 protein CTD PMID:19007764 9,10-phenanthroquinone increases metabolic processing ISO RGD:1352888 6480464 AKR1C3 protein results in increased metabolism of 9, 10-phenanthrenequinone CTD PMID:17950253 , PMID:29108775 9,10-phenanthroquinone increases reduction ISO RGD:1352888 6480464 AKR1C3 protein results in increased reduction of 9, 10-phenanthrenequinone CTD PMID:19442656 more ... 9,10-phenanthroquinone increases expression ISO RGD:1352888 6480464 9, 10-phenanthrenequinone results in increased expression of AKR1C3 protein CTD PMID:29108775 9,10-phenanthroquinone multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased reduction of 9 more ... CTD PMID:17950253 more ... 9-cis-retinal increases reduction ISO RGD:1352888 6480464 AKR1C3 protein mutant form results in increased reduction of 9-cis-retinal, AKR1C3 protein results in increased reduction of 9-cis-retinal CTD PMID:21851338 acetylsalicylic acid decreases activity ISO RGD:1352888 6480464 Aspirin results in decreased activity of AKR1C3 protein CTD PMID:19010312 acrolein multiple interactions ISO RGD:1352888 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of AKR1C3 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of AKR1C3 mRNA CTD PMID:32699268 all-trans-retinal increases reduction ISO RGD:1352888 6480464 AKR1C3 protein results in increased reduction of Retinaldehyde CTD PMID:23261716 all-trans-retinoic acid increases expression ISO RGD:1352888 6480464 Tretinoin results in increased expression of AKR1C3 mRNA CTD PMID:23724009 , PMID:33167477 all-trans-retinoic acid multiple interactions ISO RGD:1352888 6480464 [Tretinoin results in decreased activity of AKR1C3 protein] which results in increased susceptibility to Daunorubicin more ... CTD PMID:32588086 Aloe emodin decreases activity ISO RGD:1352888 6480464 aloe emodin results in decreased activity of AKR1C3 protein CTD PMID:35065925 alpha-hexylcinnamaldehyde increases expression ISO RGD:1352888 6480464 hexyl cinnamic aldehyde results in increased expression of AKR1C3 mRNA CTD PMID:20566472 alpha-hexylcinnamaldehyde affects expression ISO RGD:733290 6480464 hexyl cinnamic aldehyde affects the expression of AKR1C18 mRNA CTD PMID:22302311 alpha-pinene multiple interactions ISO RGD:1352888 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of AKR1C3 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of AKR1C3 mRNA CTD PMID:32699268 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of AKR1C18 mRNA CTD PMID:16483693 androst-4-ene-3,17-dione increases metabolic processing ISO RGD:1352888 6480464 AKR1C3 protein results in increased metabolism of Androstenedione CTD PMID:19010312 androst-4-ene-3,17-dione increases reduction ISO RGD:1352888 6480464 AKR1C3 protein results in increased reduction of Androstenedione CTD PMID:17950253 , PMID:20036328 androst-4-ene-3,17-dione multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased metabolism of Androstenedione] which results in increased chemical synthesis of Dihydrotestosterone more ... CTD PMID:17950253 more ... antimonite multiple interactions ISO RGD:1352888 6480464 [Antimony Potassium Tartrate results in increased abundance of antimonite] which results in increased expression of AKR1C3 mRNA CTD PMID:32076005 antirheumatic drug increases expression ISO RGD:1352888 6480464 Antirheumatic Agents results in increased expression of AKR1C3 mRNA CTD PMID:24449571 arsane multiple interactions ISO RGD:1352888 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of AKR1C3 mRNA CTD PMID:32525701 arsenic atom multiple interactions ISO RGD:1352888 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of AKR1C3 mRNA CTD PMID:32525701 arsenite(3-) multiple interactions ISO RGD:1352888 6480464 [sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C3 mRNA CTD PMID:32076005 arsenous acid multiple interactions ISO RGD:1352888 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1C3 protein] CTD PMID:26598702 arsenous acid increases expression ISO RGD:1352888 6480464 Arsenic Trioxide results in increased expression of AKR1C3 mRNA CTD PMID:19128835 more ... arsenous acid decreases response to substance ISO RGD:1352888 6480464 AKR1C3 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of AKR1C3 mRNA CTD PMID:21427058 avobenzone increases expression ISO RGD:1352888 6480464 avobenzone results in increased expression of AKR1C3 mRNA CTD PMID:31016361 Bandrowski's base increases expression ISO RGD:1352888 6480464 Bandrowski's base results in increased expression of AKR1C3 mRNA CTD PMID:20566472 benzbromarone decreases activity ISO RGD:1352888 6480464 Benzbromarone results in decreased activity of AKR1C3 protein CTD PMID:12604236 benzo[a]pyrene multiple interactions ISO RGD:1352888 6480464 [Butyric Acid co-treated with Benzo(a)pyrene] results in increased expression of AKR1C3 mRNA more ... CTD PMID:17612574 , PMID:30439556 benzo[a]pyrene decreases expression ISO RGD:1352888 6480464 Benzo(a)pyrene results in decreased expression of AKR1C3 mRNA CTD PMID:30439556 benzo[a]pyrene decreases expression ISO RGD:733290 6480464 Benzo(a)pyrene results in decreased expression of AKR1C18 mRNA CTD PMID:22228805 benzo[a]pyrene increases expression ISO RGD:1352888 6480464 Benzo(a)pyrene results in increased expression of AKR1C3 mRNA, Benzo(a)pyrene results in increased expression of AKR1C3 protein CTD PMID:20106945 more ... Benzo[a]pyrene-7,8-diol multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7, 8-dihydrodiol CTD PMID:21910479 benzo[a]pyrene-7,8-dione multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7, 8-dione CTD PMID:21910479 benzo[e]pyrene increases methylation ISO RGD:1352888 6480464 benzo(e)pyrene results in increased methylation of AKR1C3 intron CTD PMID:30157460 benzoic acid increases expression ISO RGD:1352888 6480464 Benzoic Acid results in increased expression of AKR1C3 mRNA CTD PMID:20566472 beta-naphthoflavone