Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Camk2a (calcium/calmodulin-dependent protein kinase II alpha) Mus musculus
Analyze
Symbol: Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
Description: Exhibits calmodulin binding activity; glutamate receptor binding activity; and protein serine/threonine kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of cardiac muscle cell apoptotic process; and protein phosphorylation. Localizes to Schaffer collateral - CA1 synapse; mitochondrion; and postsynaptic density. Is expressed in several structures, including alimentary system; early embryo; eye; genitourinary system; and nervous system. Used to study autism spectrum disorder and bipolar disorder. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 53 and autosomal recessive non-syndromic intellectual disability. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; fibroblast growth factor signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (S)-nicotine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-CaMKII; calcium/calmodulin-dependent protein kinase type II subunit alpha; caM kinase II subunit alpha; CaMK II; caMK-II subunit alpha; CaMKII; mKIAA0968; R74975
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1860,925,618 - 60,988,152 (+)EnsemblGRCm38mm10GRCm38
GRCm381860,925,307 - 60,988,152 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371861,085,286 - 61,147,806 (+)NCBIGRCm37mm9NCBIm37
MGSCv361861,051,001 - 61,113,513 (+)NCBImm8
Celera1862,212,530 - 62,274,768 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Camk2a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10284
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.