Strain Report - Rat Genome Database

Name: LEW/Crl
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: LEW/Crl
Symbol:	LEW/Crl
Strain:	LEW
Substrain:	Crl
Full Name:	Lewis
RGD ID:	737932
Citation ID:	RRID:RGD_737932
Ontology ID:	RS:0000509
Previously known as:	MDC-01-40; LEW/CrlBR
Type:	inbred
Source:	Charles River Laboratories
Origin:	Developed by Dr. Lewis from Wistar stock in the early 1950s. To Charles River from Tulane in 1970 at F34.
Last Known Status:	Unknown

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Autoimmune Encephalomyelitis (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal circulating C-reactive protein level (IAGP)

decreased aortic weight (IAGP)

decreased body weight (IAGP)

decreased heart left ventricle weight (IAGP)

decreased kidney weight (IAGP)

decreased macrophage cytokine production (IAGP)

decreased mean systemic arterial blood pressure (IAGP)

decreased renin activity (IAGP)

decreased systemic arterial diastolic blood pressure (IAGP)

decreased systemic arterial systolic blood pressure (IAGP)

increased body weight (IAGP)

increased CD4-positive, alpha beta T cell number (IAGP)

increased macrophage cell number (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

left ventricular diastolic blood pressure

left ventricular systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricular developed pressure

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

plasma anion gap

heart wet weight

heart weight to body weight ratio

lung dry weight to body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation

arterial blood flow rate

tidal volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin

mean corpuscular hemoglobin concentration

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

serum total cholesterol level

total white blood cell count

serum total bilirubin level

blood pH

partial pressure of blood oxygen

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

absolute change in mean arterial blood pressure

absolute change in heart rate

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

serum urea nitrogen level

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight to total heart left ventricle weight ratio

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

dose of methacholine at which pulmonary conductance is half its pretreatment value

fractional change in blood vessel diameter per unit change in intravascular pressure

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricular developed pressure

percent change in left ventricular systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

serum globulin level

number of individuals in a study population displaying Pasteurellaceae infection at a point in time

number of individuals in a study population displaying Haemophilus H21 infection at a point in time

number of individuals in a study population displaying Haemophilus H35 infection at a point in time

number of individuals in a study population displaying Pasteurella pneumotropica infection at a point in time

References

References - curated

#	Reference Title	Reference Citation
1.	Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility.	Behmoaras J, etal., Nat Genet. 2008 May;40(5):553-9.
2.	CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats.	Camara M, etal., J Neuroimmunol. 2013 Jul 15;260(1-2):17-27. doi: 10.1016/j.jneuroim.2013.04.014. Epub 2013 May 7.
3.	Single Nucleotide Polymorphisms associated with rat expressed sequences.	Guryev V, etal., Genome Res. 2004 Jul;14(7):1438-43.
4.	Congenic mapping of a blood pressure QTL on Chromosome 16 of Dahl rats.	Moujahidine M, etal., Mamm Genome 2002 Mar;13(3):153-6.
5.	Sex Differences in Circulating and Renal Angiotensins of Hypertensive mRen(2).Lewis but not Normotensive Lewis Rats.	Pendergrass KD, etal., Am J Physiol Heart Circ Physiol. 2008 May 2;.
6.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
7.	SNP and haplotype mapping for genetic analysis in the rat.	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
8.	Genetic variation in coding regions between and within commonly used inbred rat strains.	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

Region

Strain QTL Data

Symbol	Name	Trait
Aia10	Adjuvant induced arthritis QTL 10	joint integrity trait (VT:0010548)
Aia11	Adjuvant induced arthritis QTL 11	joint integrity trait (VT:0010548)
Aia12	Adjuvant induced arthritis QTL 12	joint integrity trait (VT:0010548)
Aia13	Adjuvant induced arthritis QTL 13	joint integrity trait (VT:0010548)
Aia14	Adjuvant induced arthritis QTL 14	joint integrity trait (VT:0010548)
Aia15	Adjuvant induced arthritis QTL 15	joint integrity trait (VT:0010548)
Aia16	Adjuvant induced arthritis QTL 16	joint integrity trait (VT:0010548)
Aia17	Adjuvant induced arthritis QTL 17	joint integrity trait (VT:0010548)
Aia18	Adjuvant induced arthritis QTL 18	joint integrity trait (VT:0010548)
Aia19	Adjuvant induced arthritis QTL 19	joint integrity trait (VT:0010548)
Aia20	Adjuvant induced arthritis QTL 20	joint integrity trait (VT:0010548)
Aia21	Adjuvant induced arthritis QTL 21	joint integrity trait (VT:0010548)
Aia22	Adjuvant induced arthritis QTL 22	joint integrity trait (VT:0010548)
Aia23	Adjuvant induced arthritis QTL 23	joint integrity trait (VT:0010548)
Aia24	Adjuvant induced arthritis QTL 24	joint integrity trait (VT:0010548)
Aia25	Adjuvant induced arthritis QTL 25	joint integrity trait (VT:0010548)
Aia26	Adjuvant induced arthritis QTL 26	joint integrity trait (VT:0010548)
Aia27	Adjuvant induced arthritis QTL 27	joint integrity trait (VT:0010548)
Aia6	Adjuvant induced arthritis QTL 6	joint integrity trait (VT:0010548)
Aia7	Adjuvant induced arthritis QTL 7	joint integrity trait (VT:0010548)
Aia8	Adjuvant induced arthritis QTL 8	joint integrity trait (VT:0010548)
Aia9	Adjuvant induced arthritis QTL 9	joint integrity trait (VT:0010548)
Ginf1	Gastrointestinal inflammation QTL 1	cecum mucosa thickness (VT:0010234)
Ginf2	Gastrointestinal inflammation QTL 2	liver integrity trait (VT:0010547)
Ginf3	Gastrointestinal inflammation QTL 3	liver integrity trait (VT:0010547)
Livw3	Liver weight QTL 3	liver mass (VT:0003402)
Wbc3	White blood cell count QTL 3	leukocyte quantity (VT:0000217)
Wbc4	White blood cell count QTL 4	leukocyte quantity (VT:0000217)
Wbc5	White blood cell count QTL 5	leukocyte quantity (VT:0000217)

Damaging Variants

	Number of Damaging Variants
Sample	Rnor_6.0	Rnor_5.0	RGSC_v3.4
LEW/Crl (ICL)			625
LEW/Crl (KNAW)		579
LEW/Crl (RGD)	893
LEW/Crl (2019)	2548
LEW/Crl (2019)

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_phys_biochem	This strain was used for genotyping candidate single nucleotide polymorphisms; SNPs obtained from this study can be found in NCBI dbSNP under accession numbers ss12535137 - ss12568440, ss12588074 - ss12588105 or Cuppen Group	737879

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: LEW/Crl

Mammalian Phenotype

Related Phenotype Data for Term "LEW/Crl" (RS:0000509)