increases expression ISO RGD:1352888 6480464 beta-Naphthoflavone results in increased expression of AKR1C3 mRNA CTD PMID:19737606 , PMID:32151702 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of AKR1C18 mRNA CTD PMID:18164116 bexarotene increases expression ISO RGD:1352888 6480464 bexarotene results in increased expression of AKR1C3 mRNA CTD PMID:17178900 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of AKR1C3 mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:1352888 6480464 bisphenol A results in increased methylation of AKR1C3 gene CTD PMID:31601247 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of AKR1C3 mRNA CTD PMID:32145629 bisphenol A affects expression ISO RGD:1352888 6480464 bisphenol A affects the expression of AKR1C3 mRNA CTD PMID:30903817 Bisphenol B increases expression ISO RGD:1352888 6480464 bisphenol B results in increased expression of AKR1C3 protein CTD PMID:34186270 bisphenol F increases expression ISO RGD:1352888 6480464 bisphenol F results in increased expression of AKR1C3 protein CTD PMID:34186270 bortezomib increases expression ISO RGD:1352888 6480464 Bortezomib results in increased expression of AKR1C3 mRNA CTD PMID:21215737 Bromazepam decreases activity ISO RGD:1352888 6480464 Bromazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 bromocriptine increases expression EXP 6480464 Bromocriptine results in increased expression of AKR1C3 mRNA CTD PMID:21427058 bromocriptine multiple interactions EXP 6480464 methyl cellosolve inhibits the reaction [Bromocriptine results in increased expression of AKR1C3 mRNA] CTD PMID:21427058 butan-1-ol multiple interactions ISO RGD:1352888 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of AKR1C3 mRNA CTD PMID:29432896 butyric acid increases expression ISO RGD:1352888 6480464 Butyric Acid results in increased expression of AKR1C3 mRNA CTD PMID:30439556 butyric acid multiple interactions ISO RGD:1352888 6480464 [Butyric Acid co-treated with Benzo(a)pyrene] results in increased expression of AKR1C3 mRNA more ... CTD PMID:30439556 cadmium atom increases expression ISO RGD:1352888 6480464 Cadmium results in increased expression of AKR1C3 mRNA CTD PMID:21120746 cadmium atom multiple interactions ISO RGD:1352888 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AKR1C3 mRNA CTD PMID:29741670 more ... cadmium atom decreases expression ISO RGD:733290 6480464 Cadmium results in decreased expression of AKR1C18 mRNA CTD PMID:24067728 cadmium dichloride multiple interactions ISO RGD:1352888 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AKR1C3 mRNA CTD PMID:29741670 more ... capecitabine increases response to substance ISO RGD:1352888 6480464 AKR1C3 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 carbamazepine affects expression ISO RGD:1352888 6480464 Carbamazepine affects the expression of AKR1C3 mRNA CTD PMID:25979313 carbon nanotube decreases expression ISO RGD:733290 6480464 Nanotubes, Carbon results in decreased expression of AKR1C18 mRNA CTD PMID:25620056 CGP 52608 multiple interactions ISO RGD:1352888 6480464 CGP 52608 promotes the reaction [RORA protein binds to AKR1C3 gene] CTD PMID:28238834 choline multiple interactions ISO RGD:733290 6480464 [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of AKR1C18 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1C18 mRNA CTD PMID:20938992 , PMID:29127188 cinnamyl alcohol increases expression ISO RGD:1352888 6480464 cinnamyl alcohol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 cisplatin increases expression ISO RGD:1352888 6480464 Cisplatin results in increased expression of AKR1C3 mRNA, Cisplatin results in increased expression of AKR1C3 protein CTD PMID:23165153 , PMID:27392435 cisplatin multiple interactions ISO RGD:1352888 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of AKR1C3 mRNA more ... CTD PMID:23165153 , PMID:27392435 cisplatin decreases response to substance ISO RGD:1352888 6480464 AKR1C3 protein results in decreased susceptibility to Cisplatin CTD PMID:23165153 Clofop increases reduction ISO RGD:1352888 6480464 AKR1C3 protein results in increased reduction of fenofibric acid CTD PMID:27599626 cloxazolam decreases activity ISO RGD:1352888 6480464 cloxazolam results in decreased activity of AKR1C3 protein CTD PMID:11995921 , PMID:12604236 cobalt dichloride decreases expression ISO RGD:1352888 6480464 cobaltous chloride results in decreased expression of AKR1C3 mRNA CTD PMID:17553155 colforsin daropate hydrochloride decreases expression ISO RGD:1352888 6480464 Colforsin results in decreased expression of AKR1C3 mRNA CTD PMID:28235592 coniferyl aldehyde increases expression ISO RGD:1352888 6480464 coniferaldehyde results in increased expression of AKR1C3 mRNA CTD PMID:26275128 copper atom multiple interactions ISO RGD:1352888 6480464 [NSC 689534 binds to Copper] which results in increased expression of AKR1C3 mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:1352888 6480464 [NSC 689534 binds to Copper] which results in increased expression of AKR1C3 mRNA CTD PMID:20971185 copper(II) sulfate increases expression ISO RGD:1352888 6480464 Copper Sulfate results in increased expression of AKR1C3 mRNA CTD PMID:19549813 crotonaldehyde increases expression ISO RGD:1352888 6480464 2-butenal results in increased expression of AKR1C3 mRNA CTD PMID:20471460 cycloheximide multiple interactions ISO RGD:1352888 6480464 Cycloheximide inhibits the reaction [cadmium acetate results in increased expression of AKR1C3 protein] CTD PMID:21787718 cyclopentanol increases oxidation ISO RGD:1352888 6480464 AKR1C3 protein results in increased oxidation of cyclopentanol CTD PMID:23261716 cyclopentanone multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein co-treated with NADP] results in increased reduction of cyclopentanone more ... CTD PMID:23261716 cyclopentanone increases reduction ISO RGD:1352888 6480464 AKR1C3 