AKR1C3 (aldo-keto reductase family 1 member C3) - Rat Genome Database
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Gene: AKR1C3 (aldo-keto reductase family 1 member C3) Homo sapiens
Analyze
Symbol: AKR1C3
Name: aldo-keto reductase family 1 member C3
RGD ID: 1352888
HGNC Page HGNC
Description: Exhibits oxidoreductase activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to metal ion; and glycoside metabolic process. Localizes to cytoplasm and nucleus. Implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Biomarker of ductal carcinoma in situ; pre-eclampsia; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type II, brain; aldo-keto reductase family 1, member C3; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); chlordecone reductase homolog HAKRb; DD3; DDX; dihydrodiol dehydrogenase 3; dihydrodiol dehydrogenase X; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; indanol dehydrogenase; KIAA0119; PGFS; prostaglandin F synthase; testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl105,035,354 - 5,107,686 (+)EnsemblGRCh38hg38GRCh38
GRCh38105,048,781 - 5,107,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37105,090,958 - 5,149,878 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,126,568 - 5,139,878 (+)NCBINCBI36hg18NCBI36
Build 34105,126,567 - 5,139,878NCBI
Celera105,076,549 - 5,089,836 (+)NCBI
Cytogenetic Map10p15.1NCBI
HuRef105,024,814 - 5,083,613 (+)NCBIHuRef
CHM1_1105,091,312 - 5,150,193 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(20S)-20-hydroxypregn-4-en-3-one  (EXP,ISO)
(E)-cinnamyl alcohol  (EXP)
(S)-naringenin  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,10-phenanthroline  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
13-dihydrodaunorubicin  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxyethyl methacrylate  (EXP)
2-hydroxypropanoic acid  (EXP)
2-methoxyethanol  (ISO)
20-hydroxypregn-4-en-3-one  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-dichloroaniline  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxybenzoic acid  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP)
5alpha-Pregnan-20alpha-ol-3-one  (EXP)
5alpha-pregnane-3,20-dione  (EXP)
6-propyl-2-thiouracil  (ISO)
7-hydroxyflavone  (EXP)
9,10-phenanthroquinone  (EXP)
9-cis-retinal  (EXP)
acetylsalicylic acid  (EXP)
all-trans-retinal  (EXP)
all-trans-retinoic acid  (EXP)
alpha-hexylcinnamaldehyde  (EXP,ISO)
ammonium chloride  (ISO)
androst-4-ene-3,17-dione  (EXP)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atrazine  (ISO)
avobenzone  (EXP)
Bandrowski's base  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (EXP)
benzo[a]pyrene-7,8-dione  (EXP)
benzo[e]pyrene  (EXP)
benzoic acid  (EXP)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (EXP)
Bromazepam  (EXP)
bromocriptine  (ISO)
butan-1-ol  (EXP)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
capecitabine  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
cinnamyl alcohol  (EXP)
cisplatin  (EXP)
Clofop  (EXP)
cloxazolam  (EXP)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP)
coniferyl aldehyde  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crotonaldehyde  (EXP)
cycloheximide  (EXP)
cyclopentanol  (EXP)
cyclopentanone  (EXP)
cyclosporin A  (EXP,ISO)
daunorubicin  (EXP)
dehydroepiandrosterone  (ISO)
desogestrel  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diazepam  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
disulfiram  (EXP)
diuron  (EXP)
dorsomorphin  (EXP)
doxifluridine  (EXP)
doxorubicin  (EXP)
dutasteride  (EXP)
dydrogesterone  (EXP)
estazolam  (EXP)
estrone  (EXP)
ethanol  (EXP)
eugenol  (EXP)
farnesal  (EXP)
farnesoic acid  (EXP)
farnesol  (EXP)
fenamic acid  (EXP)
flufenamic acid  (EXP)
flunitrazepam  (EXP)
