Camk2a (calcium/calmodulin-dependent protein kinase II alpha) - Rat Genome Database

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Gene: Camk2a (calcium/calmodulin-dependent protein kinase II alpha) Mus musculus
Analyze
Symbol: Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
RGD ID: 10284
MGI Page MGI
Description: Enables calcium/calmodulin-dependent protein kinase activity; calmodulin binding activity; and glutamate receptor binding activity. Involved in several processes, including peptidyl-threonine autophosphorylation; regulation of endocannabinoid signaling pathway; and regulation of synaptic vesicle docking. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; modulation of chemical synaptic transmission; and protein phosphorylation. Located in mitochondrion and postsynaptic density. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; early embryo; eye; genitourinary system; and nervous system. Used to study autism spectrum disorder and bipolar disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-CaMKII; calcium/calmodulin-dependent protein kinase type II subunit alpha; caM kinase II subunit alpha; CaMK II; caMK-II subunit alpha; CaMKII; mKIAA0968; R74975
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,058,704 - 61,121,224 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,058,690 - 61,121,224 (+)EnsemblGRCm39 Ensembl
GRCm381860,925,307 - 60,988,152 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1860,925,618 - 60,988,152 (+)EnsemblGRCm38mm10GRCm38
MGSCv371861,085,286 - 61,147,806 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,051,001 - 61,113,513 (+)NCBIMGSCv36mm8
Celera1862,212,530 - 62,274,768 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
7-chlorokynurenic acid  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-Zearalanol  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
azamethiphos  (ISO)
Bay-K-8644  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
cantharidin  (EXP)
capsaicin  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
decabromodiphenyl ether  (EXP,ISO)
diarsenic trioxide  (EXP)
dieldrin  (ISO)
diethyl malate  (EXP)
diethylstilbestrol  (EXP)
dizocilpine maleate  (ISO)
dopamine  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
flurotyl  (ISO)
FPL 64176  (ISO)
Glutathione ethyl ester  (EXP)
glyphosate  (ISO)
haloperidol  (ISO)
heptachlor  (ISO)
ibuprofen  (ISO)
ionomycin  (ISO)
ivermectin  (ISO)
kainic acid  (EXP)
KN-93  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lipoic acid  (EXP)
losartan  (EXP)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
memantine  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
microcystin-LR  (EXP)
monosodium L-glutamate  (ISO)
morphine  (EXP)
N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (ISO)
N-nitrosodiethylamine  (EXP)
nicardipine  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
nifedipine  (EXP,ISO)
ochratoxin A  (ISO)
olanzapine  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phencyclidine  (EXP)
phenylephrine  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
quercetin  (EXP)
resveratrol  (EXP)
risperidone  (ISO)
rotenone  (EXP)
S-allylcysteine  (ISO)
sarin  (ISO)
SCH 23390  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium benzoate  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP,ISO)
sulfur dioxide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trifluoperazine  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
U-73122  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
verapamil  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiotensin-activated signaling pathway  (ISO)
calcium ion transport  (IMP)
cellular response to interferon-beta  (ISO,ISS)
cellular response to type II interferon  (ISO)
dendrite morphogenesis  (IMP)
dendritic spine development  (ISO,ISS)
G1/S transition of mitotic cell cycle  (IMP)
ionotropic glutamate receptor signaling pathway  (ISO)
negative regulation of hydrolase activity  (IMP)
neurotransmitter receptor transport to plasma membrane  (ISO)
NMDA selective glutamate receptor signaling pathway  (ISO)
peptidyl-serine phosphorylation  (IMP,ISO)
peptidyl-threonine autophosphorylation  (IMP,ISO)
positive regulation of calcium ion transport  (IMP)
positive regulation of cardiac muscle cell apoptotic process  (IMP)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO,ISS)
postsynaptic neurotransmitter receptor diffusion trapping  (ISO)