protein results in increased reduction of cyclopentanone CTD PMID:23261716 cyclosporin A decreases expression ISO RGD:1352888 6480464 Cyclosporine results in decreased expression of AKR1C3 mRNA CTD PMID:25562108 , PMID:33631201 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of AKR1C18 mRNA CTD PMID:21865292 daunorubicin increases metabolic processing ISO RGD:1352888 6480464 AKR1C3 protein results in increased metabolism of Daunorubicin, AKR1C3 results in increased metabolism of Daunorubicin CTD PMID:20837989 more ... daunorubicin increases reduction ISO RGD:1352888 6480464 AKR1C3 protein results in increased reduction of Daunorubicin CTD PMID:33025066 , PMID:35972551 daunorubicin multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased metabolism of Daunorubicin] which results in increased abundance of daunorubicinol more ... CTD PMID:29992508 more ... daunorubicin decreases response to substance ISO RGD:1352888 6480464 AKR1C3 protein results in decreased susceptibility to Daunorubicin CTD PMID:29992508 more ... deguelin increases expression ISO RGD:1352888 6480464 deguelin results in increased expression of AKR1C3 mRNA CTD PMID:33512557 dehydroepiandrosterone affects metabolic processing EXP 6480464 AKR1C18 protein affects the metabolism of Dehydroepiandrosterone CTD PMID:15261307 desogestrel decreases activity ISO RGD:1352888 6480464 Desogestrel results in decreased activity of AKR1C3 protein CTD PMID:21182831 dexamethasone increases expression ISO RGD:1352888 6480464 Dexamethasone results in increased expression of AKR1C3 mRNA CTD PMID:25047013 dexamethasone multiple interactions ISO RGD:1352888 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C3 mRNA CTD PMID:28628672 dextran sulfate multiple interactions ISO RGD:733290 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of AKR1C18 mRNA CTD PMID:29950665 diarsenic trioxide multiple interactions ISO RGD:1352888 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1C3 protein] CTD PMID:26598702 diarsenic trioxide decreases response to substance ISO RGD:1352888 6480464 AKR1C3 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 diarsenic trioxide increases expression ISO RGD:1352888 6480464 Arsenic Trioxide results in increased expression of AKR1C3 mRNA CTD PMID:19128835 more ... diazepam decreases activity ISO RGD:1352888 6480464 Diazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 , PMID:12604236 dibenzo[a,l]pyrene multiple interactions ISO RGD:1352888 6480464 [Particulate Matter co-treated with dibenzo(a more ... CTD PMID:17612574 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of AKR1C18 mRNA CTD PMID:21266533 dicrotophos decreases expression ISO RGD:1352888 6480464 dicrotophos results in decreased expression of AKR1C3 mRNA CTD PMID:28302478 diethylstilbestrol increases expression ISO RGD:733290 6480464 Diethylstilbestrol results in increased expression of AKR1C3 mRNA CTD PMID:19665456 diethylstilbestrol multiple interactions ISO RGD:733290 6480464 sodium arsenite promotes the reaction [Diethylstilbestrol results in increased expression of AKR1C3 mRNA] CTD PMID:19665456 dioxygen multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased reduction of and affects the activity of benzo(a)pyrene-3, 6-quinone] which results in decreased abundance of Oxygen CTD PMID:21910479 dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate increases expression ISO RGD:1352888 6480464 Antimony Potassium Tartrate results in increased expression of AKR1C3 mRNA, Antimony Potassium Tartrate results in increased expression of AKR1C3 protein CTD PMID:28713220 dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate multiple interactions ISO RGD:1352888 6480464 [Antimony Potassium Tartrate results in increased abundance of antimonite] which results in increased expression of AKR1C3 mRNA CTD PMID:32076005 disulfiram increases expression ISO RGD:1352888 6480464 Disulfiram results in increased expression of AKR1C3 mRNA CTD PMID:20566472 diuron increases expression ISO RGD:1352888 6480464 Diuron metabolite results in increased expression of AKR1C3 mRNA CTD PMID:24172598 dorsomorphin multiple interactions ISO RGD:1352888 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxifluridine increases response to substance ISO RGD:1352888 6480464 AKR1C3 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 doxorubicin affects reduction ISO RGD:1352888 6480464 AKR1C3 protein affects the reduction of Doxorubicin CTD PMID:18635746 doxorubicin decreases expression ISO RGD:1352888 6480464 Doxorubicin results in decreased expression of AKR1C3 mRNA CTD PMID:29803840 doxorubicin increases metabolic processing ISO RGD:1352888 6480464 AKR1C3 results in increased metabolism of Doxorubicin CTD PMID:20837989 dutasteride increases expression ISO RGD:1352888 6480464 Dutasteride results in increased expression of AKR1C3 mRNA CTD PMID:16806904 dydrogesterone decreases activity ISO RGD:1352888 6480464 Dydrogesterone results in decreased activity of AKR1C3 protein CTD PMID:21182831 dydrogesterone decreases expression ISO RGD:1352888 6480464 Dydrogesterone results in decreased expression of AKR1C3 mRNA CTD PMID:23183084 emodin decreases activity ISO RGD:1352888 6480464 Emodin results in decreased activity of AKR1C3 protein CTD PMID:35065925 enasidenib multiple interactions ISO RGD:1352888 6480464 enasidenib inhibits the reaction [[AKR1C3 protein results in increased reduction of Daunorubicin] which results in increased abundance of daunorubicinol] more ... CTD PMID:35972551 enasidenib decreases activity ISO RGD:1352888 6480464 enasidenib results in decreased activity of AKR1C3 protein CTD PMID:35972551 estazolam decreases activity ISO RGD:1352888 6480464 Estazolam results in decreased activity of AKR1C3 protein CTD PMID:11995921 estrone increases metabolic processing ISO RGD:1352888 6480464 AKR1C3 protein results in increased metabolism