Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: AKR1C3 (aldo-keto reductase family 1 member C3) Homo sapiens
Symbol: AKR1C3
Name: aldo-keto reductase family 1 member C3
Description: Exhibits oxidoreductase activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to metal ion; and glycoside metabolic process. Localizes to the cytoplasm and nucleus. Implicated in leukemia; precursor B lymphoblastic lymphoma/leukemia; and precursor T-lymphoblastic lymphoma/leukemia. Biomarker of ductal carcinoma in situ; pre-eclampsia; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type II, brain; aldo-keto reductase family 1, member C3; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); chlordecone reductase homolog HAKRb; DD3; DDX; dihydrodiol dehydrogenase 3; dihydrodiol dehydrogenase X; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; indanol dehydrogenase; KIAA0119; PGFS; prostaglandin F synthase; testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38105,048,766 - 5,107,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37105,090,958 - 5,149,878 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,126,568 - 5,139,878 (+)NCBINCBI36hg18NCBI36
Build 34105,126,567 - 5,139,878NCBI
Celera105,076,549 - 5,089,836 (+)NCBI
Cytogenetic Map10p15.1NCBI
HuRef105,024,814 - 5,083,613 (+)NCBIHuRef
CHM1_1105,091,312 - 5,150,193 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AKR1C3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352888
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.