Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Itih5 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Itih5 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ITIH5 mRNA | CTD | PMID:36331819 | Itih5 | Rat | 1,1-dichloroethene | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of ITIH5 mRNA | CTD | PMID:26682919 | Itih5 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of ITIH5 mRNA | CTD | PMID:22206623 | Itih5 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Itih5 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of ITIH5 mRNA | CTD | PMID:17555576 | Itih5 | Rat | 17beta-estradiol | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of ITIH5 mRNA | CTD | PMID:20823114 | Itih5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ITIH5 mRNA | CTD | PMID:19933214 and PMID:26290441 | Itih5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Itih5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of ITIH5 mRNA | CTD | PMID:20702594 and PMID:26377647 | Itih5 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | affects expression | ISO | Itih5 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:20702594 | Itih5 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | affects expression | ISO | Itih5 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:38648751 | Itih5 | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | tetrabromobisphenol A results in decreased expression of ITIH5 mRNA | CTD | PMID:25172293 | Itih5 | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of ITIH5 mRNA | CTD | PMID:20188158 | Itih5 | Rat | 3,4-methylenedioxymethamphetamine | increases methylation | ISO | Itih5 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of ITIH5 promoter | CTD | PMID:26251327 | Itih5 | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of ITIH5 mRNA | CTD | PMID:26251327 | Itih5 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | bisphenol S results in increased expression of ITIH5 mRNA | CTD | PMID:30951980 | Itih5 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of ITIH5 mRNA | CTD | PMID:28973697 | Itih5 | Rat | actinomycin D | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of ITIH5 mRNA and [Dactinomycin co-treated with nutlin 3] results in increased secretion of ITIH5 protein | CTD | PMID:38460933 | Itih5 | Rat | aflatoxin B1 | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of ITIH5 mRNA | CTD | PMID:19770486 | Itih5 | Rat | aflatoxin B1 | decreases methylation | ISO | ITIH5 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of ITIH5 gene | CTD | PMID:27153756 | Itih5 | Rat | Aflatoxin B2 alpha | increases methylation | ISO | ITIH5 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of ITIH5 polyA tail | CTD | PMID:30157460 | Itih5 | Rat | antirheumatic drug | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of ITIH5 mRNA | CTD | PMID:24449571 | Itih5 | Rat | arsane | affects methylation | ISO | ITIH5 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ITIH5 gene | CTD | PMID:25304211 | Itih5 | Rat | arsenic atom | affects methylation | ISO | ITIH5 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ITIH5 gene | CTD | PMID:25304211 | Itih5 | Rat | arsenite(3-) | increases methylation | ISO | ITIH5 (Homo sapiens) | 6480464 | arsenite results in increased methylation of ITIH5 promoter | CTD | PMID:23974009 | Itih5 | Rat | belinostat | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA | CTD | PMID:27188386 | Itih5 | Rat | belinostat | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | belinostat results in increased expression of ITIH5 mRNA | CTD | PMID:26272509 | Itih5 | Rat | benzo[a]pyrene | increases methylation | ISO | ITIH5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ITIH5 exon | CTD | PMID:27901495 | Itih5 | Rat | benzo[a]pyrene | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of ITIH5 mRNA | CTD | PMID:19770486 | Itih5 | Rat | benzo[a]pyrene | affects methylation | ISO | ITIH5 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of ITIH5 promoter | CTD | PMID:27901495 | Itih5 | Rat | benzo[a]pyrene | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of ITIH5 mRNA | CTD | PMID:20106945 more ... | Itih5 | Rat | benzo[e]pyrene | increases methylation | ISO | ITIH5 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of ITIH5 polyA tail | CTD | PMID:30157460 | Itih5 | Rat | bisphenol A | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | bisphenol A results in increased expression of ITIH5 mRNA | CTD | PMID:30951980 and PMID:35598803 | Itih5 | Rat | bisphenol A | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | bisphenol A promotes the reaction [ITIH5 protein binds to ESR1 protein] | CTD | PMID:27156127 | Itih5 | Rat | bisphenol F | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | bisphenol F results in increased expression of ITIH5 mRNA | CTD | PMID:30951980 and PMID:38685157 | Itih5 | Rat | bucladesine | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of ITIH5 mRNA | CTD | PMID:20823114 | Itih5 | Rat | carbon nanotube | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | Itih5 | Rat | CGP 52608 | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ITIH5 gene] | CTD | PMID:28238834 | Itih5 | Rat | chloropicrin | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | chloropicrin results in increased expression of ITIH5 mRNA | CTD | PMID:26352163 | Itih5 | Rat | choline | multiple interactions | ISO | Itih5 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITIH5 mRNA | CTD | PMID:20938992 | Itih5 | Rat | chrysene | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | chrysene results in increased expression of ITIH5 mRNA | CTD | PMID:26377693 | Itih5 | Rat | cisplatin | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of ITIH5 mRNA | CTD | PMID:27392435 | Itih5 | Rat | cisplatin | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of ITIH5 mRNA | CTD | PMID:27392435 | Itih5 | Rat | cobalt dichloride | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of ITIH5 mRNA | CTD | PMID:20105288 | Itih5 | Rat | copper(II) sulfate | decreases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of ITIH5 mRNA | CTD | PMID:19549813 | Itih5 | Rat | cyclosporin A | decreases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of ITIH5 mRNA | CTD | PMID:25562108 and PMID:27989131 | Itih5 | Rat | deoxynivalenol | decreases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | deoxynivalenol results in decreased expression of ITIH5 mRNA | CTD | PMID:31863870 | Itih5 | Rat | dextran sulfate | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | Dextran Sulfate results in decreased expression of ITIH5 mRNA | CTD | PMID:35093514 | Itih5 | Rat | dioxygen | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of ITIH5 mRNA | CTD | PMID:24205000 | Itih5 | Rat | dioxygen | multiple interactions | ISO | Itih5 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ITIH5 mRNA | CTD | PMID:30529165 | Itih5 | Rat | dorsomorphin | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Itih5 | Rat | doxorubicin | decreases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of ITIH5 mRNA | CTD | PMID:29803840 | Itih5 | Rat | entinostat | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA | CTD | PMID:27188386 | Itih5 | Rat | entinostat | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | entinostat results in increased expression of ITIH5 mRNA | CTD | PMID:26272509 and PMID:27188386 | Itih5 | Rat | epoxiconazole | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of ITIH5 mRNA | CTD | PMID:35436446 | Itih5 | Rat | ethanol | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | Ethanol results in increased expression of ITIH5 mRNA | CTD | PMID:30319688 | Itih5 | Rat | ethanol | affects expression | ISO | Itih5 (Mus musculus) | 6480464 | Ethanol affects the expression of ITIH5 mRNA | CTD | PMID:30319688 | Itih5 | Rat | folic acid | multiple interactions | ISO | Itih5 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITIH5 mRNA | CTD | PMID:20938992 | Itih5 | Rat | furan | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | furan results in increased expression of ITIH5 mRNA | CTD | PMID:24183702 | Itih5 | Rat | L-methionine | multiple interactions | ISO | Itih5 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITIH5 mRNA | CTD | PMID:20938992 | Itih5 | Rat | lead diacetate | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | lead acetate results in increased expression of ITIH5 mRNA | CTD | PMID:21829687 | Itih5 | Rat | medroxyprogesterone acetate | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of ITIH5 mRNA | CTD | PMID:20823114 | Itih5 | Rat | mercury dibromide | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of ITIH5 mRNA | CTD | PMID:26272509 | Itih5 | Rat | mercury dibromide | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA | CTD | PMID:27188386 | Itih5 | Rat | methapyrilene | increases methylation | ISO | ITIH5 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of ITIH5 polyA tail | CTD | PMID:30157460 | Itih5 | Rat | N-nitrosodiethylamine | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | Diethylnitrosamine results in increased expression of ITIH5 mRNA | CTD | PMID:24535843 | Itih5 | Rat | nickel atom | decreases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | Nickel results in decreased expression of ITIH5 mRNA | CTD | PMID:24768652 and PMID:25583101 | Itih5 | Rat | Nutlin-3 | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of ITIH5 mRNA and [Dactinomycin co-treated with nutlin 3] results in increased secretion of ITIH5 protein | CTD | PMID:38460933 | Itih5 | Rat | ozone | multiple interactions | ISO | Itih5 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of ITIH5 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of ITIH5 mRNA | CTD | PMID:34911549 | Itih5 | Rat | panobinostat | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | Panobinostat results in increased expression of ITIH5 mRNA | CTD | PMID:26272509 | Itih5 | Rat | panobinostat | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA | CTD | PMID:27188386 | Itih5 | Rat | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of ITIH5 mRNA | CTD | PMID:32680482 | Itih5 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Itih5 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ITIH5 mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of ITIH5 mRNA | CTD | PMID:36331819 | Itih5 | Rat | phenobarbital | multiple interactions | ISO | Itih5 (Mus musculus) | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ITIH5 mRNA] | CTD | PMID:19482888 | Itih5 | Rat | phenobarbital | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of ITIH5 mRNA | CTD | PMID:19482888 | Itih5 | Rat | phenobarbital | affects expression | ISO | Itih5 (Mus musculus) | 6480464 | Phenobarbital affects the expression of ITIH5 mRNA | CTD | PMID:23091169 | Itih5 | Rat | phenylmercury acetate | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA | CTD | PMID:27188386 | Itih5 | Rat | phenylmercury acetate | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of ITIH5 mRNA | CTD | PMID:26272509 | Itih5 | Rat | pirinixic acid | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of ITIH5 mRNA | CTD | PMID:23811191 | Itih5 | Rat | resveratrol | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of ITIH5 mRNA | CTD | PMID:23557933 | Itih5 | Rat | SB 431542 | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Itih5 | Rat | silicon dioxide | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of ITIH5 mRNA | CTD | PMID:23221170 | Itih5 | Rat | sodium arsenate | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | sodium arsenate results in decreased expression of ITIH5 mRNA | CTD | PMID:21795629 | Itih5 | Rat | sodium arsenite | affects expression | ISO | Itih5 (Mus musculus) | 6480464 | sodium arsenite affects the expression of ITIH5 mRNA | CTD | PMID:26674514 | Itih5 | Rat | tamoxifen | affects expression | ISO | Itih5 (Mus musculus) | 6480464 | Tamoxifen affects the expression of ITIH5 mRNA | CTD | PMID:17555576 | Itih5 | Rat | tetrachloromethane | affects expression | ISO | Itih5 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of ITIH5 mRNA | CTD | PMID:31919559 | Itih5 | Rat | tetrachloromethane | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of ITIH5 mRNA | CTD | PMID:27339419 | Itih5 | Rat | titanium dioxide | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of ITIH5 mRNA | CTD | PMID:23557971 | Itih5 | Rat | trichostatin A | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of ITIH5 mRNA | CTD | PMID:24935251 | Itih5 | Rat | triclosan | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | Triclosan results in increased expression of ITIH5 mRNA | CTD | PMID:30510588 | Itih5 | Rat | triphenyl phosphate | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | triphenyl phosphate results in increased expression of ITIH5 mRNA | CTD | PMID:28934090 | Itih5 | Rat | triptonide | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | triptonide results in increased expression of ITIH5 mRNA | CTD | PMID:33045310 | Itih5 | Rat | troglitazone | decreases expression | ISO | Itih5 (Mus musculus) | 6480464 | Troglitazone results in decreased expression of ITIH5 mRNA | CTD | PMID:28973697 | Itih5 | Rat | valproic acid | increases expression | ISO | Itih5 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of ITIH5 mRNA | CTD | PMID:21427059 and PMID:24896083 | Itih5 | Rat | valproic acid | multiple interactions | ISO | ITIH5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA | CTD | PMID:27188386 | Itih5 | Rat | valproic acid | affects expression | ISO | ITIH5 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of ITIH5 mRNA | CTD | PMID:25979313 | Itih5 | Rat | valproic acid | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of ITIH5 mRNA | CTD | PMID:23179753 more ... | Itih5 | Rat | vorinostat | increases expression | ISO | ITIH5 (Homo sapiens) | 6480464 | Vorinostat results in increased expression of ITIH5 mRNA | CTD | PMID:27188386 | |