Cul2 (cullin 2) - Rat Genome Database

Name: Cul2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Cul2 (cullin 2) Rattus norvegicus

Analyze

Symbol:

Cul2

Name:

cullin 2

RGD ID:

1310644

Description:

Predicted to enable ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to act upstream of or within protein catabolic process. Part of VCB complex. Orthologous to human CUL2 (cullin 2); PARTICIPATES IN hypoxia inducible factor pathway; neddylation pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

cullin-2; LOC361258

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CUL2 (cullin 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Cul2 (cullin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cul2 (cullin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CUL2 (cullin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CUL2 (cullin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cul2 (cullin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CUL2 (cullin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CUL2 (cullin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cul2 (cullin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CUL2 (cullin 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cul2 (cullin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cul2 (cullin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CDC53	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Cul2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cul-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cul2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	58,864,274 - 58,905,447 (-)	NCBI		GRCr8
mRatBN7.2	17	54,169,093 - 54,210,197 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	54,169,086 - 54,209,968 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	57,335,609 - 57,376,784 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	61,338,647 - 61,379,822 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	55,496,476 - 55,537,755 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	56,952,480 - 56,992,716 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	56,952,480 - 56,992,694 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	54,986,452 - 55,026,674 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	62,701,289 - 62,741,344 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	62,712,162 - 62,752,367 (-)	NCBI
Celera	17	50,150,407 - 50,190,272 (-)	NCBI		Celera
Cytogenetic Map	17	q12.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

inflammatory bowel disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose (ISO)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

acetamide (EXP)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucosamine (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzatropine (ISO)

benzo[a]pyrene (ISO)

beta-D-glucosamine (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

clozapine (ISO)

crocidolite asbestos (ISO)

cycloheximide (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

dieldrin (EXP)

diethylstilbestrol (ISO)

dinophysistoxin 1 (ISO)

doxorubicin (ISO)

Erionite (ISO)

folic acid (ISO)

genistein (ISO)

ivermectin (ISO)

methamphetamine (EXP)

methylmercury chloride (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nickel dichloride (EXP)

Nor-9-carboxy-delta9-THC (ISO)

ochratoxin A (EXP)

ozone (ISO)

paracetamol (ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

rac-lactic acid (ISO)

rotenone (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

temozolomide (ISO)

thioacetamide (EXP)

uranium atom (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

protein catabolic process (ISO)

protein ubiquitination (IBA,IEA)

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IBA)

ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (ISO)

Cellular Component

Cul2-RING ubiquitin ligase complex (IBA,ISO)

nucleolus (ISO)

nucleoplasm (IEA,ISO)

SCF ubiquitin ligase complex (IBA)

VCB complex (IDA)

Molecular Function

protein binding (IPI,ISO)

protein-containing complex binding (IPI)

protein-macromolecule adaptor activity (IBA)

ubiquitin ligase complex scaffold activity (ISO)

ubiquitin protein ligase binding (IBA,ISO)

ubiquitin-protein transferase activity (IC)

Molecular Pathway Annotations Click to see Annotation Detail View

hypoxia inducible factor pathway (ISO)

neddylation pathway (ISS)

proteasome degradation pathway involving cullin-dependent ubiquitin ligases (ISS)

renal cell carcinoma pathway (IEA)

ubiquitin/proteasome degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2.	Choy MK, etal., J Cell Physiol. 2010 Mar;222(3):635-9.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.	Kamura T, etal., Science. 1999 Apr 23;284(5414):657-61.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.	Ohh M, etal., EMBO Rep. 2002 Feb;3(2):177-82. Epub 2002 Jan 29.
7.	Nedd8 on cullin: building an expressway to protein destruction.	Pan ZQ, etal., Oncogene. 2004 Mar 15;23(11):1985-97.
8.	The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.	Pause A, etal., Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2156-61.
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Regulation of oxygen homeostasis by hypoxia-inducible factor 1.	Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.

