Armc3 (armadillo repeat containing 3) - Rat Genome Database

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Gene: Armc3 (armadillo repeat containing 3) Rattus norvegicus
Analyze
Symbol: Armc3
Name: armadillo repeat containing 3
RGD ID: 2319961
Description: Predicted to be involved in flagellated sperm motility; ribophagy; and spermatid development. Orthologous to human ARMC3 (armadillo repeat containing 3); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: armadillo repeat-containing protein 3; Armc3 protein-like; LOC100361506
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81786,722,436 - 86,825,899 (+)NCBIGRCr8
mRatBN7.21781,814,087 - 81,917,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1781,832,518 - 81,917,531 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1785,297,704 - 85,382,538 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01789,133,120 - 89,217,975 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01783,149,878 - 83,234,738 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01785,895,841 - 86,009,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1785,914,410 - 86,009,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01787,610,808 - 87,726,061 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41793,278,359 - 93,361,623 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1781,103,766 - 81,187,813 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090   PMID:19056867  


Genomics

Comparative Map Data
Armc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81786,722,436 - 86,825,899 (+)NCBIGRCr8
mRatBN7.21781,814,087 - 81,917,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1781,832,518 - 81,917,531 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1785,297,704 - 85,382,538 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01789,133,120 - 89,217,975 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01783,149,878 - 83,234,738 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01785,895,841 - 86,009,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1785,914,410 - 86,009,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01787,610,808 - 87,726,061 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41793,278,359 - 93,361,623 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1781,103,766 - 81,187,813 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
ARMC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381022,928,053 - 23,038,523 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1022,928,024 - 23,038,523 (+)EnsemblGRCh38hg38GRCh38
GRCh371023,216,982 - 23,327,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361023,256,966 - 23,366,520 (+)NCBINCBI36Build 36hg18NCBI36
Build 341023,256,965 - 23,366,520NCBI
Celera1022,904,614 - 23,014,160 (+)NCBICelera
Cytogenetic Map10p12.2NCBI
HuRef1022,877,824 - 22,986,594 (+)NCBIHuRef
CHM1_11023,217,435 - 23,327,017 (+)NCBICHM1_1
T2T-CHM13v2.01022,947,064 - 23,057,478 (+)NCBIT2T-CHM13v2.0
Armc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39219,203,676 - 19,315,054 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl219,204,113 - 19,315,052 (+)EnsemblGRCm39 Ensembl
GRCm38219,198,865 - 19,310,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl219,199,302 - 19,310,241 (+)EnsemblGRCm38mm10GRCm38
MGSCv37219,120,745 - 19,231,861 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36219,116,872 - 19,227,988 (+)NCBIMGSCv36mm8
Celera219,104,793 - 19,208,375 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map213.2NCBI
Armc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554295,947,940 - 6,051,038 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554295,949,180 - 6,050,690 (-)NCBIChiLan1.0ChiLan1.0
ARMC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2835,527,861 - 35,721,296 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11035,533,182 - 35,724,736 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01023,085,591 - 23,196,943 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11023,460,342 - 23,570,908 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1023,460,348 - 23,570,908 (+)Ensemblpanpan1.1panPan2
ARMC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1210,201,347 - 10,302,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl210,202,329 - 10,302,733 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha28,895,514 - 8,996,035 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.028,400,242 - 8,500,787 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl28,400,246 - 8,500,665 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.127,765,696 - 7,866,137 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.027,848,514 - 7,949,051 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.028,016,960 - 8,117,519 (-)NCBIUU_Cfam_GSD_1.0
Armc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934422,746,484 - 22,844,963 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365205,116,628 - 5,211,163 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365205,116,628 - 5,211,163 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARMC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1051,959,610 - 52,049,425 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11051,959,571 - 52,050,071 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21057,615,066 - 57,704,928 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARMC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1922,683,911 - 22,800,051 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl922,685,028 - 22,800,926 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605128,442,972 - 28,564,471 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Armc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247965,678,701 - 5,778,443 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247965,679,159 - 5,781,173 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Armc3
761 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:249
Count of miRNA genes:169
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000022475, ENSRNOT00000065463, ENSRNOT00000075188
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)177177462182479847Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 7
Low 1 1 11 58 10 17 11
Below cutoff 2 22 44 29 8 29 7 9 16 20 17 7

