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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1557553 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITIH2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1557553 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITIH2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1557553 | 6480464 | Tetrachlorodibenzodioxin affects the expression of ITIH2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1345234 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ITIH2 mRNA | CTD | PMID:20106945, PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1557553 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ITIH2 mRNA | CTD | PMID:19770486, PMID:33956508 | 4,4'-sulfonyldiphenol | increases expression | ISO | RGD:1557553 | 6480464 | bis(4-hydroxyphenyl)sulfone results in increased expression of ITIH2 mRNA | CTD | PMID:30951980 | aflatoxin B1 | decreases expression | ISO | RGD:1557553 | 6480464 | Aflatoxin B1 results in decreased expression of ITIH2 mRNA | CTD | PMID:19770486 | aflatoxin B1 | affects methylation | ISO | RGD:1345234 | 6480464 | Aflatoxin B1 affects the methylation of ITIH2 promoter | CTD | PMID:30157460 | aflatoxin B1 | decreases methylation | ISO | RGD:1345234 | 6480464 | Aflatoxin B1 results in decreased methylation of ITIH2 gene | CTD | PMID:27153756 | aflatoxin M1 | decreases expression | ISO | RGD:1345234 | 6480464 | Aflatoxin M1 results in decreased expression of ITIH2 mRNA | CTD | PMID:30928695 | amiodarone | increases expression | ISO | RGD:1345234 | 6480464 | Amiodarone results in increased expression of ITIH2 mRNA | CTD | PMID:19774075 | antirheumatic drug | decreases expression | ISO | RGD:1345234 | 6480464 | Antirheumatic Agents results in decreased expression of ITIH2 mRNA | CTD | PMID:24449571 | aristolochic acid A | increases expression | ISO | RGD:1345234 | 6480464 | aristolochic acid I results in increased expression of ITIH2 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases expression | ISO | RGD:1557553 | 6480464 | Benzo(a)pyrene results in increased expression of ITIH2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases methylation | ISO | RGD:1345234 | 6480464 | Benzo(a)pyrene results in increased methylation of ITIH2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | RGD:1557553 | 6480464 | Benzo(a)pyrene results in decreased expression of ITIH2 mRNA | CTD | PMID:19770486 | bisphenol A | affects expression | ISO | RGD:1345234 | 6480464 | bisphenol A affects the expression of ITIH2 mRNA | CTD | PMID:30903817 | bisphenol A | multiple interactions | ISO | RGD:1345234 | 6480464 | [[ginger extract results in increased abundance of Oils, Volatile] which co-treated with bisphenol A] affects the expression of ITIH2 protein | CTD | PMID:33376534 | bisphenol A | increases expression | ISO | RGD:1557553 | 6480464 | bisphenol A results in increased expression of ITIH2 mRNA | CTD | PMID:30245210, PMID:30951980 | bisphenol F | increases expression | ISO | RGD:1557553 | 6480464 | bisphenol F results in increased expression of ITIH2 mRNA | CTD | PMID:30951980 | butanal | decreases expression | ISO | RGD:1345234 | 6480464 | butyraldehyde results in decreased expression of ITIH2 mRNA | CTD | PMID:26079696 | cadmium atom | affects binding | ISO | RGD:1345234 | 6480464 | ITIH2 protein binds to Cadmium | CTD | PMID:23896426 | caffeine | increases phosphorylation | ISO | RGD:1345234 | 6480464 | Caffeine results in increased phosphorylation of ITIH2 protein | CTD | PMID:35688186 | calcium atom | multiple interactions | ISO | RGD:1345234 | 6480464 | Calcium promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] | CTD | PMID:16768462 | calcium dichloride | multiple interactions | ISO | RGD:1345234 | 6480464 | Calcium Chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] | CTD | PMID:16768462 | calcium(0) | multiple interactions | ISO | RGD:1345234 | 6480464 | Calcium promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] | CTD | PMID:16768462 | chloroprene | increases expression | ISO | RGD:1557553 | 6480464 | Chloroprene results in increased expression of ITIH2 mRNA | CTD | PMID:23125180 | clofibrate | multiple interactions | ISO | RGD:1557553 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of ITIH2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ITIH2 mRNA] | CTD | PMID:17585979 | clofibrate | decreases expression | ISO | RGD:1557553 | 6480464 | Clofibrate results in decreased expression of ITIH2 mRNA | CTD | PMID:17585979 | cobalt atom | increases expression | ISO | RGD:1557553 | 6480464 | Cobalt results in increased expression of ITIH2 mRNA | CTD | PMID:34468815 | cobalt dichloride | decreases expression | ISO | RGD:1345234 | 6480464 | cobaltous chloride results in decreased expression of ITIH2 mRNA | CTD | PMID:19376846 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of ITIH2 mRNA | CTD | PMID:24386269 | copper atom | affects binding | ISO | RGD:1345234 | 6480464 | ITIH2 protein binds to Copper | CTD | PMID:23896426 | copper(0) | affects binding | ISO | RGD:1345234 | 6480464 | ITIH2 protein binds to Copper | CTD | PMID:23896426 | copper(II) sulfate | decreases expression | ISO | RGD:1345234 | 6480464 | Copper Sulfate results in decreased expression of ITIH2 mRNA | CTD | PMID:19549813 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of ITIH2 mRNA | CTD | PMID:27523638 | cyclosporin A | decreases expression | ISO | RGD:1345234 | 6480464 | Cyclosporine results in decreased expression of ITIH2 mRNA | CTD | PMID:20106945 more ... | cyproconazole | decreases expression | ISO | RGD:1557553 | 6480464 | cyproconazole results in decreased expression of ITIH2 mRNA | CTD | PMID:22334560 | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of ITIH2 mRNA | CTD | PMID:29391264 | epoxiconazole | decreases expression | ISO | RGD:1557553 | 6480464 | epoxiconazole results in decreased expression of ITIH2 mRNA | CTD | PMID:22334560 | fipronil | increases expression | EXP | | 6480464 | fipronil results in increased expression of ITIH2 mRNA | CTD | PMID:23962444 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of ITIH2 mRNA | CTD | PMID:24136188 | glycidol | increases expression | EXP | | 6480464 | glycidol results in increased expression of ITIH2 mRNA | CTD | PMID:24395379 | hydrazine | increases expression | ISO | RGD:1557553 | 6480464 | hydrazine results in increased expression of ITIH2 mRNA | CTD | PMID:15282401 | hydroxyurea | increases expression | ISO | RGD:1557553 | 6480464 | Hydroxyurea results in increased expression of ITIH2 mRNA | CTD | PMID:12929121 | magnesium atom | multiple interactions | ISO | RGD:1345234 | 6480464 | Magnesium promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] | CTD | PMID:16768462 | magnesium dichloride | multiple interactions | ISO | RGD:1345234 | 6480464 | Magnesium Chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] | CTD | PMID:16768462 | manganese atom | multiple interactions | ISO | RGD:1345234 | 6480464 | Manganese promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] | CTD | PMID:16768462 | manganese(0) | multiple interactions | ISO | RGD:1345234 | 6480464 | Manganese promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] | CTD | PMID:16768462 | manganese(II) chloride | multiple interactions | ISO | RGD:1345234 | 6480464 | manganese chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] | CTD | PMID:16768462 | N-nitrosodiethylamine | decreases expression | ISO | RGD:1345234 | 6480464 | Diethylnitrosamine results in decreased expression of ITIH2 mRNA | CTD | PMID:21527772 | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of ITIH2 mRNA | CTD | PMID:24136188 | nickel atom | affects binding | ISO | RGD:1345234 | 6480464 | ITIH2 protein binds to Nickel | CTD | PMID:23896426 | nimesulide | decreases expression | EXP | | 6480464 | nimesulide results in decreased expression of ITIH2 mRNA | CTD | PMID:24136188 | olanzapine | affects phosphorylation | ISO | RGD:1345234 | 6480464 | olanzapine affects the phosphorylation of ITIH2 protein | CTD | PMID:25821032 | ozone | multiple interactions | ISO | RGD:1557553 | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of ITIH2 mRNA, [Air Pollutants results in increased abundance of Ozone] which results in increased expression of ITIH2 mRNA | CTD | PMID:34911549 | p-anisidine | increases expression | ISO | RGD:1557553 | 6480464 | 4-anisidine results in increased expression of ITIH2 mRNA | CTD | PMID:12929121 | p-toluidine | decreases expression | EXP | | 6480464 | 4-toluidine results in decreased expression of ITIH2 mRNA | CTD | PMID:27638505 | paclitaxel | increases expression | ISO | RGD:1557553 | 6480464 | Paclitaxel results in increased expression of ITIH2 mRNA | CTD | PMID:12929121 | paracetamol | multiple interactions | ISO | RGD:1557553 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of ITIH2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ITIH2 mRNA] | CTD | PMID:17585979 | paracetamol | decreases expression | ISO | RGD:1345234 | 6480464 | Acetaminophen results in decreased expression of ITIH2 mRNA | CTD | PMID:29067470 | paracetamol | affects expression | ISO | RGD:1557553 | 6480464 | Acetaminophen affects the expression of ITIH2 mRNA | CTD | PMID:17562736 | perfluorooctanoic acid | decreases expression | ISO | RGD:1345234 | 6480464 | perfluorooctanoic acid results in decreased expression of ITIH2 protein | CTD | PMID:26879310 | phenobarbital | affects expression | ISO | RGD:1345234 | 6480464 | Phenobarbital affects the expression of ITIH2 mRNA | CTD | PMID:19159669 | pioglitazone | multiple interactions | ISO | RGD:1557553 | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ITIH2 mRNA | CTD | PMID:27935865 | pirinixic acid | multiple interactions | ISO | RGD:1557553 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ITIH2 mRNA | CTD | PMID:19710929 | potassium dichromate | decreases expression | ISO | RGD:1557553 | 6480464 | Potassium Dichromate results in decreased expression of ITIH2 mRNA | CTD | PMID:23608068 | propanal | decreases expression | ISO | RGD:1345234 | 6480464 | propionaldehyde results in decreased expression of ITIH2 mRNA | CTD | PMID:26079696 | propiconazole | decreases expression | ISO | RGD:1557553 | 6480464 | propiconazole results in decreased expression of ITIH2 mRNA | CTD | PMID:22334560 | senecionine | decreases expression | ISO | RGD:1557553 | 6480464 | senecionine results in decreased expression of ITIH2 protein | CTD | PMID:35357534 | silicon dioxide | affects secretion | ISO | RGD:1345234 | 6480464 | Silicon Dioxide analog affects the secretion of ITIH2 protein | CTD | PMID:25895662 | silicon dioxide | decreases expression | ISO | RGD:1345234 | 6480464 | Silicon Dioxide analog results in decreased expression of ITIH2 mRNA | CTD | PMID:25895662 | sodium arsenite | affects expression | ISO | RGD:1557553 | 6480464 | sodium arsenite affects the expression of ITIH2 mRNA | CTD | PMID:17450228 | sodium arsenite | decreases expression | ISO | RGD:1345234 | 6480464 | sodium arsenite results in decreased expression of ITIH2 mRNA | CTD | PMID:29301061 | sodium arsenite | affects methylation | ISO | RGD:1345234 | 6480464 | sodium arsenite affects the methylation of ITIH2 gene | CTD | PMID:28589171 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of ITIH2 mRNA | CTD | PMID:31150632 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of ITIH2 mRNA | CTD | PMID:34492290 | Tributyltin oxide | increases expression | ISO | RGD:1557553 | 6480464 | bis(tri-n-butyltin)oxide results in increased expression of ITIH2 mRNA | CTD | PMID:18958704 | trichloroethene | multiple interactions | ISO | RGD:1557553 | 6480464 | PPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of ITIH2 mRNA] | CTD | PMID:15363585 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of ITIH2 mRNA | CTD | PMID:33387578 | valproic acid | decreases expression | ISO | RGD:1345234 | 6480464 | Valproic Acid results in decreased expression of ITIH2 mRNA | CTD | PMID:29154799 | valproic acid | affects expression | ISO | RGD:1345234 | 6480464 | Valproic Acid affects the expression of ITIH2 mRNA | CTD | PMID:25979313 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of ITIH2 mRNA | CTD | PMID:23869203 | zinc atom | affects binding | ISO | RGD:1345234 | 6480464 | ITIH2 protein binds to Zinc | CTD | PMID:23896426 | zinc(0) | affects binding | ISO | RGD:1345234 | 6480464 | ITIH2 protein binds to Zinc | CTD | PMID:23896426 | |