Cacnb2 (calcium voltage-gated channel auxiliary subunit beta 2) - Rat Genome Database

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Gene: Cacnb2 (calcium voltage-gated channel auxiliary subunit beta 2) Rattus norvegicus
Analyze
Symbol: Cacnb2
Name: calcium voltage-gated channel auxiliary subunit beta 2
RGD ID: 67385
Description: Enables several functions, including actin filament binding activity; calcium channel regulator activity; and identical protein binding activity. Contributes to voltage-gated calcium channel activity. Involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; positive regulation of high voltage-gated calcium channel activity; and protein localization to plasma membrane. Part of L-type voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CAB2; Cacnlb2; calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; voltage-dependent L-type calcium channel subunit beta-2; voltage-gated calcium channel beta2i subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cacnb2_v1   Cacnb2_v2  
Is Marker For: QTLs:   Bp369  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21777,564,630 - 77,910,000 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1777,564,460 - 77,909,106 (+)Ensembl
Rnor_6.01781,673,862 - 82,019,219 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1781,798,756 - 82,017,682 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01783,418,158 - 83,762,100 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41788,832,905 - 89,078,870 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11788,864,078 - 89,089,703 (+)NCBI
Celera1776,999,835 - 77,240,592 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Abiria SA and Colbran RJ, J Neurochem. 2010 Jan;112(1):150-61. doi: 10.1111/j.1471-4159.2009.06436.x. Epub 2009 Oct 15.
2. Beguin P, etal., J Cell Biol. 2014 Apr 28;205(2):233-49. doi: 10.1083/jcb.201304101. Epub 2014 Apr 21.
3. Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947.
4. Cens T, etal., Pflugers Arch. 2011 Aug;462(2):303-14. doi: 10.1007/s00424-011-0974-x. Epub 2011 May 25.
5. Colecraft HM, etal., J Physiol 2002 Jun 1;541(Pt 2):435-52.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Gonzalez-Gutierrez G, etal., Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14198-203. doi: 10.1073/pnas.0806558105. Epub 2008 Sep 5.
8. Grueter CE, etal., Biochemistry. 2008 Feb 12;47(6):1760-7. Epub 2008 Jan 19.
9. Hong GL, etal., Genet Mol Res. 2013 Dec 4;12(4):6220-7. doi: 10.4238/2013.December.4.9.
10. Lautermilch NJ, etal., J Neurosci. 2005 Jul 27;25(30):7062-70.
11. Li L, etal., J Biol Chem. 2012 Feb 17;287(8):6002-13. doi: 10.1074/jbc.M111.310110. Epub 2011 Dec 20.
12. MGD data from the GO Consortium
13. NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline
15. Opatowsky Y, etal., J Biol Chem 2003 Dec 26;278(52):52323-32. Epub 2003 Oct 14.
16. Perez-Reyes E, etal., J Biol Chem 1992 Jan 25;267(3):1792-7.
17. Pipeline to import KEGG annotations from KEGG into RGD
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. Rokita AG and Anderson ME, Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990.
21. Stolting G, etal., J Biol Chem. 2015 Feb 20;290(8):4561-72. doi: 10.1074/jbc.M114.573956. Epub 2014 Dec 22.
22. Taviaux S, etal., Hum Genet 1997 Aug;100(2):151-4.
23. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Wu J, etal., Science. 2015 Dec 18;350(6267):aad2395. doi: 10.1126/science.aad2395.
25. Yamada Y, etal., J Biol Chem 2001 Dec 14;276(50):47163-70.
26. Zhang X, etal., Medicine (Baltimore). 2017 Jun;96(24):e7010. doi: 10.1097/MD.0000000000007010.
Additional References at PubMed
PMID:1309651   PMID:10328888   PMID:11980879   PMID:15141227   PMID:15750602   PMID:17110381   PMID:17224476   PMID:17626895   PMID:17893194   PMID:18356540   PMID:20194790   PMID:20937253  
PMID:21753737   PMID:21792084   PMID:24519939   PMID:24755552   PMID:25712868   PMID:29208674   PMID:30992131  


Genomics

Candidate Gene Status
Cacnb2 is a candidate Gene for QTL Cm57
Comparative Map Data
Cacnb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21777,564,630 - 77,910,000 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1777,564,460 - 77,909,106 (+)Ensembl
Rnor_6.01781,673,862 - 82,019,219 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1781,798,756 - 82,017,682 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01783,418,158 - 83,762,100 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41788,832,905 - 89,078,870 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11788,864,078 - 89,089,703 (+)NCBI
Celera1776,999,835 - 77,240,592 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
CACNB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1018,140,424 - 18,543,557 (+)EnsemblGRCh38hg38GRCh38
GRCh381018,140,424 - 18,545,881 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371018,429,353 - 18,832,486 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361018,469,612 - 18,870,694 (+)NCBINCBI36hg18NCBI36
Build 341018,729,966 - 18,870,044NCBI
Celera1018,116,041 - 18,517,577 (+)NCBI
Cytogenetic Map10p12.33-p12.31NCBI
HuRef1018,094,960 - 18,495,622 (+)NCBIHuRef
CHM1_11018,429,651 - 18,830,663 (+)NCBICHM1_1
Cacnb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39214,608,672 - 14,993,622 (+)NCBIGRCm39mm39
GRCm39 Ensembl214,607,899 - 14,992,719 (+)Ensembl
GRCm38214,603,861 - 14,988,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl214,603,088 - 14,987,908 (+)EnsemblGRCm38mm10GRCm38
MGSCv37214,525,933 - 14,908,560 (+)NCBIGRCm37mm9NCBIm37
MGSCv36214,522,060 - 14,904,687 (+)NCBImm8
Celera214,505,146 - 14,888,354 (+)NCBICelera
Cytogenetic Map2A2NCBI
cM Map210.7NCBI
Cacnb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554299,644,053 - 9,966,175 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554299,642,725 - 9,966,175 (-)NCBIChiLan1.0ChiLan1.0
CACNB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11018,915,315 - 19,195,226 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1018,795,832 - 19,195,226 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01018,459,528 - 18,862,495 (+)NCBIMhudiblu_PPA_v0panPan3
CACNB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1218,537,100 - 18,787,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl218,538,620 - 18,902,286 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha215,637,443 - 16,012,086 (-)NCBI
ROS_Cfam_1.0218,828,779 - 19,204,759 (-)NCBI
UMICH_Zoey_3.1216,027,565 - 16,402,179 (-)NCBI
UNSW_CanFamBas_1.0216,863,689 - 17,237,595 (-)NCBI
UU_Cfam_GSD_1.0217,483,280 - 17,857,968 (-)NCBI
Cacnb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934418,664,779 - 19,007,975 (+)NCBI
SpeTri2.0NW_0049365208,951,994 - 9,164,039 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1044,421,666 - 44,885,424 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11044,321,954 - 44,887,410 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21049,465,655 - 49,626,095 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1918,075,436 - 18,470,985 (+)NCBI
ChlSab1.1 Ensembl918,332,165 - 18,469,617 (+)Ensembl
Vero_WHO_p1.0NW_02366605123,719,856 - 24,128,137 (+)NCBI
Cacnb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247969,502,132 - 9,858,836 (-)NCBI

Position Markers
D17Wox7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,848,911 - 77,849,094 (+)MAPPERmRatBN7.2
Rnor_6.01781,959,297 - 81,959,481NCBIRnor6.0
Rnor_5.01783,701,284 - 83,701,468UniSTSRnor5.0
RGSC_v3.41789,018,677 - 89,018,862RGDRGSC3.4
RGSC_v3.41789,018,678 - 89,018,862UniSTSRGSC3.4
RGSC_v3.11789,029,511 - 89,029,695RGD
Celera1777,180,440 - 77,180,626UniSTS
RH 3.4 Map17789.9UniSTS
RH 3.4 Map17789.9RGD
RH 2.0 Map17679.3RGD
Cytogenetic Map17q12.3UniSTS
D17Got99  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,778,668 - 77,778,842 (+)MAPPERmRatBN7.2
Rnor_6.01781,889,089 - 81,889,262NCBIRnor6.0
Rnor_5.01783,631,224 - 83,631,397UniSTSRnor5.0
RGSC_v3.41788,948,948 - 88,949,122RGDRGSC3.4
RGSC_v3.41788,948,949 - 88,949,122UniSTSRGSC3.4
RGSC_v3.11788,959,782 - 88,959,955RGD
Celera1777,110,390 - 77,110,563UniSTS
RH 3.4 Map17792.5RGD
RH 3.4 Map17792.5UniSTS
Cytogenetic Map17q12.3UniSTS
D17Arb12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,907,699 - 77,907,996 (+)MAPPERmRatBN7.2
Rnor_6.01782,017,813 - 82,018,109NCBIRnor6.0
Rnor_5.01783,759,800 - 83,760,096UniSTSRnor5.0
RGSC_v3.41789,077,463 - 89,077,760RGDRGSC3.4
RGSC_v3.41789,077,464 - 89,077,760UniSTSRGSC3.4
RGSC_v3.11789,088,296 - 89,088,593RGD
Celera1777,239,186 - 77,239,482UniSTS
Cytogenetic Map17q12.3UniSTS
AU048422  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01781,909,601 - 81,909,758NCBIRnor6.0
Rnor_5.01783,651,684 - 83,651,841UniSTSRnor5.0
RGSC_v3.41788,969,056 - 88,969,213UniSTSRGSC3.4
Celera1777,130,958 - 77,131,115UniSTS
Cytogenetic Map17q12.3UniSTS
RH129340  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,908,379 - 77,908,564 (+)MAPPERmRatBN7.2
Rnor_6.01782,018,493 - 82,018,677NCBIRnor6.0
Rnor_5.01783,760,480 - 83,760,664UniSTSRnor5.0
RGSC_v3.41789,078,144 - 89,078,328UniSTSRGSC3.4
Celera1777,239,866 - 77,240,050UniSTS
RH 3.4 Map17792.5UniSTS
Cytogenetic Map17q12.3UniSTS
RH133733  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,673,275 - 77,673,474 (+)MAPPERmRatBN7.2
Rnor_6.01781,783,413 - 81,783,611NCBIRnor6.0
Rnor_5.01783,525,714 - 83,525,912UniSTSRnor5.0
RGSC_v3.41788,838,599 - 88,838,797UniSTSRGSC3.4
Celera1777,005,533 - 77,005,731UniSTS
RH 3.4 Map17809.2UniSTS
Cytogenetic Map17q12.3UniSTS
RH144615  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,766,984 - 77,767,165 (+)MAPPERmRatBN7.2
Rnor_6.01781,877,407 - 81,877,587NCBIRnor6.0
Rnor_5.01783,619,542 - 83,619,722UniSTSRnor5.0
RGSC_v3.41788,937,105 - 88,937,285UniSTSRGSC3.4
Celera1777,098,708 - 77,098,888UniSTS
RH 3.4 Map17794.5UniSTS
Cytogenetic Map17q12.3UniSTS
BE097150  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,708,702 - 77,708,868 (+)MAPPERmRatBN7.2
Rnor_6.01781,819,191 - 81,819,356NCBIRnor6.0
Rnor_5.01783,561,492 - 83,561,657UniSTSRnor5.0
RGSC_v3.41788,874,451 - 88,874,616UniSTSRGSC3.4
Celera1777,040,924 - 77,041,089UniSTS
RH 3.4 Map17794.3UniSTS
Cytogenetic Map17q12.3UniSTS
BE109990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,908,157 - 77,908,332 (+)MAPPERmRatBN7.2
Rnor_6.01782,018,271 - 82,018,445NCBIRnor6.0
Rnor_5.01783,760,258 - 83,760,432UniSTSRnor5.0
RGSC_v3.41789,077,922 - 89,078,096UniSTSRGSC3.4
Celera1777,239,644 - 77,239,818UniSTS
RH 3.4 Map17789.8UniSTS
Cytogenetic Map17q12.3UniSTS
RH138021  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,907,433 - 77,907,636 (+)MAPPERmRatBN7.2
Rnor_6.01782,017,547 - 82,017,749NCBIRnor6.0
Rnor_5.01783,759,534 - 83,759,736UniSTSRnor5.0
RGSC_v3.41789,077,198 - 89,077,400UniSTSRGSC3.4
Celera1777,238,920 - 77,239,122UniSTS
RH 3.4 Map17792.5UniSTS
Cytogenetic Map17q12.3UniSTS
RH138575  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,846,400 - 77,846,553 (+)MAPPERmRatBN7.2
Rnor_6.01781,956,792 - 81,956,944NCBIRnor6.0
Rnor_5.01783,698,875 - 83,699,027UniSTSRnor5.0
RGSC_v3.41789,016,208 - 89,016,360UniSTSRGSC3.4
Celera1777,178,062 - 77,178,214UniSTS
RH 3.4 Map17793.0UniSTS
Cytogenetic Map17q12.3UniSTS
G15938  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,907,745 - 77,907,978 (+)MAPPERmRatBN7.2
Rnor_6.01782,017,859 - 82,018,091NCBIRnor6.0
Rnor_5.01783,759,846 - 83,760,078UniSTSRnor5.0
RGSC_v3.41789,077,510 - 89,077,742UniSTSRGSC3.4
Celera1777,239,232 - 77,239,464UniSTS
Cytogenetic Map17q12.3UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)177100332581153923Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)177177462182479847Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:565
Count of miRNA genes:179
Interacting mature miRNAs:237
Transcripts:ENSRNOT00000031542, ENSRNOT00000066826
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 16 8 52 17 11
Low 3 41 41 11 41 8 10 22 35 24 8
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF394941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF423193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY190119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY190120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M80545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH423075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000031542   ⟹   ENSRNOP00000037354
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,811,451 - 77,909,106 (+)Ensembl
Rnor_6.0 Ensembl1781,922,329 - 82,017,682 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000066826   ⟹   ENSRNOP00000063474
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,767,577 - 77,909,106 (+)Ensembl
Rnor_6.0 Ensembl1781,798,756 - 82,017,481 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098193   ⟹   ENSRNOP00000086829
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,812,536 - 77,832,718 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101293   ⟹   ENSRNOP00000094678
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,812,742 - 77,909,106 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101858   ⟹   ENSRNOP00000088262
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,564,460 - 77,909,106 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103017   ⟹   ENSRNOP00000093724
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,715,696 - 77,909,106 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105795   ⟹   ENSRNOP00000094672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,811,451 - 77,909,106 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108342   ⟹   ENSRNOP00000090821
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,715,696 - 77,909,106 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113123   ⟹   ENSRNOP00000078040
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,812,536 - 77,909,106 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118698   ⟹   ENSRNOP00000093071
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,687,925 - 77,909,106 (+)Ensembl
RefSeq Acc Id: NM_053851   ⟹   NP_446303
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,688,217 - 77,908,650 (+)NCBI
Rnor_6.01781,777,719 - 82,019,219 (+)NCBI
Rnor_5.01783,418,158 - 83,762,100 (+)NCBI
RGSC_v3.41788,832,905 - 89,078,870 (+)RGD
Celera1776,999,835 - 77,240,592 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254298   ⟹   XP_006254360
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,564,947 - 77,910,000 (+)NCBI
Rnor_6.01781,673,864 - 82,018,763 (+)NCBI
Rnor_5.01783,418,158 - 83,762,100 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254301   ⟹   XP_006254363
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,811,464 - 77,910,000 (+)NCBI
Rnor_6.01781,921,314 - 82,018,763 (+)NCBI
Rnor_5.01783,418,158 - 83,762,100 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254303   ⟹   XP_006254365
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,763,556 - 77,910,000 (+)NCBI
Rnor_6.01781,877,652 - 82,018,763 (+)NCBI
Rnor_5.01783,418,158 - 83,762,100 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600435   ⟹   XP_017455924
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,564,944 - 77,910,000 (+)NCBI
Rnor_6.01781,673,862 - 82,018,763 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600436   ⟹   XP_017455925
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,811,461 - 77,910,000 (+)NCBI
Rnor_6.01781,921,314 - 82,018,763 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600438   ⟹   XP_017455927
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,564,942 - 77,910,000 (+)NCBI
Rnor_6.01781,673,863 - 82,018,763 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095295   ⟹   XP_038951223
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,564,630 - 77,910,000 (+)NCBI
RefSeq Acc Id: XM_039095296   ⟹   XP_038951224
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,564,713 - 77,910,000 (+)NCBI
RefSeq Acc Id: XM_039095297   ⟹   XP_038951225
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,564,713 - 77,910,000 (+)NCBI
RefSeq Acc Id: XM_039095298   ⟹   XP_038951226
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,564,713 - 77,910,000 (+)NCBI
RefSeq Acc Id: XM_039095299   ⟹   XP_038951227
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,763,554 - 77,910,000 (+)NCBI
RefSeq Acc Id: XM_039095300   ⟹   XP_038951228
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,688,236 - 77,910,000 (+)NCBI
RefSeq Acc Id: XM_039095301   ⟹   XP_038951229
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21777,885,015 - 77,910,000 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446303 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254360 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254363 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254365 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455924 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455925 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455927 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951223 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951224 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951225 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951226 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951227 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951228 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951229 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK14821 (Get FASTA)   NCBI Sequence Viewer  
  AAL16952 (Get FASTA)   NCBI Sequence Viewer  
  AAL47074 (Get FASTA)   NCBI Sequence Viewer  
  AAO38996 (Get FASTA)   NCBI Sequence Viewer  
  AAO38997 (Get FASTA)   NCBI Sequence Viewer  
  AYP71839 (Get FASTA)   NCBI Sequence Viewer  
  EDL78736 (Get FASTA)   NCBI Sequence Viewer  
  EDL78737 (Get FASTA)   NCBI Sequence Viewer  
  EDL78738 (Get FASTA)   NCBI Sequence Viewer  
  EDL78739 (Get FASTA)   NCBI Sequence Viewer  
  EDL78740 (Get FASTA)   NCBI Sequence Viewer  
  EDL78741 (Get FASTA)   NCBI Sequence Viewer  
  EDL78742 (Get FASTA)   NCBI Sequence Viewer  
  EDL78743 (Get FASTA)   NCBI Sequence Viewer  
  EDL78744 (Get FASTA)   NCBI Sequence Viewer  
  Q8VGC3 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446303   ⟸   NM_053851
- UniProtKB: Q8VGC3 (UniProtKB/Swiss-Prot),   A0A0G2JSZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254360   ⟸   XM_006254298
- Peptide Label: isoform X3
- UniProtKB: Q8VGC3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006254365   ⟸   XM_006254303
- Peptide Label: isoform X9
- UniProtKB: Q8VGC3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006254363   ⟸   XM_006254301
- Peptide Label: isoform X7
- UniProtKB: D3ZWK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455924   ⟸   XM_017600435
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017455927   ⟸   XM_017600438
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_017455925   ⟸   XM_017600436
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: ENSRNOP00000037354   ⟸   ENSRNOT00000031542
RefSeq Acc Id: ENSRNOP00000063474   ⟸   ENSRNOT00000066826
RefSeq Acc Id: XP_038951223   ⟸   XM_039095295
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038951224   ⟸   XM_039095296
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038951225   ⟸   XM_039095297
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038951226   ⟸   XM_039095298
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038951228   ⟸   XM_039095300
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038951227   ⟸   XM_039095299
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038951229   ⟸   XM_039095301
- Peptide Label: isoform X13
RefSeq Acc Id: ENSRNOP00000078040   ⟸   ENSRNOT00000113123
RefSeq Acc Id: ENSRNOP00000086829   ⟸   ENSRNOT00000098193
RefSeq Acc Id: ENSRNOP00000093724   ⟸   ENSRNOT00000103017
RefSeq Acc Id: ENSRNOP00000090821   ⟸   ENSRNOT00000108342
RefSeq Acc Id: ENSRNOP00000088262   ⟸   ENSRNOT00000101858
RefSeq Acc Id: ENSRNOP00000094672   ⟸   ENSRNOT00000105795
RefSeq Acc Id: ENSRNOP00000094678   ⟸   ENSRNOT00000101293
RefSeq Acc Id: ENSRNOP00000093071   ⟸   ENSRNOT00000118698
Protein Domains
SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67385 AgrOrtholog
Ensembl Genes ENSRNOG00000018378 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000037354 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000063474 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031542 UniProtKB/TrEMBL
  ENSRNOT00000066826 ENTREZGENE, UniProtKB/TrEMBL
InterPro CACNB2_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GK/Ca_channel_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_L_b2su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_L_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116600 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 116600 ENTREZGENE
Pfam Guanylate_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VGCC_beta4Aa_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cacnb2 PhenoGen
PRINTS LCACHANNELB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LCACHANNELB2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GuKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205597
UniProt A0A0G2JSZ0 ENTREZGENE, UniProtKB/TrEMBL
  CACB2_RAT UniProtKB/Swiss-Prot
  D3ZWK0 ENTREZGENE, UniProtKB/TrEMBL
  Q8VGC3 ENTREZGENE
UniProt Secondary Q811Q6 UniProtKB/Swiss-Prot
  Q811Q7 UniProtKB/Swiss-Prot
  Q91ZJ8 UniProtKB/Swiss-Prot
  Q9QUU7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Cacnb2  calcium voltage-gated channel auxiliary subunit beta 2  Cacnb2  calcium channel, voltage-dependent, beta 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Cacnb2  calcium channel, voltage-dependent, beta 2 subunit       Name updated 70584 APPROVED
2001-10-22 Cacnb2  calcium channel, voltage-dependent, beta 2 subunit      Name, Genbank IDs added from locuslink record 68916 PENDING

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain and heart 625474
gene_function L-type Ca2+ channel subunit 625474
gene_process plays a role in shaping the action potential of cardiac myocytes and is a major pathway for extracellular Ca2+ entry into cardiomyocytes 625474
gene_process promotes the transportation of Ca2+ channel to the membrane and affects the activation and inactivation kinetics 625474
gene_process acts to increase peak currents, accelerate activation kinetics, and shift the current-voltage relationship toward more hyperpolarized potentials 632405