protein autophosphorylation  (IMP,ISO)
protein phosphorylation  (ISO)
regulation of endocannabinoid signaling pathway  (IMP)
regulation of mitochondrial membrane permeability involved in apoptotic process  (IMP)
regulation of neuron migration  (ISO,ISS)
regulation of neuronal synaptic plasticity  (IBA,IMP)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
regulation of neurotransmitter secretion  (IMP)
regulation of protein localization to plasma membrane  (IBA,ISO)
regulation of synaptic vesicle docking  (IDA,IMP)
response to ischemia  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal avoidance learning behavior  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal contextual conditioning behavior  (IAGP)
abnormal cued conditioning behavior  (IAGP)
abnormal cutaneous/subcutaneous mechanoreceptor morphology  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal excitatory postsynaptic currents  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal hippocampus granule cell morphology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal long-term depression  (IAGP)
abnormal long-term potentiation  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal postsynaptic density morphology  (IAGP)
abnormal response to social novelty  (IAGP)
abnormal short-term spatial reference memory  (IAGP)
abnormal skin condition  (IAGP)
abnormal social/conspecific interaction behavior  (IAGP)
abnormal spatial learning  (IAGP)
abnormal synapse morphology  (IAGP)
abnormal synaptic plasticity  (IAGP)
abnormal synaptic transmission  (IAGP)
abnormal synaptic vesicle morphology  (IAGP)
abnormal synaptic vesicle number  (IAGP)
absent long-term depression  (IAGP)
circling  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body weight  (IAGP)
decreased depression-related behavior  (IAGP)
decreased exploration in new environment  (IAGP)
decreased paired-pulse facilitation  (IAGP)
decreased survivor rate  (IAGP)
enhanced coordination  (IAGP)
enhanced long-term potentiation  (IAGP)
hyperactivity  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired long-term object recognition memory  (IAGP)
impaired spatial learning  (IAGP)
impaired spatial working memory  (IAGP)
impaired synaptic plasticity  (IAGP)
increased aggression towards mice  (IAGP)
increased cell proliferation  (IAGP)
increased cerebral infarct size  (IAGP)
increased locomotor activity  (IAGP)
increased thigmotaxis  (IAGP)
increased vertical activity  (IAGP)
premature death  (IAGP)
reduced long-term depression  (IAGP)
reduced long-term potentiation  (IAGP)
seizures  (IAGP)
sporadic seizures  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Localization of CaMKIIalpha in rat primary sensory neurons: increase in inflammation. Carlton SM Brain Res. 2002 Aug 30;947(2):252-9.
2. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
3. Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory. Frankland PW, etal., Nature 2001 May 17;411(6835):309-13.
4. Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Giese KP, etal., Science 1998 Feb 6;279(5352):870-3.
5. Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activation. Jones TL, etal., Anesth Analg. 2007 Dec;105(6):1650-6, table of contents.
6. Mechanisms of CaMKII action in long-term potentiation. Lisman J, etal., Nat Rev Neurosci. 2012 Feb 15;13(3):169-82. doi: 10.1038/nrn3192.
7. Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion. Matsumoto S, etal., J Cereb Blood Flow Metab 2004 Jan;24(1):54-61.
8. Phosphorylation state, solubility, and activity of calcium/calmodulin-dependent protein kinase II alpha in transient focal ischemia in mouse brain. Mengesdorf T, etal., Neurochem Res. 2002 Jun;27(6):477-84.
9. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats. Song B, etal., Neurosci Lett. 2003 Oct 9;349(3):183-6.
20. Trichostatin A protects against cisplatin-induced ototoxicity by regulating expression of genes related to apoptosis and synaptic function. Wang P, etal., Neurotoxicology. 2013 Jul;37:51-62. doi: 10.1016/j.neuro.2013.03.007. Epub 2013 Apr 1.
21. The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. Wang YJ, etal., Brain Res. 2005 Jan 7;1031(1):101-8. doi: 10.1016/j.brainres.2004.10.061.
22. A 63 signature genes prediction system is effective for glioblastoma prognosis. Zhang Y, etal., Int J Mol Med. 2018 Apr;41(4):2070-2078. doi: 10.3892/ijmm.2018.3422. Epub 2018 Jan 25.
Additional References at PubMed
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PMID:30770570   PMID:30814928   PMID:30894537   PMID:30992372   PMID:31034488   PMID:31064859   PMID:31134625   PMID:31151856   PMID:31239443   PMID:31445077   PMID:31481791   PMID:31530151  
PMID:31600191   PMID:31712124   PMID:31800021   PMID:31836540   PMID:31914378   PMID:31983435   PMID:32001612   PMID:32005752   PMID:32005763   PMID:32019829   PMID:32407818   PMID:32434143  
PMID:32776935   PMID:32887881   PMID:33086056   PMID:33497737   PMID:33601422   PMID:33786818   PMID:33804598   PMID:33946543   PMID:34062838   PMID:34103655   PMID:34297923   PMID:34558218  
PMID:34572045   PMID:34587162   PMID:34628110   PMID:34687697   PMID:34908526   PMID:34932950   PMID:35649371   PMID:35901933   PMID:36304100   PMID:36337049   PMID:36417873   PMID:36808153  
PMID:36949663   PMID:37142655   PMID:37155709   PMID:37186439   PMID:37307456   PMID:37490545   PMID:37672577   PMID:37725078   PMID:37874884   PMID:38565288   PMID:38571281   PMID:38653356  
PMID:38936066   PMID:38995900   PMID:39134250   PMID:39390438  


Genomics

Comparative Map Data
Camk2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,058,704 - 61,121,224 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,058,690 - 61,121,224 (+)EnsemblGRCm39 Ensembl
GRCm381860,925,307 - 60,988,152 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1860,925,618 - 60,988,152 (+)EnsemblGRCm38mm10GRCm38
MGSCv371861,085,286 - 61,147,806 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,051,001 - 61,113,513 (+)NCBIMGSCv36mm8
Celera1862,212,530 - 62,274,768 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
CAMK2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,219,491 - 150,290,130 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,219,491 - 150,290,093 (-)EnsemblGRCh38hg38GRCh38
GRCh375149,599,054 - 149,669,693 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,579,248 - 149,649,529 (-)NCBINCBI36Build 36hg18NCBI36
Build 345149,579,247 - 149,649,529NCBI
Celera5145,680,447 - 145,750,799 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5144,747,170 - 144,817,356 (-)NCBIHuRef
CHM1_15149,031,647 - 149,101,993 (-)NCBICHM1_1
T2T-CHM13v2.05150,756,093 - 150,826,669 (-)NCBIT2T-CHM13v2.0
Camk2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,648,779 - 56,711,505 (+)NCBIGRCr8
mRatBN7.21854,378,642 - 54,441,120 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,378,784 - 54,438,994 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,467,554 - 56,526,074 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,182,163 - 57,240,684 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,002,670 - 55,061,881 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,193,978 - 56,295,869 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,193,978 - 56,295,869 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,428,487 - 55,463,016 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01855,514,559 - 55,529,045 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,879,247 - 56,948,537 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11856,951,478 - 57,020,769 (+)NCBI
Celera1852,533,226 - 52,592,130 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Camk2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,247,014 - 4,307,458 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554154,247,307 - 4,307,402 (+)NCBIChiLan1.0ChiLan1.0
CAMK2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24145,448,477 - 145,518,496 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15143,588,026 - 143,658,043 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05145,644,164 - 145,714,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15151,649,062 - 151,719,373 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,649,062 - 151,719,373 (-)Ensemblpanpan1.1panPan2
CAMK2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,800,818 - 58,865,830 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,800,813 - 58,865,830 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,567,052 - 58,631,982 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0459,281,664 - 59,346,612 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,281,703 - 59,346,615 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,070,398 - 59,135,346 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,184,686 - 59,249,804 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,715,947 - 59,780,872 (+)NCBIUU_Cfam_GSD_1.0
Camk2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,064,159 - 143,126,577 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,638,176 - 4,700,984 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365044,636,863 - 4,700,887 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAMK2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2151,248,358 - 151,308,706 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12151,248,356 - 151,353,907 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22158,335,771 - 158,396,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAMK2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12352,829,438 - 52,899,428 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2352,829,350 - 52,899,375 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603424,817,181 - 24,887,318 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Camk2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,526,323 - 9,585,649 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,526,323 - 9,585,647 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Camk2a
2017 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3348
Count of miRNA genes:789
Interacting mature miRNAs:1060
Transcripts:ENSMUST00000025519, ENSMUST00000039904, ENSMUST00000102888, ENSMUST00000115295, ENSMUST00000115297, ENSMUST00000134496, ENSMUST00000137805
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
12910791Pwgrq8_mpre-weaning growth rate QTL 8 (mouse)185802139969349142Mouse
4141431Msmr2_mMSM lymphoma resistance 2 (mouse)Not determined5497587361238870Mouse
10412183Sstapa2_mSuseptibility to Staphylococus aureus infection 2 (mouse)Not determined185679463066952485Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
1301215Thcr_mT helper cell response (mouse)Not determined184513060468778777Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185329102276914293Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
1302050Radpf4_mradiation pulmonary fibrosis 4 (mouse)Not determined185296615668778777Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186013307280043215Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse
27226720Tibw5_mtibia width 5, proximal, 10 week (mouse)185043306762633071Mouse

Markers in Region
RH125135  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381860,987,492 - 60,987,609UniSTSGRCm38
MGSCv371861,147,146 - 61,147,263UniSTSGRCm37
Celera1862,274,420 - 62,274,537UniSTS
Cytogenetic Map18E1UniSTS
cM Map1833.0UniSTS
UniSTS:225275  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381860,987,359 - 60,987,514UniSTSGRCm38
MGSCv371861,147,013 - 61,147,168UniSTSGRCm37
Celera1862,274,287 - 62,274,442UniSTS
Cytogenetic Map18E1UniSTS
cM Map1833.0UniSTS
Camk2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381860,984,406 - 60,984,834UniSTSGRCm38
MGSCv371861,144,060 - 61,144,488UniSTSGRCm37
Celera1862,271,342 - 62,271,770UniSTS
Cytogenetic Map18E1UniSTS
cM Map1833.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001286809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_177407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ222796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW490258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB659027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY713276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X87142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000025519   ⟹   ENSMUSP00000025519
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,058,704 - 61,119,479 (+)Ensembl
GRCm38.p6 Ensembl1860,925,632 - 60,986,407 (+)Ensembl
Ensembl Acc Id: ENSMUST00000039904   ⟹   ENSMUSP00000048325
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,096,672 - 61,118,769 (+)Ensembl
GRCm38.p6 Ensembl1860,963,600 - 60,985,697 (+)Ensembl
Ensembl Acc Id: ENSMUST00000102888   ⟹   ENSMUSP00000099952
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,058,690 - 61,121,224 (+)Ensembl
GRCm38.p6 Ensembl1860,925,618 - 60,988,152 (+)Ensembl
Ensembl Acc Id: ENSMUST00000115295   ⟹   ENSMUSP00000110950
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,096,626 - 61,117,935 (+)Ensembl
GRCm38.p6 Ensembl1860,963,554 - 60,984,863 (+)Ensembl
Ensembl Acc Id: ENSMUST00000115297   ⟹   ENSMUSP00000110952
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,058,797 - 61,076,468 (+)Ensembl
GRCm38.p6 Ensembl1860,925,725 - 60,943,396 (+)Ensembl
Ensembl Acc Id: ENSMUST00000134496
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,058,704 - 61,076,450 (+)Ensembl
GRCm38.p6 Ensembl1860,925,632 - 60,943,378 (+)Ensembl
Ensembl Acc Id: ENSMUST00000137805   ⟹   ENSMUSP00000123480
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,060,021 - 61,088,711 (+)Ensembl
GRCm38.p6 Ensembl1860,926,949 - 60,955,639 (+)Ensembl
RefSeq Acc Id: NM_001286809   ⟹   NP_001273738
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391861,096,626 - 61,121,224 (+)NCBI
GRCm381860,963,554 - 60,988,152 (+)NCBI
Celera1862,212,530 - 62,274,768 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001403309   ⟹   NP_001390238
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391861,058,704 - 61,121,224 (+)NCBI
RefSeq Acc Id: NM_001403312   ⟹   NP_001390241
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391861,058,704 - 61,117,633 (+)NCBI
RefSeq Acc Id: NM_009792   ⟹   NP_033922
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391861,096,626 - 61,121,224 (+)NCBI
GRCm381860,963,554 - 60,988,152 (+)NCBI
MGSCv371861,085,286 - 61,147,806 (+)RGD
Celera1862,212,530 - 62,274,768 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_177407   ⟹   NP_803126
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391861,058,704 - 61,121,224 (+)NCBI
GRCm381860,925,632 - 60,988,152 (+)NCBI
MGSCv371861,085,286 - 61,147,806 (+)RGD
Celera1862,212,530 - 62,274,768 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033922   ⟸   NM_009792
- Peptide Label: isoform 1
- UniProtKB: P11798 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_803126   ⟸   NM_177407
- Peptide Label: isoform 2
- UniProtKB: Q61284 (UniProtKB/Swiss-Prot),   Q6ZWN4 (UniProtKB/Swiss-Prot),   P11798 (UniProtKB/Swiss-Prot),   Q80TN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273738   ⟸   NM_001286809
- Peptide Label: isoform 3
- UniProtKB: F8WHB5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000110952   ⟸   ENSMUST00000115297
Ensembl Acc Id: ENSMUSP00000110950   ⟸   ENSMUST00000115295
Ensembl Acc Id: ENSMUSP00000123480   ⟸   ENSMUST00000137805
Ensembl Acc Id: ENSMUSP00000025519   ⟸   ENSMUST00000025519
Ensembl Acc Id: ENSMUSP00000048325   ⟸   ENSMUST00000039904
Ensembl Acc Id: ENSMUSP00000099952   ⟸   ENSMUST00000102888
RefSeq Acc Id: NP_001390238   ⟸   NM_001403309
- Peptide Label: isoform 4
- UniProtKB: F8WIS9 (UniProtKB/TrEMBL),   Q80TN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001390241   ⟸   NM_001403312
- Peptide Label: isoform 2
- UniProtKB: Q80TN1 (UniProtKB/TrEMBL)
Protein Domains
Calcium/calmodulin-dependent protein kinase II   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11798-F1-model_v2 AlphaFold P11798 1-478 view protein structure

Promoters
RGD ID:13677922
Promoter ID:EPDNEW_M23110
Type:initiation region
Name:Camk2a_1
Description:Mus musculus calcium/calmodulin-dependent protein kinase II alpha, transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381860,925,632 - 60,925,692EPDNEW
RGD ID:6829126
Promoter ID:MM_KWN:25410
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000025519,   ENSMUST00000115297,   OTTMUST00000039175,   OTTMUST00000039177
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361861,084,766 - 61,085,367 (+)MPROMDB
RGD ID:6829128
Promoter ID:MM_KWN:25411
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000039179
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361861,086,566 - 61,087,066 (+)MPROMDB
RGD ID:6829125
Promoter ID:MM_KWN:25412
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000039904,   NM_009792
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361861,123,016 - 61,123,617 (+)MPROMDB
RGD ID:6847487
Promoter ID:MM_ACW:25101
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain
Transcripts:CAMK2A.ISEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361861,137,586 - 61,138,086 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88256 AgrOrtholog
Ensembl Genes ENSMUSG00000024617 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025519 ENTREZGENE
  ENSMUST00000025519.11 UniProtKB/TrEMBL
  ENSMUST00000039904 ENTREZGENE
  ENSMUST00000039904.7 UniProtKB/TrEMBL
  ENSMUST00000102888 ENTREZGENE
  ENSMUST00000102888.10 UniProtKB/Swiss-Prot
  ENSMUST00000115295 ENTREZGENE
  ENSMUST00000115295.9 UniProtKB/Swiss-Prot
  ENSMUST00000115297.8 UniProtKB/TrEMBL
  ENSMUST00000137805.3 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.620 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ca/CaM-dep_prot_kinase-assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTF2-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12322 UniProtKB/Swiss-Prot
MGD MGI:88256 ENTREZGENE
NCBI Gene 12322 ENTREZGENE
PANTHER CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CaMKII_AD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Camk2a PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54427 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z7K9_MOUSE UniProtKB/TrEMBL
  F6WHR9_MOUSE UniProtKB/TrEMBL
  F8WHB5 ENTREZGENE, UniProtKB/TrEMBL
  F8WIS9 ENTREZGENE, UniProtKB/TrEMBL
  KCC2A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q61284 ENTREZGENE
  Q6ZWN4 ENTREZGENE
  Q80TN1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q61284 UniProtKB/Swiss-Prot
  Q6ZWN4 UniProtKB/Swiss-Prot