Gtpbp4 (GTP binding protein 4) - Rat Genome Database

Name: Gtpbp4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Gtpbp4 (GTP binding protein 4) Rattus norvegicus

Analyze

Symbol:

Gtpbp4

Name:

GTP binding protein 4

RGD ID:

620783

Description:

Predicted to enable GTP binding activity; GTPase activity; and RNA binding activity. Predicted to be involved in several processes, including negative regulation of collagen binding activity; protein stabilization; and regulation of protein modification process. Predicted to act upstream of or within maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleus. Used to study end stage renal disease. Orthologous to human GTPBP4 (GTP binding protein 4); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

chronic renal failure gene protein; Crfg; G protein-binding protein CRFG; GTP-binding protein 4; LOC498786; LOC683324; LOC689822; nucleolar GTP-binding protein 1; RGD1563564; similar to GTP-binding protein NGB; similar to Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GTPBP4 (GTP binding protein 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther
Mus musculus (house mouse):	Gtpbp4 (GTP binding protein 4)	HGNC	EggNOG, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Gtpbp4 (GTP binding protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GTPBP4 (GTP binding protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GTPBP4 (GTP binding protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gtpbp4 (GTP binding protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GTPBP4 (GTP binding protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GTPBP4 (GTP binding protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gtpbp4 (GTP binding protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GTPBP4 (GTP binding protein 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gtpbp4 (GTP binding protein 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gtpbp4 (GTP binding protein 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NOG1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Non1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nog-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	61,308,033 - 61,328,184 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	17	61,308,014 - 61,418,009 (+)	Ensembl
Rnor_6.0	17	63,111,086 - 63,145,618 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	63,110,254 - 63,145,577 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	59,576,852 - 59,621,031 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	17	64,910,285 - 64,916,648 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	17	64,882,150 - 64,895,590 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	72,100,899 - 72,120,636 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	17	72,111,731 - 72,131,468 (+)	NCBI
Celera	17	59,257,948 - 59,272,929 (-)	NCBI		Celera
Cytogenetic Map	17	q12.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

end stage renal disease (IDA)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-butoxyethanol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

5-fluorouracil (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid (ISO)

Aroclor 1254 (ISO)

benzatropine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (EXP,ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

dioxygen (ISO)

disodium selenite (ISO)

ethanol (ISO)

fluoranthene (ISO)

flutamide (EXP)

hydrogen peroxide (ISO)

isobutanol (ISO)

ivermectin (ISO)

menadione (ISO)

methotrexate (ISO)

microcystin-LR (ISO)

paracetamol (ISO)

paraquat (EXP)

pentachlorophenol (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

sirolimus (EXP)

sulforaphane (ISO)

tacrolimus hydrate (EXP)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

tetrahydropalmatine (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (EXP)

Triptolide (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (ISO)

negative regulation of cell migration (ISO,ISS)

negative regulation of cell population proliferation (ISO,ISS)

negative regulation of cell-cell adhesion (ISO,ISS)

negative regulation of collagen binding (ISO,ISS)

negative regulation of DNA replication (ISO,ISS)

negative regulation of protein ubiquitination (ISO,ISS)

protein stabilization (ISO,ISS)

regulation of cyclin-dependent protein serine/threonine kinase activity (ISO,ISS)

ribosomal large subunit biogenesis (IBA)

ribosome biogenesis (IEA)

Cellular Component

cytoplasm (ISO,ISS)

cytosol (ISO)

nuclear membrane (ISO)

nucleolus (IBA,IEA,ISO)

nucleoplasm (ISO)

nucleus (IDA,ISO,ISS)

perinuclear region of cytoplasm (ISO,ISS)

Molecular Function

GTP binding (IEA,ISO,ISS)

GTPase activity (IBA,ISO,ISS)

protein binding (ISO)

RNA binding (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

ribosome biogenesis pathway (IEA)

External Pathway Database Links

KEGG Pathway

Ribosome biogenesis in eukaryotes

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease.	Laping NJ, etal., J Am Soc Nephrol 2001 May;12(5):883-90.
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:16210410	PMID:17210637	PMID:19946888	PMID:21630459	PMID:22658674	PMID:22681889	PMID:25190460

Genomics

Comparative Map Data

Gtpbp4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	61,308,033 - 61,328,184 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	17	61,308,014 - 61,418,009 (+)	Ensembl
Rnor_6.0	17	63,111,086 - 63,145,618 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	63,110,254 - 63,145,577 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	59,576,852 - 59,621,031 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	17	64,910,285 - 64,916,648 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	17	64,882,150 - 64,895,590 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	72,100,899 - 72,120,636 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	17	72,111,731 - 72,131,468 (+)	NCBI
Celera	17	59,257,948 - 59,272,929 (-)	NCBI		Celera
Cytogenetic Map	17	q12.1	NCBI

GTPBP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	988,434 - 1,019,932 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	10	988,434 - 1,019,932 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	1,034,374 - 1,065,872 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	1,024,349 - 1,053,708 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	10	1,024,348 - 1,053,707	NCBI
Celera	10	984,242 - 1,013,986 (+)	NCBI
Cytogenetic Map	10	p15.3	NCBI
HuRef	10	973,776 - 1,003,177 (+)	NCBI		HuRef
CHM1_1	10	1,033,522 - 1,062,866 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	985,662 - 1,017,099 (+)	NCBI

Gtpbp4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	9,022,106 - 9,046,144 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	13	9,016,367 - 9,046,119 (-)	Ensembl
GRCm38	13	8,972,070 - 8,996,116 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	8,966,331 - 8,996,083 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	8,971,710 - 8,995,258 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	13	8,971,710 - 8,995,258 (-)	NCBI			mm8
Celera	13	8,914,114 - 8,937,545 (-)	NCBI		Celera
Cytogenetic Map	13	A1	NCBI

Gtpbp4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955492	5,594 - 34,111 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955492	5,594 - 33,558 (-)	NCBI	ChiLan1.0	ChiLan1.0

GTPBP4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	10	1,071,809 - 1,103,527 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	1,071,809 - 1,103,521 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	10	1,023,295 - 1,055,818 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

GTPBP4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	33,936,629 - 33,955,947 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	33,936,637 - 34,024,769 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	30,973,045 - 30,991,292 (-)	NCBI
ROS_Cfam_1.0	2	34,322,186 - 34,341,038 (-)	NCBI
ROS_Cfam_1.0 Ensembl	2	34,322,193 - 34,340,957 (-)	Ensembl
UMICH_Zoey_3.1	2	31,405,444 - 31,424,272 (-)	NCBI
UNSW_CanFamBas_1.0	2	32,245,151 - 32,263,987 (-)	NCBI
UU_Cfam_GSD_1.0	2	32,992,243 - 33,011,090 (-)	NCBI

Gtpbp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	36,936,100 - 36,961,994 (-)	NCBI
SpeTri2.0	NW_004936484	13,101,328 - 13,127,211 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GTPBP4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	68,547,317 - 68,568,713 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	68,547,316 - 68,566,040 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	75,547,092 - 75,575,126 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GTPBP4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	953,062 - 981,213 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	9	952,663 - 981,353 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666051	6,007,162 - 6,035,503 (+)	NCBI	Vero_WHO_p1.0

Gtpbp4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624775	9,933,339 - 9,965,761 (-)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624775	9,933,500 - 9,965,816 (-)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

RH137031

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	61,328,594 - 61,328,807 (-)	MAPPER	mRatBN7.2
mRatBN7.2	17	61,328,594 - 61,328,807 (+)	MAPPER	mRatBN7.2
mRatBN7.2	17	61,417,889 - 61,418,102 (+)	MAPPER	mRatBN7.2
mRatBN7.2	17	61,417,889 - 61,418,102 (-)	MAPPER	mRatBN7.2
Rnor_6.0	17	57,811,450 - 57,811,662	NCBI	Rnor6.0
Rnor_6.0	17	63,110,347 - 63,110,559	NCBI	Rnor6.0
Rnor_5.0	17	64,881,240 - 64,881,452	UniSTS	Rnor5.0
Rnor_5.0	17	59,620,726 - 59,620,938	UniSTS	Rnor5.0
Cytogenetic Map	17	q12.1	UniSTS

AU049302

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	61,400,626 - 61,400,896 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	57,788,636 - 57,788,919	NCBI	Rnor6.0
Rnor_6.0	17	57,643,170 - 57,643,435	NCBI	Rnor6.0
Rnor_5.0	17	59,597,912 - 59,598,195	UniSTS	Rnor5.0
Rnor_5.0	17	59,456,474 - 59,456,739	UniSTS	Rnor5.0
Cytogenetic Map	17	q12.1	UniSTS

