Chrm3 (cholinergic receptor, muscarinic 3) - Rat Genome Database

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Gene: Chrm3 (cholinergic receptor, muscarinic 3) Rattus norvegicus
Analyze
Symbol: Chrm3
Name: cholinergic receptor, muscarinic 3
RGD ID: 2343
Description: Enables G protein-coupled acetylcholine receptor activity; G protein-coupled acetylcholine receptor binding activity; and acetylcholine binding activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; negative regulation of heart rate by acetylcholine; and positive regulation of vascular associated smooth muscle contraction. Located in several cellular components, including asymmetric synapse; axon terminus; and dendrite. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic membrane. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family; cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cholinergic receptor, muscarinic 3, cardiac; muscarinic acetylcholine receptor M3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Cm15
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21760,005,137 - 60,467,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1760,005,202 - 60,467,278 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1763,209,233 - 63,671,688 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01767,212,340 - 67,674,776 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01761,366,663 - 61,834,600 (+)NCBIRnor_WKY
Rnor_6.01763,990,599 - 64,463,222 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1763,990,599 - 63,994,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01765,753,665 - 66,217,211 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41771,214,906 - 71,218,463 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11771,081,449 - 71,229,296 (+)NCBI
Celera1760,109,356 - 60,562,246 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2-deoxy-D-glucose  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-DAMP methiodide  (IDA)
4-DAMP(1+)  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylcholine  (EXP,ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atropine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bethanechol  (ISO)
bisphenol A  (EXP)
brucine  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
caracurine VII  (ISO)
carbachol  (EXP,ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (EXP)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
darifenacin  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorvos  (EXP)
diethylstilbestrol  (EXP)
dimethoate  (EXP,ISO)
disulfoton  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fipronil  (EXP)
fructose  (EXP)
furan  (EXP)
furtrethonium  (ISO)
genistein  (EXP,ISO)
glycidol  (EXP)
guanosine 5'-[beta,gamma-imido]triphosphate  (ISO)
hexacosan-1-ol  (EXP)
histamine  (ISO)
hydrogen chloride  (EXP)
inulin  (ISO)
ketamine  (ISO)
KT 5720  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
methscopolamine  (EXP,ISO)
methylmercury chloride  (ISO)
metoclopramide  (EXP)
N-acetyl-L-cysteine  (ISO)
nafenopin  (EXP)
nickel atom  (ISO)
oxotremorine M  (ISO)
oxybutynin  (ISO)
pancuronium  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraoxon  (ISO)
parathion-methyl  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
picrotoxin  (EXP)
Pipecuronium  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propanal  (ISO)
quercetin  (EXP)
resveratrol  (EXP)
rocuronium  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
Securinine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Solifenacin succinate  (ISO)
staurosporine  (EXP)
streptozocin  (EXP)
strychnine  (EXP,ISO)
sunitinib  (ISO)
taurodeoxycholic acid  (ISO)
taurolithocholic acid  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thiopental  (ISO)
tiotropium bromide  (ISO)
tolterodine tartrate  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tropicamide  (ISO)
valproic acid  (ISO)
vecuronium bromide  (ISO)
vorinostat  (ISO)
zinc oxide  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Muscarinic receptor antagonists for overactive bladder. Abrams P and Andersson KE, BJU Int. 2007 Nov;100(5):987-1006.
2. Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro. Asano K, etal., Int J Chron Obstruct Pulmon Dis. 2008;3(4):781-9.
3. Identification of a family of muscarinic acetylcholine receptor genes. Bonner TI, etal., Science 1987 Jul 31;237(4814):527-32.
4. Mediation by M3-muscarinic receptors of both endothelium-dependent contraction and relaxation to acetylcholine in the aorta of the spontaneously hypertensive rat. Boulanger CM, etal., Br J Pharmacol. 1994 Jun;112(2):519-24.
5. A novel subtype of muscarinic receptor identified by homology screening. Braun T, etal., Biochem Biophys Res Commun 1987 Nov 30;149(1):125-32.
