Gene: Actn2 (actinin alpha 2) Rattus norvegicus
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Symbol: Actn2
Name: actinin alpha 2
Description: ENCODES a protein that exhibits actin filament binding (ortholog); cytoskeletal protein binding (ortholog); FATZ binding (ortholog); INVOLVED IN actin filament uncapping (ortholog); cardiac muscle cell development (ortholog); focal adhesion assembly (ortholog); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; Entamoebiasis pathway; systemic lupus erythematosus pathway; ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); cardiomyopathy (ortholog); Cardiomyopathy, Familial Hypertrophic, 23 (ortholog); FOUND IN cortical actin cytoskeleton; glutamatergic synapse; postsynaptic density membrane; INTERACTS WITH 17beta-estradiol; acrylamide; benzo[a]pyrene
AGR Description: Predicted to have several functions, including cytoskeletal protein binding activity, ion channel binding activity, and protein domain specific binding activity; predicted to be involved in several processes, including actin filament uncapping, positive regulation of transport, and striated muscle cell development; localizes to the glutamatergic synapse, postsynaptic density membrane, and postsynaptic density, intracellular component; colocalizes with the cortical actin cytoskeleton; orthologous to human ACTN2 (actinin alpha 2).
Merged Description: Predicted to have several functions, including cytoskeletal protein binding activity, ion channel binding activity, and protein domain specific binding activity; predicted to be involved in several processes, including actin filament uncapping, positive regulation of transport, and striated muscle cell development; localizes to the glutamatergic synapse, postsynaptic density membrane, and postsynaptic density, intracellular component; colocalizes with the cortical actin cytoskeleton; orthologous to human ACTN2 (actinin alpha 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; Entamoebiasis pathway; systemic lupus erythematosus pathway; INTERACTS WITH 17beta-estradiol; acrylamide; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-actinin-2; LOC291245
Orthologs:
Homo sapiens (human) : ACTN2 (actinin alpha 2)  HGNC  Alliance
Mus musculus (house mouse) : Actn2 (actinin alpha 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Actn2 (actinin alpha 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTN2 (actinin alpha 2)
Canis lupus familiaris (dog) : ACTN2 (actinin alpha 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Actn2 (actinin alpha 2)
Sus scrofa (pig) : ACTN2 (actinin alpha 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01766,304,530 - 66,397,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01768,050,946 - 68,143,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,705,160 - 68,773,261 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11768,681,756 - 68,784,094 (+)NCBI
Celera1762,323,048 - 62,390,681 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

Comparative Map Data
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QTLs in Region (Rnor_6.0)
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Sequence

Nucleotide Sequences
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
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Additional Information

External Database Links
Nomenclature History
 
More on Actn2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308097
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.