Itih2 (inter-alpha-trypsin inhibitor heavy chain 2)

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Gene: Itih2 (inter-alpha-trypsin inhibitor heavy chain 2) Rattus norvegicus

Analyze

Symbol:

Itih2

Name:

inter-alpha-trypsin inhibitor heavy chain 2

RGD ID:

1565426

Description:

Predicted to enable hyaluronic acid binding activity. Predicted to be involved in hyaluronan metabolic process and negative regulation of peptidase activity. Predicted to be located in extracellular region. Orthologous to human ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2); INTERACTS WITH cobalt dichloride; Cuprizon; endosulfan.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC498793; similar to inter-alpha-inhibitor H2 chain

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	68,375,518 - 68,411,849 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	68,375,567 - 68,411,841 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	17	72,160,734 - 72,197,248 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	72,160,735 - 72,195,509 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	73,846,130 - 73,882,952 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	79,688,702 - 79,726,869 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	17	67,862,012 - 67,898,344 (+)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hypoparathyroidism-deafness-renal disease syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

aflatoxin M1 (ISO)

amiodarone (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium atom (ISO)

caffeine (ISO)

calcium atom (ISO)

calcium dichloride (ISO)

calcium(0) (ISO)

chloroprene (ISO)

clofibrate (ISO)

cobalt atom (ISO)

cobalt dichloride (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

cyproconazole (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

fipronil (EXP)

flutamide (EXP)

glycidol (EXP)

hydrazine (ISO)

hydroxyurea (ISO)

magnesium atom (ISO)

magnesium dichloride (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

N-nitrosodiethylamine (ISO)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

olanzapine (ISO)

ozone (ISO)

p-anisidine (ISO)

p-toluidine (EXP)

paclitaxel (ISO)

paracetamol (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pioglitazone (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

propanal (ISO)

propiconazole (ISO)

senecionine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

Tributyltin oxide (ISO)

trichloroethene (EXP,ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

hyaluronan metabolic process (IEA)

negative regulation of peptidase activity (IEA)

Cellular Component

extracellular region (IEA)

Molecular Function

hyaluronic acid binding (ISO)

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	GOA pipeline	RGD automated data pipeline
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:20458337	PMID:22516433	PMID:23533145	PMID:24006456

Genomics

Comparative Map Data

Itih2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	68,375,518 - 68,411,849 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	68,375,567 - 68,411,841 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	17	72,160,734 - 72,197,248 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	72,160,735 - 72,195,509 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	73,846,130 - 73,882,952 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	79,688,702 - 79,726,869 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	17	67,862,012 - 67,898,344 (+)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

ITIH2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	7,703,316 - 7,749,520 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	10	7,703,316 - 7,749,520 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	7,745,279 - 7,791,483 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	7,785,242 - 7,831,489 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	7,785,342 - 7,831,488	NCBI
Celera	10	7,671,050 - 7,717,293 (+)	NCBI		Celera
Cytogenetic Map	10	p14	NCBI
HuRef	10	7,663,584 - 7,709,831 (+)	NCBI		HuRef
CHM1_1	10	7,745,665 - 7,791,444 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	7,703,948 - 7,750,283 (+)	NCBI		T2T-CHM13v2.0

Itih2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	10,099,402 - 10,135,494 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	10,099,404 - 10,136,207 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	10,094,591 - 10,130,683 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	10,094,593 - 10,131,396 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	10,016,218 - 10,052,310 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	10,012,444 - 10,048,517 (-)	NCBI		MGSCv36	mm8
Celera	2	10,033,646 - 10,069,833 (-)	NCBI		Celera
Cytogenetic Map	2	A1	NCBI
cM Map	2	6.89	NCBI

Itih2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955421	24,150,526 - 24,189,810 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955421	24,149,081 - 24,189,810 (+)	NCBI	ChiLan1.0	ChiLan1.0

ITIH2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	10	7,713,517 - 7,762,756 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	7,713,454 - 7,762,756 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	10	7,732,931 - 7,782,362 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

ITIH2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	28,367,842 - 28,403,610 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	28,367,908 - 28,403,667 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	25,408,695 - 25,444,418 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	28,749,446 - 28,785,349 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	28,749,543 - 28,785,325 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	25,855,861 - 25,891,725 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	26,697,790 - 26,733,520 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	27,415,891 - 27,451,788 (-)	NCBI		UU_Cfam_GSD_1.0

Itih2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	30,900,059 - 30,936,820 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	7,065,406 - 7,101,855 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936484	7,064,836 - 7,101,872 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ITIH2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	63,635,210 - 63,672,163 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	63,635,206 - 63,672,200 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	69,732,423 - 69,752,000 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ITIH2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	7,748,818 - 7,794,932 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	7,749,464 - 7,794,933 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	13,144,753 - 13,190,763 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Itih2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624775	2,667,781 - 2,707,046 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624775	2,667,840 - 2,706,951 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Itih2
278 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	89
Count of miRNA genes:	76
Interacting mature miRNAs:	81
Transcripts:	ENSRNOT00000038817
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	31368391	73951021	Rat
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	31990784	76990784	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	31990784	81292925	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	34550843	73951021	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	35837085	69599340	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	37479847	82479847	Rat
2317054	Aia12	Adjuvant induced arthritis QTL 12	4.24		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	38281509	83281509	Rat
2317060	Aia26	Adjuvant induced arthritis QTL 26	3.22		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	38281509	83281509	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40540041	80387013	Rat
1358295	Aocep1	Aortic cell protein QTL 1	6.1	0.00000071	thoracic aorta cellular protein amount (VT:0010598)	aortic cell percentage	17	40990005	85990005	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	17	42073160	69599340	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	42073160	69599340	Rat
7411575	Bw140	Body weight QTL 140	30.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
8694181	Bw151	Body weight QTL 151	4.36	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	49920154	86533673	Rat
2303580	Gluco49	Glucose level QTL 49	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	50040271	86533673	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	50909099	86022412	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	53498828	82479847	Rat
70210	Cm15	Cardiac mass QTL 15	6.5		heart right ventricle mass (VT:0007033)	heart right ventricle wet weight (CMO:0000072)	17	57246723	70156904	Rat
1600398	Edcs5	Endometrial carcinoma susceptibility QTL 5	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	17	57246723	70852846	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	57246843	82046127	Rat
7488963	Bp369	Blood pressure QTL 369		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	59005649	77910000	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	60781426	86533673	Rat
7411577	Bw141	Body weight QTL 141		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	62619516	86533673	Rat
1300131	Bp193	Blood pressure QTL 193	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	63640009	73951021	Rat
631502	Cm26	Cardiac mass QTL 26	3.71		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	65703580	81153923	Rat

