Akr1c2 (aldo-keto reductase family 1, member C2)

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Gene: Akr1c2 (aldo-keto reductase family 1, member C2) Rattus norvegicus

Analyze

Symbol:

Akr1c2

Name:

aldo-keto reductase family 1, member C2

RGD ID:

1311841

Description:

Predicted to enable several functions, including NADP binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including cellular response to hormone stimulus; glycoside metabolic process; and positive regulation of protein kinase B signaling. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C2 (aldo-keto reductase family 1 member C2) and AKR1C4 (aldo-keto reductase family 1 member C4); INTERACTS WITH (+)-schisandrin B; 3,3',4,4',5-pentachlorobiphenyl; 3,4,5,3',4',5'-Hexachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 3(17)alpha-hydroxysteroid dehydrogenase; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase; Akr1c21; aldo-keto reductase family 1 member C21; aldo-keto reductase family 1, member C21; LOC291283; RAKg

RGD Orthologs

Human

Mouse

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AKR1C2 (aldo-keto reductase family 1 member C2)	HGNC	Ensembl, HomoloGene, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Akr1c21 (aldo-keto reductase family 1, member C21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	AKR1C1 (aldo-keto reductase family 1 member C1)	HGNC	HomoloGene, OrthoDB, PhylomeDB
Homo sapiens (human):	AKR1C4 (aldo-keto reductase family 1 member C4)	HGNC	OrthoDB, PhylomeDB, Treefam
Homo sapiens (human):	AKR1C3 (aldo-keto reductase family 1 member C3)	HGNC	OrthoDB, PhylomeDB, Treefam
Alliance orthologs ³
Mus musculus (house mouse):	Akr1c21 (aldo-keto reductase family 1, member C21)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AKR1C4 (aldo-keto reductase family 1 member C4)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Homo sapiens (human):	AKR1C2 (aldo-keto reductase family 1 member C2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OMA\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG12766	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG6083	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6084	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG9436	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	GCY1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector)
Caenorhabditis elegans (roundworm):	Y39G8B.1	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	YPR1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG10638	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG10863	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	65,759,778 - 65,808,013 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	65,759,788 - 65,775,764 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	69,255,523 - 69,303,728 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	17	73,084,375 - 73,132,581 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	17	67,127,357 - 67,175,563 (-)	NCBI	Rnor_WKY
Rnor_6.0	17	69,388,337 - 69,435,160 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	69,388,335 - 69,404,341 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	71,102,094 - 71,148,911 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	77,034,737 - 77,081,406 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	77,045,579 - 77,092,239 (-)	NCBI
Celera	17	65,292,033 - 65,339,839 (-)	NCBI		Celera
Cytogenetic Map	17	q12.2	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

46,XY sex reversal 8 (ISO)

autism spectrum disorder (ISO)

CIC-rearranged sarcoma (ISO)

contact dermatitis (ISO)

disorder of sexual development (ISO)

endometriosis (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

hypoparathyroidism-deafness-renal disease syndrome (ISO)

Neoplasms, Hormone-Dependent (ISO)

Neoplastic Cell Transformation (ISO)

obesity (ISO)

osteoarthritis (ISO)

polycystic ovary syndrome (ISO)

schizophrenia (ISO)

Weight Gain (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

(20S)-20-hydroxypregn-4-en-3-one (ISO)

(E)-cinnamyl alcohol (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

1,10-phenanthroline (ISO)

1,2-dimethylhydrazine (ISO)

1,3-benzothiazole-2-thiol (ISO)

1,4-benzoquinone (ISO)

1,4-phenylenediamine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

1-phenyl-1,2-propanedione (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2-(chloromethyl)pyridine (ISO)

2-aminophenol (ISO)

2-hexenal (ISO)

2-hydroxyethyl methacrylate (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5-triiodo-L-thyronine (ISO)

3,4,5,3',4',5'-Hexachlorobiphenyl (EXP)

3,4-dichloroaniline (ISO)

3-Nitrobenzanthrone (ISO)

3-phenylprop-2-enal (ISO)

3alpha-hydroxy-5beta-pregnan-20-one (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (ISO)

4-hydroxybenzoic acid (ISO)

4-nitro-1,2-phenylenediamine (ISO)

4-nitrobenzyl bromide (ISO)

5-alpha-THDOC (ISO)