of Estrone CTD PMID:19010312 estrone increases reduction ISO RGD:1352888 6480464 AKR1C3 protein results in increased reduction of Estrone CTD PMID:20036328 estrone multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased metabolism of Estrone] which results in increased chemical synthesis of Estradiol, [AKR1C3 protein results in increased reduction of Estrone] which results in increased chemical synthesis of Estradiol CTD PMID:19010312 , PMID:20036328 ethanol multiple interactions ISO RGD:1352888 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of AKR1C3 mRNA CTD PMID:29432896 eugenol increases expression ISO RGD:1352888 6480464 Eugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 farnesal increases reduction ISO RGD:1352888 6480464 AKR1C3 protein results in increased reduction of farnesal CTD PMID:21187079 farnesoic acid multiple interactions ISO RGD:1352888 6480464 [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid, [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid CTD PMID:21187079 farnesol increases chemical synthesis ISO RGD:1352888 6480464 AKR1C3 protein results in increased chemical synthesis of Farnesol CTD PMID:21187079 farnesol multiple interactions ISO RGD:1352888 6480464 [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol, [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol CTD PMID:21187079 fenamic acid decreases activity ISO RGD:1352888 6480464 fenamic acid analog results in decreased activity of AKR1C3 protein CTD PMID:19010312 flufenamic acid affects binding ISO RGD:1352888 6480464 Flufenamic Acid binds to AKR1C3 protein CTD PMID:14996743 flufenamic acid multiple interactions ISO RGD:1352888 6480464 Flufenamic Acid inhibits the reaction [AKR1C3 protein affects the susceptibility to oxaliplatin], Flufenamic Acid inhibits the reaction [AKR1C3 protein results in increased metabolism of Dihydrotestosterone] CTD PMID:14672942 , PMID:23933386 flufenamic acid decreases activity ISO RGD:1352888 6480464 Flufenamic Acid results in decreased activity of AKR1C3 protein CTD PMID:12604236 flunitrazepam decreases activity ISO RGD:1352888 6480464 Flunitrazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 flurbiprofen multiple interactions ISO RGD:1352888 6480464 [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid, [Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol CTD PMID:21187079 flurbiprofen decreases activity ISO RGD:1352888 6480464 Flurbiprofen results in decreased activity of AKR1C3 protein CTD PMID:19010312 , PMID:21187079 folic acid multiple interactions ISO RGD:733290 6480464 [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of AKR1C18 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1C18 mRNA CTD PMID:20938992 , PMID:29127188 formaldehyde decreases expression ISO RGD:1352888 6480464 Formaldehyde results in decreased expression of AKR1C3 mRNA CTD PMID:23649840 formaldehyde increases expression ISO RGD:1352888 6480464 Formaldehyde results in increased expression of AKR1C3 mRNA CTD PMID:28937961 Frangulin A decreases activity ISO RGD:1352888 6480464 frangulin A results in decreased activity of AKR1C3 protein CTD PMID:35065925 Frangulin B decreases activity ISO RGD:1352888 6480464 frangulin B results in decreased activity of AKR1C3 protein CTD PMID:35065925 furan increases expression ISO RGD:733290 6480464 furan results in increased expression of AKR1C18 mRNA CTD PMID:24183702 geranylgeraniol increases chemical synthesis ISO RGD:1352888 6480464 AKR1C3 protein results in increased chemical synthesis of geranylgeraniol CTD PMID:21187079 gliclazide decreases activity ISO RGD:1352888 6480464 Gliclazide results in decreased activity of AKR1C3 protein CTD PMID:26362498 glimepiride decreases activity ISO RGD:1352888 6480464 glimepiride results in decreased activity of AKR1C3 protein CTD PMID:26362498 glipizide decreases activity ISO RGD:1352888 6480464 Glipizide results in decreased activity of AKR1C3 protein CTD PMID:26362498 glyburide decreases activity ISO RGD:1352888 6480464 Glyburide results in decreased activity of AKR1C3 protein CTD PMID:26362498 glycidyl methacrylate decreases expression ISO RGD:1352888 6480464 glycidyl methacrylate results in decreased expression of AKR1C3 protein CTD PMID:36641056 glycyrrhetinate affects activity ISO RGD:1352888 6480464 18alpha-glycyrrhetinic acid affects the activity of AKR1C3 protein CTD PMID:11165023 glycyrrhetinate decreases activity ISO RGD:1352888 6480464 Glycyrrhetinic Acid results in decreased activity of AKR1C3 protein CTD PMID:12604236 glycyrrhetinic acid affects activity ISO RGD:1352888 6480464 18alpha-glycyrrhetinic acid affects the activity of AKR1C3 protein CTD PMID:11165023 glycyrrhetinic acid decreases activity ISO RGD:1352888 6480464 Glycyrrhetinic Acid results in decreased activity of AKR1C3 protein CTD PMID:12604236 glyphosate decreases expression ISO RGD:733290 6480464 glyphosate results in decreased expression of AKR1C18 protein CTD PMID:37208198 gold atom increases expression ISO RGD:1352888 6480464 Gold results in increased expression of AKR1C3 mRNA CTD PMID:29705079 gold(0) increases expression ISO RGD:1352888 6480464 Gold results in increased expression of AKR1C3 mRNA CTD PMID:29705079 hexane increases expression ISO RGD:1352888 6480464 n-hexane results in increased expression of AKR1C3 mRNA CTD PMID:20566472 hexestrol decreases activity ISO RGD:1352888 6480464 Hexestrol results in decreased activity of AKR1C3 protein CTD PMID:12604236 hydrogen peroxide multiple interactions ISO RGD:1352888 6480464 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to Hydrogen Peroxide] more ... CTD PMID:21910479 , PMID:22964423 hydrogen peroxide increases expression ISO RGD:1352888 6480464 Hydrogen Peroxide results in increased expression of AKR1C3 protein CTD PMID:22964423 hydrogen peroxide increases response to substance ISO RGD:1352888 6480464 AKR1C3 mutant