Akr1c2 (aldo-keto reductase family 1, member C2) - Rat Genome Database

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Gene: Akr1c2 (aldo-keto reductase family 1, member C2) Rattus norvegicus
Analyze
Symbol: Akr1c2
Name: aldo-keto reductase family 1, member C2
RGD ID: 1311841
Description: Predicted to enable several functions, including NADP binding activity; ketosteroid monooxygenase activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including cellular response to prostaglandin D stimulus; glycoside metabolic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C2 (aldo-keto reductase family 1 member C2) and AKR1C4 (aldo-keto reductase family 1 member C4); INTERACTS WITH (+)-schisandrin B; 3,3',4,4',5-pentachlorobiphenyl; 3,4,5,3',4',5'-Hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 3(17)alpha-hydroxysteroid dehydrogenase; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase; Akr1c21; aldo-keto reductase family 1 member C21; aldo-keto reductase family 1, member C21; LOC291283; RAKg
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81770,669,684 - 70,717,935 (-)NCBIGRCr8
mRatBN7.21765,759,778 - 65,808,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1765,759,788 - 65,775,764 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,255,523 - 69,303,728 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,084,375 - 73,132,581 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,127,357 - 67,175,563 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,388,337 - 69,435,160 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,388,335 - 69,404,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,102,094 - 71,148,911 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,034,737 - 77,081,406 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,045,579 - 77,092,239 (-)NCBI
Celera1765,292,033 - 65,339,839 (-)NCBICelera
Cytogenetic Map17q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-20-hydroxypregn-4-en-3-one  (ISO)
(E)-cinnamyl alcohol  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-phenyl-1,2-propanedione  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-dimethoxyphenol  (ISO)
2-(chloromethyl)pyridine  (ISO)
2-aminophenol  (ISO)
2-hexenal  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxybenzoic acid  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-nitrobenzyl bromide  (ISO)
5-alpha-THDOC  (ISO)
5-fluorouracil  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
9,10-phenanthroquinone  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
ampicillin  (ISO)
androstane-3,17-diol  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzyl cinnamate  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
celastrol  (ISO)
chenodeoxycholic acid  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chlorohydrocarbon  (EXP)
chloromethylisothiazolinone  (ISO)
chloropicrin  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
citral  (ISO)
clodronic acid  (ISO)
Clofop  (ISO)
cloxazolam  (ISO)
cobalt dichloride  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclopentanol  (ISO)
cyclopentanone  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
dibenzo[a,l]pyrene  (ISO)
dienogest  (ISO)
diethyl maleate  (ISO)
diethyl sulfate  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
dutasteride  (ISO)
dydrogesterone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
estazolam  (ISO)
Ethyl acrylate  (ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol dimethacrylate  (ISO)
ethylparaben  (ISO)
eugenol  (ISO)
farnesal  (ISO)
fenamic acid  (ISO)
fenofibrate  (ISO)
flufenamic acid  (ISO)
flunitrazepam  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
gedunin  (ISO)
geranial  (ISO)
glipizide  (ISO)
glyburide  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyoxal  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexestrol  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
imidurea  (ISO)
indometacin  (ISO)
isoeugenol  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
linalool  (ISO)
lithocholic acid  (ISO)
LY294002  (ISO)
malathion  (ISO)
meclofenamic acid  (ISO)
Medazepam  (ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methyl methanesulfonate  (ISO)
methyl non-2-ynoate  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
n-propyl gallate  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalenes  (ISO)
naproxen  (ISO)
nitrazepam  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
octadecanoic acid  (ISO)
octyl gallate  (ISO)
oxcarbazepine  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
Panaxytriol  (ISO)
para-Cresidine  (ISO)
paracetamol  (ISO)
Paraoxon-methyl  (ISO)
parathion-methyl  (ISO)
perfluorodecanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenolphthalein  (ISO)
Phenyl glycidyl ether  (ISO)
phenylacetaldehyde  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium bromate  (EXP)
progesterone  (ISO)
prostaglandin F2alpha  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
reactive oxygen species  (ISO)
Ro 31-8220  (ISO)
rotenone  (EXP)
salicylic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trans-isoeugenol  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanillin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc sulfate  (ISO)
zoledronic acid  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8573067   PMID:15577209   PMID:17034817   PMID:17442338   PMID:18508192   PMID:19487289   PMID:20124700   PMID:20837989   PMID:21232532   PMID:21492153   PMID:21851338  