Additional References at PubMed

PMID:15601820	PMID:16129783	PMID:17636018

Genomics

Comparative Map Data

Cul2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	58,864,274 - 58,905,447 (-)	NCBI		GRCr8
mRatBN7.2	17	54,169,093 - 54,210,197 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	54,169,086 - 54,209,968 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	57,335,609 - 57,376,784 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	61,338,647 - 61,379,822 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	55,496,476 - 55,537,755 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	56,952,480 - 56,992,716 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	56,952,480 - 56,992,694 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	54,986,452 - 55,026,674 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	62,701,289 - 62,741,344 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	62,712,162 - 62,752,367 (-)	NCBI
Celera	17	50,150,407 - 50,190,272 (-)	NCBI		Celera
Cytogenetic Map	17	q12.1	NCBI

CUL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	35,008,551 - 35,127,006 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	35,008,504 - 35,127,006 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	35,297,479 - 35,379,542 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	35,338,804 - 35,419,300 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	35,338,813 - 35,419,300	NCBI
Celera	10	35,064,147 - 35,144,640 (-)	NCBI		Celera
Cytogenetic Map	10	p11.21	NCBI
HuRef	10	35,016,158 - 35,098,233 (-)	NCBI		HuRef
CHM1_1	10	35,298,728 - 35,380,758 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	35,037,104 - 35,155,467 (-)	NCBI		T2T-CHM13v2.0

Cul2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	3,382,970 - 3,436,700 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	3,382,988 - 3,436,377 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	3,382,970 - 3,436,700 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	3,382,988 - 3,436,377 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	3,383,223 - 3,436,698 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	3,383,029 - 3,436,372 (+)	NCBI		MGSCv36	mm8
Celera	18	3,432,713 - 3,487,378 (+)	NCBI		Celera
Cytogenetic Map	18	A1	NCBI
cM Map	18	2.21	NCBI

Cul2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955462	2,580,117 - 2,661,561 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955462	2,580,117 - 2,659,849 (+)	NCBI	ChiLan1.0	ChiLan1.0

CUL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	47,649,997 - 47,730,921 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	47,655,268 - 47,736,246 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	35,127,771 - 35,210,108 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	35,705,442 - 35,787,248 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	35,704,964 - 35,787,014 (-)	Ensembl	panpan1.1		panPan2

CUL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	1,830,046 - 1,994,418 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	1,897,309 - 2,175,909 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	1,920,061 - 2,084,989 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	2,111,788 - 2,276,949 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	2,178,615 - 2,278,532 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	1,883,731 - 2,049,588 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	1,926,447 - 2,092,740 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	2,050,312 - 2,216,547 (+)	NCBI		UU_Cfam_GSD_1.0

Cul2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	13,810,807 - 13,908,887 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936574	3,309,941 - 3,408,370 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936574	3,310,304 - 3,408,389 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CUL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	57,700,683 - 57,799,264 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	57,700,667 - 57,829,388 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	63,254,465 - 63,302,289 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CUL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	34,294,885 - 34,381,140 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	34,294,362 - 34,364,122 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	43,445,984 - 43,532,095 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cul2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624805	6,992,546 - 7,094,855 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cul2
234 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	744
Count of miRNA genes:	296
Interacting mature miRNAs:	382
Transcripts:	ENSRNOT00000066805
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15330613	55836425	Rat
1354640	Scl32	Serum cholesterol level QTL 32	5.4		blood HDL cholesterol amount (VT:0000184)	blood high density lipoprotein cholesterol level (CMO:0000052)	17	15781592	60781592	Rat
1354659	Scl68	Serum cholesterol level QTL 68	3.9		blood VLDL cholesterol amount (VT:0005144)	blood very low density lipoprotein cholesterol level (CMO:0000648)	17	15781592	60781592	Rat
7394837	Memor18	Memory QTL 18			exploratory behavior trait (VT:0010471)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	17	18640182	63640182	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21293039	60781592	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23080567	59555013	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	57246843	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27027949	56836890	Rat
4889955	Bss93	Bone structure and strength QTL 93	4.4		tibia size trait (VT:0100001)	tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)	17	27027949	60463643	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	31368391	62109574	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	31368391	73951021	Rat
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	31990784	76990784	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	31990784	81292925	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	34550843	73951021	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	35837085	69599340	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	37479847	82479847	Rat
2317054	Aia12	Adjuvant induced arthritis QTL 12	4.24		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	38281509	83281509	Rat
2317060	Aia26	Adjuvant induced arthritis QTL 26	3.22		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	38281509	83281509	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40540041	80387013	Rat
1358295	Aocep1	Aortic cell protein QTL 1	6.1	0.00000071	thoracic aorta cellular protein amount (VT:0010598)	aortic cell percentage	17	40990005	85990005	Rat
631497	Bp98	Blood pressure QTL 98	3.66		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	41354651	60463643	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	17	42073160	69599340	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	42073160	69599340	Rat
7411575	Bw140	Body weight QTL 140	30.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
8694181	Bw151	Body weight QTL 151	4.36	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	49920154	86533673	Rat
2303580	Gluco49	Glucose level QTL 49	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	50040271	86533673	Rat
1354629	Scl31	Serum cholesterol level QTL 31	4.1		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	17	50890908	60781592	Rat
1354654	Spl7	Serum phospholipid level QTL 7	5.5		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	17	50890908	60781592	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	50909099	86022412	Rat
2317053	Aia25	Adjuvant induced arthritis QTL 25	2.69		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	50909196	60781426	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	53498828	82479847	Rat
61466	Niddm12	Non-insulin dependent diabetes mellitus QTL 12	3.2	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	54029929	60463637	Rat