6. Interaction between muscarinic receptor subtype signal transduction pathways mediating bladder contraction. Braverman AS, etal., Am J Physiol Regul Integr Comp Physiol 2002 Sep;283(3):R663-8.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function. Guo ML, etal., EMBO J. 2010 Jun 16;29(12):2070-81. doi: 10.1038/emboj.2010.93. Epub 2010 May 11.
10. Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts. Haag S, etal., Eur Respir J. 2008 Sep;32(3):555-62. Epub 2008 May 14.
11. Use of an in situ disulfide cross-linking strategy to map proximities between amino acid residues in transmembrane domains I and VII of the M3 muscarinic acetylcholine receptor. Hamdan FF, etal., Biochemistry 2002 Jun 18;41(24):7647-58.
12. Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies. Hersch SM, etal., J Neurosci. 1994 May;14(5 Pt 2):3351-63.
13. Differentiation of muscarinic receptors mediating negative chronotropic and vasoconstrictor responses to acetylcholine in isolated rat hearts. Hoover DB and Neely DA, J Pharmacol Exp Ther. 1997 Sep;282(3):1337-44.
14. Acute exposure to methylmercury causes Ca2+ dysregulation and neuronal death in rat cerebellar granule cells through an M3 muscarinic receptor-linked pathway. Limke TL, etal., Toxicol Sci. 2004 Jul;80(1):60-8. Epub 2004 May 12.
15. Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airway hyperresponsiveness. Lin LH, etal., Eur J Pharmacol. 2008 Apr 28;584(2-3):398-404. Epub 2008 Feb 19.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Mediation by the same muscarinic receptor subtype of phasic and tonic contractile activities in the rat isolated portal vein. Pfaffendorf M and Van Zwieten PA, Br J Pharmacol. 1993 Jan;108(1):132-8.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Morphological and molecular characteristics of "difficult" asthma. Selivanova PA, etal., J Asthma. 2010 Apr;47(3):269-75.
26. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
27. Muscarinic signaling in the brain. Thiele A Annu Rev Neurosci. 2013 Jul 8;36:271-94. doi: 10.1146/annurev-neuro-062012-170433.
28. Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus. Tseng J, etal., Hear Res 2002 Dec;174(1-2):86-92.
29. Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants. Wess J, etal., J Biol Chem. 1992 Sep 25;267(27):19313-9.
30. Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Yamada M, etal., Nature 2001 Mar 8;410(6825):207-12.
31. The M3-muscarinic cholinoceptor subtype in rat prostate and its down regulation by aging. Yazawa H and Honda K, Jpn J Pharmacol. 1993 Apr;61(4):319-24.
32. Distinct roles of cholinergic receptors in small cell lung cancer cells. Zhang S, etal., Anticancer Res. 2010 Jan;30(1):97-106.
Additional References at PubMed
PMID:1657592   PMID:2380182   PMID:3272174   PMID:9972520   PMID:10944224   PMID:12925702   PMID:14766941   PMID:15062561   PMID:15350825   PMID:15572356   PMID:15870064   PMID:16093246  
PMID:16709645   PMID:17065150   PMID:17478539   PMID:17596535   PMID:17845913   PMID:18237275   PMID:18246091   PMID:18938154   PMID:19111904   PMID:19160866   PMID:19416629   PMID:19473345  
PMID:19494196   PMID:19554469   PMID:19627722   PMID:19666081   PMID:19685039   PMID:19741053   PMID:19779020   PMID:20445960   PMID:20541544   PMID:20600670   PMID:20655720   PMID:21054404  
PMID:21056967   PMID:21126518   PMID:21543213   PMID:21913336   PMID:22031716   PMID:22141271   PMID:22358844   PMID:22396777   PMID:22513211   PMID:22990911   PMID:23184186   PMID:24028210  
PMID:24866457   PMID:25417050   PMID:25474381   PMID:25681120   PMID:25891767   PMID:25920933   PMID:26033578   PMID:26626425   PMID:27858307   PMID:30354759   PMID:32534071   PMID:36445617  


Genomics

Comparative Map Data
Chrm3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21760,005,137 - 60,467,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1760,005,202 - 60,467,278 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1763,209,233 - 63,671,688 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01767,212,340 - 67,674,776 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01761,366,663 - 61,834,600 (+)NCBIRnor_WKY
Rnor_6.01763,990,599 - 64,463,222 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1763,990,599 - 63,994,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01765,753,665 - 66,217,211 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41771,214,906 - 71,218,463 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11771,081,449 - 71,229,296 (+)NCBI
Celera1760,109,356 - 60,562,246 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
CHRM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381239,386,568 - 239,915,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1239,386,565 - 239,915,452 (+)EnsemblGRCh38hg38GRCh38
GRCh371239,549,868 - 240,078,750 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361237,858,996 - 238,139,343 (+)NCBINCBI36Build 36hg18NCBI36
Build 341236,118,413 - 236,398,756NCBI
Celera1213,047,986 - 213,328,202 (+)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1210,250,783 - 210,531,551 (+)NCBIHuRef
CHM1_11241,065,995 - 241,346,299 (+)NCBICHM1_1
T2T-CHM13v2.01238,798,998 - 239,328,607 (+)NCBIT2T-CHM13v2.0
Chrm3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39139,925,522 - 10,411,131 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl139,925,522 - 10,410,883 (-)EnsemblGRCm39 Ensembl
GRCm38139,875,486 - 10,361,062 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl139,875,486 - 10,360,847 (-)EnsemblGRCm38mm10GRCm38
MGSCv37139,875,859 - 10,360,049 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36139,875,859 - 10,360,049 (-)NCBIMGSCv36mm8
Celera139,820,205 - 10,316,018 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map133.72NCBI
Chrm3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955492958,949 - 960,721 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955492958,347 - 1,429,832 (-)NCBIChiLan1.0ChiLan1.0
CHRM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan119,478,692 - 10,000,004 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01214,931,514 - 215,452,739 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11219,927,079 - 220,446,830 (+)NCBIpanpan1.1PanPan1.1panPan2
CHRM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.14504,663 - 999,550 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl4506,990 - 520,613 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha4547,625 - 1,042,706 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.04528,395 - 1,026,611 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.14522,413 - 1,023,728 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.04628,064 - 1,134,213 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.04882,752 - 1,377,924 (-)NCBIUU_Cfam_GSD_1.0
Chrm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934437,787,915 - 38,208,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648413,954,887 - 13,956,659 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648413,953,141 - 14,373,174 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,828,231 - 51,830,003 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,818,625 - 52,363,662 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21455,361,402 - 55,363,168 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHRM3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12576,772,212 - 77,009,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2577,001,477 - 77,003,249 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605578,598,053 - 79,113,674 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrm3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477510,949,983 - 10,951,755 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477510,948,075 - 11,427,898 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chrm3
3125 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:98
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000075651
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)175089090860781592Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)175089090860781592Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)175090919660781426Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)175402992960463637Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat

Markers in Region
D17Mit4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21760,463,412 - 60,463,643 (-)MAPPERmRatBN7.2
Rnor_6.01763,994,205 - 63,994,435NCBIRnor6.0
Rnor_5.01765,757,271 - 65,757,501UniSTSRnor5.0
RGSC_v3.41771,214,626 - 71,214,857RGDRGSC3.4
RGSC_v3.41771,214,627 - 71,214,857UniSTSRGSC3.4
RGSC_v3.11771,225,459 - 71,225,690RGD
Celera1760,112,962 - 60,113,192UniSTS
RH 3.4 Map17559.3UniSTS
RH 3.4 Map17559.3RGD
RH 2.0 Map17498.3RGD
Cytogenetic Map17q12.1UniSTS
D17Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21760,463,405 - 60,463,642 (-)MAPPERmRatBN7.2
Rnor_6.01763,994,206 - 63,994,442NCBIRnor6.0
Rnor_5.01765,757,272 - 65,757,508UniSTSRnor5.0
RGSC_v3.41771,214,619 - 71,214,856RGDRGSC3.4
RGSC_v3.41771,214,620 - 71,214,856UniSTSRGSC3.4
RGSC_v3.11771,225,452 - 71,225,689RGD
Celera1760,112,963 - 60,113,199UniSTS
SHRSP x BN Map1732.6199UniSTS
SHRSP x BN Map1732.6199RGD
Cytogenetic Map17q12.1UniSTS
D17Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21760,463,500 - 60,463,637 (-)MAPPERmRatBN7.2
Rnor_6.01763,994,211 - 63,994,347NCBIRnor6.0
Rnor_5.01765,757,277 - 65,757,413UniSTSRnor5.0
RGSC_v3.41771,214,714 - 71,214,851RGDRGSC3.4
RGSC_v3.41771,214,715 - 71,214,851UniSTSRGSC3.4
RGSC_v3.11771,225,547 - 71,225,684RGD
Celera1760,112,968 - 60,113,104UniSTS
RH 3.4 Map17559.0UniSTS
RH 3.4 Map17559.0RGD
RH 2.0 Map17514.1RGD
Cytogenetic Map17q12.1UniSTS
D17Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21760,463,483 - 60,463,633 (-)MAPPERmRatBN7.2
Rnor_6.01763,994,215 - 63,994,364NCBIRnor6.0
Rnor_5.01765,757,281 - 65,757,430UniSTSRnor5.0
RGSC_v3.41771,214,697 - 71,214,847RGDRGSC3.4
RGSC_v3.41771,214,698 - 71,214,847UniSTSRGSC3.4
RGSC_v3.11771,225,530 - 71,225,680RGD
Celera1760,112,972 - 60,113,121UniSTS
RH 2.0 Map17511.6RGD
Cytogenetic Map17q12.1UniSTS
D17Wox1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,465,698 - 5,465,879 (+)MAPPERmRatBN7.2
Rnor_6.0175,841,679 - 5,841,859NCBIRnor6.0
Rnor_5.0178,064,007 - 8,064,187UniSTSRnor5.0
RGSC_v3.41711,399,694 - 11,399,874UniSTSRGSC3.4
RGSC_v3.11711,399,693 - 11,399,874RGD
Celera175,580,639 - 5,580,819UniSTS
RH 3.4 Map1774.1UniSTS
RH 3.4 Map1774.1RGD
Cytogenetic Map17p14UniSTS
Cytogenetic Map17q12.1UniSTS
D17Mit4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01763,994,206 - 63,994,435NCBIRnor6.0
Rnor_5.01765,757,272 - 65,757,501UniSTSRnor5.0
RGSC_v3.41771,214,627 - 71,214,856UniSTSRGSC3.4
Celera1760,112,963 - 60,113,192UniSTS
Cytogenetic Map17q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 1
Low 3 11 14 6 10 6 1 31 35 29 9
Below cutoff 32 37 31 7 31 8 10 6 8 2 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075651   ⟹   ENSRNOP00000067435
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1760,439,032 - 60,467,278 (+)Ensembl
Rnor_6.0 Ensembl1763,990,599 - 63,994,169 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102670   ⟹   ENSRNOP00000090085
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1760,005,202 - 60,467,278 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103154   ⟹   ENSRNOP00000090433
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1760,005,202 - 60,467,278 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107962   ⟹   ENSRNOP00000086603
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1760,005,202 - 60,467,278 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113544   ⟹   ENSRNOP00000087869
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1760,005,259 - 60,467,278 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118676   ⟹   ENSRNOP00000080306
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1760,005,202 - 60,467,278 (+)Ensembl
RefSeq Acc Id: NM_012527   ⟹   NP_036659
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21760,005,505 - 60,467,249 (+)NCBI
Rnor_6.01763,990,599 - 64,463,222 (-)NCBI
Rnor_5.01765,753,665 - 66,217,211 (-)NCBI
RGSC_v3.41771,214,906 - 71,218,463 (+)RGD
Celera1760,109,356 - 60,562,246 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600449   ⟹   XP_017455938
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21760,005,137 - 60,467,250 (+)NCBI
Rnor_6.01763,990,603 - 64,462,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600451   ⟹   XP_017455940
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21760,360,801 - 60,467,250 (+)NCBI
Rnor_6.01763,990,603 - 64,095,891 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095336   ⟹   XP_038951264
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21760,005,137 - 60,467,250 (+)NCBI
RefSeq Acc Id: XM_039095337   ⟹   XP_038951265
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21760,005,137 - 60,467,250 (+)NCBI
RefSeq Acc Id: XM_039095338   ⟹   XP_038951266
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21760,125,139 - 60,467,250 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036659   ⟸   NM_012527
- UniProtKB: Q9QWK9 (UniProtKB/Swiss-Prot),   P08483 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017455938   ⟸   XM_017600449
- Peptide Label: isoform X1
- UniProtKB: Q9QWK9 (UniProtKB/Swiss-Prot),   P08483 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017455940   ⟸   XM_017600451
- Peptide Label: isoform X1
- UniProtKB: Q9QWK9 (UniProtKB/Swiss-Prot),   P08483 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067435   ⟸   ENSRNOT00000075651
RefSeq Acc Id: XP_038951265   ⟸   XM_039095337
- Peptide Label: isoform X1
- UniProtKB: Q9QWK9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038951264   ⟸   XM_039095336
- Peptide Label: isoform X1
- UniProtKB: Q9QWK9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038951266   ⟸   XM_039095338
- Peptide Label: isoform X1
- UniProtKB: Q9QWK9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000090085   ⟸   ENSRNOT00000102670
RefSeq Acc Id: ENSRNOP00000087869   ⟸   ENSRNOT00000113544
RefSeq Acc Id: ENSRNOP00000090433   ⟸   ENSRNOT00000103154
RefSeq Acc Id: ENSRNOP00000086603   ⟸   ENSRNOT00000107962
RefSeq Acc Id: ENSRNOP00000080306   ⟸   ENSRNOT00000118676

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08483-F1-model_v2 AlphaFold P08483 1-589 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2343 AgrOrtholog
BioCyc Gene G2FUF-8916 BioCyc
Ensembl Genes ENSRNOG00000049410 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000067435 ENTREZGENE
  ENSRNOP00000067435.1 UniProtKB/Swiss-Prot
  ENSRNOP00000080306 ENTREZGENE
  ENSRNOP00000080306.1 UniProtKB/Swiss-Prot
  ENSRNOP00000086603 ENTREZGENE
  ENSRNOP00000086603.1 UniProtKB/Swiss-Prot
  ENSRNOP00000087869.1 UniProtKB/Swiss-Prot
  ENSRNOP00000090085 ENTREZGENE
  ENSRNOP00000090085.1 UniProtKB/Swiss-Prot
  ENSRNOP00000090433.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000075651 ENTREZGENE
  ENSRNOT00000075651.3 UniProtKB/Swiss-Prot
  ENSRNOT00000102670 ENTREZGENE
  ENSRNOT00000102670.1 UniProtKB/Swiss-Prot
  ENSRNOT00000103154.1 UniProtKB/Swiss-Prot
  ENSRNOT00000107962 ENTREZGENE
  ENSRNOT00000107962.1 UniProtKB/Swiss-Prot
  ENSRNOT00000113544.1 UniProtKB/Swiss-Prot
  ENSRNOT00000118676 ENTREZGENE
  ENSRNOT00000118676.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Musac_Ach_M3_rcpt UniProtKB/Swiss-Prot
  Musac_Ach_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:24260 UniProtKB/Swiss-Prot
NCBI Gene 24260 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot
  MUSCARINIC ACETYLCHOLINE RECEPTOR M3 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB CHRM3 RGD
PhenoGen Chrm3 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  MUSCARINICR UniProtKB/Swiss-Prot
  MUSCRINICM3R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt ACM3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QWK9 ENTREZGENE
UniProt Secondary Q9QWK9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Chrm3  cholinergic receptor, muscarinic 3  Chrm3  cholinergic receptor, muscarinic 3, cardiac  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Chrm3  cholinergic receptor, muscarinic 3, cardiac  Chrm3  cholinergic receptor, muscarinic 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Chrm3  cholinergic receptor, muscarinic 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function G protein-coupled receptor  
gene_process controls smooth muscle contraction and secretion in glandular tissue  
gene_process acts with M2 receptor to control smooth muscle contraction in the bladder 724728