form results in increased susceptibility to Hydrogen Peroxide CTD PMID:22964423 ibuprofen decreases activity ISO RGD:1352888 6480464 Ibuprofen results in decreased activity of AKR1C3 protein CTD PMID:19010312 indometacin multiple interactions ISO RGD:1352888 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C3 mRNA more ... CTD PMID:17950253 , PMID:28628672 indometacin decreases activity ISO RGD:1352888 6480464 Indomethacin analog results in decreased activity of AKR1C3 protein, Indomethacin results in decreased activity of AKR1C3 protein CTD PMID:12604236 more ... indometacin affects binding ISO RGD:1352888 6480464 Indomethacin binds to AKR1C3 protein CTD PMID:14996743 inulin multiple interactions ISO RGD:733290 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of AKR1C18 mRNA CTD PMID:36331819 isoeugenol increases expression ISO RGD:1352888 6480464 isoeugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 Isoxanthohumol decreases activity ISO RGD:1352888 6480464 isoxanthohumol results in decreased activity of AKR1C3 protein CTD PMID:35065925 ivermectin decreases expression ISO RGD:1352888 6480464 Ivermectin results in decreased expression of AKR1C3 protein CTD PMID:32959892 L-methionine multiple interactions ISO RGD:733290 6480464 [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of AKR1C18 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1C18 mRNA CTD PMID:20938992 , PMID:29127188 levonorgestrel decreases activity ISO RGD:1352888 6480464 Levonorgestrel results in decreased activity of AKR1C3 protein CTD PMID:21182831 lithocholic acid decreases activity ISO RGD:1352888 6480464 Lithocholic Acid results in decreased activity of AKR1C3 protein CTD PMID:12604236 , PMID:21851338 LY294002 multiple interactions ISO RGD:1352888 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium acetate results in increased expression of AKR1C3 protein] CTD PMID:21787718 meclofenamic acid decreases activity ISO RGD:1352888 6480464 Meclofenamic Acid results in decreased activity of AKR1C3 protein CTD PMID:19010312 more ... Medazepam decreases activity ISO RGD:1352888 6480464 Medazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 , PMID:12604236 medroxyprogesterone acetate multiple interactions ISO RGD:1352888 6480464 [Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12 more ... CTD PMID:19997560 , PMID:23261716 medroxyprogesterone acetate decreases activity ISO RGD:1352888 6480464 Medroxyprogesterone Acetate results in decreased activity of AKR1C3 protein CTD PMID:12604236 more ... mefenamic acid decreases activity ISO RGD:1352888 6480464 Mefenamic Acid analog results in decreased activity of AKR1C3 protein CTD PMID:19010312 mercury dibromide increases expression ISO RGD:1352888 6480464 mercuric bromide results in increased expression of AKR1C3 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:1352888 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C3 mRNA CTD PMID:27188386 methapyrilene increases methylation ISO RGD:1352888 6480464 Methapyrilene results in increased methylation of AKR1C3 intron CTD PMID:30157460 methyl salicylate increases expression ISO RGD:1352888 6480464 methyl salicylate results in increased expression of AKR1C3 mRNA CTD PMID:20566472 methylglyoxal increases expression ISO RGD:1352888 6480464 Pyruvaldehyde results in increased expression of AKR1C3 mRNA CTD PMID:25451587 methylmercury chloride increases expression ISO RGD:733290 6480464 methylmercuric chloride results in increased expression of AKR1C18 mRNA CTD PMID:20061341 methylmercury chloride increases expression ISO RGD:1352888 6480464 methylmercuric chloride results in increased expression of AKR1C3 mRNA CTD PMID:28001369 midostaurin decreases activity ISO RGD:1352888 6480464 midostaurin results in decreased activity of AKR1C3 protein CTD PMID:33025066 midostaurin multiple interactions ISO RGD:1352888 6480464 midostaurin inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin], midostaurin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin] CTD PMID:33025066 N-acetyl-L-cysteine multiple interactions ISO RGD:1352888 6480464 Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of AKR1C3 protein], Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AKR1C3 mRNA] CTD PMID:18829485 , PMID:21787718 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression ISO RGD:1352888 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1C3 mRNA CTD PMID:21215737 , PMID:23165153 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1352888 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [tolfenamic acid inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Cisplatin]] CTD PMID:23165153 N-nitrosodiethylamine increases expression ISO RGD:733290 6480464 Diethylnitrosamine results in increased expression of AKR1C18 mRNA CTD PMID:24535843 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of AKR1C18 mRNA CTD PMID:18164116 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of AKR1C18 protein CTD PMID:19716841 NAD zwitterion multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol more ... CTD PMID:25446855 NAD(+) multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol more ... CTD PMID:25446855 NADP zwitterion multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:14672942 more ... NADP(+) multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:14672942 more ... naphthalenes multiple interactions ISO RGD:1352888 6480464 AKR1C3 protein results in increased reduction of and affects the activity of Naphthalenes CTD PMID:21910479 naproxen decreases activity ISO RGD:1352888 6480464 Naproxen results in decreased activity of AKR1C3 protein CTD PMID:19010312 nickel atom decreases expression ISO RGD:1352888 6480464 Nickel results in decreased expression of AKR1C3 mRNA CTD PMID:23195993 nickel sulfate increases expression ISO RGD:1352888 6480464 nickel sulfate results in increased