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Gene: Akr1c6 (aldo-keto reductase family 1, member C6) Mus musculus
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Symbol: Akr1c6
Name: aldo-keto reductase family 1, member C6
Description: Exhibits estradiol 17-beta-dehydrogenase activity. Involved in negative regulation of mRNA splicing, via spliceosome and steroid metabolic process. Predicted to localize to cytosol and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Is expressed in several structures, including alimentary system; liver and biliary system; lung; metanephros; and sensory organ. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1) and AKR1C3 (aldo-keto reductase family 1 member C3); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH 1,2-dichloroethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 17-beta-HSD 5; 17HSD type 5; 3alpha-HSD; Akr1c1; aldo-keto reductase family 1, member C1 (aldehyde reductase); estradiol 17 beta-dehydrogenase 5; estradiol 17-beta-dehydrogenase (A-specific); Hsd17b5; hydroxysteroid 17-beta dehydrogenase 5
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl134,434,306 - 4,457,877 (+)EnsemblGRCm38mm10GRCm38
GRCm38134,434,311 - 4,457,530 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37134,433,589 - 4,456,776 (+)NCBIGRCm37mm9NCBIm37
MGSCv36134,433,637 - 4,456,642 (+)NCBImm8
Celera134,408,738 - 4,431,843 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.48NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Akr1c6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315696
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.