Markers in Region

D17Got89

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	68,380,268 - 68,380,486 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	72,166,081 - 72,166,298	NCBI	Rnor6.0
Rnor_5.0	17	73,851,470 - 73,851,687	UniSTS	Rnor5.0
RGSC_v3.4	17	79,695,097 - 79,695,315	RGD	RGSC3.4
RGSC_v3.4	17	79,695,098 - 79,695,315	UniSTS	RGSC3.4
RGSC_v3.1	17	79,705,931 - 79,706,148	RGD
Celera	17	67,866,764 - 67,866,981	UniSTS
RH 3.4 Map	17	649.2	UniSTS
RH 3.4 Map	17	649.2	RGD
RH 2.0 Map	17	593.2	RGD
Cytogenetic Map	17	q12.3	UniSTS

RH139079

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	68,375,573 - 68,375,718 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	72,160,797 - 72,160,941	NCBI	Rnor6.0
Rnor_5.0	17	73,846,186 - 73,846,330	UniSTS	Rnor5.0
RGSC_v3.4	17	79,689,919 - 79,690,063	UniSTS	RGSC3.4
Celera	17	67,862,070 - 67,862,214	UniSTS
RH 3.4 Map	17	657.0	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High			7	7		7
Medium			35	34		34					1
Low		2	9		5		5	5	9	11	25	5	5
Below cutoff	1	22	6		11		3	4	39	15	11	3	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XR_005495483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_009617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_596896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC100087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000038817 ⟹ ENSRNOP00000036443

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	68,375,567 - 68,409,899 (+)	Ensembl
Rnor_6.0 Ensembl	17	72,160,735 - 72,195,509 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107455 ⟹ ENSRNOP00000088103

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	68,375,567 - 68,410,659 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000120221 ⟹ ENSRNOP00000082662

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	68,375,567 - 68,411,841 (+)	Ensembl

RefSeq Acc Id:

XR_005495483

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	68,375,518 - 68,411,849 (+)	NCBI

Protein Sequences


GenBank Protein	AAI00088	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000036443 ⟸ ENSRNOT00000038817

RefSeq Acc Id:

ENSRNOP00000082662 ⟸ ENSRNOT00000120221

RefSeq Acc Id:

ENSRNOP00000088103 ⟸ ENSRNOT00000107455

Protein Domains

VIT VWFA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZFH5-F1-model_v2	AlphaFold	D3ZFH5	1-826	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700565

Promoter ID:

EPDNEW_R11082

Type:

initiation region

Name:

Itih2_1

Description:

inter-alpha-trypsin inhibitor heavy chain 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	72,160,797 - 72,160,857	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565426	AgrOrtholog
BioCyc Gene	G2FUF-8757	BioCyc
Ensembl Genes	ENSRNOG00000001066	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000036443.7	UniProtKB/TrEMBL
	ENSRNOP00000082662.1	UniProtKB/TrEMBL
	ENSRNOP00000088103.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000038817.7	UniProtKB/TrEMBL
	ENSRNOT00000107455.1	UniProtKB/TrEMBL
	ENSRNOT00000120221	ENTREZGENE
	ENSRNOT00000120221.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.410	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7370417	IMAGE-MGC_LOAD
InterPro	ITI_HC_C	UniProtKB/TrEMBL
	VIT	UniProtKB/TrEMBL
	VWF_A	UniProtKB/TrEMBL
	vWFA_dom_sf	UniProtKB/TrEMBL
MGC_CLONE	MGC:112781	IMAGE-MGC_LOAD
NCBI Gene	Itih2	ENTREZGENE
Pfam	ITI_HC_C	UniProtKB/TrEMBL
	VIT	UniProtKB/TrEMBL
	VWA	UniProtKB/TrEMBL
PhenoGen	Itih2	PhenoGen
PROSITE	VIT	UniProtKB/TrEMBL
	VWFA	UniProtKB/TrEMBL
SMART	VIT	UniProtKB/TrEMBL
	VWA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53300	UniProtKB/TrEMBL
UniProt	A0A8I5ZVC4_RAT	UniProtKB/TrEMBL
	A0A8I6A7A2_RAT	UniProtKB/TrEMBL
	D3ZFH5_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-09	Itih2	inter-alpha-trypsin inhibitor heavy chain 2	LOC498793	similar to inter-alpha-inhibitor H2 chain	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC498793	similar to inter-alpha-inhibitor H2 chain			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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