expression of AKR1C3 mRNA CTD PMID:20566472 nitrazepam decreases activity ISO RGD:1352888 6480464 Nitrazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 norethisterone decreases activity ISO RGD:1352888 6480464 Norethindrone results in decreased activity of AKR1C3 protein CTD PMID:21182831 ochratoxin A decreases expression ISO RGD:1352888 6480464 ochratoxin A results in decreased expression of AKR1C3 mRNA CTD PMID:19287073 , PMID:32905824 octyl gallate decreases activity ISO RGD:1352888 6480464 octyl gallate results in decreased activity of AKR1C3 protein CTD PMID:27163852 oxaliplatin multiple interactions ISO RGD:1352888 6480464 alpha-methylcinnamic acid inhibits the reaction [AKR1C3 protein affects the susceptibility to oxaliplatin] more ... CTD PMID:23933386 oxaliplatin affects response to substance ISO RGD:1352888 6480464 AKR1C3 protein affects the susceptibility to oxaliplatin CTD PMID:23933386 oxcarbazepine increases reduction ISO RGD:1352888 6480464 AKR1C3 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 oxidopamine increases expression ISO RGD:1352888 6480464 Oxidopamine results in increased expression of AKR1C3 mRNA, Oxidopamine results in increased expression of AKR1C3 protein CTD PMID:33486071 oxycodone decreases expression EXP 6480464 Oxycodone results in decreased expression of AKR1C3 mRNA CTD PMID:23439660 ozone multiple interactions ISO RGD:1352888 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of AKR1C3 mRNA more ... CTD PMID:32699268 p-chloromercuribenzoic acid increases expression ISO RGD:1352888 6480464 p-Chloromercuribenzoic Acid results in increased expression of AKR1C3 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:1352888 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C3 mRNA CTD PMID:27188386 paracetamol decreases expression ISO RGD:1352888 6480464 Acetaminophen results in decreased expression of AKR1C3 mRNA CTD PMID:21420995 paracetamol multiple interactions ISO RGD:733290 6480464 PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of AKR1C18 mRNA] CTD PMID:29246445 paracetamol increases expression ISO RGD:733290 6480464 Acetaminophen results in increased expression of AKR1C18 mRNA CTD PMID:29246445 paracetamol affects expression ISO RGD:733290 6480464 Acetaminophen affects the expression of AKR1C18 mRNA CTD PMID:17562736 paraquat multiple interactions ISO RGD:733290 6480464 [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of AKR1C3 mRNA CTD PMID:28012437 perfluorooctane-1-sulfonic acid affects expression ISO RGD:733290 6480464 perfluorooctane sulfonic acid affects the expression of AKR1C18 mRNA, perfluorooctane sulfonic acid affects the expression of AKR1C3 mRNA CTD PMID:19429403 perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:733290 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of AKR1C18 mRNA CTD PMID:36331819 perfluorooctanoic acid affects expression ISO RGD:733290 6480464 perfluorooctanoic acid affects the expression of AKR1C18 mRNA, perfluorooctanoic acid affects the expression of AKR1C3 mRNA CTD PMID:19429403 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of AKR1C18 mRNA CTD PMID:16221955 , PMID:19162173 perfluorooctanoic acid increases expression ISO RGD:733290 6480464 perfluorooctanoic acid results in increased expression of AKR1C3 mRNA CTD PMID:17681415 phenethyl caffeate decreases activity ISO RGD:1352888 6480464 caffeic acid phenethyl ester results in decreased activity of AKR1C3 protein CTD PMID:27163852 phenobarbital increases expression ISO RGD:1352888 6480464 Phenobarbital results in increased expression of AKR1C3 protein CTD PMID:35881160 phenolphthalein multiple interactions ISO RGD:1352888 6480464 Phenolphthalein inhibits the reaction [AKR1C3 protein affects the susceptibility to oxaliplatin] CTD PMID:23933386 phenolphthalein decreases activity ISO RGD:1352888 6480464 Phenolphthalein results in decreased activity of AKR1C3 protein CTD PMID:12604236 phenylmercury acetate increases expression ISO RGD:1352888 6480464 Phenylmercuric Acetate results in increased expression of AKR1C3 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1352888 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C3 mRNA CTD PMID:27188386 phthalaldehyde affects expression ISO RGD:733290 6480464 o-Phthalaldehyde affects the expression of AKR1C18 mRNA CTD PMID:22302311 picoxystrobin increases expression ISO RGD:1352888 6480464 picoxystrobin results in increased expression of AKR1C3 mRNA CTD PMID:33512557 pirinixic acid multiple interactions ISO RGD:733290 6480464 PPARA protein promotes the reaction [pirinixic acid results in increased expression of AKR1C18 mRNA] CTD PMID:17950772 , PMID:20032461 pirinixic acid increases expression ISO RGD:733290 6480464 pirinixic acid results in increased expression of AKR1C18 mRNA CTD PMID:17950772 more ... potassium chromate multiple interactions ISO RGD:1352888 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AKR1C3 mRNA CTD PMID:22079256 potassium chromate decreases expression ISO RGD:1352888 6480464 potassium chromate(VI) results in decreased expression of AKR1C3 mRNA CTD PMID:22079256 pravastatin decreases expression ISO RGD:733290 6480464 Pravastatin results in decreased expression of AKR1C18 mRNA CTD PMID:27225895 pravastatin decreases expression EXP 6480464 Pravastatin results in decreased expression of AKR1C3 mRNA CTD PMID:27225895 progesterone multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone, [AKR1C3 protein results in increased reduction of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone CTD PMID:19010312 , PMID:20036328 progesterone increases metabolic processing EXP 6480464 AKR1C18 protein results in increased metabolism of Progesterone CTD PMID:8172618 progesterone affects metabolic processing EXP 6480464 AKR1C18 protein affects the metabolism of Progesterone CTD PMID:15261307 progesterone increases metabolic processing ISO