Predicted to enable several functions, including cytoskeletal protein binding activity; nuclear receptor coactivator activity; and protein domain specific binding activity. Predicted to be involved in several processes, including focal adhesion assembly; muscle cell development; and regulation of ion transmembrane transporter activity. Predicted to act upstream of or within muscle contraction. Is active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic density, intracellular component. Colocalizes with cortical actin cytoskeleton. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and dilated cardiomyopathy 1AA. Orthologous to human ACTN2 (actinin alpha 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; Entamoebiasis pathway; systemic lupus erythematosus pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
[[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in decreased expression of ACTN2 mRNA
[[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of ACTN2 mRNA
[BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of ACTN2 mRNA, [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of ACTN2 protein
[LDN 193189 co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with EGF protein co-treated with FGF2 protein] results in increased expression of ACTN2 mRNA
[[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of ACTN2 mRNA, [[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in decreased expression of ACTN2 mRNA