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Gene: Chrm3 (cholinergic receptor, muscarinic 3, cardiac) Mus musculus
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Symbol: Chrm3
Name: cholinergic receptor, muscarinic 3, cardiac
Description: Predicted to have G protein-coupled acetylcholine receptor activity; G protein-coupled serotonin receptor activity; and acetylcholine binding activity. Involved in several processes, including cholinergic synaptic transmission; positive regulation of smooth muscle contraction; and saliva secretion. Predicted to localize to several cellular components, including the axon terminus; glutamatergic synapse; and integral component of synaptic membrane. Used to study megacystis-microcolon-intestinal hypoperistalsis syndrome. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family; cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-deoxy-D-glucose; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AChR M3; Chrm-3; M3; M3R; mm3 mAChR; muscarinic acetylcholine receptor 3; muscarinic acetylcholine receptor M3
Orthologs:
Homo sapiens (human) : CHRM3 (cholinergic receptor muscarinic 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Chrm3 (cholinergic receptor, muscarinic 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrm3 (cholinergic receptor muscarinic 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRM3 (cholinergic receptor muscarinic 3)
Canis lupus familiaris (dog) : CHRM3 (cholinergic receptor muscarinic 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrm3 (cholinergic receptor muscarinic 3)
Sus scrofa (pig) : CHRM3 (cholinergic receptor muscarinic 3)
Chlorocebus sabaeus (green monkey) : CHRM3 (cholinergic receptor muscarinic 3)
Heterocephalus glaber (naked mole-rat) : Chrm3 (cholinergic receptor muscarinic 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl139,875,486 - 10,360,847 (-)Ensembl
GRCm38139,875,486 - 10,361,062 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37139,875,859 - 10,360,049 (-)NCBIGRCm37mm9NCBIm37
MGSCv36139,875,859 - 10,360,049 (-)NCBImm8
Celera139,820,205 - 10,316,018 (-)NCBICelera
Cytogenetic Map13 A1NCBI
cM Map133.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Chrm3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737208
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.