Markers in Region

AI598891

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	54,169,152 - 54,169,257 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	56,952,547 - 56,952,651	NCBI	Rnor6.0
Rnor_5.0	17	54,986,519 - 54,986,623	UniSTS	Rnor5.0
RGSC_v3.4	17	62,701,356 - 62,701,460	UniSTS	RGSC3.4
Celera	17	50,150,474 - 50,150,578	UniSTS
RH 3.4 Map	17	554.7	UniSTS
Cytogenetic Map	17	q12.1	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	42	57	41	19	41	8	10	74	35	39	11	8
Low		1						1			2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001399213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600628	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000066805 ⟹ ENSRNOP00000061765

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	54,169,086 - 54,209,968 (-)	Ensembl
Rnor_6.0 Ensembl	17	56,952,480 - 56,992,489 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000079607 ⟹ ENSRNOP00000074075

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	54,170,475 - 54,209,968 (-)	Ensembl
Rnor_6.0 Ensembl	17	56,952,485 - 56,992,694 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000106539 ⟹ ENSRNOP00000089738

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	54,170,284 - 54,209,929 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108140 ⟹ ENSRNOP00000081844

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	54,170,040 - 54,209,931 (-)	Ensembl

RefSeq Acc Id:

NM_001399213 ⟹ NP_001386142

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	58,864,274 - 58,905,132 (-)	NCBI
mRatBN7.2	17	54,169,093 - 54,209,952 (-)	NCBI

RefSeq Acc Id:

XM_006254073 ⟹ XP_006254135

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	58,865,217 - 58,905,447 (-)	NCBI
mRatBN7.2	17	54,169,093 - 54,210,197 (-)	NCBI
Rnor_6.0	17	56,952,487 - 56,992,716 (-)	NCBI
Rnor_5.0	17	54,986,452 - 55,026,674 (-)	NCBI

Sequence:

show sequence

TCCTGCGGGTGTGTGAGTGCAAGAGGCTGAAAGAGCGGAGCGGAGGGCGTGTGTCGGGCAAAGC
CCGGAGCCCCGGAGGACGACTGCCTCCTGGAGCCCGCCACCAGCCCGCCCTCCTCCCTTGACCT
CGTCGCGCCTCGCCGCAGCGGCCTTGTCTGCAAGGCTCCCTCGGGAGCAGGTTTTAACACTAAA
CTTGCACAATGTCTTTAAAACCAAGAGTAGTGGATTTTGATGAGACGTGGAACAAGCTGCTAAC
TACAATCAAGGCTGTCGTTATGTTGGAATATGTAGAGAGAGCAACATGGAACGACCGCTTCTCA
GACATCTATGCTTTATGTGTGGCCTATCCTGAACCACTTGGAGAAAGACTTTATGCGGAAACAA
AGATTTTTTTGGAAAATCACGTTCGGCATTTATATAAGAGAGTTCTGGAGTCTGAAGAACAAGT
GCTTGTTATGTATCATAGGTACTGGGAAGAATACAGCAAGGGTGCTGACTATATGGACTGCTTA
TATAGGTATCTCAATACCCAGTATATTAAAAAGAATAAATTGACGGAAGCTGATTTACAGTATG
GCTATGGTGGAGTAGATATGAATGAACCACTTATGGAAATAGGAGAGCTAGCATTGGATATGTG
GAGGAAGTTAATGGTTGAACCCCTTCAGAACATCCTCATCCGGATGCTGCTTCGAGAAATTAAA
AATGATCGTGGTGGAGAAGACCCAAACCAGAAAGTAATCCATGGGGTTATTAACTCCTTTGTTC
ATGTTGAACAGTATAAGAAAAAATTCCCCTTAAAGTTTTATCAGGGAATATTTGTGTCTCCCTT
TCTGACCGAAACGGGAGAATATTACAAGCAAGAAGCTTCAAATTTATTACAAGAATCAAATTGT
TCACAGTATATGGAAAAGGTTCTAGGTAGATTAAAAGATGAAGAAATTAGATGTCGAAAATATT
TGCATCCAAGTTCATATACGAAAGTGATTCACGAGTGTCAGCAGCGGATGGTGGCAGACCACTT
GCAGTTCTTACACTCAGAGTGCCACAGCATTATTCGGCACGAGAGGAAGAACGACATGGCAAAT
ATGTACGTCTTACTTCGTGCTGTGTCCAGTGGTTTACCTCATATGATTGAGGAGCTACAGAGAC
ACATCCACGATGAGGGCCTTCGAGCGACCAGTAACCTTACTCAGGAACATATGCCAACACTATT
TGTGGAATCAGTTTTGGAAGTGCACGGTAAATTCGTTCAACTTATCAACACTGTTTTGAATGGT
GATCAGCATTTTATGAGTGCTTTAGATAAGGCCCTTACGTCTGTTGTAAATTACAGAGAACCCA
AGTCTGTTTGCAAAGCACCTGAACTGCTTGCTAAGTACTGTGACAACTTGCTAAAGAAGTCAGC
AAAGGGGATGACGGAGAATGAAGTAGAGGACAAGCTTACCAGCTTCATCACAGTTTTCAAGTAC
ATCGATGACAAGGACGTCTTTCAGAAGTTCTATGCAAGAATGCTAGCAAAACGTCTAATTCACG
GGCTGTCTATGTCTATGGATTCTGAAGAAGCCATGATCAATAAATTAAAGCAAGCCTGTGGGTA
TGAGTTTACCAGCAAGCTGCATCGGATGTACACAGACATGAGTGTCAGCGCCGACCTCAACAAC
AAGTTCAACAATTTCATCAGAAACCAAGACACTGTGATCGATTTGGGGATTAGTTTCCAAATAT
ATGTCCTTCAGGCTGGTGCGTGGCCTCTCACCCAGGCTCCGTCGTCCACATTTGCGATCCCCCA
AGAGTTAGAGAAAAGTGTACAGATGTTTGAATTGTTTTATAGCCAGCATTTCAGTGGAAGGAAA
CTGACATGGTTACATTATCTCTGTACAGGTGAAGTTAAAATGAACTATTTGGGGAAACCATATG
