Akr1c1 Rat (-)-epigallocatechin 3-gallate increases expression ISO AKR1C1 (Homo sapiens) 6480464 epigallocatechin gallate results in increased expression of AKR1C1 mRNA CTD PMID:32512070 Akr1c1 Rat (E)-cinnamyl alcohol increases expression ISO AKR1C1 (Homo sapiens) 6480464 cinnamyl alcohol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat (S)-naringenin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 naringenin binds to and results in decreased activity of AKR1C1 protein CTD PMID:16962702 Akr1c1 Rat 1,10-phenanthroline decreases activity ISO AKR1C1 (Homo sapiens) 6480464 1 and 10-phenanthroline results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:8573067 Akr1c1 Rat 1,2-dichloroethane decreases expression ISO Akr1c6 (Mus musculus) 6480464 ethylene dichloride results in decreased expression of AKR1C6 mRNA CTD PMID:28189721 and PMID:28960355 Akr1c1 Rat 1,7-phenanthroline decreases activity ISO AKR1C1 (Homo sapiens) 6480464 1 and 7-phenanthroline results in decreased activity of AKR1C1 protein CTD PMID:8573067 Akr1c1 Rat 1,8-Dinitropyrene multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein results in increased degradation of 1 and 8-dinitropyrene] which results in increased abundance of 1-amino-8-nitropyrene CTD PMID:36399404 Akr1c1 Rat 1-Aminopyrene multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein results in increased degradation of 1-nitropyrene] which results in increased abundance of 1-aminopyrene CTD PMID:36399404 Akr1c1 Rat 1-chloro-2,4-dinitrobenzene increases expression ISO AKR1C1 (Homo sapiens) 6480464 Dinitrochlorobenzene results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat 1-naphthyl isothiocyanate decreases expression ISO Akr1c6 (Mus musculus) 6480464 1-Naphthylisothiocyanate results in decreased expression of AKR1C6 mRNA CTD PMID:15913567 Akr1c1 Rat 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of AKR1C1 mRNA CTD PMID:25380136 Akr1c1 Rat 1-nitropyrene multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein results in increased degradation of 1-nitropyrene] which results in increased abundance of 1-aminopyrene CTD PMID:36399404 Akr1c1 Rat 17beta-estradiol increases expression ISO AKR1C1 (Homo sapiens) 6480464 Estradiol results in increased expression of AKR1C1 mRNA CTD PMID:19619570 Akr1c1 Rat 17beta-estradiol multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AKR1C1 mRNA CTD PMID:19619570 Akr1c1 Rat 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 Flufenamic Acid inhibits the reaction [AKR1C1 protein results in increased metabolism of Dihydrotestosterone] CTD PMID:14672942 Akr1c1 Rat 17beta-hydroxy-5alpha-androstan-3-one increases metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased metabolism of Dihydrotestosterone CTD PMID:14672942 Akr1c1 Rat 2,2',4,4',5,5'-hexachlorobiphenyl increases expression ISO AKR1C1 (Homo sapiens) 6480464 2 more ... CTD PMID:38568856 Akr1c1 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Akr1c6 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1C6 mRNA CTD PMID:21354282 and PMID:28213091 Akr1c1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of AKR1C1 mRNA CTD PMID:22298810 Akr1c1 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1C1 mRNA CTD PMID:19619570 Akr1c1 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AKR1C1 mRNA CTD PMID:19619570 Akr1c1 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1C1 mRNA and Tetrachlorodibenzodioxin results in decreased expression of AKR1C6 mRNA CTD PMID:18796159 and PMID:21215274 Akr1c1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Akr1c6 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of AKR1C6 mRNA CTD PMID:26377647 Akr1c1 Rat 2,3-dimethoxynaphthalene-1,4-dione increases expression ISO AKR1C1 (Homo sapiens) 6480464 2 more ... CTD PMID:9973208 Akr1c1 Rat 2,6-dinitrotoluene affects expression EXP 6480464 2 and 6-dinitrotoluene affects the expression of AKR1C6 mRNA CTD PMID:21346803 Akr1c1 Rat 2-hydroxypropanoic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 Lactic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20566472 and PMID:30851411 Akr1c1 Rat 2-tert-butylhydroquinone increases expression ISO AKR1C1 (Homo sapiens) 6480464 2-tert-butylhydroquinone results in increased expression of AKR1C1 mRNA CTD PMID:30806763 and PMID:9973208 Akr1c1 Rat 3,3',4,4',5-pentachlorobiphenyl multiple interactions EXP 6480464 [3 more ... CTD PMID:30744511 Akr1c1 Rat 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO Akr1c6 (Mus musculus) 6480464 3 more ... CTD PMID:19467301 Akr1c1 Rat 3,3',5-triiodo-L-thyronine increases expression ISO AKR1C1 (Homo sapiens) 6480464 Triiodothyronine results in increased expression of AKR1C1 mRNA CTD PMID:15507505 Akr1c1 Rat 3,4,5,3',4',5'-Hexachlorobiphenyl multiple interactions EXP 6480464 [3 more ... CTD PMID:30744511 Akr1c1 Rat 3,4-dichloroaniline increases expression ISO AKR1C1 (Homo sapiens) 6480464 3 and 4-dichloroaniline results in increased expression of AKR1C1 mRNA CTD PMID:24172598 Akr1c1 Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1C1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C1 mRNA CTD PMID:28628672 Akr1c1 Rat 3-methylcholanthrene increases expression ISO AKR1C1 (Homo sapiens) 6480464 Methylcholanthrene results in increased expression of AKR1C1 mRNA CTD PMID:9973208 Akr1c1 Rat 3-Nitrobenzanthrone increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone CTD PMID:30406992 Akr1c1 Rat 3-Nitrobenzanthrone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone and [AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone CTD PMID:30406992 Akr1c1 Rat 3-phenylprop-2-enal increases expression ISO AKR1C1 (Homo sapiens) 6480464 cinnamaldehyde results in increased expression of AKR1C1 mRNA CTD PMID:19524605 Akr1c1 Rat 3alpha-hydroxy-5beta-pregnan-20-one affects metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the metabolism of Pregnanolone CTD PMID:12604236 Akr1c1 Rat 3alpha-hydroxy-5beta-pregnan-20-one increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of Pregnanolone CTD PMID:11995921 Akr1c1 Rat 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of AKR1C1 mRNA CTD PMID:25380136 Akr1c1 Rat 4,4'-sulfonyldiphenol decreases expression ISO AKR1C1 (Homo sapiens) 6480464 bisphenol S results in decreased expression of AKR1C1 mRNA CTD PMID:38568856 Akr1c1 Rat 4,4'-sulfonyldiphenol increases expression ISO AKR1C1 (Homo sapiens) 6480464 bisphenol S results in increased expression of AKR1C1 protein CTD PMID:34186270 Akr1c1 Rat 4,4'-sulfonyldiphenol multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1C1 mRNA CTD PMID:28628672 Akr1c1 Rat 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:11306090 Akr1c1 Rat 