RGD:733290 6480464 AKR1C18 protein results in increased metabolism of Progesterone CTD PMID:17122075 progesterone affects metabolic processing ISO RGD:733290 6480464 AKR1C18 protein affects the metabolism of Progesterone CTD PMID:15471942 progesterone affects abundance ISO RGD:733290 6480464 AKR1C18 protein affects the abundance of Progesterone CTD PMID:15471942 progesterone increases reduction ISO RGD:1352888 6480464 AKR1C3 protein results in increased reduction of Progesterone CTD PMID:20036328 , PMID:25463305 progesterone decreases expression ISO RGD:1352888 6480464 Progesterone results in decreased expression of AKR1C3 mRNA CTD PMID:23183084 progesterone increases expression ISO RGD:1352888 6480464 Progesterone results in increased expression of AKR1C3 mRNA CTD PMID:23183084 progesterone increases metabolic processing ISO RGD:1352888 6480464 AKR1C3 protein results in increased metabolism of Progesterone CTD PMID:19010312 propan-2-ol increases expression ISO RGD:1352888 6480464 2-Propanol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 prostaglandin D2 increases metabolic processing ISO RGD:1352888 6480464 AKR1C3 protein results in increased metabolism of Prostaglandin D2 CTD PMID:19010312 prostaglandin D2 increases reduction ISO RGD:1352888 6480464 AKR1C3 protein results in increased reduction of Prostaglandin D2 CTD PMID:20036328 prostaglandin D2 decreases response to substance ISO RGD:1352888 6480464 AKR1C3 protein results in decreased susceptibility to Prostaglandin D2 CTD PMID:20036328 prostaglandin D2 decreases metabolic processing ISO RGD:1352888 6480464 AKR1C3 protein results in decreased metabolism of Prostaglandin D2 CTD PMID:20036328 prostaglandin D2 multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in decreased metabolism of Prostaglandin D2] which results in decreased chemical synthesis of 9-deoxy-delta-9-prostaglandin D2 more ... CTD PMID:19997560 , PMID:20036328 prostaglandin F2alpha multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased reduction of Prostaglandin D2] which results in increased chemical synthesis of Dinoprost more ... CTD PMID:19997560 , PMID:20036328 prostaglandin J2 multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in decreased metabolism of Prostaglandin D2] which results in decreased chemical synthesis of 9-deoxy-delta-9-prostaglandin D2 CTD PMID:20036328 quercetin decreases activity ISO RGD:1352888 6480464 Quercetin results in decreased activity of AKR1C3 protein CTD PMID:19007764 rac-lactic acid increases expression ISO RGD:1352888 6480464 Lactic Acid results in increased expression of AKR1C3 mRNA CTD PMID:20566472 resveratrol multiple interactions EXP 6480464 [resveratrol co-treated with Streptozocin] results in decreased expression of AKR1C3 mRNA CTD PMID:25905778 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of AKR1C3 mRNA CTD PMID:28374803 salicylic acid decreases activity ISO RGD:1352888 6480464 Salicylic Acid results in decreased activity of AKR1C3 protein CTD PMID:19010312 SB 431542 multiple interactions ISO RGD:1352888 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silibinin decreases activity ISO RGD:1352888 6480464 Silybin results in decreased activity of AKR1C3 protein CTD PMID:19007764 silicon dioxide decreases expression ISO RGD:1352888 6480464 Silicon Dioxide analog results in decreased expression of AKR1C3 mRNA CTD PMID:25895662 silicon dioxide decreases expression ISO RGD:733290 6480464 Silicon Dioxide results in decreased expression of AKR1C18 mRNA CTD PMID:29341224 silicon dioxide increases expression ISO RGD:1352888 6480464 Silicon Dioxide results in increased expression of AKR1C3 mRNA CTD PMID:25351596 silicon dioxide increases secretion ISO RGD:1352888 6480464 Silicon Dioxide analog results in increased secretion of AKR1C3 protein CTD PMID:25895662 simvastatin decreases expression ISO RGD:1352888 6480464 Simvastatin results in decreased expression of AKR1C3 mRNA CTD PMID:18192897 sodium arsenate multiple interactions ISO RGD:1352888 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of AKR1C3 mRNA CTD PMID:32525701 sodium arsenite increases expression ISO RGD:1352888 6480464 sodium arsenite results in increased expression of AKR1C3 mRNA, sodium arsenite results in increased expression of AKR1C3 protein CTD PMID:12727804 more ... sodium arsenite multiple interactions ISO RGD:1352888 6480464 [sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C3 mRNA CTD PMID:32076005 sodium arsenite multiple interactions ISO RGD:733290 6480464 sodium arsenite promotes the reaction [Diethylstilbestrol results in increased expression of AKR1C3 mRNA] CTD PMID:19665456 sodium arsenite affects expression ISO RGD:733290 6480464 sodium arsenite affects the expression of AKR1C18 mRNA CTD PMID:16507464 sodium arsenite decreases expression ISO RGD:733290 6480464 sodium arsenite results in decreased expression of AKR1C18 mRNA CTD PMID:17350061 sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of AKR1C3 mRNA CTD PMID:25993096 sodium dodecyl sulfate increases expression ISO RGD:1352888 6480464 Sodium Dodecyl Sulfate results in increased expression of AKR1C3 mRNA CTD PMID:20566472 sodium dodecyl sulfate decreases expression ISO RGD:1352888 6480464 Sodium Dodecyl Sulfate results in decreased expression of AKR1C3 mRNA CTD PMID:31734321 sodium dodecyl sulfate decreases expression EXP 6480464 Sodium Dodecyl Sulfate results in decreased expression of AKR1C18 mRNA CTD PMID:12815608 streptozocin multiple interactions EXP 6480464 [resveratrol co-treated with Streptozocin] results in decreased expression of AKR1C3 mRNA CTD PMID:25905778 streptozocin multiple interactions ISO RGD:733290 6480464 [Streptozocin co-treated with Dietary Fats] results in increased expression of AKR1C18 mRNA CTD PMID:29127188 sulforaphane increases expression ISO RGD:1352888 6480464 sulforaphane results in increased expression