Actn2 (actinin alpha 2) - Rat Genome Database

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Gene: Actn2 (actinin alpha 2) Rattus norvegicus
Analyze
Symbol: Actn2
Name: actinin alpha 2
RGD ID: 1308097
Description: A structural constituent of postsynaptic actin cytoskeleton. Predicted to be involved in several processes, including focal adhesion assembly; regulation of monoatomic ion transmembrane transporter activity; and striated muscle cell development. Located in cortical actin cytoskeleton. Is active in glutamatergic synapse; postsynaptic actin cytoskeleton; and postsynaptic density. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; congenital myopathy 8; and dilated cardiomyopathy 1AA. Orthologous to human ACTN2 (actinin alpha 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; Entamoebiasis pathway; systemic lupus erythematosus pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-actinin-2; LOC291245
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81762,835,055 - 62,902,331 (+)NCBIGRCr8
mRatBN7.21758,143,334 - 58,210,622 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1758,142,625 - 58,210,622 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1761,331,681 - 61,398,784 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01765,334,806 - 65,401,909 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01759,489,000 - 59,556,099 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01766,304,530 - 66,397,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1766,304,501 - 66,397,653 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01768,050,946 - 68,143,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,705,160 - 68,773,261 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11768,681,756 - 68,784,094 (+)NCBI
Celera1762,323,048 - 62,390,681 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
arotinoid acid  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
CHIR 99021  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Echimidine  (EXP)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
glycidyl methacrylate  (ISO)
graphite  (ISO)
Heliotrine  (EXP)
heroin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maraviroc  (ISO)
mercury dichloride  (EXP)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel dichloride  (EXP)
nickel subsulfide  (EXP)
nitrofen  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pioglitazone  (ISO)
resveratrol  (ISO)
ribavirin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
spermine  (ISO)
sunitinib  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Familial effort polymorphic ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy map to chromosome 1q42-43. Bauce B, etal., Am J Cardiol. 2000 Mar 1;85(5):573-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. α-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons. Hodges JL, etal., PLoS One. 2014 Jul 9;9(7):e101770. doi: 10.1371/journal.pone.0101770. eCollection 2014.
5. Eosinophil degranulation is more important than eosinophilia in identifying asthma in chronic cough. Kim CK, etal., J Asthma. 2011 Dec;48(10):994-1000. doi: 10.3109/02770903.2011.623335. Epub 2011 Oct 24.
6. Alpha-actinin associates with polycystin-2 and regulates its channel activity. Li Q, etal., Hum Mol Genet. 2005 Jun 15;14(12):1587-603. Epub 2005 Apr 20.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RIL. Schulz TW, etal., J Neurosci. 2004 Sep 29;24(39):8584-94.
14. Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A. Torrado M, etal., Invest Ophthalmol Vis Sci 2004 Nov;45(11):3955-63.
15. Differential regional expression and ultrastructural localization of alpha-actinin-2, a putative NMDA receptor-anchoring protein, in rat brain. Wyszynski M, etal., J Neurosci. 1998 Feb 15;18(4):1383-92.
Additional References at PubMed
PMID:8618961   PMID:8943213   PMID:9501083   PMID:10391924   PMID:10427098   PMID:10812072   PMID:11101506   PMID:11699871   PMID:11846417   PMID:12356918   PMID:15072553   PMID:15465019  
PMID:15665106   PMID:16120608   PMID:16407236   PMID:16585392   PMID:16807302   PMID:17110593   PMID:17360664   PMID:17944866   PMID:18761673   PMID:19040707   PMID:19815520   PMID:19932097  
PMID:19943616   PMID:20124353   PMID:20215401   PMID:20368620   PMID:21518265   PMID:22972877   PMID:23376485   PMID:23533145   PMID:24840128   PMID:25416956   PMID:25433700   PMID:25502805  
PMID:26143257   PMID:29206857   PMID:31515488   PMID:33098872   PMID:35352799   PMID:38990270  


Genomics

Comparative Map Data
Actn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81762,835,055 - 62,902,331 (+)NCBIGRCr8
mRatBN7.21758,143,334 - 58,210,622 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1758,142,625 - 58,210,622 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1761,331,681 - 61,398,784 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01765,334,806 - 65,401,909 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01759,489,000 - 59,556,099 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01766,304,530 - 66,397,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1766,304,501 - 66,397,653 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01768,050,946 - 68,143,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,705,160 - 68,773,261 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11768,681,756 - 68,784,094 (+)NCBI
Celera1762,323,048 - 62,390,681 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
ACTN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381236,686,499 - 236,764,631 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1236,664,141 - 236,764,631 (+)EnsemblGRCh38hg38GRCh38
GRCh371236,849,799 - 236,927,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361234,916,422 - 234,993,863 (+)NCBINCBI36Build 36hg18NCBI36
Build 341233,175,848 - 233,253,281NCBI
Celera1210,097,994 - 210,176,743 (+)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1207,337,725 - 207,384,040 (+)NCBIHuRef
CHM1_11238,123,313 - 238,199,388 (+)NCBICHM1_1
T2T-CHM13v2.01236,087,386 - 236,175,684 (+)NCBIT2T-CHM13v2.0
Actn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391312,284,312 - 12,355,613 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1312,284,312 - 12,355,641 (-)EnsemblGRCm39 Ensembl
GRCm381312,269,426 - 12,340,732 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1312,269,426 - 12,340,760 (-)EnsemblGRCm38mm10GRCm38
MGSCv371312,361,693 - 12,432,999 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361312,323,759 - 12,395,065 (-)NCBIMGSCv36mm8
Celera1312,189,170 - 12,257,137 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.54NCBI
Actn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554923,483,511 - 3,555,190 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554923,483,704 - 3,554,831 (-)NCBIChiLan1.0ChiLan1.0
ACTN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,395,471 - 12,501,244 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,611,346 - 12,711,988 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01212,245,742 - 212,323,387 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11217,276,899 - 217,321,103 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1217,272,597 - 217,321,103 (+)Ensemblpanpan1.1panPan2
ACTN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.143,348,529 - 3,415,275 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl43,348,449 - 3,415,273 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha43,395,551 - 3,461,987 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.043,368,361 - 3,435,149 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl43,366,635 - 3,434,981 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.143,368,494 - 3,434,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.043,498,915 - 3,565,693 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.043,719,762 - 3,786,237 (-)NCBIUU_Cfam_GSD_1.0
Actn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934440,023,215 - 40,083,168 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648416,186,642 - 16,248,400 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648416,186,844 - 16,248,394 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1454,666,623 - 54,742,778 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11454,670,727 - 54,742,717 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21458,645,069 - 58,717,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12573,827,900 - 73,904,516 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2573,827,874 - 73,905,146 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605575,920,990 - 76,003,746 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477513,916,883 - 13,989,153 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477513,917,215 - 13,989,093 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Actn2
666 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:28
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000024098