5-fluorouracil (ISO)

5alpha-pregnane-3,20-dione (ISO)

9,10-phenanthroquinone (ISO)

acetylsalicylic acid (ISO)

acrylamide (EXP)

adefovir pivoxil (ISO)

aflatoxin B1 (ISO)

ampicillin (ISO)

androstane-3,17-diol (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

avobenzone (ISO)

azathioprine (ISO)

benzbromarone (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

Benzo[a]pyrene-7,8-diol (ISO)

benzo[a]pyrene-7,8-dione (ISO)

benzyl cinnamate (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bortezomib (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cadmium sulfate (ISO)

celastrol (ISO)

chenodeoxycholic acid (ISO)

chlorambucil (ISO)

chloroacetaldehyde (ISO)

chlorohydrocarbon (EXP)

chloromethylisothiazolinone (ISO)

chloropicrin (ISO)

cidofovir anhydrous (ISO)

ciglitazone (ISO)

cinnamyl alcohol (ISO)

cisplatin (ISO)

citral (ISO)

clodronic acid (ISO)

Clofop (ISO)

cloxazolam (ISO)

cobalt dichloride (ISO)

coniferyl aldehyde (ISO)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclopentanol (ISO)

cyclopentanone (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

diazepam (ISO)

dibenzo[a,l]pyrene (ISO)

dienogest (ISO)

diethyl maleate (ISO)

diethyl sulfate (ISO)

dioxygen (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO)

diquat (ISO)

diuron (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

dutasteride (ISO)

dydrogesterone (ISO)

entinostat (ISO)

epoxiconazole (ISO)

estazolam (ISO)

Ethyl acrylate (ISO)

ethyl methanesulfonate (ISO)

ethylene glycol dimethacrylate (ISO)

eugenol (ISO)

farnesal (ISO)

fenamic acid (ISO)

fenofibrate (ISO)

flufenamic acid (ISO)

flunitrazepam (ISO)

fluorescein 5-isothiocyanate (ISO)

flurbiprofen (ISO)

folic acid (ISO)

formaldehyde (ISO)

gedunin (ISO)

geranial (ISO)

glipizide (ISO)

glyburide (ISO)

glycyrrhetinate (ISO)

glycyrrhetinic acid (ISO)

glyoxal (ISO)

gold atom (ISO)

gold(0) (ISO)

hexestrol (ISO)

hydralazine (ISO)

hydrogen peroxide (ISO)

ibuprofen (ISO)

ifosfamide (ISO)

imidurea (ISO)

indometacin (ISO)

isoeugenol (ISO)

ivermectin (ISO)

L-ascorbic acid (ISO)

lead diacetate (ISO)

lead(0) (ISO)

lead(2+) (ISO)

lead(II) chloride (ISO)

linalool (ISO)

lithocholic acid (ISO)

malathion (ISO)

meclofenamic acid (ISO)

Medazepam (ISO)

medroxyprogesterone acetate (ISO)

mefenamic acid (ISO)

menadione (ISO)

mercury dibromide (ISO)

methyl methanesulfonate (ISO)

methyl non-2-ynoate (ISO)

methylmercury chloride (EXP,ISO)

n-propyl gallate (ISO)

NAD zwitterion (ISO)

NAD(+) (ISO)

NADP zwitterion (ISO)

NADP(+) (ISO)

naphthalenes (ISO)

naproxen (ISO)

nitrazepam (ISO)

ochratoxin A (EXP,ISO)

octadecanoic acid (ISO)

octyl gallate (ISO)

oxcarbazepine (ISO)

p-chloromercuribenzoic acid (ISO)

paclitaxel (ISO)

para-Cresidine (ISO)

paracetamol (ISO)

Paraoxon-methyl (ISO)

parathion-methyl (ISO)

perfluorooctanoic acid (ISO)

phenethyl caffeate (ISO)

phenolphthalein (ISO)

Phenyl glycidyl ether (ISO)

phenylacetaldehyde (ISO)

phenylmercury acetate (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

potassium bromate (EXP)

progesterone (ISO)

prostaglandin F2alpha (ISO)

quercetin (ISO)

quinolin-8-ol (ISO)

reactive oxygen species (ISO)

rotenone (EXP)

salicylic acid (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

sulforaphane (ISO)

sulindac (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

testosterone enanthate (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trans-isoeugenol (ISO)

Tributyltin oxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

tris(2-butoxyethyl) phosphate (ISO)

tunicamycin (ISO)

urethane (ISO)

ursodeoxycholic acid (ISO)

valproic acid (ISO)

vanillin (ISO)

vinclozolin (EXP)

vitamin E (ISO)

vorinostat (ISO)

zinc sulfate (ISO)

zoledronic acid (ISO)

zomepirac (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to jasmonic acid stimulus (ISO)

cellular response to prostaglandin D stimulus (ISO)

daunorubicin metabolic process (ISO)

digestion (ISO)

doxorubicin metabolic process (ISO)

epithelial cell differentiation (ISO)

G protein-coupled receptor signaling pathway (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of protein kinase B signaling (ISO)

progesterone metabolic process (ISO)

prostaglandin metabolic process (ISO)

steroid metabolic process (IBA,IEA,ISO)

Cellular Component

cytosol (IBA)

Molecular Function

17-beta-hydroxysteroid dehydrogenase (NADP+) activity (IEA,ISO)

17-beta-ketosteroid reductase activity (IEA,ISO)

5alpha-androstane-3beta,17beta-diol dehydrogenase activity (IEA,ISO)

alditol:NADP+ 1-oxidoreductase activity (IBA,ISO)

androsterone dehydrogenase activity (IEA,ISO)

bile acid binding (ISO)

carboxylic acid binding (ISO)

ketosteroid monooxygenase activity (IBA,ISO)

lithocholic acid binding (IEA,ISO)

NADP+ binding (IEA,ISO)

NADPH binding (IEA,ISO)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (ISO)

phenanthrene 9,10-monooxygenase activity (ISO)

steroid binding (ISO)

steroid dehydrogenase activity (IBA)

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (ISO)

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:8573067	PMID:15577209	PMID:17034817	PMID:17442338	PMID:18508192	PMID:19487289	PMID:20124700	PMID:20837989	PMID:21232532	PMID:21492153	PMID:21851338

Genomics

Comparative Map Data

Akr1c2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	65,759,778 - 65,808,013 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	65,759,788 - 65,775,764 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	69,255,523 - 69,303,728 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	17	73,084,375 - 73,132,581 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	17	67,127,357 - 67,175,563 (-)	NCBI	Rnor_WKY
Rnor_6.0	17	69,388,337 - 69,435,160 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	69,388,335 - 69,404,341 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	71,102,094 - 71,148,911 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	77,034,737 - 77,081,406 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	77,045,579 - 77,092,239 (-)	NCBI
Celera	17	65,292,033 - 65,339,839 (-)	NCBI		Celera
Cytogenetic Map	17	q12.2	NCBI

AKR1C2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	4,987,775 - 5,018,000 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	10	4,987,775 - 5,018,031 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	5,029,967 - 5,060,192 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	5,021,965 - 5,050,207 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	5,021,965 - 5,050,207	NCBI
Celera	10	4,972,245 - 5,000,184 (-)	NCBI		Celera
Cytogenetic Map	10	p15.1	NCBI
HuRef	10	4,920,321 - 4,955,422 (+)	NCBI		HuRef
CHM1_1	10	5,030,308 - 5,060,576 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	4,988,109 - 5,018,344 (-)	NCBI		T2T-CHM13v2.0

Akr1c21
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	4,624,074 - 4,636,542 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	4,624,074 - 4,636,540 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	4,574,075 - 4,586,543 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	4,574,075 - 4,586,541 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	4,573,321 - 4,585,789 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	4,573,321 - 4,585,787 (+)	NCBI		MGSCv36	mm8
Celera	13	4,543,969 - 4,562,535 (+)	NCBI		Celera
Cytogenetic Map	13	A1	NCBI