TAGCTATGGTTACAACCTACCAAATGGCAGTTCTTCTTGCCTTTAACAACAGTGAAACTGTCAG
CTACAAAGAGCTTCAAGACAGCACCCAGATGAATGAAAAGGAGCTAACTAAAACAATCAAATCA
TTACTTGATGTGAAAATGATTAACCATGATTCAGAAAAGGAAGATATCGATGCAGAATCTTCAT
TTTCACTAAATATGAGCTTCAGCAGTAAGAGAACAAAATTTAAGATTACTACATCAATGCAGAA
GGATACACCACAAGAACTGGAACAGACTAGAAGTGCTGTAGATGAGGACCGGAAAATGTATCTT
CAAGCTGCTATTGTCCGCATCATGAAAGCACGGAAAGTGCTTCGGCACAACGCCCTCATTCAGG
AGGTAATCAGCCAGTCAAGAGCCAGGTTCAATCCCAGTATCAGCATGATTAAGAAGTGCATAGA
AGTTCTGATAGACAAGCAGTACATCGAGCGCAGCCAAGCATCTGCAGATGAATACAGTTACGTT
GCGTGACGCCTTCTCCTGGTGCGGGTGTGAGGTCATTGCCATCCCCATTTGGTGAGCTCCTGTG
GGAGAAAGCAGGCCTGTGCCTCCATACTTTGGTCGTCTGGCAGCCCCTGTTTTTCTGCTGTTTA
CAACATCACCAGTGCCACGTCATGAGCGTCAGAGAAAATGCCTAGAGATATTCAAGCTCATGTC
ATTATGACGTTTCTTAAAACTTTATTAAAAGAATGAGTGAAGTATTGCTGAGATGTGGAATTCG
GCTGGGTACCATGCTTTCTCCCCTTCACGTTTGCAGTTGATGTGTTTTTTTTTTTTTTTTAAAT
GTATCTTAAAGGACATAAAATAAAAACTTAAATATTGTAATATGACAGATAACCTAATAATTGT
ATCTACATTAAAATGACAAACATGATGTTGCTGCTTGTCAAATAAAAAAAAATAAACATAACGC
CTTTTTTCTATGTTGATGGAATATCAGGTTGGACAGAAAATAAGACAGTTGTAAATGCCCACCC
AAGCAGCAAACAGCGTTCCTTCATTCATCTTGGTGATGAATTCACTTGGGCCCCCATCTATTCT
TCAACTAAAACTGCCAGGGTTCTCTTTTTAAATACATAAGATTGTGAATTTGAGCTAATGGTGT
AGTAAGCAGGTTTTGTATTTTGAGGAGGATGTGTCTGGTGGTGGTGTGGTTACAACAGAAATGA
GTAGTAGCTACTGTGCAGGGACTTGTGGACCAGCAGAAAAGAACTGCTCACTCTTGACCTATTC
ATGATGCATGGATACTAACATAATGGCTGTGGCTCGTTTCCCAGAGTTTAGGAGGCTGATTACA
ATGAGTTCCTTCTAGCTCTCCCTGCCCATCACTGGCACCCTTCCCCAGTGCAGATGACTCCTCC
ATGACAAGTTGATAACAGTGCCCCCATAACACTAGGCCATTCCACCAGGCACCTGTATATGGAC
ATGAGATTTCATGAGTTTGTTTCTTGTAGACAACAGGGGCATTCAAATACTCTGGGTACCGTAT
TCTCCACCATCTCTGTATCACATCGCTAGAGTATTTACATCTTAACAGATAAGGCCTTAAACCC
ACAGTAATATTCCGAACAAATAAACAGCACTTCATTTTCATTCTCATGTGGTTCATATTTAAAT
TTATTTAATGATTGGTTGATTTGATTGCAAATCTTTTGTATCTCAAGTGTTCAAAAATCTCCTG
GACTTCTAATGGTTTCCGCTGTCTTTATGTATGGTTTTGCCTTCCTACCTCGTGTGGATAAGGG
CAGAGCATATACTATTGTACATTCGTGGTCAAAGAACAAGGCCTTTGTTTTGATAACTTGTTGA
TAAGTTTTCCAAATTTATAAATATTAAATTAAGTCGTAACCTGA