flurbiprofen  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (ISO)
geranylgeraniol  (EXP)
gliclazide  (EXP)
glimepiride  (EXP)
glipizide  (EXP)
glyburide  (EXP)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
hexane  (EXP)
hexestrol  (EXP)
hydrogen peroxide  (EXP)
ibuprofen  (EXP)
indometacin  (EXP)
isoeugenol  (EXP)
L-methionine  (ISO)
levonorgestrel  (EXP)
lithocholic acid  (EXP)
LY294002  (EXP)
meclofenamic acid  (EXP)
Medazepam  (EXP)
medroxyprogesterone acetate  (EXP)
mefenamic acid  (EXP)
mercury dibromide  (EXP)
methapyrilene  (EXP)
methyl salicylate  (EXP)
methylglyoxal  (EXP)
methylmercury chloride  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naphthalenes  (EXP)
naproxen  (EXP)
nickel atom  (EXP)
nickel sulfate  (EXP)
nitrazepam  (EXP)
norethisterone  (EXP)
ochratoxin A  (EXP)
octyl gallate  (EXP)
oxaliplatin  (EXP)
oxcarbazepine  (EXP)
oxycodone  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenolphthalein  (EXP)
phenylmercury acetate  (EXP)
phthalaldehyde  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
pravastatin  (ISO)
progesterone  (EXP,ISO)
propan-2-ol  (EXP)
prostaglandin D2  (EXP)
prostaglandin F2alpha  (EXP)
prostaglandin J2  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
salicylic acid  (EXP)
SB 431542  (EXP)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP,ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
sulindac  (EXP)
sulpiride  (ISO)
superoxide  (EXP)
testosterone  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
tolfenamic acid  (EXP)
trans-isoeugenol  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
umbelliferone  (EXP)
uranium atom  (EXP)
urethane  (EXP)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (EXP)
zaragozic acid A  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zomepirac  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cadmium ion  (IDA)
cellular response to calcium ion  (IDA)
cellular response to corticosteroid stimulus  (IDA)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to forskolin  (ISO)
cellular response to gonadotropin-releasing hormone  (ISO)
cellular response to jasmonic acid stimulus  (IDA)
cellular response to prolactin  (ISO)
cellular response to prostaglandin D stimulus  (IDA)
cellular response to prostaglandin stimulus  (IDA)
cellular response to reactive oxygen species  (IDA)
cellular response to starvation  (IEP)
cellular response to testosterone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cyclooxygenase pathway  (TAS)
daunorubicin metabolic process  (IBA,IMP)
doxorubicin metabolic process  (IBA,IMP)
farnesol catabolic process  (IDA)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (IDA)
keratinocyte differentiation  (IEP)
macromolecule metabolic process  (IEP)
male gonad development  (IEP)
negative regulation of retinoic acid biosynthetic process  (IDA)
obsolete oxidation-reduction process  (IDA,IEA,TAS)
parturition  (ISO)
positive regulation of cell death  (IDA)
positive regulation of cell population proliferation  (IDA,IMP)
positive regulation of endothelial cell apoptotic process  (IDA)
positive regulation of protein kinase B signaling  (IDA)
positive regulation of reactive oxygen species metabolic process  (IDA)
progesterone catabolic process  (ISO)
progesterone metabolic process  (IBA,IDA)
prostaglandin metabolic process  (IBA,IEP,TAS)
regulation of retinoic acid receptor signaling pathway  (IDA)
regulation of steroid biosynthetic process  (ISO)
regulation of testosterone biosynthetic process  (IMP)
renal absorption  (NAS)
response to nutrient  (IEP)
retinal metabolic process  (IDA)
retinoid metabolic process  (TAS)
retinol metabolic process  (IEA)
steroid metabolic process  (IBA,IEP)
testosterone biosynthetic process  (IMP)

Cellular Component
cytoplasm  (IDA)
cytosol  (IBA,TAS)
extracellular exosome  (HDA)
nucleus  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7626489   PMID:7650035   PMID:7788527   PMID:7789999   PMID:8274401   PMID:8718859   PMID:8889549   PMID:9415401   PMID:9792917   PMID:9862446   PMID:9927279   PMID:10393440  
PMID:10557352   PMID:10622721   PMID:10672042   PMID:10998348   PMID:11076863   PMID:11165022   PMID:11256614   PMID:12477932   PMID:13678667   PMID:14671194   PMID:14979715   PMID:14996743  
PMID:14997212   PMID:15087468   PMID:15164054   PMID:15212687   PMID:15284179   PMID:15489334   PMID:15489336   PMID:15582534   PMID:15781210   PMID:15814298   PMID:16157291   PMID:16169070  
PMID:16189514   PMID:16263811   PMID:16302261   PMID:16337083   PMID:16338060   PMID:16381901   PMID:16475787   PMID:16480815   PMID:16601286   PMID:16983398   PMID:17071532   PMID:17149600  
PMID:17166832   PMID:17220347   PMID:17507624   PMID:17583494   PMID:17697149   PMID:17940109   PMID:18306354   PMID:18508192   PMID:18552976   PMID:18574251   PMID:18632753   PMID:18641923  
PMID:18676680   PMID:18692800   PMID:18984855   PMID:18996480   PMID:19007764   PMID:19162045   PMID:19170196   PMID:19273550   PMID:19320734   PMID:19336370   PMID:19336506   PMID:19423521  
PMID:19442656   PMID:19460435   PMID:19487289   PMID:19574343   PMID:19625176   PMID:19692168   PMID:19846565   PMID:19942269   PMID:20036328   PMID:20086173   PMID:20126582   PMID:20145130  
PMID:20201926   PMID:20379614   PMID:20453000   PMID:20634197   PMID:20661409   PMID:20689807   PMID:20734064   PMID:20837989   PMID:21039282   PMID:21151387   PMID:21187079   PMID:21232532  
PMID:21323680   PMID:21365123   PMID:21444150   PMID:21521174   PMID:21787718   PMID:21851338   PMID:21873635   PMID:21886157   PMID:22170488   PMID:22505408   PMID:22670171   PMID:23024260  
PMID:23116553   PMID:23165153   PMID:23183084   PMID:23376485   PMID:23519145   PMID:23533145   PMID:23748150   PMID:24012099   PMID:24228104   PMID:24244276   PMID:24316309   PMID:24832494  
PMID:24838369   PMID:24917395   PMID:25419901   PMID:25446850   PMID:25514466   PMID:25522430   PMID:25649766   PMID:25661377   PMID:25754347   PMID:25849402   PMID:26160177   PMID:26170067  
PMID:26186194   PMID:26209609   PMID:26308156   PMID:26429394   PMID:27019068   PMID:27055738   PMID:27082632   PMID:27085562   PMID:27111237   PMID:27385003   PMID:27485119   PMID:28025170  
PMID:28259989   PMID:28359237   PMID:28457968   PMID:28514442   PMID:29777907   PMID:29920533   PMID:29987050   PMID:30139661   PMID:30367463   PMID:30575818   PMID:31125365   PMID:31253396  
PMID:31294486   PMID:31308078   PMID:31436131   PMID:31780644   PMID:33096057  


Genomics

Comparative Map Data
AKR1C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl105,035,354 - 5,107,686 (+)EnsemblGRCh38hg38GRCh38
GRCh38105,048,781 - 5,107,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37105,090,958 - 5,149,878 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,126,568 - 5,139,878 (+)NCBINCBI36hg18NCBI36
Build 34105,126,567 - 5,139,878NCBI
Celera105,076,549 - 5,089,836 (+)NCBI
Cytogenetic Map10p15.1NCBI
HuRef105,024,814 - 5,083,613 (+)NCBIHuRef
CHM1_1105,091,312 - 5,150,193 (+)NCBICHM1_1
Akr1c18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,182,614 - 4,200,645 (-)NCBIGRCm39mm39
GRCm38134,132,615 - 4,150,646 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,132,615 - 4,150,654 (-)EnsemblGRCm38mm10GRCm38
MGSCv37134,131,873 - 4,149,877 (-)NCBIGRCm37mm9NCBIm37
MGSCv36134,131,873 - 4,149,877 (-)NCBImm8
Celera134,108,614 - 4,126,601 (-)NCBICelera
Cytogenetic Map13A1NCBI
Akr1c3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01769,761,126 - 69,778,021 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,761,118 - 69,778,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,465,942 - 71,482,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,269,626 - 77,286,521 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11777,280,458 - 77,297,354 (+)NCBI
Celera1765,626,116 - 65,643,004 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
AKR1C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl230,674,558 - 30,690,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1230,661,333 - 30,691,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1

Position Markers
RH25343  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37105,136,591 - 5,136,711UniSTSGRCh37
Build 36105,126,591 - 5,126,711RGDNCBI36
Celera105,076,572 - 5,076,692RGD
Cytogenetic Map10p15-p14UniSTS
HuRef105,070,349 - 5,070,469UniSTS
D10S1443  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37105,148,075 - 5,148,229UniSTSGRCh37
Build 36105,138,075 - 5,138,229RGDNCBI36
Celera105,088,031 - 5,088,185RGD
Cytogenetic Map10p15-p14UniSTS
HuRef105,081,802 - 5,081,956UniSTS
Whitehead-YAC Contig Map10 UniSTS
SHGC-31479  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37105,149,699 - 5,149,851UniSTSGRCh37
Build 36105,139,699 - 5,139,851RGDNCBI36
Celera105,089,657 - 5,089,809RGD
Cytogenetic Map10p15-p14UniSTS
HuRef105,083,434 - 5,083,586UniSTS
Stanford-G3 RH Map10161.0UniSTS
GeneMap99-GB4 RH Map1048.24UniSTS
Whitehead-RH Map1049.5UniSTS
NCBI RH Map10107.6UniSTS
GeneMap99-G3 RH Map10161.0UniSTS
RH1568  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37105,149,748 - 5,149,847UniSTSGRCh37
Build 36105,139,748 - 5,139,847RGDNCBI36
Celera105,089,706 - 5,089,805RGD
Cytogenetic Map10p15-p14UniSTS
HuRef105,083,483 - 5,083,582UniSTS
GeneMap99-GB4 RH Map1048.24UniSTS
NCBI RH Map10107.6UniSTS
G62081  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10p15-p14UniSTS
Cytogenetic Map10p15.1UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1133
Count of miRNA genes:594
Interacting mature miRNAs:647
Transcripts:ENST00000380554, ENST00000439082, ENST00000470862, ENST00000480697, ENST00000480822, ENST00000602997, ENST00000603312, ENST00000603484, ENST00000605149, ENST00000605322, ENST00000605781
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 2 2 3 2 14
Medium 1665 1652 1307 576 287 450 3257 1148 1116 335 568 1321 132 1201 2181
Low 749 1322 407 42 1091 9 1050 1031 2576 72 854 239 37 3 605 1
Below cutoff 14 8 4 1 201 1 27 10 16 12 21 25 1 1 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_047094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001253908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001253909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB018580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB028065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB032157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF149416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL391427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV761799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG547635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D17793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ269985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  H79159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF455197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S68288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000380554   ⟹   ENSP00000369927
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl105,094,414 - 5,107,686 (+)Ensembl
RefSeq Acc Id: ENST00000439082   ⟹   ENSP00000401327
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl105,048,812 - 5,107,503 (+)Ensembl
RefSeq Acc Id: ENST00000470862
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl105,035,357 - 5,097,533 (+)Ensembl
RefSeq Acc Id: ENST00000480697
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl105,094,414 - 5,098,176 (+)Ensembl
RefSeq Acc Id: ENST00000480822
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl105,035,358 - 5,097,537 (+)Ensembl
RefSeq Acc Id: ENST00000602997   ⟹   ENSP00000474188
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl105,048,789 - 5,099,414 (+)Ensembl
RefSeq Acc Id: ENST00000603312
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl105,096,145 - 5,097,528 (+)Ensembl
RefSeq Acc Id: ENST00000603484
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl105,105,275 - 5,107,686 (+)Ensembl
RefSeq Acc Id: ENST00000605149   ⟹   ENSP00000474882
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl105,077,638 - 5,107,680 (+)Ensembl
RefSeq Acc Id: ENST00000605322
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl105,094,418 - 5,099,893 (+)Ensembl
RefSeq Acc Id: ENST00000605781
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl105,035,354 - 5,102,210 (+)Ensembl
RefSeq Acc Id: NM_001253908   ⟹   NP_001240837
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,048,781 - 5,107,686 (+)NCBI
GRCh37105,090,958 - 5,149,878 (+)NCBI
HuRef105,024,814 - 5,083,613 (+)NCBI
CHM1_1105,091,312 - 5,150,193 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001253909   ⟹   NP_001240838
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,094,414 - 5,098,176 (+)NCBI
GRCh37105,090,958 - 5,149,878 (+)NCBI
HuRef105,024,814 - 5,083,613 (+)NCBI
CHM1_1105,136,906 - 5,140,705 (+)NCBI
Sequence:
RefSeq Acc Id: NM_003739   ⟹   NP_003730
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,094,414 - 5,107,686 (+)NCBI
GRCh37105,090,958 - 5,149,878 (+)NCBI
Build 36105,126,568 - 5,139,878 (+)NCBI Archive
HuRef105,024,814 - 5,083,613 (+)NCBI
CHM1_1105,136,906 - 5,150,193 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003730   ⟸   NM_003739
- Peptide Label: isoform 1
- UniProtKB: P42330 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001240837   ⟸   NM_001253908
- Peptide Label: isoform 2
- UniProtKB: P42330 (UniProtKB/Swiss-Prot),   A0A0A0MSS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001240838   ⟸   NM_001253909
- Peptide Label: isoform 3
- UniProtKB: B4DKT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000401327   ⟸   ENST00000439082
RefSeq Acc Id: ENSP00000474188   ⟸   ENST00000602997
RefSeq Acc Id: ENSP00000369927   ⟸   ENST00000380554
RefSeq Acc Id: ENSP00000474882   ⟸   ENST00000605149
Protein Domains
Aldo_ket_red

Promoters
RGD ID:7216891
Promoter ID:EPDNEW_H14190
Type:initiation region
Name:AKR1C3_1
Description:aldo-keto reductase family 1 member C3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14189  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,094,376 - 5,094,436EPDNEW
RGD ID:6787346
Promoter ID:HG_KWN:8424
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   HeLa_S3
Transcripts:ENST00000386638,   OTTHUMT00000046533,   OTTHUMT00000046536
Position:
Human AssemblyChrPosition (strand)Source
Build 36105,126,414 - 5,126,914 (+)MPROMDB
RGD ID:6850646
Promoter ID:EP73117
Type:initiation region
Name:HS_AKR1C3
Description:Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroiddehydrogenase, type II).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36105,126,606 - 5,126,666EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10p15.3-14(chr10:90421-6769994)x3 copy number gain See cases [RCV000051132] Chr10:90421..6769994 [GRCh38]
Chr10:224406..6811956 [GRCh37]
Chr10:126361..6851962 [NCBI36]
Chr10:10p15.3-14
pathogenic
GRCh38/hg38 10p15.3-14(chr10:90421-8442783)x3 copy number gain See cases [RCV000051107] Chr10:90421..8442783 [GRCh38]
Chr10:224406..8484746 [GRCh37]
Chr10:126361..8524752 [NCBI36]
Chr10:10p15.3-14
pathogenic
GRCh38/hg38 10p15.3-15.1(chr10:69260-6209368)x1 copy number loss See cases [RCV000052493] Chr10:69260..6209368 [GRCh38]
Chr10:224406..6251331 [GRCh37]
Chr10:105200..6291337 [NCBI36]
Chr10:10p15.3-15.1
pathogenic
GRCh38/hg38 10p15.3-13(chr10:90421-15569528)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052496]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052496]|See cases [RCV000052496] Chr10:90421..15569528 [GRCh38]
Chr10:224406..15611527 [GRCh37]
Chr10:126361..15651533 [NCBI36]
Chr10:10p15.3-13
pathogenic
GRCh38/hg38 10p15.1-13(chr10:4802753-16823491)x1 copy number loss See cases [RCV000052500] Chr10:4802753..16823491 [GRCh38]
Chr10:4844945..16865490 [GRCh37]
Chr10:4834945..16905496 [NCBI36]
Chr10:10p15.1-13
pathogenic
GRCh38/hg38 10p15.3-12.31(chr10:69261-19184047)x3 copy number gain See cases [RCV000053507] Chr10:69261..19184047 [GRCh38]
Chr10:224406..19472976 [GRCh37]
Chr10:105201..19512982 [NCBI36]
Chr10:10p15.3-12.31
pathogenic
GRCh38/hg38 10p15.3-12.2(chr10:90221-22567425)x3 copy number gain See cases [RCV000053508] Chr10:90221..22567425 [GRCh38]
Chr10:224406..22856354 [GRCh37]
Chr10:126161..22896360 [NCBI36]
Chr10:10p15.3-12.2
pathogenic
GRCh38/hg38 10p15.3-14(chr10:90421-7085100)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053511]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053511]|See cases [RCV000053511] Chr10:90421..7085100 [GRCh38]
Chr10:224406..7127062 [GRCh37]
Chr10:126361..7167068 [NCBI36]
Chr10:10p15.3-14
pathogenic
GRCh38/hg38 10p15.3-12.1(chr10:90421-29058318)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053512]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053512]|See cases [RCV000053512] Chr10:90421..29058318 [GRCh38]
Chr10:224406..29347247 [GRCh37]
Chr10:126361..29387253 [NCBI36]
Chr10:10p15.3-12.1
pathogenic
NM_003739.5(AKR1C3):c.465G>A (p.Lys155=) single nucleotide variant Malignant melanoma [RCV000062040] Chr10:5099344 [GRCh38]
Chr10:5141536 [GRCh37]
Chr10:5131536 [NCBI36]
Chr10:10p15.1
not provided
NM_003739.6(AKR1C3):c.643G>A (p.Ala215Thr) single nucleotide variant Hypotension [RCV000119259] Chr10:5102173 [GRCh38]
Chr10:5144365 [GRCh37]
Chr10:10p15.1
not provided
NM_003739.6(AKR1C3):c.27G>T (p.Lys9Asn) single nucleotide variant Malignant tumor of prostate [RCV000149154] Chr10:5094471 [GRCh38]
Chr10:5136663 [GRCh37]
Chr10:10p15.1
uncertain significance
GRCh37/hg19 10p15.3-15.1(chr10:138878-5160945)x3 copy number gain See cases [RCV000184089] Chr10:138878..5160945 [GRCh37]
Chr10:10p15.3-15.1
pathogenic
GRCh38/hg38 10p15.3-13(chr10:73856-12815915)x3 copy number gain See cases [RCV000135340] Chr10:73856..12815915 [GRCh38]
Chr10:119796..12857914 [GRCh37]
Chr10:109796..12897920 [NCBI36]
Chr10:10p15.3-13
pathogenic
GRCh38/hg38 10p15.1-14(chr10:4605831-7403265)x1 copy number loss See cases [RCV000135820] Chr10:4605831..7403265 [GRCh38]
Chr10:4648023..7445227 [GRCh37]
Chr10:4638023..7485233 [NCBI36]
Chr10:10p15.1-14
uncertain significance
GRCh38/hg38 10p15.3-14(chr10:90421-11713049)x3 copy number gain See cases [RCV000135533] Chr10:90421..11713049 [GRCh38]
Chr10:224406..11755048 [GRCh37]
Chr10:126361..11795054 [NCBI36]
Chr10:10p15.3-14
pathogenic|uncertain significance
GRCh38/hg38 10p15.1(chr10:4871826-5811361)x3 copy number gain See cases [RCV000137253] Chr10:4871826..5811361 [GRCh38]
Chr10:4914018..5853324 [GRCh37]
Chr10:4904018..5893330 [NCBI36]
Chr10:10p15.1
uncertain significance
GRCh38/hg38 10p15.3-13(chr10:70478-15373336)x3 copy number gain See cases [RCV000137384] Chr10:70478..15373336 [GRCh38]
Chr10:224406..15415335 [GRCh37]
Chr10:106418..15455341 [NCBI36]
Chr10:10p15.3-13
uncertain significance
GRCh38/hg38 10p15.1(chr10:4836712-5161722)x1 copy number loss See cases [RCV000138260] Chr10:4836712..5161722 [GRCh38]
Chr10:4878904..5203685 [GRCh37]
Chr10:4868904..5193685 [NCBI36]
Chr10:10p15.1
likely benign
GRCh38/hg38 10p15.3-12.1(chr10:90205-26339978)x3 copy number gain See cases [RCV000138428] Chr10:90205..26339978 [GRCh38]
Chr10:224406..26628907 [GRCh37]
Chr10:126145..26668913 [NCBI36]
Chr10:10p15.3-12.1
pathogenic
GRCh38/hg38 10p15.3-13(chr10:70478-13736564)x1 copy number loss See cases [RCV000138960] Chr10:70478..13736564 [GRCh38]
Chr10:224406..13778564 [GRCh37]
Chr10:106418..13818570 [NCBI36]
Chr10:10p15.3-13
pathogenic
GRCh38/hg38 10p15.1-q11.22(chr10:4604734-48074662)x3 copy number gain See cases [RCV000141497] Chr10:4604734..48074662 [GRCh38]
Chr10:4646926..47531169 [GRCh37]
Chr10:4636926..47125152 [NCBI36]
Chr10:10p15.1-q11.22
benign
GRCh38/hg38 10p15.3-13(chr10:54086-13205916)x3 copy number gain See cases [RCV000142292] Chr10:54086..13205916 [GRCh38]
Chr10:100026..13247916 [GRCh37]
Chr10:90026..13287922 [NCBI36]
Chr10:10p15.3-13
pathogenic
GRCh38/hg38 10p15.3-14(chr10:1601172-9203729)x3 copy number gain See cases [RCV000142241] Chr10:1601172..9203729 [GRCh38]
Chr10:1643367..9245692 [GRCh37]
Chr10:1633367..9285698 [NCBI36]
Chr10:10p15.3-14
likely pathogenic
GRCh38/hg38 10p15.1(chr10:4892139-5164086)x1 copy number loss See cases [RCV000142243] Chr10:4892139..5164086 [GRCh38]
Chr10:4934331..5206049 [GRCh37]
Chr10:4924331..5196049 [NCBI36]
Chr10:10p15.1
likely benign
GRCh38/hg38 10p15.3-12.31(chr10:54086-19336980)x1 copy number loss See cases [RCV000143703] Chr10:54086..19336980 [GRCh38]
Chr10:100026..19625909 [GRCh37]
Chr10:90026..19665915 [NCBI36]
Chr10:10p15.3-12.31
pathogenic|likely pathogenic
GRCh37/hg19 10p15.3-14(chr10:2593113-8484746)x1 copy number loss See cases [RCV000239795] Chr10:2593113..8484746 [GRCh37]
Chr10:10p15.3-14
pathogenic
GRCh37/hg19 10p15.1(chr10:5129841-5217161)x1 copy number loss See cases [RCV000446790] Chr10:5129841..5217161 [GRCh37]
Chr10:10p15.1
uncertain significance
GRCh37/hg19 10p15.3-14(chr10:136361-8850609)x1 copy number loss See cases [RCV000446357] Chr10:136361..8850609 [GRCh37]
Chr10:10p15.3-14
pathogenic
GRCh37/hg19 10p15.1(chr10:4934331-5203316)x1 copy number loss See cases [RCV000447225] Chr10:4934331..5203316 [GRCh37]
Chr10:10p15.1
likely benign
GRCh37/hg19 10p15.3-11.23(chr10:100026-30278548)x3 copy number gain See cases [RCV000447131] Chr10:100026..30278548 [GRCh37]
Chr10:10p15.3-11.23
pathogenic
GRCh37/hg19 10p15.3-14(chr10:2116123-8856296)x3 copy number gain See cases [RCV000445989] Chr10:2116123..8856296 [GRCh37]
Chr10:10p15.3-14
uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q11.23(chr10:100026-50961640)x3 copy number gain See cases [RCV000510893] Chr10:100026..50961640 [GRCh37]
Chr10:10p15.3-q11.23
pathogenic
GRCh37/hg19 10p15.3-13(chr10:100026-12842179)x1 copy number loss See cases [RCV000512541] Chr10:100026..12842179 [GRCh37]
Chr10:10p15.3-13
pathogenic
GRCh37/hg19 10p15.1(chr10:5056553-5174423)x1 copy number loss not provided [RCV000845662] Chr10:5056553..5174423 [GRCh37]
Chr10:10p15.1
uncertain significance
Single allele deletion Hypoparathyroidism-deafness-renal disease syndrome [RCV000735901] Chr10:4689760..19120882 [GRCh37]
Chr10:10p15.1-12.31
pathogenic
GRCh37/hg19 10p15.1(chr10:5018712-5144037)x1 copy number loss not provided [RCV000736999] Chr10:5018712..5144037 [GRCh37]
Chr10:10p15.1
benign
GRCh37/hg19 10p15.1(chr10:5063398-5121745)x3 copy number gain not provided [RCV000737000] Chr10:5063398..5121745 [GRCh37]
Chr10:10p15.1
benign
GRCh37/hg19 10p15.1(chr10:5084728-5136651)x3 copy number gain not provided [RCV000737001] Chr10:5084728..5136651 [GRCh37]
Chr10:10p15.1
benign
Single allele duplication Schizophrenia [RCV000754118] Chr10:3076972..6208037 [GRCh38]