Variants

Variants in Akr1c2
87 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	179
Count of miRNA genes:	140
Interacting mature miRNAs:	150
Transcripts:	ENSRNOT00000051342, ENSRNOT00000066282
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70210	Cm15	Cardiac mass QTL 15	6.5		heart right ventricle mass (VT:0007033)	heart right ventricle wet weight (CMO:0000072)	17	57246723	70156904	Rat
2303580	Gluco49	Glucose level QTL 49	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	50040271	86533673	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	57246843	82046127	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	35837085	69599340	Rat
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	31990784	76990784	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	31368391	73951021	Rat
631502	Cm26	Cardiac mass QTL 26	3.71		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	65703580	81153923	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40540041	80387013	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	37479847	82479847	Rat
1600398	Edcs5	Endometrial carcinoma susceptibility QTL 5	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	17	57246723	70852846	Rat
1300131	Bp193	Blood pressure QTL 193	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	63640009	73951021	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	34550843	73951021	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	17	42073160	69599340	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	42073160	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	31990784	81292925	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	49920154	86533673	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	60781426	86533673	Rat
2317054	Aia12	Adjuvant induced arthritis QTL 12	4.24		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	38281509	83281509	Rat
2317060	Aia26	Adjuvant induced arthritis QTL 26	3.22		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	38281509	83281509	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	53498828	82479847	Rat
1358295	Aocep1	Aortic cell protein QTL 1	6.1	0.00000071	thoracic aorta cellular protein amount (VT:0010598)	aortic cell percentage	17	40990005	85990005	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	50909099	86022412	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat
7411577	Bw141	Body weight QTL 141		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	62619516	86533673	Rat
7411575	Bw140	Body weight QTL 140	30.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
7488963	Bp369	Blood pressure QTL 369		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	59005649	77910000	Rat
8694181	Bw151	Body weight QTL 151	4.36	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			9	9		9				8	1
Low			4	4		4			1	7	4	3
Below cutoff	1	7	18	3	16	3	8	10	10		12	5	8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254183	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254184	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC078957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	LC420024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000051342 ⟹ ENSRNOP00000045355

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	65,759,788 - 65,775,764 (-)	Ensembl
Rnor_6.0 Ensembl	17	69,388,347 - 69,404,323 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000066282 ⟹ ENSRNOP00000063166

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	65,759,788 - 65,775,764 (-)	Ensembl
Rnor_6.0 Ensembl	17	69,388,335 - 69,404,341 (-)	Ensembl

RefSeq Acc Id:

NM_001013057 ⟹ NP_001013075

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	65,759,778 - 65,807,957 (-)	NCBI
Rnor_6.0	17	69,388,337 - 69,435,148 (-)	NCBI
Rnor_5.0	17	71,102,094 - 71,148,911 (-)	NCBI
RGSC_v3.4	17	77,034,737 - 77,081,406 (-)	RGD
Celera	17	65,292,033 - 65,339,839 (-)	RGD

Sequence:

show sequence

GGGATACGTTTCTCGACCCCAGTGCACTGGTTTCTGTCATCCCATGAAATTGCAGCAAGGGCAG
TCTCTTTTGTGGGAACAGATTAACTCCTACACATGATGTAGATTCAACACCTGCCAGGAAAGCA
GAAGCATTACTTAAGTGTCCTGTGAAGGCAAACATCAAGTCAATTCAGCTTATCTTGAAGAGTG
GCAAACCATGAACTCCAAATGTCATTGTGTGAAACTGAACGATGGTCATTTCATTCCGGTGCTG
GGTTTTGGAACTGCTATGCCTTCAGAGTTACCCAAGAGTAAAGCTAAGGAGGTCACCAAAATAG
CTATAGATGCTGGTTTCCATCATTTTGATTCTGCTTTTGTCTACAATACCGAAGATCATGTAGG
AGAGGCCATCCGAGAGAAGATTGCCAATGGCACTACAAGGAGAGAAGATATATTTTACACATCA
AAGCTTTGGTGTACGAGCCTTCACCCAGAACTGGTGAGATCTTCCTTGGAATGTTCACTGAAGA
AACTTCAGTTGGACTATGTGGACCTGTATCTCATACATTTTCCGATGGCCTTGAAACCAGGAGA
TGAAAATTTTCCAGTAGATGAACATGGAAAGTTACTATTTGACACAGTAGATCTCTGTGCTACC
TGGGAGGCCATGGAGAAGTGTAAGGATGCAGGACTGGCCAAGTCCATCGGGGTGTCCAACTTTA
ACCGCAGGCAGCTGGAGAAGATCCTGAACAAGCCGGGGCTCAAATACAAGCCTGTGTGCAACCA
GGTAGAATGCCATCTTTATCTCAACCAAATGAAACTGCTGGATTTCTGCAAGACAAATGGCATT
ATACTGGTTGCCTATGGAGTTCTGGGAACACAACGATATAACGGATGGGTAGACCAGAACTCCC
CTGTTCTCTTGAATGAACCAGTTCTTAGTTCCATGGCAAAAAAATACAATCAAACTCCAGCCTT
GATTGCCCTTCGCCATCAGTTGCAGCGTGGGATTGTGGTACTTAACACCAGTCTCAAAGAAGAG
CGGATCAAAGAGAACATGAAGCTGAGTCCAGAAGATATGAAAGTCCTTGATGACCTGAACAGAA
ATTTGCGGTACATAGCTGGTGGAATATTTGAAGGCCACCCTAATTTTCCGTTTTTGGATGAATA
CTAACATCTTCAGGGAAGATGTCTCCCGAAAGACCTATGGTTGGAACACTGCTCAGCTGCTGCT
GAGACTTGTCACTTGTCTACAGACTTGTCACTTCTGCTTTGTTGCAGTTGAGAACTTCCTGGAG
CTACTCTTCAGCTAAGACAAAAAAAATAAATAAATAAAAATAAAAATAAAAATAAAAAATACCA
CTCTGAAAACAAATTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006254183 ⟹ XP_006254245