hide sequence

RefSeq Acc Id:

XM_017600628 ⟹ XP_017456117

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	58,865,217 - 58,905,150 (-)	NCBI
mRatBN7.2	17	54,169,093 - 54,209,974 (-)	NCBI
Rnor_6.0	17	56,952,487 - 56,992,491 (-)	NCBI

Sequence:

show sequence

TGGCGGTGGCCGGCCGGGGAGGCGGCCTCGGCGCACAGTAATGGCAGCGCTGTGAGCCGGGGAA
CGCGAGCTGACAGCCGCCGCCGCCCACCCTCGGAGCCGGGGGCTTCGTCCTTCACGCCTGCGGG
TTGCCTCCCTCCCCGGGCTCCTGCCCTCGCCCTGCTTTTGCAGAAGACAGTGAAGATTGATAGC
TTTGGGGAGGAGTATTCTACGTGCATGCTACACCTCTTGCCTCAACACTTATGGGCTGGTGAAA
TAAGAGCCTTAGATTCTCTCCAGCATTTGTTTACATACTAGACTCTTAAACCCTTCCTTACCAT
TACCGTTTTAACACTAAACTTGCACAATGTCTTTAAAACCAAGAGTAGTGGATTTTGATGAGAC
GTGGAACAAGCTGCTAACTACAATCAAGGCTGTCGTTATGTTGGAATATGTAGAGAGAGCAACA
TGGAACGACCGCTTCTCAGACATCTATGCTTTATGTGTGGCCTATCCTGAACCACTTGGAGAAA
GACTTTATGCGGAAACAAAGATTTTTTTGGAAAATCACGTTCGGCATTTATATAAGAGAGTTCT
GGAGTCTGAAGAACAAGTGCTTGTTATGTATCATAGGTACTGGGAAGAATACAGCAAGGGTGCT
GACTATATGGACTGCTTATATAGGTATCTCAATACCCAGTATATTAAAAAGAATAAATTGACGG
AAGCTGATTTACAGTATGGCTATGGTGGAGTAGATATGAATGAACCACTTATGGAAATAGGAGA
GCTAGCATTGGATATGTGGAGGAAGTTAATGGTTGAACCCCTTCAGAACATCCTCATCCGGATG
CTGCTTCGAGAAATTAAAAATGATCGTGGTGGAGAAGACCCAAACCAGAAAGTAATCCATGGGG
TTATTAACTCCTTTGTTCATGTTGAACAGTATAAGAAAAAATTCCCCTTAAAGTTTTATCAGGG
AATATTTGTGTCTCCCTTTCTGACCGAAACGGGAGAATATTACAAGCAAGAAGCTTCAAATTTA
TTACAAGAATCAAATTGTTCACAGTATATGGAAAAGGTTCTAGGTAGATTAAAAGATGAAGAAA
TTAGATGTCGAAAATATTTGCATCCAAGTTCATATACGAAAGTGATTCACGAGTGTCAGCAGCG
GATGGTGGCAGACCACTTGCAGTTCTTACACTCAGAGTGCCACAGCATTATTCGGCACGAGAGG
AAGAACGACATGGCAAATATGTACGTCTTACTTCGTGCTGTGTCCAGTGGTTTACCTCATATGA
TTGAGGAGCTACAGAGACACATCCACGATGAGGGCCTTCGAGCGACCAGTAACCTTACTCAGGA
ACATATGCCAACACTATTTGTGGAATCAGTTTTGGAAGTGCACGGTAAATTCGTTCAACTTATC
AACACTGTTTTGAATGGTGATCAGCATTTTATGAGTGCTTTAGATAAGGCCCTTACGTCTGTTG
TAAATTACAGAGAACCCAAGTCTGTTTGCAAAGCACCTGAACTGCTTGCTAAGTACTGTGACAA
CTTGCTAAAGAAGTCAGCAAAGGGGATGACGGAGAATGAAGTAGAGGACAAGCTTACCAGCTTC
ATCACAGTTTTCAAGTACATCGATGACAAGGACGTCTTTCAGAAGTTCTATGCAAGAATGCTAG
CAAAACGTCTAATTCACGGGCTGTCTATGTCTATGGATTCTGAAGAAGCCATGATCAATAAATT
AAAGCAAGCCTGTGGGTATGAGTTTACCAGCAAGCTGCATCGGATGTACACAGACATGAGTGTC
AGCGCCGACCTCAACAACAAGTTCAACAATTTCATCAGAAACCAAGACACTGTGATCGATTTGG
GGATTAGTTTCCAAATATATGTCCTTCAGGCTGGTGCGTGGCCTCTCACCCAGGCTCCGTCGTC
CACATTTGCGATCCCCCAAGAGTTAGAGAAAAGTGTACAGATGTTTGAATTGTTTTATAGCCAG
CATTTCAGTGGAAGGAAACTGACATGGTTACATTATCTCTGTACAGGTGAAGTTAAAATGAACT
