Strain Report - Rat Genome Database

Name: LEW/Crl
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Functional Annotation	Annotation Distribution	Genomic Variants

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General

Strain: LEW/Crl
Symbol:	LEW/Crl
Strain:	LEW
Substrain:	Crl
Full Name:	Lewis
Ontology ID:	RS:0000509
Also known as:	MDC-01-40; LEW/CrlBR
Type:	inbred
Source:	Charles River Laboratories
Origin:	Developed by Dr. Lewis from Wistar stock in the early 1950s. To Charles River from Tulane in 1970 at F34.
Last Known Status:	Unknown

Annotation (Toggle Annotation Detail/Summary View)

Phenotype Values via Phenominer

Related Phenotype Data for Term "LEW/Crl" (RS:0000509)

Rat Strains:

LEW/Crl

Clinical Measurements:

absolute change in blood pH
absolute change in body temperature
absolute change in heart rate
absolute change in mean arterial blood pressure
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in plasma renin activity level
acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction
arterial blood flow rate
blood eosinophil count
blood hemoglobin level
blood lymphocyte count
blood monocyte count
blood neutrophil count
blood pH
body temperature
body weight
calculated pulmonary vascular resistance normalized to body weight
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
creatinine clearance
dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)
FAPGG metabolism-surface area product
fractional change in blood vessel diameter per unit change in intravascular pressure
heart contraction pressure
heart effluent lactate dehydrogenase activity level normalized to heart weight
heart left ventricle infarction weight as percentage of total heart left ventricle weight
heart rate
heart right ventricle weight to left ventricle weight ratio
heart weight as percentage of body weight
heart wet weight
hematocrit
hypoxia-induced blood vessel dilation expressed as percent of force at maximum constriction
left ventricular developed pressure
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
lung dry weight to body weight ratio
maximum contractile force per wet weight of aorta
mean arterial blood pressure
mean corpuscular hemoglobin concentration
mean corpuscular hemoglobin level
mean corpuscular volume
methylene blue metabolism-surface area product after auto-oxidation
methylene blue metabolism-surface area product without auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
minute ventilation (VE)
partial pressure of blood carbon dioxide (Pco2)
partial pressure of blood oxygen (Po2)
percent change in arterial blood flow rate
percent change in heart rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
percent change in respiration rate
percent change in tidal volume
percent change in ventilation
plasma anion gap
plasma creatinine level
plasma renin activity level
red blood cell count
respiration rate
serum alanine aminotransferase activity level
serum albumin level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum bicarbonate level
serum calcium level
serum chloride level
serum globulin level
serum glucose level
serum phosphate level
serum potassium level
serum sodium level
serum total cholesterol level
serum total protein level
serum urea nitrogen level
sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constriction
tidal volume
time to onset of heart contraction
time to peak heart contraction
total serum bilirubin level
total white blood cell count
urine albumin excretion rate
urine sodium excretion rate
urine total protein excretion rate

Experimental Conditions:

acetylcholine
air carbon dioxide content
air oxygen content
angiotensin
controlled oxygen content Kreb's solution perfusate
controlled oxygen content physiological salt solution perfusate
controlled sodium content diet
drug dose time series
FAPGG
furosemide
Kreb's solution perfusate
methacholine
methylene blue
naive control condition
norepinephrine
perfusate suspended
phenylephrine
potassium ion
resting on treadmill
running on treadmill
sample resting period
sodium nitroprusside
walking on treadmill

Measurement Methods:

automated blood cell counting method
automated blood gas analysis using a Bayer analyzer
automated plasma creatinine analysis
automated urine analysis
balloon tipped catheter with pressure transducer in isolated perfused heart
digital rectal thermometry
digital scale post excision weight measurement
flame atomic emission spectrometry
fluid-filled catheter with pressure transducer in isolated perfused lung
intra-aortic abdominal radiotelemetry
isolated perfused heart effluent collection
isolated perfused lung vascular effluent collection
microhematocrit tube assay with visual assessment
radioimmunoassay
standard blood chemistry panel
stop flow air displacement plethysmography
urine creatinine analysis
vascular fluid filled catheter
whole body digital scale
wire myography using a Digi-Med tissue force analysis system with force transducer

Experimental Data Annotations

Rat Strain

LEW/Crl (IEA)

Phenotype Values via Phenominer

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Clinical Measurement

heart rate

left ventricular diastolic blood pressure

left ventricular systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricular developed pressure

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

plasma anion gap

heart wet weight

heart weight as percentage of body weight

lung dry weight to body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation (VE)

arterial blood flow rate

tidal volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin level

mean corpuscular hemoglobin concentration

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

serum total cholesterol level

total white blood cell count

total serum bilirubin level

blood pH

partial pressure of blood oxygen (Po2)

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

absolute change in mean arterial blood pressure

absolute change in heart rate

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

serum urea nitrogen level

absolute change in plasma renin activity level

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight as percentage of total heart left ventricle weight

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)

fractional change in blood vessel diameter per unit change in intravascular pressure

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction

sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constriction

hypoxia-induced blood vessel dilation expressed as percent of force at maximum constriction

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricular developed pressure

percent change in left ventricular systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

serum globulin level

References - curated

1.	Guryev V, etal., Genome Res. 2004 Jul;14(7):1438-43.
2.	RGD Automated Pipelines
3.	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
4.	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

Region

Strain QTL Data

Symbol	Name	Trait
Aia10	Adjuvant induced arthritis QTL 10	joint integrity trait (VT:0010548)
Aia11	Adjuvant induced arthritis QTL 11	joint integrity trait (VT:0010548)
Aia12	Adjuvant induced arthritis QTL 12	joint integrity trait (VT:0010548)
Aia13	Adjuvant induced arthritis QTL 13	joint integrity trait (VT:0010548)
Aia14	Adjuvant induced arthritis QTL 14	joint integrity trait (VT:0010548)
Aia15	Adjuvant induced arthritis QTL 15	joint integrity trait (VT:0010548)
Aia16	Adjuvant induced arthritis QTL 16	joint integrity trait (VT:0010548)
Aia17	Adjuvant induced arthritis QTL 17	joint integrity trait (VT:0010548)
Aia18	Adjuvant induced arthritis QTL 18	joint integrity trait (VT:0010548)
Aia19	Adjuvant induced arthritis QTL 19	joint integrity trait (VT:0010548)
Aia20	Adjuvant induced arthritis QTL 20	joint integrity trait (VT:0010548)
Aia21	Adjuvant induced arthritis QTL 21	joint integrity trait (VT:0010548)
Aia22	Adjuvant induced arthritis QTL 22	joint integrity trait (VT:0010548)
Aia23	Adjuvant induced arthritis QTL 23	joint integrity trait (VT:0010548)
Aia24	Adjuvant induced arthritis QTL 24	joint integrity trait (VT:0010548)
Aia25	Adjuvant induced arthritis QTL 25	joint integrity trait (VT:0010548)
Aia26	Adjuvant induced arthritis QTL 26	joint integrity trait (VT:0010548)
Aia27	Adjuvant induced arthritis QTL 27	joint integrity trait (VT:0010548)
Aia6	Adjuvant induced arthritis QTL 6	joint integrity trait (VT:0010548)
Aia7	Adjuvant induced arthritis QTL 7	joint integrity trait (VT:0010548)
Aia8	Adjuvant induced arthritis QTL 8	joint integrity trait (VT:0010548)
Aia9	Adjuvant induced arthritis QTL 9	joint integrity trait (VT:0010548)
Ginf1	Gastrointestinal inflammation QTL 1	cecum mucosa thickness (VT:0010234)
Ginf2	Gastrointestinal inflammation QTL 2	liver integrity trait (VT:0010547)
Ginf3	Gastrointestinal inflammation QTL 3	liver integrity trait (VT:0010547)
Livw3	Liver weight QTL 3	liver mass (VT:0003402)
Wbc3	White blood cell count QTL 3	leukocyte quantity (VT:0000217)
Wbc4	White blood cell count QTL 4	leukocyte quantity (VT:0000217)
Wbc5	White blood cell count QTL 5	leukocyte quantity (VT:0000217)

Damaging Variants

	Number of Damaging Variants
Sample	Rnor_6.0	Rnor_5.0	RGSC_v3.4
LEW/Crl (ICL)			628
LEW/Crl (KNAW)		571
LEW/Crl (RGD)	862

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_phys_biochem	This strain was used for genotyping candidate single nucleotide polymorphisms; SNPs obtained from this study can be found in NCBI dbSNP under accession numbers ss12535137 - ss12568440, ss12588074 - ss12588105 or Cuppen Group	737879

More on this Strain
	Strain Nomenclature
	Strain Registration

RGD Object Information
RGD ID:	737932
Created:	2004-03-29
Species:	Rattus norvegicus
Last Modified:	2009-06-11
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Strain: LEW/Crl

Related Phenotype Data for Term "LEW/Crl" (RS:0000509)