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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306847
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1c1
Name: aldo-keto reductase family 1, member C1
Acc ID: CHEBI:42638
Term: flufenamic acid
Definition: An aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders.
Chemical ID: MESH:D005439
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c1decreases activityISOAKR1C1 (Homo sapiens)6480464CTDFlufenamic Acid results in decreased activity of AKR1C1 proteinPMID:12604236 PMID:8573067
Akr1c1multiple interactionsISOAKR1C1 (Homo sapiens)6480464CTDFlufenamic Acid inhibits the reaction [AKR1C1 protein affects the susceptibility to Oxaliplatin]; Flufenamic Acid inhibits the reaction [AKR1C1 protein results in increased metabolism of Dihydrotestosterone]PMID:14672942 PMID:23933386
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