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Gene: Akr1c1 (aldo-keto reductase family 1, member C1) Rattus norvegicus
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Symbol: Akr1c1
Name: aldo-keto reductase family 1, member C1
Description: Exhibits 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and testosterone 17-beta-dehydrogenase (NADP+) activity. Involved in response to drug and response to estrogen. Localizes to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C4 (aldo-keto reductase family 1 member C4); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); Akr1c6; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1, 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); aldo-keto reductase family 1, member C6; Hsd17b5; LOC307092; MGC125057; type 5 17beta-hydroxysteroid dehydrogenase
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01769,441,253 - 69,460,334 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,441,223 - 69,460,321 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,155,010 - 71,174,079 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,084,306 - 77,112,994 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11777,095,138 - 77,123,818 (-)NCBI
Celera1765,342,356 - 65,364,506 (-)NCBICelera
Cytogenetic Map17q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Akr1c1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1306847
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.