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
7394837	Memor18	Memory QTL 18			exploratory behavior trait (VT:0010471)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	17	18640182	63640182	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	31368391	62109574	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	31368391	73951021	Rat
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	31990784	76990784	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	31990784	81292925	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	34550843	73951021	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	35837085	69599340	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	37479847	82479847	Rat
2317054	Aia12	Adjuvant induced arthritis QTL 12	4.24		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	38281509	83281509	Rat
2317060	Aia26	Adjuvant induced arthritis QTL 26	3.22		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	38281509	83281509	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40540041	80387013	Rat
1358295	Aocep1	Aortic cell protein QTL 1	6.1	0.00000071	thoracic aorta cellular protein amount (VT:0010598)	aortic cell percentage	17	40990005	85990005	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	17	42073160	69599340	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	42073160	69599340	Rat
7411575	Bw140	Body weight QTL 140	30.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
8694181	Bw151	Body weight QTL 151	4.36	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	49920154	86533673	Rat
2303580	Gluco49	Glucose level QTL 49	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	50040271	86533673	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	50909099	86022412	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	53498828	82479847	Rat
70210	Cm15	Cardiac mass QTL 15	6.5		heart right ventricle mass (VT:0007033)	heart right ventricle wet weight (CMO:0000072)	17	57246723	70156904	Rat
1600398	Edcs5	Endometrial carcinoma susceptibility QTL 5	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	17	57246723	70852846	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	57246843	82046127	Rat
7488963	Bp369	Blood pressure QTL 369		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	59005649	77910000	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	60781426	86533673	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	121
Count of miRNA genes:	93
Interacting mature miRNAs:	101
Transcripts:	ENSRNOT00000051390, ENSRNOT00000074389
Prediction methods:	Miranda, Pita, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	27	52	36	19	36	1	3	74	35	40	11	1
Low		16	5	5		5	7	8			1		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053689	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF325355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CD371777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000074389 ⟹ ENSRNOP00000064860

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	61,308,046 - 61,328,891 (+)	Ensembl
Rnor_6.0 Ensembl	17	63,110,254 - 63,145,577 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095348 ⟹ ENSRNOP00000085242

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	61,308,056 - 61,418,009 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095660 ⟹ ENSRNOP00000087877

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	61,308,056 - 61,418,009 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097067 ⟹ ENSRNOP00000092243

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	61,308,014 - 61,328,357 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109185 ⟹ ENSRNOP00000088986

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	61,310,668 - 61,328,891 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000110840 ⟹ ENSRNOP00000085602

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	61,308,046 - 61,328,891 (+)	Ensembl

RefSeq Acc Id:

NM_053689 ⟹ NP_446141

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	61,308,033 - 61,328,184 (+)	NCBI
Rnor_6.0	17	63,111,086 - 63,145,618 (-)	NCBI
Rnor_5.0	17	64,910,285 - 64,916,648 (-)	NCBI
RGSC_v3.4	17	72,100,899 - 72,120,636 (+)	RGD
Celera	17	59,257,948 - 59,272,929 (-)	NCBI

Sequence:

show sequence

CCTCCGCTTCTCCAGGTTTCCTCGTGCGTTCCACCGCCGGCATGGCGCATTACAACTTCAAGAA
GATTACGGTGGTGCCGTCAGCCAAGGACTTTATTGACCTGACATTATCCAAGACACAACGAAAG
ACTCCAACGGTTATTCATAAACATTATCAAATTCATCGAATTCGACATTTTTATATGAGAAAAG
TCAAATTTACTCAACAGAATTATCATGACAGACTGTCACAGATTCTGTCCGATTTCCCCAAATT
GGATGATATCCATCCATTTTATGCTGACTTGATGAATATTCTCTATGACAAGGATCACTACAAG
TTGGCTCTAGGACAAATAAATATTGCCAAAAACTTGGTGGACAATGTTGCTAAAGATTACGTGC
GACTTATGAAGTATGGTGATTCTCTCTACCGATGCAAGCAGCTGAAGCGCGCTGCCCTGGGGCG
AATGTGTACGATTATCAAGAGGCAGAGGCAGAGTTTGGAGTACTTGGAACAAGTACGTCAACAT
CTATCCCGCTTGCCAACCATTGATCCAAATACAAGGACTCTACTTTTGTGTGGGTATCCAAATG
TTGGGAAATCCAGCTTCATCAATAAGGTGACAAGAGCAGATGTGGATGTTCAGCCCTATGCATT
TACCACCAAGTCTCTGTTTGTCGGGCACATGGATTATAAGTATCTGCGCTGGCAGGTTGTAGAT
ACTCCAGGGATTTCGGATCATCCTTTGGAGGATCGGAACACCATTGAGATGCAGGCCATCACAG
CCCTGGCCCAGCCCCGAGCTGCAGTTCTGTATGTGATGGATTTGTCTGAGCAGTGTGGACATGG
GTTGAAGGAGCAATTAGAACTCTTCCAGAATATCAGACCCCTGTTTATCAACAAGCCTCTTATT
GTTGTAGCAAACAAATGTGATGTGAAGAGAATAGCTGAACTTTCTGAAGAAGATCAGAAAATAT
TTCTAGACTTGCAGGCTGAAGGATTTCCTGTCATCGAGACCAGCACCCTGACTGAGGAAGGTGT
CATTCAAGTTAAAACGGAGGCTTGTGATAGGCTTTTGGCTCACCGAGTAGAAACGAAAATGAAA
GGAAATAAAGTGAATGAGGTTCTGAACAGATTGCACTTAGCTGTGCCCAACAAGAGAGATGACA
AGGAGAGACCCCCGTTCATCCCAGAAGGAGTGGTAGCTCGTCGGAAGAGAATGGAGATCGCAGA
ACCCAAGAAGAAGAGGGAACGAGATCTTGAGCTGGAAATGGGAGATGATTATATTTTGGATCTT
CAGAAATACTGGGACTTAATGAATTCATCTGAGAAGTATGATAAGATACCAGAGATTTGGGAAG
GCCACAATGTTGCTGATTATATCGATCCTGCTATCATGAAGAAATTAGAAGAGTTGGAAAAGGA
AGAAGAGCTCCGAACAGCTGCTGGGGAGTATGACAGTGAGTCTGAGAGTGAAGACGAGGAAATG
GTGGAAATCCGACAGCTGGCAAAACAAATTAGAGAGAAGAAGAAGTTGAAAATTCTACAGTCCA
AAGAAAAGAACACACAGGGACCCCGCATGCCCCGGACTGCTAAGAAGGTTCAACGGGCAGATTT
AGAGAATGAGATGCGTAGTCTTGGCGTGGACATGGATGATAAAGACAATGCCCACTATGCAGTC
CAGGCCAGAAGATCTCGGAGTGTCACCAGGAAAAGAAAACGAGAAGAGTCTGTTCCTCCCTCTT
CCATAGCCCGCAGTCGCAGTCGGAGTTGCTCTAAAACGCCACGTGATGTTTCTGGTCTTCGGGA
TGTCAAGATGGTGAAGAAAGCCAAGACCATGATGAAGAAAGCCCAGAAGAAGATGAATCGCTTG
GGGAAGAAGGGGGAAGCAGATAGGCATGTGTTTGATATGAAGCCCAAGCACCTACTCTCTGGGA
AGAGGAAAGCTGGTAAAAAGGACAGGAGATAATGTCCTCTTCGGTCGGAGTAGTTTAACTAGAC
CCGTGATTATTTCTGAGTGTGTGATGGTGTGTTTTATAGAATTTGGGATCAACATCTGTTAACC
AAAGAAACGATGGAAATGACTTTTAAATGCTTGTTGCTGTGCTGAAAACTGGTAAAGCCGAGTA
AGCGTGTGGTGCCGTGGCCCTGTGCAGTCAGATGTTACCTGCAGAGCGCTCTGTACTGGATGAC
GCGCTTCTTTCACAGCCAAGGGACTCATTTTGCAGAAAAGATGTATTGGTGTAAGGAGGCTGCT
TTGGTGGGGGAAAACTTTTGTAGTAGATCTTTTGACACCCAAAATACCTATTTTTGTTAAGAAA
GTATTCCTGCTGGGAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_446141	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK13446	(Get FASTA)	NCBI Sequence Viewer
	Q99P77	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_446141 ⟸ NM_053689

- Sequence:

show sequence

MAHYNFKKITVVPSAKDFIDLTLSKTQRKTPTVIHKHYQIHRIRHFYMRKVKFTQQNYHDRLSQ
ILSDFPKLDDIHPFYADLMNILYDKDHYKLALGQINIAKNLVDNVAKDYVRLMKYGDSLYRCKQ
LKRAALGRMCTIIKRQRQSLEYLEQVRQHLSRLPTIDPNTRTLLLCGYPNVGKSSFINKVTRAD
VDVQPYAFTTKSLFVGHMDYKYLRWQVVDTPGISDHPLEDRNTIEMQAITALAQPRAAVLYVMD
LSEQCGHGLKEQLELFQNIRPLFINKPLIVVANKCDVKRIAELSEEDQKIFLDLQAEGFPVIET
STLTEEGVIQVKTEACDRLLAHRVETKMKGNKVNEVLNRLHLAVPNKRDDKERPPFIPEGVVAR
RKRMEIAEPKKKRERDLELEMGDDYILDLQKYWDLMNSSEKYDKIPEIWEGHNVADYIDPAIMK
KLEELEKEEELRTAAGEYDSESESEDEEMVEIRQLAKQIREKKKLKILQSKEKNTQGPRMPRTA
KKVQRADLENEMRSLGVDMDDKDNAHYAVQARRSRSVTRKRKREESVPPSSIARSRSRSCSKTP
RDVSGLRDVKMVKKAKTMMKKAQKKMNRLGKKGEADRHVFDMKPKHLLSGKRKAGKKDRR

hide sequence

RefSeq Acc Id:

ENSRNOP00000064860 ⟸ ENSRNOT00000074389

RefSeq Acc Id:

ENSRNOP00000087877 ⟸ ENSRNOT00000095660

RefSeq Acc Id:

ENSRNOP00000088986 ⟸ ENSRNOT00000109185

RefSeq Acc Id:

ENSRNOP00000085602 ⟸ ENSRNOT00000110840

RefSeq Acc Id:

ENSRNOP00000085242 ⟸ ENSRNOT00000095348

RefSeq Acc Id:

ENSRNOP00000092243 ⟸ ENSRNOT00000097067

Protein Domains

OBG-type G

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99P77-F1-model_v2	AlphaFold	Q99P77	1-637	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700535

Promoter ID:

EPDNEW_R11059

Type:

initiation region

Name:

Gtpbp4_1

Description:

GTP binding protein 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	63,145,626 - 63,145,686	EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)

ACI/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620783	AgrOrtholog
BioCyc Gene	G2FUF-8899	BioCyc
Ensembl Genes	ENSRNOG00000016217	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000064860	ENTREZGENE
	ENSRNOP00000064860.2	UniProtKB/TrEMBL
	ENSRNOP00000085242.1	UniProtKB/TrEMBL
	ENSRNOP00000085602.1	UniProtKB/TrEMBL
	ENSRNOP00000087877.1	UniProtKB/TrEMBL
	ENSRNOP00000088986.1	UniProtKB/TrEMBL
	ENSRNOP00000092243.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000074389	ENTREZGENE
	ENSRNOT00000074389.3	UniProtKB/TrEMBL
	ENSRNOT00000095348.1	UniProtKB/TrEMBL
	ENSRNOT00000095660.1	UniProtKB/TrEMBL
	ENSRNOT00000097067.1	UniProtKB/TrEMBL
	ENSRNOT00000109185.1	UniProtKB/TrEMBL
	ENSRNOT00000110840.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	G_OBG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GTP_binding_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NOG1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NOG1_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NOG1_Rossman_fold_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NOG_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
KEGG Report	rno:114300	UniProtKB/TrEMBL
NCBI Gene	114300	ENTREZGENE
Pfam	NOG1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NOG1_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NOGCT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Gtpbp4	PhenoGen
PIRSF	NOG1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	GTP1OBG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_OBG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	small_GTP	UniProtKB/TrEMBL
UniProt	A0A8I6A3N8_RAT	UniProtKB/TrEMBL
	A0A8I6A3Y7_RAT	UniProtKB/TrEMBL
	A0A8I6A8W6_RAT	UniProtKB/TrEMBL
	A0A8I6ADM2_RAT	UniProtKB/TrEMBL
	M0R623_RAT	UniProtKB/TrEMBL
	NOG1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-29	Gtpbp4	GTP binding protein 4	LOC689822	similar to Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)	Data Merged	737654	PROVISIONAL
2015-07-29	Gtpbp4	GTP binding protein 4	RGD1563564	similar to GTP-binding protein NGB	Data Merged	737654	PROVISIONAL
2013-04-17	Gtpbp4	GTP binding protein 4	LOC683324	similar to Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)	Data Merged	737654	PROVISIONAL
2008-04-30	RGD1563564	similar to GTP-binding protein NGB	RGD1563564_predicted	similar to GTP-binding protein NGB (predicted)	'predicted' is removed	2292626	APPROVED
2006-11-19	LOC689822	similar to Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC683324	similar to Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-03-07	RGD1563564_predicted	similar to GTP-binding protein NGB (predicted)	LOC498786	similar to GTP-binding protein NGB	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498786	similar to GTP-binding protein NGB			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-11-17	Gtpbp4	GTP binding protein 4			Name updated	1299863	APPROVED
2004-09-10	Gtpbp4	G protein-binding protein CRFG	Crfg		Symbol and Name updated	1299863	APPROVED
2002-08-07	Crfg	G protein-binding protein CRFG			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in outer medulla of kidney, enriched in epithelial cells	632611

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)

External Pathway Database Links

External Pathway Database Links