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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306847
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1c1
Name: aldo-keto reductase family 1, member C1
Acc ID: CHEBI:521033
Term: dutasteride
Definition: An aza-steroid that is inasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, dutasteride is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. Dutasteride is used for the treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate gland.
Chemical ID: MESH:D000068538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c1increases expressionISOAKR1C1 (Homo sapiens)6480464CTDDutasteride results in increased expression of AKR1C1 mRNAPMID:16806904
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