4-hydroxybenzoic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 4-hydroxybenzoic acid analog results in decreased activity of AKR1C1 protein CTD PMID:27163852 Akr1c1 Rat 4-hydroxyphenyl retinamide increases expression ISO AKR1C1 (Homo sapiens) 6480464 Fenretinide results in increased expression of AKR1C1 mRNA CTD PMID:16671099 Akr1c1 Rat 4-phenylbutyric acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 4-phenylbutyric acid results in increased expression of AKR1C1 mRNA CTD PMID:14583596 Akr1c1 Rat 5-alpha-THDOC affects oxidation ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the oxidation of tetrahydrodeoxycorticosterone CTD PMID:12604236 Akr1c1 Rat 5-fluorouracil affects expression ISO AKR1C1 (Homo sapiens) 6480464 Fluorouracil affects the expression of AKR1C1 mRNA CTD PMID:16584549 Akr1c1 Rat 5-fluorouracil affects response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 Akr1c1 Rat 5alpha-pregnane-3,20-dione affects reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the reduction of 5-alpha-Dihydroprogesterone CTD PMID:12604236 Akr1c1 Rat 5alpha-pregnane-3,20-dione increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of 5-alpha-Dihydroprogesterone CTD PMID:11995921 Akr1c1 Rat 7-hydroxyflavone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 7-hydroxyflavone binds to and results in decreased activity of AKR1C1 protein CTD PMID:16962702 Akr1c1 Rat 9,10-phenanthroquinone increases metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased metabolism of 9 and 10-phenanthrenequinone CTD PMID:17950253 Akr1c1 Rat 9,10-phenanthroquinone increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of 9 and 10-phenanthrenequinone CTD PMID:21851338 and PMID:23261716 Akr1c1 Rat 9,10-phenanthroquinone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of and affects the activity of 9 and 10-phenanthrenequinone CTD PMID:21910479 Akr1c1 Rat 9-cis-retinal increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of 9-cis-retinal CTD PMID:21851338 Akr1c1 Rat acetylsalicylic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Aspirin results in decreased activity of AKR1C1 protein CTD PMID:19010312 Akr1c1 Rat aflatoxin B1 decreases expression ISO Akr1c6 (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of AKR1C6 mRNA CTD PMID:19770486 Akr1c1 Rat aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of AKR1C1 mRNA CTD PMID:22484513 Akr1c1 Rat aflatoxin B1 decreases methylation ISO AKR1C1 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of AKR1C1 gene CTD PMID:27153756 Akr1c1 Rat aldehydo-D-glucose multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of AKR1C6 mRNA CTD PMID:37567420 Akr1c1 Rat alpha-hexylcinnamaldehyde increases expression ISO AKR1C1 (Homo sapiens) 6480464 hexyl cinnamic aldehyde results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat amiodarone increases expression ISO AKR1C1 (Homo sapiens) 6480464 Amiodarone results in increased expression of AKR1C1 mRNA CTD PMID:21163907 Akr1c1 Rat anthranilic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 anthranilic acid analog results in decreased activity of AKR1C1 protein CTD PMID:19007763 Akr1c1 Rat arsane increases expression ISO AKR1C1 (Homo sapiens) 6480464 Arsenic results in increased expression of AKR1C1 mRNA CTD PMID:36861143 Akr1c1 Rat arsenic atom increases expression ISO AKR1C1 (Homo sapiens) 6480464 Arsenic results in increased expression of AKR1C1 mRNA CTD PMID:36861143 Akr1c1 Rat arsenite(3-) multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA and SQSTM1 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA] CTD PMID:31781319 Akr1c1 Rat arsenous acid decreases response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 Akr1c1 Rat arsenous acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Arsenic Trioxide co-treated with Bortezomib] results in increased expression of AKR1C1 mRNA and Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1C1 protein] CTD PMID:25913414 and PMID:26598702 Akr1c1 Rat astilbin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA CTD PMID:29471006 Akr1c1 Rat avobenzone increases expression ISO AKR1C1 (Homo sapiens) 6480464 avobenzone results in increased expression of AKR1C1 mRNA CTD PMID:31016361 Akr1c1 Rat azathioprine increases expression ISO AKR1C1 (Homo sapiens) 6480464 Azathioprine results in increased expression of AKR1C1 mRNA CTD PMID:22623647 Akr1c1 Rat Bandrowski's base increases expression ISO AKR1C1 (Homo sapiens) 6480464 Bandrowski's base results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat benzbromarone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 Benzbromarone binds to and results in decreased activity of AKR1C1 protein CTD PMID:12604236 Akr1c1 Rat Benzo[a]fluorene increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzo(a)fluorene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 Akr1c1 Rat benzo[a]pyrene decreases expression ISO Akr1c6 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of AKR1C6 mRNA CTD PMID:19770486 Akr1c1 Rat benzo[a]pyrene multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Butyric Acid co-treated with Benzo(a)pyrene] results in increased expression of AKR1C1 mRNA more ... CTD PMID:17612574 more ... Akr1c1 Rat benzo[a]pyrene decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of AKR1C1 mRNA CTD PMID:16545412 Akr1c1 Rat benzo[a]pyrene increases expression ISO AKR1C1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of AKR1C1 mRNA CTD PMID:15735009 more ... Akr1c1 Rat benzo[a]pyrene affects response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the susceptibility to Benzo(a)pyrene CTD PMID:19800895 Akr1c1 Rat Benzo[a]pyrene-7,8-diol multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 and 8-dihydrodiol CTD PMID:21910479 Akr1c1 Rat benzo[a]pyrene-7,8-dione increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzo(a)pyrene-7 and 8-dione results in increased expression of AKR1C1 mRNA CTD PMID:9973208 Akr1c1 Rat benzo[a]pyrene-7,8-dione multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7 and 8-dione CTD PMID:21910479 Akr1c1 Rat benzo[b]fluoranthene increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzo(b)fluoranthene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 Akr1c1 Rat Benzo[b]fluorene increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzo(b)fluorene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 Akr1c1 Rat Benzo[k]fluoranthene increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzo(k)fluoranthene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 Akr1c1 Rat benzoic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 Benzoic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat beta-naphthoflavone increases expression ISO AKR1C1 (Homo sapiens) 6480464 beta-Naphthoflavone results in increased expression of AKR1C1 mRNA CTD PMID:17253728 and PMID:32151702 Akr1c1 Rat bexarotene increases expression ISO AKR1C1 (Homo sapiens) 6480464 Bexarotene results in increased expression of AKR1C1 mRNA CTD PMID:17178900 Akr1c1 Rat bis(2-ethylhexyl) phthalate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of AKR1C1 mRNA CTD PMID:28412506 Akr1c1 Rat bisphenol A increases expression ISO Akr1c6 (Mus musculus) 6480464 bisphenol A results in increased expression of AKR1C6 mRNA CTD PMID:30245210 Akr1c1 Rat bisphenol A increases expression ISO AKR1C1 (Homo sapiens) 6480464 bisphenol A results in increased expression of AKR1C1 protein CTD PMID:34186270 Akr1c1 Rat bisphenol A decreases methylation ISO AKR1C1 (Homo sapiens) 6480464 bisphenol A results in decreased methylation of AKR1C1 gene CTD PMID:31601247 Akr1c1 Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of AKR1C1 mRNA CTD PMID:30903817 Akr1c1 Rat bisphenol A affects expression ISO AKR1C1 (Homo sapiens) 6480464 bisphenol A affects the expression of AKR1C1 mRNA CTD PMID:30903817 Akr1c1 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of AKR1C1 mRNA CTD PMID:32145629 Akr1c1 Rat bisphenol A decreases expression ISO AKR1C1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of AKR1C1 mRNA CTD PMID:38568856 Akr1c1 Rat Bisphenol B increases expression ISO AKR1C1 (Homo sapiens) 6480464 bisphenol B results in increased expression of AKR1C1 protein CTD PMID:34186270 Akr1c1 Rat bisphenol F increases expression ISO AKR1C1 (Homo sapiens) 6480464 bisphenol F results in increased expression of AKR1C1 protein CTD PMID:34186270 Akr1c1 Rat bortezomib increases expression ISO AKR1C1 (Homo sapiens) 6480464 Bortezomib results in increased expression of AKR1C1 mRNA CTD PMID:21215737 Akr1c1 Rat bortezomib multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Arsenic Trioxide co-treated with Bortezomib] results in increased expression of AKR1C1 mRNA CTD PMID:25913414 Akr1c1 Rat butyric acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Butyric Acid co-treated with Benzo(a)pyrene] results in increased expression of AKR1C1 mRNA CTD PMID:30439556 Akr1c1 Rat cadmium atom increases expression ISO AKR1C1 (Homo sapiens) 6480464 Cadmium results in increased expression of AKR1C1 mRNA CTD PMID:21172416 Akr1c1 Rat cadmium atom multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AKR1C1 mRNA CTD PMID:29741670 and PMID:31738976 Akr1c1 Rat cadmium dichloride increases expression ISO AKR1C1 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of AKR1C1 mRNA CTD PMID:38568856 Akr1c1 Rat cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of AKR1C1 mRNA CTD PMID:25993096 Akr1c1 Rat cadmium dichloride multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AKR1C1 mRNA CTD PMID:29741670 and PMID:31738976 Akr1c1 Rat cadmium sulfate multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C1 mRNA CTD PMID:18654764 Akr1c1 Rat calcitriol increases expression ISO AKR1C1 (Homo sapiens) 6480464 Calcitriol results in increased expression of AKR1C1 mRNA CTD PMID:12040012 and PMID:21592394 Akr1c1 Rat calcitriol multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of AKR1C1 mRNA CTD PMID:21592394 Akr1c1 Rat carbon nanotube decreases expression ISO Akr1c6 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25620056 Akr1c1 Rat carmustine affects response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 mRNA affects the susceptibility to Carmustine CTD PMID:16365179 Akr1c1 Rat celastrol increases expression ISO AKR1C1 (Homo sapiens) 6480464 celastrol results in increased expression of AKR1C1 mRNA CTD PMID:17010675 Akr1c1 Rat CGP 52608 multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to AKR1C1 gene] CTD PMID:28238834 Akr1c1 Rat chenodeoxycholic acid decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Chenodeoxycholic Acid results in decreased expression of AKR1C1 mRNA CTD PMID:27174168 Akr1c1 Rat chlorohydrocarbon multiple interactions EXP 6480464 [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in decreased expression of AKR1C1 mRNA CTD PMID:30744511 Akr1c1 Rat chrysene increases expression ISO AKR1C1 (Homo sapiens) 6480464 chrysene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 Akr1c1 Rat ciglitazone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [ciglitazone binds to PPARG protein alternative form] which results in increased expression of AKR1C1 mRNA and [ciglitazone binds to PPARG protein] which results in increased expression of AKR1C1 mRNA CTD PMID:16197558 Akr1c1 Rat cinnamyl alcohol increases expression ISO AKR1C1 (Homo sapiens) 6480464 cinnamyl alcohol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat cisplatin increases expression ISO AKR1C1 (Homo sapiens) 6480464 Cisplatin results in increased expression of AKR1C1 mRNA CTD PMID:23165153 and PMID:27392435 Akr1c1 Rat cisplatin decreases response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in decreased susceptibility to Cisplatin CTD PMID:20953859 and PMID:23165153 Akr1c1 Rat cisplatin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA more ... CTD PMID:23165153 more ... Akr1c1 Rat clofibrate multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of AKR1C6 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AKR1C6 mRNA] CTD PMID:17585979 Akr1c1 Rat Clofop increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of fenofibric acid CTD PMID:27599626 Akr1c1 Rat cloxazolam decreases activity ISO AKR1C1 (Homo sapiens) 6480464 cloxazolam results in decreased activity of AKR1C1 protein CTD PMID:12604236 Akr1c1 Rat cobalt atom multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [tungsten carbide binds to Cobalt] which results in decreased expression of AKR1C1 mRNA CTD PMID:20105288 Akr1c1 Rat cobalt dichloride multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C1 mRNA CTD PMID:18654764 Akr1c1 Rat cobalt dichloride increases expression ISO AKR1C1 (Homo sapiens) 6480464 cobaltous chloride results in increased expression of AKR1C1 mRNA CTD PMID:20105288 Akr1c1 Rat coniferyl aldehyde increases expression ISO AKR1C1 (Homo sapiens) 6480464 coniferaldehyde results in increased expression of AKR1C1 mRNA and coniferaldehyde results in increased expression of AKR1C1 protein CTD PMID:26275128 Akr1c1 Rat coniferyl aldehyde multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein] CTD PMID:26275128 Akr1c1 Rat copper atom multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of AKR1C1 mRNA CTD PMID:20971185 Akr1c1 Rat copper(0) multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of AKR1C1 mRNA CTD PMID:20971185 