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	65,759,895 - 65,808,013 (-)	NCBI
Rnor_6.0	17	69,388,374 - 69,435,160 (-)	NCBI
Rnor_5.0	17	71,102,094 - 71,148,911 (-)	NCBI

Sequence:

show sequence

CTACCCCTGCATGGGATACGTTTCTCGACCCCAGTGCACTGGTTTCTGTCATCCCATGAAATTG
CAGCAAGGGCAGTCTCTTTTGTGGGAACAGATTAACTCCTACACATGATGTAGATTCAACACCT
GCCAGGAAAGCAGAAGCATTACTTAAGTGTCCTGTGAAGGCAAACATCAAGTCAATTCAGCTTA
TCTTGAAGAGTGGCAAACCATGAACTCCAAATGTCATTGTGTGAAACTGAACGATGGTCATTTC
ATTCCGGTGCTGGGTTTTGGAACTGCTATGCCTTCAGAGTTACCCAAGAGTAAAGCTAAGGAGG
TCACCAAAATAGCTATAGATGCTGGTTTCCATCATTTTGATTCTGCTTTTGTCTACAATACCGA
AGATCATGTAGGAGAGGCCATCCGAGAGAAGATTGCCAATGGCACTACAAGGAGAGAAGATATA
TTTTACACATCAAAGCTTTGGTGTACGAGCCTTCACCCAGAACTGGTGAGATCTTCCTTGGAAT
GTTCACTGAAGAAACTTCAGTTGGACTATGTGGACCTGTATCTCATACATTTTCCGATGGCCTT
GAAACCAGGAGATGAAAATTTTCCAGTAGATGAACATGGAAAGTTACTATTTGACACAGTAGAT
CTCTGTGCTACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGACTGGCCAAGTCCATCGGGG
TGTCCAACTTTAACCGCAGGCAGCTGGAGAAGATCCTGAACAAGCCGGGGCTCAAATACAAGCC
TGTGTGCAACCAGGTAGAATGCCATCTTTATCTCAACCAAATGAAACTGCTGGATTTCTGCAAG
ACAAATGGCATTATACTGGTTGCCTATGGAGTTCTGGGAACACAACGATATAACGGATGGGTAG
ACCAGAACTCCCCTGTTCTCTTGAATGAACCAGTTCTTAGTTCCATGGCAAAAAAATACAATCA
AACTCCAGCCTTGATTGCCCTTCGCCATCAGTTGCAGCGTGGGATTGTGGTACTTAACACCAGT
CTCAAAGAAGAGCGGATCAAAGAGAACATGAAGGTTTTTGAATTCCAGCTGAGTCCAGAAGATA
TGAAAGTCCTTGATGACCTGAACAGAAATTTGCGGTACATAGCTGGTGGAATATTTGAAGGCCA
CCCTAATTTTCCGTTTTTGGATGAATACTAACATCTTCAGGGAAGATGTCTCCCGAAAGACCTA
TGGTTGGAACACTGCTCAGCTGCTGCTGAGACTTGTCACTTGTCTACAGACTTGTCACTTCTGC
TTTGTTGCAGTTGAGAACTTCCTGGAGCTACTCTTCAGCTAAGACAAAAAAAATAAATAAATAA
AAATAAAAATAAAAA

hide sequence

RefSeq Acc Id:

XM_006254185 ⟹ XP_006254247

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	65,759,895 - 65,808,013 (-)	NCBI
Rnor_6.0	17	69,388,375 - 69,435,160 (-)	NCBI
Rnor_5.0	17	71,102,094 - 71,148,911 (-)	NCBI

Sequence:

show sequence

CTACCCCTGCATGGGATACGTTTCTCGACCCCAGTGCACTGGTTTCTGTCATCCCATGAAATTG
CAGCAAGGGCAGTCTCTTTTGTGGGAACAGATTAACTCCTACACATGATGTAGATTCAACACCT
GCCAGGAAAGCAGAAGCATTACTTAAGTGTCCTGTGAAGGCAAACATCAAGTCAATTCAGCTTA
TCTTGAAGAGTGGCAAACCATGAACTCCAAATGTCATTGTGTGAAACTGAACGATGGTCATTTC
ATTCCGGTGCTGGGTTTTGGAACTGCTATGCCTTCAGAGTTACCCAAGAGTAAAGCTAAGGAGG
TCACCAAAATAGCTATAGATGCTGGTTTCCATCATTTTGATTCTGCTTTTGTCTACAATACCGA
AGATCATGTAGGAGAGGCCATCCGAGAGAAGATTGCCAATGGCACTACAAGGAGAGAAGATATA
TTTTACACATCAAAGCTTTGGTGTACGAGCCTTCACCCAGAACTGGTGAGATCTTCCTTGGAAT
GTTCACTGAAGAAACTTCAGTTGGACTATGTGGACCTGTATCTCATACATTTTCCGATGGCCTT
GAAAGCCATGGAGAAGTGTAAGGATGCAGGACTGGCCAAGTCCATCGGGGTGTCCAACTTTAAC
CGCAGGCAGCTGGAGAAGATCCTGAACAAGCCGGGGCTCAAATACAAGCCTGTGTGCAACCAGG
TAGAATGCCATCTTTATCTCAACCAAATGAAACTGCTGGATTTCTGCAAGACAAATGGCATTAT
ACTGGTTGCCTATGGAGTTCTGGGAACACAACGATATAACGGATGGGTAGACCAGAACTCCCCT
GTTCTCTTGAATGAACCAGTTCTTAGTTCCATGGCAAAAAAATACAATCAAACTCCAGCCTTGA
TTGCCCTTCGCCATCAGTTGCAGCGTGGGATTGTGGTACTTAACACCAGTCTCAAAGAAGAGCG
GATCAAAGAGAACATGAAGGTTTTTGAATTCCAGCTGAGTCCAGAAGATATGAAAGTCCTTGAT
GACCTGAACAGAAATTTGCGGTACATAGCTGGTGGAATATTTGAAGGCCACCCTAATTTTCCGT
TTTTGGATGAATACTAACATCTTCAGGGAAGATGTCTCCCGAAAGACCTATGGTTGGAACACTG
CTCAGCTGCTGCTGAGACTTGTCACTTGTCTACAGACTTGTCACTTCTGCTTTGTTGCAGTTGA
GAACTTCCTGGAGCTACTCTTCAGCTAAGACAAAAAAAATAAATAAATAAAAATAAAAATAAAA

hide sequence

RefSeq Acc Id:

XM_039095531 ⟹ XP_038951459

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	65,759,895 - 65,807,943 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001013075	(Get FASTA)	NCBI Sequence Viewer
	XP_006254245	(Get FASTA)	NCBI Sequence Viewer
	XP_006254247	(Get FASTA)	NCBI Sequence Viewer
	XP_038951459	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78957	(Get FASTA)	NCBI Sequence Viewer
	BBG31757	(Get FASTA)	NCBI Sequence Viewer
	Q6AYQ2	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001013075 ⟸ NM_001013057

- UniProtKB:

Q6AYQ2 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MNSKCHCVKLNDGHFIPVLGFGTAMPSELPKSKAKEVTKIAIDAGFHHFDSAFVYNTEDHVGEA
IREKIANGTTRREDIFYTSKLWCTSLHPELVRSSLECSLKKLQLDYVDLYLIHFPMALKPGDEN
FPVDEHGKLLFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEKILNKPGLKYKPVCNQVE
CHLYLNQMKLLDFCKTNGIILVAYGVLGTQRYNGWVDQNSPVLLNEPVLSSMAKKYNQTPALIA
LRHQLQRGIVVLNTSLKEERIKENMKLSPEDMKVLDDLNRNLRYIAGGIFEGHPNFPFLDEY

hide sequence

RefSeq Acc Id:

XP_006254247 ⟸ XM_006254185

- Peptide Label:

isoform X2

- Sequence:

show sequence

MNSKCHCVKLNDGHFIPVLGFGTAMPSELPKSKAKEVTKIAIDAGFHHFDSAFVYNTEDHVGEA
IREKIANGTTRREDIFYTSKLWCTSLHPELVRSSLECSLKKLQLDYVDLYLIHFPMALKAMEKC
KDAGLAKSIGVSNFNRRQLEKILNKPGLKYKPVCNQVECHLYLNQMKLLDFCKTNGIILVAYGV
LGTQRYNGWVDQNSPVLLNEPVLSSMAKKYNQTPALIALRHQLQRGIVVLNTSLKEERIKENMK
VFEFQLSPEDMKVLDDLNRNLRYIAGGIFEGHPNFPFLDEY

hide sequence

RefSeq Acc Id:	XP_006254245 ⟸ XM_006254183
- Peptide Label:	isoform X1
- UniProtKB:	A0A387KBL1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNSKCHCVKLNDGHFIPVLGFGTAMPSELPKSKAKEVTKIAIDAGFHHFDSAFVYNTEDHVGEA IREKIANGTTRREDIFYTSKLWCTSLHPELVRSSLECSLKKLQLDYVDLYLIHFPMALKPGDEN FPVDEHGKLLFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEKILNKPGLKYKPVCNQVE CHLYLNQMKLLDFCKTNGIILVAYGVLGTQRYNGWVDQNSPVLLNEPVLSSMAKKYNQTPALIA LRHQLQRGIVVLNTSLKEERIKENMKVFEFQLSPEDMKVLDDLNRNLRYIAGGIFEGHPNFPFL DEY hide sequence

RefSeq Acc Id:

ENSRNOP00000045355 ⟸ ENSRNOT00000051342

RefSeq Acc Id:

ENSRNOP00000063166 ⟸ ENSRNOT00000066282

RefSeq Acc Id:	XP_038951459 ⟸ XM_039095531
- Peptide Label:	isoform X1
- UniProtKB:	A0A387KBL1 (UniProtKB/TrEMBL)

Protein Domains

NADP-dependent oxidoreductase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AYQ2-F1-model_v2	AlphaFold	Q6AYQ2	1-318	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311841	AgrOrtholog
BioCyc Gene	G2FUF-8841	BioCyc
Ensembl Genes	ENSRNOG00000029844	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000045355	ENTREZGENE
	ENSRNOP00000045355.4	UniProtKB/TrEMBL
	ENSRNOP00000063166.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000051342	ENTREZGENE
	ENSRNOT00000051342.5	UniProtKB/TrEMBL
	ENSRNOT00000066282.3	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.100	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7110806	IMAGE-MGC_LOAD
InterPro	AKR1C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldo/ket_reductase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldo/keto_reductase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NADP_OxRdtase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NADP_OxRdtase_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:291283	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93821	IMAGE-MGC_LOAD
NCBI Gene	291283	ENTREZGENE
PANTHER	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C21	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALDO/KETO REDUCTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Aldo_ket_red	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Akr1c2	PhenoGen
PIRSF	AKR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	ALDKETRDTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ALDOKETO_REDUCTASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF51430	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A387KBL1	ENTREZGENE, UniProtKB/TrEMBL
	AK1CL_RAT	UniProtKB/Swiss-Prot
	F1LQ80_RAT	UniProtKB/TrEMBL
	Q6AYQ2	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-04-15	Akr1c2	aldo-keto reductase family 1, member C2	Akr1c21	aldo-keto reductase family 1, member C21	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Akr1c21	aldo-keto reductase family 1, member C21	Akr1c21_predicted	aldo-keto reductase family 1, member C21 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Akr1c21_predicted	aldo-keto reductase family 1, member C21 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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