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Gene: Cacnb2 (calcium voltage-gated channel auxiliary subunit beta 2) Rattus norvegicus
Symbol: Cacnb2
Name: calcium voltage-gated channel auxiliary subunit beta 2
Description: Exhibits several functions, including actin filament binding activity; calcium channel regulator activity; and identical protein binding activity. Contributes to voltage-gated calcium channel activity. Involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; positive regulation of high voltage-gated calcium channel activity; and protein localization to plasma membrane. Localizes to the L-type voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Also known as: CAB2; Cacnlb2; calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; voltage-dependent L-type calcium channel subunit beta-2
Allele / Splice: Cacnb2_v1   Cacnb2_v2  
Is Marker For: QTLs:   Bp369  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01781,673,862 - 82,019,219 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01783,418,158 - 83,762,100 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41788,832,905 - 89,078,870 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11788,864,078 - 89,089,703 (+)NCBI
Celera1776,999,835 - 77,240,592 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cacnb2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 67385
Created: 2001-06-01
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.