ATTTGGGGAAACCATATGTAGCTATGGTTACAACCTACCAAATGGCAGTTCTTCTTGCCTTTAA
CAACAGTGAAACTGTCAGCTACAAAGAGCTTCAAGACAGCACCCAGATGAATGAAAAGGAGCTA
ACTAAAACAATCAAATCATTACTTGATGTGAAAATGATTAACCATGATTCAGAAAAGGAAGATA
TCGATGCAGAATCTTCATTTTCACTAAATATGAGCTTCAGCAGTAAGAGAACAAAATTTAAGAT
TACTACATCAATGCAGAAGGATACACCACAAGAACTGGAACAGACTAGAAGTGCTGTAGATGAG
GACCGGAAAATGTATCTTCAAGCTGCTATTGTCCGCATCATGAAAGCACGGAAAGTGCTTCGGC
ACAACGCCCTCATTCAGGAGGTAATCAGCCAGTCAAGAGCCAGGTTCAATCCCAGTATCAGCAT
GATTAAGAAGTGCATAGAAGTTCTGATAGACAAGCAGTACATCGAGCGCAGCCAAGCATCTGCA
GATGAATACAGTTACGTTGCGTGACGCCTTCTCCTGGTGCGGGTGTGAGGTCATTGCCATCCCC
ATTTGGTGAGCTCCTGTGGGAGAAAGCAGGCCTGTGCCTCCATACTTTGGTCGTCTGGCAGCCC
CTGTTTTTCTGCTGTTTACAACATCACCAGTGCCACGTCATGAGCGTCAGAGAAAATGCCTAGA
GATATTCAAGCTCATGTCATTATGACGTTTCTTAAAACTTTATTAAAAGAATGAGTGAAGTATT
GCTGAGATGTGGAATTCGGCTGGGTACCATGCTTTCTCCCCTTCACGTTTGCAGTTGATGTGTT
TTTTTTTTTTTTTTAAATGTATCTTAAAGGACATAAAATAAAAACTTAAATATTGTAATATGAC
AGATAACCTAATAATTGTATCTACATTAAAATGACAAACATGATGTTGCTGCTTGTCAAATAAA
AAAAAATAAACATAACGCCTTTTTTCTATGTTGATGGAATATCAGGTTGGACAGAAAATAAGAC
AGTTGTAAATGCCCACCCAAGCAGCAAACAGCGTTCCTTCATTCATCTTGGTGATGAATTCACT
TGGGCCCCCATCTATTCTTCAACTAAAACTGCCAGGGTTCTCTTTTTAAATACATAAGATTGTG
AATTTGAGCTAATGGTGTAGTAAGCAGGTTTTGTATTTTGAGGAGGATGTGTCTGGTGGTGGTG
TGGTTACAACAGAAATGAGTAGTAGCTACTGTGCAGGGACTTGTGGACCAGCAGAAAAGAACTG
CTCACTCTTGACCTATTCATGATGCATGGATACTAACATAATGGCTGTGGCTCGTTTCCCAGAG
TTTAGGAGGCTGATTACAATGAGTTCCTTCTAGCTCTCCCTGCCCATCACTGGCACCCTTCCCC
AGTGCAGATGACTCCTCCATGACAAGTTGATAACAGTGCCCCCATAACACTAGGCCATTCCACC
AGGCACCTGTATATGGACATGAGATTTCATGAGTTTGTTTCTTGTAGACAACAGGGGCATTCAA
ATACTCTGGGTACCGTATTCTCCACCATCTCTGTATCACATCGCTAGAGTATTTACATCTTAAC
AGATAAGGCCTTAAACCCACAGTAATATTCCGAACAAATAAACAGCACTTCATTTTCATTCTCA
TGTGGTTCATATTTAAATTTATTTAATGATTGGTTGATTTGATTGCAAATCTTTTGTATCTCAA
GTGTTCAAAAATCTCCTGGACTTCTAATGGTTTCCGCTGTCTTTATGTATGGTTTTGCCTTCCT
ACCTCGTGTGGATAAGGGCAGAGCATATACTATTGTACATTCGTGGTCAAAGAACAAGGCCTTT
GTTTTGATAACTTGTTGATAAGTTTTCCAAATTTATAAATATTAAATTAAGTCGTAACCTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001386142	(Get FASTA)	NCBI Sequence Viewer
	XP_006254135	(Get FASTA)	NCBI Sequence Viewer
	XP_017456117	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL87461	(Get FASTA)	NCBI Sequence Viewer
	EDL87462	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000061765.1
	ENSRNOP00000074075.2
	ENSRNOP00000081844
	ENSRNOP00000081844.1
	ENSRNOP00000089738.1