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)175089090860781592Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)175089090860781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)175402992960463637Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)175090919660781426Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)175639647763640182Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat

Markers in Region
D17Rat149  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,165,311 - 58,165,446 (-)MAPPERmRatBN7.2
Rnor_6.01766,349,744 - 66,349,878NCBIRnor6.0
Rnor_5.01768,095,697 - 68,095,831UniSTSRnor5.0
RGSC_v3.41768,727,524 - 68,727,658UniSTSRGSC3.4
RGSC_v3.41768,727,275 - 68,727,788RGDRGSC3.4
RGSC_v3.11768,738,108 - 68,738,673RGD
Celera1762,367,974 - 62,368,106UniSTS
RH 3.4 Map17608.2RGD
RH 3.4 Map17608.2UniSTS
SHRSP x BN Map1732.6999RGD
SHRSP x BN Map1732.6999UniSTS
Cytogenetic Map17q12.1UniSTS
AW531528  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,179,874 - 58,180,060 (-)MAPPERmRatBN7.2
Rnor_6.01766,335,095 - 66,335,280NCBIRnor6.0
Rnor_5.01768,081,199 - 68,081,384UniSTSRnor5.0
RGSC_v3.41768,742,534 - 68,742,719UniSTSRGSC3.4
Celera1762,353,369 - 62,353,554UniSTS
RH 3.4 Map17600.5UniSTS
Cytogenetic Map17q12.1UniSTS
Actn2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,170,971 - 58,172,160 (-)MAPPERmRatBN7.2
Rnor_6.01766,343,009 - 66,344,197NCBIRnor6.0
Rnor_5.01768,089,352 - 68,090,540UniSTSRnor5.0
RGSC_v3.41768,733,003 - 68,734,191UniSTSRGSC3.4
Celera1762,361,269 - 62,362,457UniSTS
Cytogenetic Map17q12.1UniSTS
ha2028  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X125,999,885 - 126,000,624 (+)MAPPERmRatBN7.2
mRatBN7.220235,421 - 236,610 (+)MAPPERmRatBN7.2
Rnor_6.020381,420 - 382,608NCBIRnor6.0
Rnor_6.0X133,645,066 - 133,645,804NCBIRnor6.0
Rnor_5.0X133,721,173 - 133,721,911UniSTSRnor5.0
Rnor_5.020367,136 - 368,324UniSTSRnor5.0
RGSC_v3.41768,765,642 - 68,767,052UniSTSRGSC3.4
Celera201,101,967 - 1,103,262UniSTS
CeleraX124,972,833 - 124,973,571UniSTS
Cytogenetic Map17q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024098   ⟹   ENSRNOP00000024098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1758,143,334 - 58,210,622 (+)Ensembl
Rnor_6.0 Ensembl1766,304,501 - 66,397,653 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101075   ⟹   ENSRNOP00000097425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1758,143,334 - 58,208,209 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101663   ⟹   ENSRNOP00000079744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1758,142,625 - 58,210,622 (+)Ensembl
RefSeq Acc Id: NM_001170325   ⟹   NP_001163796
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81762,835,055 - 62,902,331 (+)NCBI
mRatBN7.21758,143,334 - 58,210,622 (+)NCBI
Rnor_6.01766,304,530 - 66,397,647 (-)NCBI
Rnor_5.01768,050,946 - 68,143,522 (-)NCBI
RGSC_v3.41768,705,160 - 68,773,261 (+)RGD
Celera1762,323,048 - 62,390,681 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001163796 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06982 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024098.5
  ENSRNOP00000079744.1
  ENSRNOP00000097425.1
RefSeq Acc Id: NP_001163796   ⟸   NM_001170325
- UniProtKB: D3ZCV0 (UniProtKB/TrEMBL),   A6KN31 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024098   ⟸   ENSRNOT00000024098
Ensembl Acc Id: ENSRNOP00000079744   ⟸   ENSRNOT00000101663
Ensembl Acc Id: ENSRNOP00000097425   ⟸   ENSRNOT00000101075
Protein Domains
Calponin-homology (CH)   EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCV0-F1-model_v2 AlphaFold D3ZCV0 1-894 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700537
Promoter ID:EPDNEW_R11061
Type:single initiation site
Name:Actn2_1
Description:actinin alpha 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01766,397,662 - 66,397,722EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308097 AgrOrtholog
BioCyc Gene G2FUF-8937 BioCyc
Ensembl Genes ENSRNOG00000017833 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024098.8 UniProtKB/TrEMBL
  ENSRNOT00000101075.1 UniProtKB/TrEMBL
  ENSRNOT00000101663.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  Calponin-like_dom_sf UniProtKB/TrEMBL
  Calponin_act-bd UniProtKB/TrEMBL
  EF-hand-like_dom UniProtKB/TrEMBL
  EF-hand_Ca_insen UniProtKB/TrEMBL
  EF_hand_Ca-bd UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
KEGG Report rno:291245 UniProtKB/TrEMBL
NCBI Gene 291245 ENTREZGENE
PANTHER ALPHA-ACTININ-2 UniProtKB/TrEMBL
  SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  efhand_Ca_insen UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PhenoGen Actn2 PhenoGen
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017833 RatGTEx
SMART EFh UniProtKB/TrEMBL
  efhand_Ca_insen UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  Spectrin repeat UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
UniProt A0A8I5ZN92_RAT UniProtKB/TrEMBL
  A0A8I6ARF4_RAT UniProtKB/TrEMBL
  A6KN31 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCV0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Actn2  actinin alpha 2   Actn2_predicted  actinin alpha 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Actn2_predicted  actinin alpha 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED