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Gene: Camk2a (calcium/calmodulin-dependent protein kinase II alpha) Mus musculus
Symbol: Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
Description: Exhibits calmodulin binding activity; glutamate receptor binding activity; and protein serine/threonine kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of cardiac muscle cell apoptotic process; and protein phosphorylation. Localizes to Schaffer collateral - CA1 synapse; mitochondrion; and postsynaptic density. Is expressed in several structures, including alimentary system; early embryo; eye; genitourinary system; and nervous system. Used to study autism spectrum disorder and bipolar disorder. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 53 and autosomal recessive non-syndromic intellectual disability. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; fibroblast growth factor signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (S)-nicotine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-CaMKII; calcium/calmodulin-dependent protein kinase type II subunit alpha; caM kinase II subunit alpha; CaMK II; caMK-II subunit alpha; CaMKII; mKIAA0968; R74975
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1860,925,618 - 60,988,152 (+)EnsemblGRCm38mm10GRCm38
GRCm381860,925,307 - 60,988,152 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371861,085,286 - 61,147,806 (+)NCBIGRCm37mm9NCBIm37
MGSCv361861,051,001 - 61,113,513 (+)NCBImm8
Celera1862,212,530 - 62,274,768 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Camk2a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10284
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.