Chr10:10p15.2-15.1
likely pathogenic
GRCh37/hg19 10p15.3-13(chr10:69083-12887271)x3 copy number gain not provided [RCV000749463] Chr10:69083..12887271 [GRCh37]
Chr10:10p15.3-13
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
NM_003739.6(AKR1C3):c.568C>T (p.Gln190Ter) single nucleotide variant not provided [RCV000965719] Chr10:5099447 [GRCh38]
Chr10:5141639 [GRCh37]
Chr10:10p15.1
likely benign
NM_003739.6(AKR1C3):c.596G>A (p.Arg199Gln) single nucleotide variant not provided [RCV000950745] Chr10:5102126 [GRCh38]
Chr10:5144318 [GRCh37]
Chr10:10p15.1
benign
NM_003739.6(AKR1C3):c.197G>A (p.Arg66Gln) single nucleotide variant not provided [RCV000965130] Chr10:5096522 [GRCh38]
Chr10:5138714 [GRCh37]
Chr10:10p15.1
benign
NM_003739.6(AKR1C3):c.459G>A (p.Lys153=) single nucleotide variant not provided [RCV000959861] Chr10:5099338 [GRCh38]
Chr10:5141530 [GRCh37]
Chr10:10p15.1
benign
GRCh37/hg19 10p15.1(chr10:4893720-5273767)x1 copy number loss not provided [RCV001006292] Chr10:4893720..5273767 [GRCh37]
Chr10:10p15.1
likely benign
GRCh37/hg19 10p15.3-13(chr10:100026-15273144)x3 copy number gain not provided [RCV000848062] Chr10:100026..15273144 [GRCh37]
Chr10:10p15.3-13
pathogenic
GRCh37/hg19 10p15.3-13(chr10:100026-15273144)x3 copy number gain not provided [RCV000848090] Chr10:100026..15273144 [GRCh37]
Chr10:10p15.3-13
pathogenic
NM_003739.6(AKR1C3):c.434G>A (p.Cys145Tyr) single nucleotide variant not provided [RCV000906158] Chr10:5098866 [GRCh38]
Chr10:5141058 [GRCh37]
Chr10:10p15.1
benign
NM_003739.6(AKR1C3):c.584C>T (p.Pro195Leu) single nucleotide variant not provided [RCV000889342] Chr10:5102114 [GRCh38]
Chr10:5144306 [GRCh37]
Chr10:10p15.1
likely benign
GRCh37/hg19 10p15.1(chr10:4504067-5395279)x3 copy number gain not provided [RCV001006290] Chr10:4504067..5395279 [GRCh37]
Chr10:10p15.1
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:386 AgrOrtholog
COSMIC AKR1C3 COSMIC
Ensembl Genes ENSG00000196139 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000369927 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000401327 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000474188 UniProtKB/TrEMBL
  ENSP00000474882 UniProtKB/TrEMBL
Ensembl Transcript ENST00000380554 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000439082 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000480697 ENTREZGENE
  ENST00000602997 UniProtKB/TrEMBL
  ENST00000605149 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000196139 GTEx
HGNC ID HGNC:386 ENTREZGENE
Human Proteome Map AKR1C3 Human Proteome Map
InterPro Aldo/ket_reductase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8644 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 8644 ENTREZGENE
OMIM 603966 OMIM
PANTHER PTHR11732 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AKR1C3 RGD, PharmGKB
PIRSF AKR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.78183 ENTREZGENE
UniProt A0A0A0MSS8 ENTREZGENE, UniProtKB/TrEMBL
  AK1C3_HUMAN UniProtKB/Swiss-Prot
  B4DKT3 ENTREZGENE, UniProtKB/TrEMBL
  P42330 ENTREZGENE
  S4R3D5_HUMAN UniProtKB/TrEMBL
  S4R3Z2_HUMAN UniProtKB/TrEMBL
UniProt Secondary A8K2V0 UniProtKB/Swiss-Prot
  B4DL37 UniProtKB/Swiss-Prot
  Q5T2L1 UniProtKB/Swiss-Prot
  Q96DJ1 UniProtKB/Swiss-Prot
  Q96KI8 UniProtKB/Swiss-Prot
  Q99530 UniProtKB/Swiss-Prot
  Q9UCX1 UniProtKB/Swiss-Prot
  Q9UII3 UniProtKB/Swiss-Prot
  Q9UKL9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-23 AKR1C3  aldo-keto reductase family 1 member C3  AKR1C3  aldo-keto reductase family 1, member C3  Symbol and/or name change 5135510 APPROVED
2012-12-12 AKR1C3  aldo-keto reductase family 1, member C3  AKR1C3  aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)  Symbol and/or name change 5135510 APPROVED