Akr1c1 Rat copper(II) chloride increases expression ISO AKR1C1 (Homo sapiens) 6480464 cupric chloride results in increased expression of AKR1C1 mRNA CTD PMID:38568856 Akr1c1 Rat copper(II) sulfate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Copper Sulfate results in increased expression of AKR1C1 mRNA CTD PMID:19549813 Akr1c1 Rat coumarin decreases expression EXP 6480464 coumarin results in decreased expression of AKR1C6 mRNA CTD PMID:18480146 Akr1c1 Rat crotonaldehyde increases expression ISO AKR1C1 (Homo sapiens) 6480464 2-butenal results in increased expression of AKR1C1 mRNA CTD PMID:20471460 Akr1c1 Rat cyclopentanol increases oxidation ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased oxidation of cyclopentanol CTD PMID:23261716 Akr1c1 Rat cyclopentanone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 NADP promotes the reaction [AKR1C1 protein results in increased reduction of cyclopentanone] CTD PMID:23261716 Akr1c1 Rat cyclopentanone increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of cyclopentanone CTD PMID:23261716 Akr1c1 Rat cyclosporin A increases expression ISO AKR1C1 (Homo sapiens) 6480464 Cyclosporine results in increased expression of AKR1C1 mRNA CTD PMID:25562108 Akr1c1 Rat cylindrospermopsin decreases expression ISO Akr1c6 (Mus musculus) 6480464 cylindrospermopsin results in decreased expression of AKR1C6 mRNA CTD PMID:20936652 Akr1c1 Rat D-glucose multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of AKR1C6 mRNA CTD PMID:37567420 Akr1c1 Rat DDE decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene results in decreased expression of AKR1C1 mRNA CTD PMID:38568856 Akr1c1 Rat dexamethasone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1C1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C1 mRNA CTD PMID:28628672 Akr1c1 Rat dexamethasone increases expression ISO AKR1C1 (Homo sapiens) 6480464 Dexamethasone results in increased expression of AKR1C1 mRNA CTD PMID:25047013 Akr1c1 Rat diallyl trisulfide increases expression ISO AKR1C1 (Homo sapiens) 6480464 diallyl trisulfide results in increased expression of AKR1C1 mRNA CTD PMID:34995734 Akr1c1 Rat diarsenic trioxide multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Arsenic Trioxide co-treated with Bortezomib] results in increased expression of AKR1C1 mRNA and Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1C1 protein] CTD PMID:25913414 and PMID:26598702 Akr1c1 Rat diarsenic trioxide decreases response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 Akr1c1 Rat diazepam decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Diazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 and PMID:12604236 Akr1c1 Rat Dibenz[a,c]anthracene increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzotriphenylene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 Akr1c1 Rat dibenz[a,h]anthracene increases expression ISO AKR1C1 (Homo sapiens) 6480464 1 more ... CTD PMID:17253728 Akr1c1 Rat dibenzo[a,l]pyrene multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Particulate Matter co-treated with dibenzo(a more ... CTD PMID:17612574 Akr1c1 Rat dibutyl phthalate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Dibutyl Phthalate results in increased expression of AKR1C1 mRNA CTD PMID:18214805 Akr1c1 Rat dicoumarol decreases activity EXP 6480464 Dicumarol results in decreased activity of AKR1C6 protein CTD PMID:16788056 Akr1c1 Rat dienogest decreases expression ISO AKR1C1 (Homo sapiens) 6480464 dienogest results in decreased expression of AKR1C1 mRNA CTD PMID:23183084 Akr1c1 Rat dimethylarsinous acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 dimethylarsinous acid results in increased expression of AKR1C1 mRNA CTD PMID:23487506 Akr1c1 Rat diquat increases expression ISO AKR1C1 (Homo sapiens) 6480464 Diquat results in increased expression of AKR1C1 mRNA CTD PMID:21172416 Akr1c1 Rat disulfiram increases expression ISO AKR1C1 (Homo sapiens) 6480464 Disulfiram results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat diuron increases expression ISO AKR1C1 (Homo sapiens) 6480464 Diuron metabolite results in increased expression of AKR1C1 mRNA CTD PMID:24172598 Akr1c1 Rat dorsomorphin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Akr1c1 Rat dutasteride increases expression ISO AKR1C1 (Homo sapiens) 6480464 Dutasteride results in increased expression of AKR1C1 mRNA CTD PMID:16806904 Akr1c1 Rat dydrogesterone increases expression ISO AKR1C1 (Homo sapiens) 6480464 Dydrogesterone results in increased expression of AKR1C1 mRNA CTD PMID:23183084 Akr1c1 Rat dydrogesterone increases metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased metabolism of Dydrogesterone CTD PMID:21182831 Akr1c1 Rat dydrogesterone decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Dydrogesterone results in decreased activity of AKR1C1 protein CTD PMID:21182831 Akr1c1 Rat dydrogesterone decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Dydrogesterone results in decreased expression of AKR1C1 mRNA CTD PMID:23183084 Akr1c1 Rat entinostat decreases expression ISO AKR1C1 (Homo sapiens) 6480464 entinostat results in decreased expression of AKR1C1 mRNA CTD PMID:27188386 Akr1c1 Rat estazolam decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Estazolam results in decreased activity of AKR1C1 protein CTD PMID:11995921 Akr1c1 Rat etacrynic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 Ethacrynic Acid results in increased expression of AKR1C1 mRNA CTD PMID:9973208 Akr1c1 Rat ethyl methanesulfonate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of AKR1C1 mRNA CTD PMID:23649840 Akr1c1 Rat eugenol increases expression ISO AKR1C1 (Homo sapiens) 6480464 Eugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat farnesol increases expression ISO AKR1C1 (Homo sapiens) 6480464 Farnesol results in increased expression of AKR1C1 mRNA CTD PMID:30806763 Akr1c1 Rat fenamic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 fenamic acid analog results in decreased activity of AKR1C1 protein CTD PMID:19010312 Akr1c1 Rat flufenamic acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 Flufenamic Acid inhibits the reaction [AKR1C1 protein affects the susceptibility to Oxaliplatin] and Flufenamic Acid inhibits the reaction [AKR1C1 protein results in increased metabolism of Dihydrotestosterone] CTD PMID:14672942 and PMID:23933386 Akr1c1 Rat flufenamic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Flufenamic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:8573067 Akr1c1 Rat flunitrazepam decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Flunitrazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 Akr1c1 Rat flurbiprofen decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Flurbiprofen results in decreased activity of AKR1C1 protein CTD PMID:19010312 Akr1c1 Rat flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 Akr1c1 Rat fructose multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of AKR1C6 mRNA CTD PMID:37567420 Akr1c1 Rat furan decreases expression EXP 6480464 furan results in decreased expression of AKR1C1 mRNA CTD PMID:25539665 Akr1c1 Rat gamma-linolenic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 gamma-Linolenic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20664735 Akr1c1 Rat gedunin increases expression ISO AKR1C1 (Homo sapiens) 6480464 gedunin results in increased expression of AKR1C1 mRNA CTD PMID:17010675 Akr1c1 Rat genistein decreases activity EXP 6480464 Genistein results in decreased activity of AKR1C6 protein CTD PMID:16788056 Akr1c1 Rat geraniol increases expression ISO AKR1C1 (Homo sapiens) 6480464 geraniol results in increased expression of AKR1C1 mRNA CTD PMID:30806763 Akr1c1 Rat glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 Akr1c1 Rat glimepiride decreases activity ISO AKR1C1 (Homo sapiens) 6480464 glimepiride results in decreased activity of AKR1C1 protein CTD PMID:26362498 Akr1c1 Rat glipizide decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Glipizide results in decreased activity of AKR1C1 protein CTD PMID:26362498 Akr1c1 Rat glucose multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of AKR1C6 mRNA CTD PMID:37567420 Akr1c1 Rat glyburide decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Glyburide results in decreased activity of AKR1C1 protein CTD PMID:26362498 Akr1c1 Rat glycidyl methacrylate decreases expression ISO AKR1C1 (Homo sapiens) 6480464 glycidyl methacrylate results in decreased expression of AKR1C1 protein CTD PMID:36641056 Akr1c1 Rat glycyrrhetinate decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Glycyrrhetinic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 Akr1c1 Rat glycyrrhetinic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Glycyrrhetinic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 Akr1c1 Rat glyphosate multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of AKR1C6 mRNA CTD PMID:37567420 Akr1c1 Rat hexane increases expression ISO AKR1C1 (Homo sapiens) 6480464 n-hexane results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat hexestrol decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Hexestrol results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:8573067 Akr1c1 Rat hydrogen peroxide decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of AKR1C1 protein CTD PMID:34581912 Akr1c1 Rat hydrogen peroxide multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 mRNA and [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 protein CTD PMID:19320734 Akr1c1 Rat hydrogen peroxide increases expression ISO AKR1C1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of AKR1C1 mRNA CTD PMID:9973208 Akr1c1 Rat ibuprofen decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Ibuprofen results in decreased activity of AKR1C1 protein CTD PMID:19010312 Akr1c1 Rat Indeno[1,2,3-cd]pyrene increases expression ISO AKR1C1 (Homo sapiens) 6480464 indeno(1 more ... CTD PMID:17253728 Akr1c1 Rat indometacin decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Indomethacin results in decreased activity of AKR1C1 protein CTD PMID:12604236 more ... Akr1c1 Rat indometacin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1C1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C1 mRNA CTD PMID:28628672 Akr1c1 Rat isoeugenol increases expression ISO AKR1C1 (Homo sapiens) 6480464 isoeugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat ivermectin decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Ivermectin results in decreased expression of AKR1C1 protein CTD PMID:32959892 Akr1c1 Rat lead diacetate increases expression ISO AKR1C1 (Homo sapiens) 6480464 lead acetate results in increased expression of AKR1C1 mRNA CTD PMID:22839698 and PMID:38568856 Akr1c1 Rat lead(0) affects splicing ISO AKR1C1 (Homo sapiens) 6480464 Lead affects the splicing of AKR1C1 mRNA CTD PMID:28903495 Akr1c1 Rat lead(II) chloride increases expression ISO AKR1C1 (Homo sapiens) 6480464 lead chloride results in increased expression of AKR1C1 mRNA CTD PMID:18654764 Akr1c1 Rat lead(II) chloride multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C1 mRNA CTD PMID:18654764 Akr1c1 Rat leflunomide decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Leflunomide results in decreased expression of AKR1C1 mRNA CTD PMID:28988120 Akr1c1 Rat leflunomide decreases expression EXP 6480464 Leflunomide results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 Akr1c1 Rat lipopolysaccharide multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [S-(1 more ... CTD PMID:35811015 Akr1c1 Rat lithocholic acid affects binding ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein binds to Lithocholic Acid CTD PMID:8573067 Akr1c1 Rat lithocholic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Lithocholic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:8573067 Akr1c1 Rat malathion increases expression ISO AKR1C1 (Homo sapiens) 6480464 Malathion results in increased expression of AKR1C1 mRNA CTD PMID:16079077 and PMID:18214805 Akr1c1 Rat meclofenamic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Meclofenamic Acid results in decreased activity of AKR1C1 protein CTD PMID:19010312 more ... Akr1c1 Rat Medazepam decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Medazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 and PMID:12604236 Akr1c1 Rat medroxyprogesterone acetate decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Medroxyprogesterone Acetate results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:21182831 Akr1c1 Rat medroxyprogesterone acetate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Medroxyprogesterone Acetate results in increased expression of AKR1C1 mRNA CTD PMID:18497975 and PMID:23183084 Akr1c1 Rat medroxyprogesterone acetate decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Medroxyprogesterone Acetate results in decreased expression of AKR1C1 mRNA CTD PMID:23183084 Akr1c1 Rat mefenamic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Mefenamic Acid analog results in decreased activity of AKR1C1 protein CTD PMID:19010312 Akr1c1 Rat menadione affects expression ISO AKR1C1 (Homo sapiens) 6480464 Vitamin K 3 affects the expression of AKR1C1 mRNA CTD PMID:20044591 Akr1c1 Rat mercury dibromide multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 Akr1c1 Rat mercury dibromide increases expression ISO AKR1C1 (Homo sapiens) 6480464 mercuric