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Gene: Akr1c3 (aldo-keto reductase family 1, member C3) Rattus norvegicus
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Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Description: Exhibits 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and alditol:NADP+ 1-oxidoreductase activity. Involved in several processes, including cellular response to forskolin; cellular response to hormone stimulus; and progesterone metabolic process. Localizes to the cytosol and nucleus. Biomarker of polycystic ovary syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in leukemia; precursor B lymphoblastic lymphoma/leukemia; and precursor T-lymphoblastic lymphoma/leukemia. Orthologous to human AKR1C3 (aldo-keto reductase family 1 member C3); PARTICIPATES IN isoprenoid metabolic pathway; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (20R)-20-hydroxypregn-4-en-3-one; (20S)-20-hydroxypregn-4-en-3-one; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20alpha-hydroxysteroid dehydrogenase; Akr1c18; aldo-keto reductase family 1 member C18; aldo-keto reductase family 1, member C18; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); HSD1; LOC171516
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01769,761,126 - 69,778,021 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01771,465,942 - 71,482,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,269,626 - 77,286,521 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11777,280,458 - 77,297,354 (+)NCBI
Celera1765,626,116 - 65,643,004 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Akr1c3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 708428
Created: 2003-09-23
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.