Genomics

Comparative Map Data
Akr1c2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81770,669,684 - 70,717,935 (-)NCBIGRCr8
mRatBN7.21765,759,778 - 65,808,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1765,759,788 - 65,775,764 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,255,523 - 69,303,728 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,084,375 - 73,132,581 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,127,357 - 67,175,563 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,388,337 - 69,435,160 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,388,335 - 69,404,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,102,094 - 71,148,911 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,034,737 - 77,081,406 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,045,579 - 77,092,239 (-)NCBI
Celera1765,292,033 - 65,339,839 (-)NCBICelera
Cytogenetic Map17q12.2NCBI
AKR1C2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38104,987,775 - 5,018,000 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl104,987,775 - 5,018,031 (-)EnsemblGRCh38hg38GRCh38
GRCh37105,029,967 - 5,060,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,021,965 - 5,050,207 (-)NCBINCBI36Build 36hg18NCBI36
Build 34105,021,965 - 5,050,207NCBI
Celera104,972,245 - 5,000,184 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef104,920,321 - 4,955,422 (+)NCBIHuRef
CHM1_1105,030,308 - 5,060,576 (-)NCBICHM1_1
T2T-CHM13v2.0104,988,109 - 5,018,344 (-)NCBIT2T-CHM13v2.0
Akr1c21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,624,074 - 4,636,542 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,624,074 - 4,636,540 (+)EnsemblGRCm39 Ensembl
GRCm38134,574,075 - 4,586,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,574,075 - 4,586,541 (+)EnsemblGRCm38mm10GRCm38
MGSCv37134,573,321 - 4,585,789 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,573,321 - 4,585,787 (+)NCBIMGSCv36mm8
Celera134,543,969 - 4,562,535 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.56NCBI

Variants

.
Variants in Akr1c2
110 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:140
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000051342, ENSRNOT00000066282
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176364000973951021Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 10 12 41 56 55 31 20 31 6 113 49 24 20 33 24

Sequence


Ensembl Acc Id: ENSRNOT00000051342   ⟹   ENSRNOP00000045355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1765,759,788 - 65,775,764 (-)Ensembl
Rnor_6.0 Ensembl1769,388,347 - 69,404,323 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000066282   ⟹   ENSRNOP00000063166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1765,759,788 - 65,775,764 (-)Ensembl
Rnor_6.0 Ensembl1769,388,335 - 69,404,341 (-)Ensembl
RefSeq Acc Id: NM_001013057   ⟹   NP_001013075
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,700 - 70,717,880 (-)NCBI
mRatBN7.21765,759,778 - 65,807,957 (-)NCBI
Rnor_6.01769,388,337 - 69,435,148 (-)NCBI
Rnor_5.01771,102,094 - 71,148,911 (-)NCBI
RGSC_v3.41777,034,737 - 77,081,406 (-)RGD
Celera1765,292,033 - 65,339,839 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254183   ⟹   XP_006254245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,684 - 70,717,935 (-)NCBI
mRatBN7.21765,759,895 - 65,808,013 (-)NCBI
Rnor_6.01769,388,374 - 69,435,160 (-)NCBI
Rnor_5.01771,102,094 - 71,148,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006254185   ⟹   XP_006254247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,684 - 70,717,935 (-)NCBI
mRatBN7.21765,759,895 - 65,808,013 (-)NCBI
Rnor_6.01769,388,375 - 69,435,160 (-)NCBI
Rnor_5.01771,102,094 - 71,148,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095531   ⟹   XP_038951459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,684 - 70,717,897 (-)NCBI
mRatBN7.21765,759,895 - 65,807,943 (-)NCBI
RefSeq Acc Id: XM_063276235   ⟹   XP_063132305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,684 - 70,717,897 (-)NCBI
RefSeq Acc Id: NP_001013075   ⟸   NM_001013057
- UniProtKB: Q6AYQ2 (UniProtKB/Swiss-Prot),   F1LQ80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254247   ⟸   XM_006254185
- Peptide Label: isoform X2
- UniProtKB: F1LQ80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254245   ⟸   XM_006254183
- Peptide Label: isoform X1
- UniProtKB: A0A387KBL1 (UniProtKB/TrEMBL),   F1LQ80 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045355   ⟸   ENSRNOT00000051342
Ensembl Acc Id: ENSRNOP00000063166   ⟸   ENSRNOT00000066282
RefSeq Acc Id: XP_038951459   ⟸   XM_039095531
- Peptide Label: isoform X1
- UniProtKB: A0A387KBL1 (UniProtKB/TrEMBL),   F1LQ80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132305   ⟸   XM_063276235
- Peptide Label: isoform X2
- UniProtKB: F1LQ80 (UniProtKB/TrEMBL)
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYQ2-F1-model_v2 AlphaFold Q6AYQ2 1-318 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311841 AgrOrtholog
BioCyc Gene G2FUF-8841 BioCyc
Ensembl Genes ENSRNOG00000029844 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051342.5 UniProtKB/TrEMBL
  ENSRNOT00000066282.3 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110806 IMAGE-MGC_LOAD
InterPro AKR1C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:291283 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93821 IMAGE-MGC_LOAD
NCBI Gene 291283 ENTREZGENE
PANTHER ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Akr1c2 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029844 RatGTEx
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A387KBL1 ENTREZGENE, UniProtKB/TrEMBL
  AK1CL_RAT UniProtKB/Swiss-Prot
  F1LQ80 ENTREZGENE, UniProtKB/TrEMBL
  Q6AYQ2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-15 Akr1c2  aldo-keto reductase family 1, member C2  Akr1c21  aldo-keto reductase family 1, member C21  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Akr1c21  aldo-keto reductase family 1, member C21  Akr1c21_predicted  aldo-keto reductase family 1, member C21 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Akr1c21_predicted  aldo-keto reductase family 1, member C21 (predicted)      Symbol and Name status set to approved 70820 APPROVED