bromide results in increased expression of AKR1C1 mRNA CTD PMID:26272509 Akr1c1 Rat mercury dichloride increases expression ISO AKR1C1 (Homo sapiens) 6480464 Mercuric Chloride results in increased expression of AKR1C1 mRNA CTD PMID:38568856 Akr1c1 Rat methidathion decreases expression ISO Akr1c6 (Mus musculus) 6480464 methidathion results in decreased expression of AKR1C6 mRNA CTD PMID:34813904 Akr1c1 Rat methyl methanesulfonate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of AKR1C1 mRNA CTD PMID:23649840 Akr1c1 Rat methyl salicylate increases expression ISO AKR1C1 (Homo sapiens) 6480464 methyl salicylate results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat methylmercury chloride multiple interactions EXP 6480464 [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in decreased expression of AKR1C1 mRNA CTD PMID:30744511 Akr1c1 Rat methylmercury chloride increases expression ISO AKR1C1 (Homo sapiens) 6480464 methylmercuric chloride results in increased expression of AKR1C1 mRNA CTD PMID:28001369 Akr1c1 Rat methylparaben decreases expression ISO AKR1C1 (Homo sapiens) 6480464 methylparaben results in decreased expression of AKR1C1 mRNA CTD PMID:38568856 Akr1c1 Rat monosodium L-glutamate increases expression ISO Akr1c6 (Mus musculus) 6480464 Sodium Glutamate results in increased expression of AKR1C6 mRNA CTD PMID:25473020 Akr1c1 Rat N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin]] CTD PMID:23165153 Akr1c1 Rat N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1C1 mRNA CTD PMID:21215737 and PMID:23165153 Akr1c1 Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AKR1C6 mRNA CTD PMID:28943392 Akr1c1 Rat N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of AKR1C1 mRNA CTD PMID:25380136 Akr1c1 Rat NAD zwitterion multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol more ... CTD PMID:25446855 Akr1c1 Rat NAD(+) multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol more ... CTD PMID:25446855 Akr1c1 Rat NADP zwitterion multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:21910479 and PMID:23261716 Akr1c1 Rat NADP(+) multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:21910479 and PMID:23261716 Akr1c1 Rat naproxen decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Naproxen results in decreased activity of AKR1C1 protein CTD PMID:19010312 Akr1c1 Rat nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 Akr1c1 Rat neoastilbin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA CTD PMID:29471006 Akr1c1 Rat nickel sulfate increases expression ISO AKR1C1 (Homo sapiens) 6480464 nickel sulfate results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat nitrazepam decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Nitrazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 Akr1c1 Rat norethisterone decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Norethindrone results in decreased activity of AKR1C1 protein CTD PMID:21182831 Akr1c1 Rat ochratoxin A decreases expression ISO AKR1C1 (Homo sapiens) 6480464 ochratoxin A results in decreased expression of AKR1C1 mRNA CTD PMID:19287073 and PMID:32905824 Akr1c1 Rat octadecanoic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 stearic acid results in increased expression of AKR1C1 mRNA CTD PMID:32347412 Akr1c1 Rat octyl gallate decreases activity ISO AKR1C1 (Homo sapiens) 6480464 octyl gallate results in decreased activity of AKR1C1 protein CTD PMID:27163852 Akr1c1 Rat oxaliplatin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 alpha-methylcinnamic acid inhibits the reaction [AKR1C1 protein affects the susceptibility to Oxaliplatin] more ... CTD PMID:23933386 Akr1c1 Rat oxaliplatin affects response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the susceptibility to Oxaliplatin CTD PMID:23933386 Akr1c1 Rat oxcarbazepine increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of Oxcarbazepine CTD PMID:25063510 Akr1c1 Rat p-chloromercuribenzoic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 p-Chloromercuribenzoic Acid results in increased expression of AKR1C1 mRNA CTD PMID:26272509 Akr1c1 Rat p-chloromercuribenzoic acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 Akr1c1 Rat paracetamol affects expression ISO Akr1c6 (Mus musculus) 6480464 Acetaminophen affects the expression of AKR1C6 mRNA CTD PMID:17562736 Akr1c1 Rat paracetamol increases expression ISO AKR1C1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of AKR1C1 mRNA CTD PMID:21420995 Akr1c1 Rat paracetamol decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of AKR1C1 mRNA CTD PMID:26690555 Akr1c1 Rat paracetamol decreases expression ISO Akr1c6 (Mus musculus) 6480464 Acetaminophen results in decreased expression of AKR1C6 mRNA CTD PMID:11264010 and PMID:17585979 Akr1c1 Rat paracetamol multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of AKR1C6 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AKR1C6 mRNA] CTD PMID:17585979 Akr1c1 Rat Paraoxon-methyl multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with methylparaoxon] CTD PMID:19800895 Akr1c1 Rat Paraoxon-methyl increases expression ISO AKR1C1 (Homo sapiens) 6480464 methylparaoxon results in increased expression of AKR1C1 mRNA CTD PMID:19800895 Akr1c1 Rat parathion-methyl increases activity ISO AKR1C1 (Homo sapiens) 6480464 Methyl Parathion results in increased activity of AKR1C1 protein CTD PMID:19800895 Akr1c1 Rat parathion-methyl increases expression ISO AKR1C1 (Homo sapiens) 6480464 Methyl Parathion results in increased expression of AKR1C1 mRNA CTD PMID:19800895 Akr1c1 Rat parathion-methyl multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion] more ... CTD PMID:19800895 Akr1c1 Rat perfluorodecanoic acid decreases expression ISO AKR1C1 (Homo sapiens) 6480464 perfluorodecanoic acid results in decreased expression of AKR1C1 mRNA CTD PMID:38568856 Akr1c1 Rat perfluorononanoic acid decreases expression ISO AKR1C1 (Homo sapiens) 6480464 perfluoro-n-nonanoic acid results in decreased expression of AKR1C1 mRNA CTD PMID:38568856 Akr1c1 Rat perfluorooctane-1-sulfonic acid affects expression ISO Akr1c6 (Mus musculus) 6480464 perfluorooctane sulfonic acid affects the expression of AKR1C6 mRNA CTD PMID:19429403 Akr1c1 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of AKR1C6 mRNA CTD PMID:36331819 Akr1c1 Rat perfluorooctanoic acid affects expression ISO Akr1c6 (Mus musculus) 6480464 perfluorooctanoic acid affects the expression of AKR1C6 mRNA CTD PMID:19429403 Akr1c1 Rat perfluorooctanoic acid decreases expression ISO AKR1C1 (Homo sapiens) 6480464 perfluorooctanoic acid results in decreased expression of AKR1C1 mRNA CTD PMID:23978341 and PMID:38568856 Akr1c1 Rat phenanthrene decreases expression