Sequence


RefSeq Acc Id: ENSRNOT00000075188   ⟹   ENSRNOP00000065974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1781,832,518 - 81,917,531 (+)Ensembl
Rnor_6.0 Ensembl1785,914,410 - 86,009,396 (+)Ensembl
RefSeq Acc Id: NM_001287020   ⟹   NP_001273949
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,741,067 - 86,825,899 (+)NCBI
mRatBN7.21781,832,695 - 81,917,531 (+)NCBI
Rnor_6.01785,914,587 - 86,009,403 (+)NCBI
Celera1781,103,766 - 81,187,813 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600428   ⟹   XP_017455917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,740,999 - 86,825,899 (+)NCBI
mRatBN7.21781,832,628 - 81,917,534 (+)NCBI
Rnor_6.01785,914,525 - 86,009,403 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600429   ⟹   XP_017455918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,722,436 - 86,825,899 (+)NCBI
mRatBN7.21781,814,087 - 81,917,413 (+)NCBI
Rnor_6.01785,895,841 - 86,009,403 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600430   ⟹   XP_017455919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,740,999 - 86,825,899 (+)NCBI
mRatBN7.21781,832,628 - 81,917,531 (+)NCBI
Rnor_6.01785,914,524 - 86,009,399 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600431   ⟹   XP_017455920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,740,999 - 86,825,899 (+)NCBI
mRatBN7.21781,832,628 - 81,917,531 (+)NCBI
Rnor_6.01785,914,524 - 86,009,399 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095275   ⟹   XP_038951203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,740,999 - 86,825,899 (+)NCBI
mRatBN7.21781,832,628 - 81,917,531 (+)NCBI
RefSeq Acc Id: XM_063276004   ⟹   XP_063132074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,740,999 - 86,825,899 (+)NCBI
RefSeq Acc Id: NP_001273949   ⟸   NM_001287020
- UniProtKB: M0R914 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455918   ⟸   XM_017600429
- Peptide Label: isoform X1
- UniProtKB: M0R914 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455919   ⟸   XM_017600430
- Peptide Label: isoform X2
- UniProtKB: M0R914 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455920   ⟸   XM_017600431
- Peptide Label: isoform X4
- UniProtKB: A6JM99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455917   ⟸   XM_017600428
- Peptide Label: isoform X1
- UniProtKB: M0R914 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065974   ⟸   ENSRNOT00000075188
RefSeq Acc Id: XP_038951203   ⟸   XM_039095275
- Peptide Label: isoform X5
- UniProtKB: A6JM99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132074   ⟸   XM_063276004
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R914-F1-model_v2 AlphaFold M0R914 1-900 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2319961 AgrOrtholog
BioCyc Gene G2FUF-8537 BioCyc
Ensembl Genes ENSRNOG00000016716 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075188 ENTREZGENE
  ENSRNOT00000075188.4 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
NCBI Gene 100361506 ENTREZGENE
PANTHER ARMADILLO REPEAT-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
  ARMADILLO REPEAT-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
Pfam Arm UniProtKB/TrEMBL
  EDR1 UniProtKB/TrEMBL
  HEAT_2 UniProtKB/TrEMBL
PhenoGen Armc3 PhenoGen
PROSITE ARM_REPEAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016716 RatGTEx
SMART ARM UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A6JM99 ENTREZGENE, UniProtKB/TrEMBL
  M0R914 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-13 Armc3  armadillo repeat containing 3  LOC100361506  Armc3 protein-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100361506  Armc3 protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL