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Gene: Chrm3 (cholinergic receptor, muscarinic 3, cardiac) Mus musculus
Symbol: Chrm3
Name: cholinergic receptor, muscarinic 3, cardiac
Description: Predicted to have G protein-coupled acetylcholine receptor activity; G protein-coupled serotonin receptor activity; and acetylcholine binding activity. Involved in several processes, including cholinergic synaptic transmission; positive regulation of smooth muscle contraction; and saliva secretion. Predicted to localize to several cellular components, including the axon terminus; glutamatergic synapse; and integral component of synaptic membrane. Used to study megacystis-microcolon-intestinal hypoperistalsis syndrome. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family; cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-deoxy-D-glucose; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AChR M3; Chrm-3; M3; M3R; mm3 mAChR; muscarinic acetylcholine receptor 3; muscarinic acetylcholine receptor M3
Homo sapiens (human) : CHRM3 (cholinergic receptor muscarinic 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Chrm3 (cholinergic receptor, muscarinic 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrm3 (cholinergic receptor muscarinic 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRM3 (cholinergic receptor muscarinic 3)
Canis lupus familiaris (dog) : CHRM3 (cholinergic receptor muscarinic 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrm3 (cholinergic receptor muscarinic 3)
Sus scrofa (pig) : CHRM3 (cholinergic receptor muscarinic 3)
Chlorocebus sabaeus (green monkey) : CHRM3 (cholinergic receptor muscarinic 3)
Heterocephalus glaber (naked mole-rat) : Chrm3 (cholinergic receptor muscarinic 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl139,875,486 - 10,360,847 (-)Ensembl
GRCm38139,875,486 - 10,361,062 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37139,875,859 - 10,360,049 (-)NCBIGRCm37mm9NCBIm37
MGSCv36139,875,859 - 10,360,049 (-)NCBImm8
Celera139,820,205 - 10,316,018 (-)NCBICelera
Cytogenetic Map13 A1NCBI
cM Map133.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Chrm3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737208
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.