ISO AKR1C1 (Homo sapiens) 6480464 phenanthrene results in decreased expression of AKR1C1 mRNA CTD PMID:38568856 Akr1c1 Rat phenethyl caffeate decreases activity ISO AKR1C1 (Homo sapiens) 6480464 caffeic acid phenethyl ester results in decreased activity of AKR1C1 protein CTD PMID:27163852 Akr1c1 Rat phenobarbital decreases expression ISO Akr1c6 (Mus musculus) 6480464 Phenobarbital results in decreased expression of AKR1C6 protein CTD PMID:35881160 Akr1c1 Rat phenolphthalein decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Phenolphthalein results in decreased activity of AKR1C1 protein CTD PMID:12604236 Akr1c1 Rat phenolphthalein multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 Phenolphthalein inhibits the reaction [AKR1C1 protein affects the susceptibility to Oxaliplatin] CTD PMID:23933386 Akr1c1 Rat phenylmercury acetate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of AKR1C1 mRNA CTD PMID:26272509 Akr1c1 Rat phenylmercury acetate multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 Akr1c1 Rat pirinixic acid multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [pirinixic acid co-treated with PPARA] results in decreased expression of AKR1C6 mRNA CTD PMID:20813756 Akr1c1 Rat pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of AKR1C1 mRNA CTD PMID:22484513 Akr1c1 Rat pirinixic acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AKR1C1 mRNA CTD PMID:19710929 Akr1c1 Rat pirinixic acid decreases expression ISO Akr1c6 (Mus musculus) 6480464 pirinixic acid results in decreased expression of AKR1C6 mRNA CTD PMID:20813756 Akr1c1 Rat potassium dichromate affects expression ISO Akr1c6 (Mus musculus) 6480464 Potassium Dichromate affects the expression of AKR1C6 mRNA CTD PMID:23608068 Akr1c1 Rat pregnenolone 16alpha-carbonitrile decreases expression ISO Akr1c6 (Mus musculus) 6480464 Pregnenolone Carbonitrile results in decreased expression of AKR1C6 mRNA CTD PMID:28903501 Akr1c1 Rat progesterone affects reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the reduction of Progesterone CTD PMID:12604236 and PMID:16338060 Akr1c1 Rat progesterone increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of Progesterone CTD PMID:11995921 and PMID:22245609 Akr1c1 Rat progesterone decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Progesterone results in decreased expression of AKR1C1 mRNA CTD PMID:23183084 Akr1c1 Rat progesterone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the metabolism of and results in decreased activity of Progesterone CTD PMID:16962702 Akr1c1 Rat propan-2-ol increases expression ISO AKR1C1 (Homo sapiens) 6480464 2-Propanol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat prostaglandin G2 increases metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased metabolism of prostaglandin G2 CTD PMID:8573067 Akr1c1 Rat pyrimidine decreases activity ISO AKR1C1 (Homo sapiens) 6480464 pyrimidine analog results in decreased activity of AKR1C1 protein CTD PMID:19007763 Akr1c1 Rat quercetin decreases activity EXP 6480464 Quercetin results in decreased activity of AKR1C6 protein CTD PMID:16788056 Akr1c1 Rat quinolin-8-ol increases expression ISO AKR1C1 (Homo sapiens) 6480464 Oxyquinoline results in increased expression of AKR1C1 mRNA CTD PMID:21632981 Akr1c1 Rat quinomethionate affects expression ISO AKR1C1 (Homo sapiens) 6480464 quinomethionate affects the expression of AKR1C1 mRNA CTD PMID:15387888 Akr1c1 Rat quinomethionate increases expression ISO AKR1C1 (Homo sapiens) 6480464 quinomethionate results in increased expression of AKR1C1 mRNA CTD PMID:18214805 Akr1c1 Rat rac-lactic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 Lactic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20566472 and PMID:30851411 Akr1c1 Rat reactive oxygen species increases expression ISO AKR1C1 (Homo sapiens) 6480464 Reactive Oxygen Species results in increased expression of AKR1C1 mRNA CTD PMID:9973208 Akr1c1 Rat reactive oxygen species multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 mRNA and [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 protein CTD PMID:19320734 Akr1c1 Rat resorcinol increases expression ISO AKR1C1 (Homo sapiens) 6480464 resorcinol results in increased expression of AKR1C1 mRNA CTD PMID:30806763 Akr1c1 Rat rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of AKR1C1 mRNA CTD PMID:28374803 Akr1c1 Rat S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [S-(1 more ... CTD PMID:35811015 Akr1c1 Rat S-(1,2-dichlorovinyl)-L-cysteine increases expression ISO AKR1C1 (Homo sapiens) 6480464 S-(1 and 2-dichlorovinyl)cysteine results in increased expression of AKR1C1 mRNA CTD PMID:35811015 Akr1c1 Rat salicylic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Salicylic Acid results in decreased activity of AKR1C1 protein CTD PMID:19010312 and PMID:23165153 Akr1c1 Rat salicylic acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin]] and Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin] CTD PMID:23165153 Akr1c1 Rat SB 431542 multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Akr1c1 Rat silicon dioxide decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of AKR1C1 mRNA CTD PMID:25895662 Akr1c1 Rat silver atom multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 NFE2L2 protein promotes the reaction [Silver results in increased expression of AKR1C1 mRNA] CTD PMID:22036727 Akr1c1 Rat silver atom increases expression ISO AKR1C1 (Homo sapiens) 6480464 Silver results in increased expression of AKR1C1 mRNA CTD PMID:22036727 Akr1c1 Rat silver(0) increases expression ISO AKR1C1 (Homo sapiens) 6480464 Silver results in increased expression of AKR1C1 mRNA CTD PMID:22036727 Akr1c1 Rat silver(0) multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 NFE2L2 protein promotes the reaction [Silver results in increased expression of AKR1C1 mRNA] CTD PMID:22036727 Akr1c1 Rat simvastatin increases expression ISO AKR1C1 (Homo sapiens) 6480464 Simvastatin results in increased expression of AKR1C1 mRNA CTD PMID:17428261 Akr1c1 Rat sodium arsenate increases expression ISO AKR1C1 (Homo sapiens) 6480464 sodium arsenate results in increased expression of AKR1C1 mRNA CTD PMID:12727804 Akr1c1 Rat sodium arsenite increases expression ISO Akr1c6 (Mus musculus) 6480464 sodium arsenite results in increased expression of AKR1C6 mRNA and sodium arsenite results in increased expression of AKR1C6 protein CTD PMID:17077188 and PMID:29044176 Akr1c1 Rat sodium arsenite affects expression ISO AKR1C1 (Homo sapiens) 6480464 sodium arsenite affects the expression of AKR1C1 mRNA CTD PMID:29319823 Akr1c1 Rat sodium arsenite multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA and SQSTM1 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA] CTD PMID:31781319 Akr1c1 Rat sodium arsenite increases expression ISO AKR1C1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of AKR1C1 mRNA and sodium arsenite results in increased expression of AKR1C1 protein CTD PMID:19696165 more ... Akr1c1 Rat sodium arsenite decreases expression ISO Akr1c6 (Mus musculus) 6480464 sodium arsenite results in decreased expression of AKR1C6 mRNA CTD PMID:17350061 and PMID:17451858 Akr1c1 Rat sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of AKR1C1 mRNA CTD PMID:25993096 Akr1c1 Rat sodium dodecyl sulfate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Sodium Dodecyl Sulfate results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat sulforaphane increases expression ISO AKR1C1 (Homo sapiens) 6480464 sulforaphane results in increased expression of AKR1C1 mRNA CTD PMID:24383545 more ... Akr1c1 Rat sulforaphane multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 NFE2L2 protein affects the reaction [sulforaphane results in increased expression of AKR1C1 mRNA] CTD PMID:31518892 Akr1c1 Rat sulindac decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Sulindac results in decreased activity of AKR1C1 protein CTD PMID:19010312 Akr1c1 Rat sulindac sulfide increases expression ISO AKR1C1 (Homo sapiens) 6480464 sulindac sulfide results in increased expression of AKR1C1 mRNA CTD PMID:16184548 Akr1c1 Rat sunitinib decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Sunitinib results in decreased expression of AKR1C1 mRNA CTD PMID:31533062 Akr1c1 Rat temozolomide affects response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 mRNA affects the susceptibility to Temozolomide CTD PMID:16365179 Akr1c1 Rat tert-butyl hydroperoxide increases expression ISO AKR1C1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of AKR1C1 mRNA CTD PMID:15336504 Akr1c1 Rat testosterone increases oxidation EXP 6480464 AKR1C6 protein results in increased oxidation of Testosterone CTD PMID:16788056 Akr1c1 Rat testosterone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of AKR1C1 mRNA CTD PMID:21592394 Akr1c1 Rat testosterone increases expression ISO AKR1C1 (Homo sapiens) 6480464 Testosterone results in increased expression of AKR1C1 mRNA CTD PMID:21592394 Akr1c1 Rat testosterone enanthate affects expression ISO AKR1C1 (Homo sapiens) 6480464 testosterone enanthate affects the expression of AKR1C1 mRNA CTD PMID:17440010 Akr1c1 Rat tetrachloromethane decreases expression ISO Akr1c6 (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of AKR1C6 mRNA CTD PMID:31919559 Akr1c1 Rat tetraphene increases expression ISO AKR1C1 (Homo sapiens) 6480464 benz(a)anthracene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 and PMID:22236718 Akr1c1 Rat thioacetamide multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AKR1C6 mRNA CTD PMID:28943392 Akr1c1 Rat thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of AKR1C1 mRNA CTD PMID:23411599 more ... Akr1c1 Rat thiram increases expression ISO AKR1C1 (Homo sapiens) 6480464 Thiram results in increased expression of AKR1C1 mRNA CTD PMID:38568856 Akr1c1 Rat titanium dioxide affects expression ISO Akr1c6 (Mus musculus) 6480464 titanium dioxide affects the expression of AKR1C6 mRNA CTD PMID:23557971 Akr1c1 Rat tofacitinib increases metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased metabolism of tofacitinib metabolite CTD PMID:27117606 Akr1c1 Rat tolcapone affects binding EXP 6480464 Tolcapone binds to AKR1C1 protein CTD PMID:19783845 Akr1c1 Rat trans-isoeugenol increases expression ISO AKR1C1 (Homo sapiens) 6480464 isoeugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 Akr1c1 Rat trichloroethene increases methylation EXP 6480464 Trichloroethylene results in increased methylation of AKR1C1 gene CTD PMID:27618143 Akr1c1 Rat trichostatin A multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 Akr1c1 Rat trichostatin A increases expression ISO AKR1C1 (Homo sapiens) 6480464 trichostatin A results in increased expression of AKR1C1 mRNA CTD PMID:24935251 and PMID:26272509 Akr1c1 Rat triclosan decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Triclosan results in decreased expression of AKR1C1 mRNA CTD PMID:30510588 Akr1c1 Rat Triptolide decreases expression ISO Akr1c6 (Mus musculus) 6480464 triptolide results in decreased expression of AKR1C6 mRNA CTD PMID:32835833 Akr1c1 Rat tris(2-butoxyethyl) phosphate decreases expression ISO AKR1C1 (Homo sapiens) 6480464 tris(2-butoxyethyl) phosphate results in decreased expression of AKR1C1 mRNA CTD PMID:29024780 Akr1c1 Rat Tungsten carbide multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [tungsten carbide binds to Cobalt] which results in decreased expression of AKR1C1 mRNA CTD PMID:20105288 Akr1c1 Rat Tungsten carbide decreases expression ISO AKR1C1 (Homo sapiens) 6480464 tungsten carbide results in decreased expression of AKR1C1 mRNA CTD PMID:20105288 Akr1c1 Rat urethane decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Urethane results in decreased expression of AKR1C1 mRNA CTD PMID:28818685 Akr1c1 Rat ursodeoxycholic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Ursodeoxycholic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 Akr1c1 Rat valdecoxib decreases expression EXP 6480464 valdecoxib results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 Akr1c1 Rat valproic acid affects expression ISO Akr1c6 (Mus musculus) 6480464 Valproic Acid affects the expression of AKR1C6 mRNA CTD PMID:17292431 Akr1c1 Rat valproic acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 Akr1c1 Rat valproic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 Valproic Acid results in increased expression of AKR1C1 mRNA CTD PMID:23179753 more ... Akr1c1 Rat vitamin D increases expression ISO AKR1C1 (Homo sapiens) 6480464 Vitamin D results in increased expression of AKR1C1 mRNA and Vitamin D results in increased expression of AKR1C1 protein CTD PMID:30698894 Akr1c1 Rat vorinostat increases expression ISO AKR1C1 (Homo sapiens) 6480464 Vorinostat results in increased expression of AKR1C1 mRNA CTD PMID:26272509 Akr1c1 Rat vorinostat multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 Akr1c1 Rat zinc atom multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [PCI 5002 co-treated with Zinc] results in decreased expression of AKR1C1 mRNA CTD PMID:18593933 Akr1c1 Rat zinc(0) multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [PCI 5002 co-treated with Zinc] results in decreased expression of AKR1C1 mRNA CTD PMID:18593933 Akr1c1 Rat zomepirac decreases activity ISO AKR1C1 (Homo sapiens) 6480464 zomepirac results in decreased activity of AKR1C1 protein CTD PMID:19010312