Akr1c19 (aldo-keto reductase family 1, member C19) - Rat Genome Database

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Gene: Akr1c19 (aldo-keto reductase family 1, member C19) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Akr1c19
Name: aldo-keto reductase family 1, member C19
RGD ID: 1562954
Description: Predicted to enable alditol:NADP+ 1-oxidoreductase activity; ketosteroid monooxygenase activity; and steroid dehydrogenase activity. Predicted to be involved in steroid metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C4 (aldo-keto reductase family 1 member C4).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC307096; NAD-preferring dehydrogenase for 17beta-hydroxysteroids and 9-hydroxyprostaglandins; RAKi; RGD1562954; similar to aldo-keto reductase family 1, member C12
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81770,913,916 - 70,934,959 (+)NCBIGRCr8
mRatBN7.21766,001,358 - 66,027,226 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,004,002 - 66,025,047 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,485,917 - 69,506,991 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,314,763 - 73,335,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,357,741 - 67,378,816 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,653,003 - 69,675,204 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,654,170 - 69,675,203 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,361,590 - 71,384,879 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,162,221 - 77,183,258 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1765,520,952 - 65,541,998 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1793046   PMID:33482148  


Genomics

Variants

.
Variants in Akr1c19
65 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:73
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000058351
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176364000973951021Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 12 13 10 7 10 2 2 27 23 11 2
Low 29 44 31 12 31 6 9 58 8 18 6
Below cutoff 2 12

Sequence


RefSeq Acc Id: ENSRNOT00000058351   ⟹   ENSRNOP00000055152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1766,004,002 - 66,025,047 (+)Ensembl
Rnor_6.0 Ensembl1769,654,170 - 69,675,203 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109545   ⟹   ENSRNOP00000080058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1766,004,002 - 66,023,967 (+)Ensembl
RefSeq Acc Id: NM_001100576   ⟹   NP_001094046
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,913,916 - 70,934,959 (+)NCBI
mRatBN7.21766,004,002 - 66,025,047 (+)NCBI
Rnor_6.01769,654,170 - 69,675,203 (+)NCBI
Rnor_5.01771,361,590 - 71,384,879 (+)NCBI
RGSC_v3.41777,162,221 - 77,183,258 (+)RGD
Celera1765,520,952 - 65,541,998 (+)RGD
Sequence:
RefSeq Acc Id: XM_039095774   ⟹   XP_038951702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,914,050 - 70,934,959 (+)NCBI
mRatBN7.21766,004,520 - 66,027,226 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001094046 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951702 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB21513 (Get FASTA)   NCBI Sequence Viewer  
  BCM29195 (Get FASTA)   NCBI Sequence Viewer  
  EDL78570 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000055152
  ENSRNOP00000055152.1
  ENSRNOP00000080058.1
RefSeq Acc Id: NP_001094046   ⟸   NM_001100576
- UniProtKB: D3ZEL2 (UniProtKB/TrEMBL),   A6JLP3 (UniProtKB/TrEMBL),   A0A7I8HPA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000055152   ⟸   ENSRNOT00000058351
RefSeq Acc Id: XP_038951702   ⟸   XM_039095774
- Peptide Label: isoform X1
- UniProtKB: D3ZEL2 (UniProtKB/TrEMBL),   A6JLP3 (UniProtKB/TrEMBL),   A0A7I8HPA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000080058   ⟸   ENSRNOT00000109545
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZEL2-F1-model_v2 AlphaFold D3ZEL2 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700545
Promoter ID:EPDNEW_R11068
Type:multiple initiation site
Name:Akr1c19_1
Description:aldo-keto reductase family 1, member C19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01769,659,498 - 69,659,558EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562954 AgrOrtholog
BioCyc Gene G2FUF-8835 BioCyc
Ensembl Genes ENSRNOG00000038319 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058351 ENTREZGENE
  ENSRNOT00000058351.2 UniProtKB/TrEMBL
  ENSRNOT00000109545.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro AKR1C UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/TrEMBL
  Aldo/keto_reductase_sg UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
KEGG Report rno:307096 UniProtKB/TrEMBL
NCBI Gene 307096 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1, MEMBER C19 UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
PhenoGen Akr1c19 PhenoGen
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038319 RatGTEx
Superfamily-SCOP Aldo/ket_red UniProtKB/TrEMBL
UniProt A0A7I8HPA0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPB2_RAT UniProtKB/TrEMBL
  A6JLP3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZEL2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-03 Akr1c19  aldo-keto reductase family 1, member C19  RGD1562954_predicted  similar to aldo-keto reductase family 1, member C12 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562954_predicted  similar to aldo-keto reductase family 1, member C12 (predicted)  LOC307096  similar to aldo-keto reductase family 1, member C12  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC307096  similar to aldo-keto reductase family 1, member C12      Symbol and Name status set to provisional 70820 PROVISIONAL