of AKR1C3 mRNA, sulforaphane results in increased expression of AKR1C3 protein CTD PMID:24383545 , PMID:31746589 sulindac decreases activity ISO RGD:1352888 6480464 Sulindac results in decreased activity of AKR1C3 protein CTD PMID:19010312 sulpiride decreases expression EXP 6480464 Sulpiride results in decreased expression of AKR1C3 mRNA CTD PMID:21427058 superoxide multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased reduction of 9 more ... CTD PMID:19442656 , PMID:21910479 testosterone increases abundance ISO RGD:1352888 6480464 AKR1C3 promoter SNP results in increased abundance of Testosterone CTD PMID:16263811 testosterone multiple interactions ISO RGD:1352888 6480464 [AKR1C3 protein results in increased metabolism of Androstenedione] which results in increased chemical synthesis of Testosterone, [AKR1C3 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of Testosterone CTD PMID:19010312 , PMID:20036328 testosterone enanthate affects expression ISO RGD:1352888 6480464 testosterone enanthate affects the expression of AKR1C3 mRNA CTD PMID:17440010 tetrachloromethane increases expression ISO RGD:733290 6480464 Carbon Tetrachloride results in increased expression of AKR1C18 mRNA CTD PMID:27339419 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of AKR1C3 mRNA CTD PMID:31150632 tetraphene increases expression ISO RGD:1352888 6480464 benz(a)anthracene results in increased expression of AKR1C3 mRNA CTD PMID:22236718 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of AKR1C18 mRNA, Thioacetamide results in decreased expression of AKR1C3 mRNA CTD PMID:23411599 , PMID:34492290 titanium dioxide affects expression ISO RGD:733290 6480464 titanium dioxide affects the expression of AKR1C18 mRNA CTD PMID:23557971 titanium dioxide multiple interactions ISO RGD:733290 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of AKR1C18 mRNA CTD PMID:29950665 titanium dioxide increases expression ISO RGD:733290 6480464 titanium dioxide results in increased expression of AKR1C18 mRNA CTD PMID:23131501 tolcapone decreases expression EXP 6480464 tolcapone results in decreased expression of AKR1C3 mRNA CTD PMID:24136188 tolfenamic acid decreases activity ISO RGD:1352888 6480464 tolfenamic acid results in decreased activity of AKR1C3 protein CTD PMID:21187079 , PMID:23165153 tolfenamic acid multiple interactions ISO RGD:1352888 6480464 [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid more ... CTD PMID:21187079 , PMID:23165153 trans-isoeugenol increases expression ISO RGD:1352888 6480464 isoeugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 trichloroethene increases expression ISO RGD:733290 6480464 Trichloroethylene results in increased expression of AKR1C18 mRNA CTD PMID:25549359 trichostatin A increases expression ISO RGD:1352888 6480464 trichostatin A results in increased expression of AKR1C3 mRNA CTD PMID:24935251 , PMID:26705709 triclosan decreases expression ISO RGD:1352888 6480464 Triclosan results in decreased expression of AKR1C3 mRNA CTD PMID:30510588 trimellitic anhydride increases expression ISO RGD:733290 6480464 trimellitic anhydride results in increased expression of AKR1C18 mRNA CTD PMID:19042947 trimellitic anhydride affects expression ISO RGD:733290 6480464 trimellitic anhydride affects the expression of AKR1C18 mRNA CTD PMID:22302311 troglitazone increases expression ISO RGD:733290 6480464 troglitazone results in increased expression of AKR1C3 mRNA CTD PMID:28973697 umbelliferone increases expression ISO RGD:1352888 6480464 7-hydroxycoumarin results in increased expression of AKR1C3 mRNA, 7-hydroxycoumarin results in increased expression of AKR1C3 protein CTD PMID:22964423 , PMID:28263721 umbelliferone multiple interactions ISO RGD:1352888 6480464 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal], 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to Hydrogen Peroxide] CTD PMID:22964423 uranium atom affects expression ISO RGD:1352888 6480464 Uranium affects the expression of AKR1C3 mRNA CTD PMID:15672453 urethane decreases expression ISO RGD:1352888 6480464 Urethane results in decreased expression of AKR1C3 mRNA CTD PMID:28818685 ursodeoxycholic acid decreases activity ISO RGD:1352888 6480464 Ursodeoxycholic Acid results in decreased activity of AKR1C3 protein CTD PMID:12604236 valproic acid decreases methylation ISO RGD:1352888 6480464 Valproic Acid results in decreased methylation of AKR1C3 gene CTD PMID:29154799 valproic acid multiple interactions ISO RGD:1352888 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C3 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1352888 6480464 Valproic Acid results in increased expression of AKR1C3 mRNA CTD PMID:23179753 more ... valproic acid affects expression ISO RGD:733290 6480464 Valproic Acid affects the expression of AKR1C18 mRNA CTD PMID:17292431 valproic acid affects expression ISO RGD:1352888 6480464 Valproic Acid affects the expression of AKR1C3 mRNA CTD PMID:25979313 vorinostat increases expression ISO RGD:1352888 6480464 vorinostat results in increased expression of AKR1C3 mRNA CTD PMID:18769122 vorinostat decreases expression ISO RGD:1352888 6480464 vorinostat results in decreased expression of AKR1C3 mRNA CTD PMID:18769122 zaragozic acid A increases expression EXP 6480464 squalestatin 1 results in increased expression of AKR1C3 mRNA CTD PMID:27225895 zaragozic acid A affects expression ISO RGD:733290 6480464 squalestatin 1 affects the expression of AKR1C18 mRNA CTD PMID:27225895 zinc atom decreases expression ISO RGD:1352888 6480464 Zinc deficiency results in decreased expression of AKR1C3 mRNA CTD PMID:22171008 zinc(0) decreases expression ISO RGD:1352888 6480464 Zinc deficiency results in decreased expression of AKR1C3 mRNA CTD PMID:22171008 zomepirac decreases activity ISO RGD:1352888 6480464 zomepirac results in decreased activity of AKR1C3 protein CTD PMID:19010312