RefSeq Acc Id:	XP_006254135 ⟸ XM_006254073
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6G8I6 (UniProtKB/TrEMBL), A6K9G9 (UniProtKB/TrEMBL), D4A0H4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYAETKIF LENHVRHLYKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQYIKKNKLTEADLQYGYG GVDMNEPLMEIGELALDMWRKLMVEPLQNILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVE QYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHP SSYTKVIHECQQRMVADHLQFLHSECHSIIRHERKNDMANMYVLLRAVSSGLPHMIEELQRHIH DEGLRATSNLTQEHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSV CKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLS MSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQDTVIDLGISFQIYVL QAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAM VTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSL NMSFSSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVI SQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA hide sequence

RefSeq Acc Id:	XP_017456117 ⟸ XM_017600628
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6G8I6 (UniProtKB/TrEMBL), A6K9G9 (UniProtKB/TrEMBL), D4A0H4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYAETKIF LENHVRHLYKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQYIKKNKLTEADLQYGYG GVDMNEPLMEIGELALDMWRKLMVEPLQNILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVE QYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHP SSYTKVIHECQQRMVADHLQFLHSECHSIIRHERKNDMANMYVLLRAVSSGLPHMIEELQRHIH DEGLRATSNLTQEHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSV CKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLS MSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQDTVIDLGISFQIYVL QAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAM VTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSL NMSFSSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVI SQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA hide sequence

RefSeq Acc Id:

ENSRNOP00000074075 ⟸ ENSRNOT00000079607

RefSeq Acc Id:

ENSRNOP00000061765 ⟸ ENSRNOT00000066805

RefSeq Acc Id:

ENSRNOP00000089738 ⟸ ENSRNOT00000106539

RefSeq Acc Id:

ENSRNOP00000081844 ⟸ ENSRNOT00000108140

RefSeq Acc Id:	NP_001386142 ⟸ NM_001399213
- UniProtKB:	A0A8I6G8I6 (UniProtKB/TrEMBL), A6K9G9 (UniProtKB/TrEMBL), D4A0H4 (UniProtKB/TrEMBL)

Protein Domains

Cullin family profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K761-F1-model_v2	AlphaFold	A0A0G2K761	1-745	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700529

Promoter ID:

EPDNEW_R11052

Type:

multiple initiation site

Name:

Cul2_1

Description:

cullin 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	56,992,455 - 56,992,515	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310644	AgrOrtholog
BioCyc Gene	G2FUF-8992	BioCyc
Ensembl Genes	ENSRNOG00000015292	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066805.3	UniProtKB/TrEMBL
	ENSRNOT00000079607.2	UniProtKB/TrEMBL
	ENSRNOT00000106539.1	UniProtKB/TrEMBL
	ENSRNOT00000108140	ENTREZGENE
	ENSRNOT00000108140.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	6.10.280.240	UniProtKB/TrEMBL
	Cullin Repeats	UniProtKB/TrEMBL
InterPro	Cullin	UniProtKB/TrEMBL
	Cullin_CS	UniProtKB/TrEMBL
	Cullin_homology	UniProtKB/TrEMBL
	Cullin_homology_sf	UniProtKB/TrEMBL
	Cullin_N	UniProtKB/TrEMBL
	Cullin_neddylation_domain	UniProtKB/TrEMBL
	Cullin_repeat-like_dom	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	rno:361258	UniProtKB/TrEMBL
NCBI Gene	361258	ENTREZGENE
PANTHER	CULLIN-2	UniProtKB/TrEMBL
	PTHR11932	UniProtKB/TrEMBL
Pfam	Cullin	UniProtKB/TrEMBL
	Cullin_Nedd8	UniProtKB/TrEMBL
PhenoGen	Cul2	PhenoGen
PROSITE	CULLIN_1	UniProtKB/TrEMBL
	CULLIN_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015292	RatGTEx
SMART	CULLIN	UniProtKB/TrEMBL
	Cullin_Nedd8	UniProtKB/TrEMBL
Superfamily-SCOP	Cullin_homology	UniProtKB/TrEMBL
	Cullin_repeat-like	UniProtKB/TrEMBL
	SSF46785	UniProtKB/TrEMBL
UniProt	A0A0G2K761_RAT	UniProtKB/TrEMBL
	A0A8I6A9D2_RAT	UniProtKB/TrEMBL
	A0A8I6G8I6	ENTREZGENE, UniProtKB/TrEMBL
	A6K9G9	ENTREZGENE, UniProtKB/TrEMBL
	D4A0H4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Cul2	cullin 2	Cul2_predicted	cullin 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Cul2_predicted	cullin 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)