RGD Reference Report - Voltage-gated calcium channels. - Rat Genome Database

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Voltage-gated calcium channels.

Authors: Catterall, WA 
Citation: Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947.
RGD ID: 7204688
Pubmed: PMID:21746798   (View Abstract at PubMed)
PMCID: PMC3140680   (View Article at PubMed Central)
DOI: DOI:10.1101/cshperspect.a003947   (Journal Full-text)

Voltage-gated calcium (Ca(2+)) channels are key transducers of membrane potential changes into intracellular Ca(2+) transients that initiate many physiological events. There are ten members of the voltage-gated Ca(2+) channel family in mammals, and they serve distinct roles in cellular signal transduction. The Ca(V)1 subfamily initiates contraction, secretion, regulation of gene expression, integration of synaptic input in neurons, and synaptic transmission at ribbon synapses in specialized sensory cells. The Ca(V)2 subfamily is primarily responsible for initiation of synaptic transmission at fast synapses. The Ca(V)3 subfamily is important for repetitive firing of action potentials in rhythmically firing cells such as cardiac myocytes and thalamic neurons. This article presents the molecular relationships and physiological functions of these Ca(2+) channel proteins and provides information on their molecular, genetic, physiological, and pharmacological properties.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
calcium transport pathway   TAS 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688 RGD 
calcium transport pathway   ISOCACNA1A (Homo sapiens)7204688; 7204688 RGD 
calcium transport pathway   ISOCACNA1B (Homo sapiens)7204688; 7204688 RGD 
calcium transport pathway   ISOCACNA1C (Homo sapiens)7204688; 7204688 RGD 
calcium transport pathway   ISOCACNA1D (Homo sapiens)7204688; 7204688 RGD 
calcium transport pathway   ISOCACNA1E (Homo sapiens)7204688; 7204688 RGD 
calcium transport pathway   ISOCACNA1F (Homo sapiens)7204688; 7204688 RGD 
calcium transport pathway   ISOCACNA1G (Homo sapiens)7204688; 7204688 RGD 
calcium transport pathway   ISOCACNA1H (Homo sapiens)7204688; 7204688 RGD 
calcium transport pathway   ISOCACNA1I (Homo sapiens)7204688; 7204688 RGD 
calcium transport pathway   ISOCACNA1S (Homo sapiens)7204688; 7204688 RGD 
calcium transport pathway   ISOCACNB1 (Homo sapiens)7204688; 7204688 RGD 
calcium transport pathway   ISOCACNB2 (Homo sapiens)7204688; 7204688 RGD 
calcium transport pathway   ISOCACNB3 (Homo sapiens)7204688; 7204688 RGD 
calcium transport pathway   ISOCACNB4 (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   TAS 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNA1A (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNA1B (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNA1C (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNA1D (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNA1E (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNA1F (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNA1G (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNA1H (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNA1I (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNA1S (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNB1 (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNB2 (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNB3 (Homo sapiens)7204688; 7204688 RGD 
calcium/calcium-mediated signaling pathway   ISOCACNB4 (Homo sapiens)7204688; 7204688 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Cacna1a  (calcium voltage-gated channel subunit alpha1 A)
Cacna1b  (calcium voltage-gated channel subunit alpha1 B)
Cacna1c  (calcium voltage-gated channel subunit alpha1 C)
Cacna1d  (calcium voltage-gated channel subunit alpha1 D)
Cacna1e  (calcium voltage-gated channel subunit alpha1 E)
Cacna1f  (calcium voltage-gated channel subunit alpha1 F)
Cacna1g  (calcium voltage-gated channel subunit alpha1 G)
Cacna1h  (calcium voltage-gated channel subunit alpha1 H)
Cacna1i  (calcium voltage-gated channel subunit alpha1 I)
Cacna1s  (calcium voltage-gated channel subunit alpha1 S)
Cacnb1  (calcium voltage-gated channel auxiliary subunit beta 1)
Cacnb2  (calcium voltage-gated channel auxiliary subunit beta 2)
Cacnb3  (calcium voltage-gated channel auxiliary subunit beta 3)
Cacnb4  (calcium voltage-gated channel auxiliary subunit beta 4)

Genes (Mus musculus)
Cacna1a  (calcium channel, voltage-dependent, P/Q type, alpha 1A subunit)
Cacna1b  (calcium channel, voltage-dependent, N type, alpha 1B subunit)
Cacna1c  (calcium channel, voltage-dependent, L type, alpha 1C subunit)
Cacna1d  (calcium channel, voltage-dependent, L type, alpha 1D subunit)
Cacna1e  (calcium channel, voltage-dependent, R type, alpha 1E subunit)
Cacna1f  (calcium channel, voltage-dependent, alpha 1F subunit)
Cacna1g  (calcium channel, voltage-dependent, T type, alpha 1G subunit)
Cacna1h  (calcium channel, voltage-dependent, T type, alpha 1H subunit)
Cacna1i  (calcium channel, voltage-dependent, alpha 1I subunit)
Cacna1s  (calcium channel, voltage-dependent, L type, alpha 1S subunit)
Cacnb1  (calcium channel, voltage-dependent, beta 1 subunit)
Cacnb2  (calcium channel, voltage-dependent, beta 2 subunit)
Cacnb3  (calcium channel, voltage-dependent, beta 3 subunit)
Cacnb4  (calcium channel, voltage-dependent, beta 4 subunit)

Genes (Homo sapiens)
CACNA1A  (calcium voltage-gated channel subunit alpha1 A)
CACNA1B  (calcium voltage-gated channel subunit alpha1 B)
CACNA1C  (calcium voltage-gated channel subunit alpha1 C)
CACNA1D  (calcium voltage-gated channel subunit alpha1 D)
CACNA1E  (calcium voltage-gated channel subunit alpha1 E)
CACNA1F  (calcium voltage-gated channel subunit alpha1 F)
CACNA1G  (calcium voltage-gated channel subunit alpha1 G)
CACNA1H  (calcium voltage-gated channel subunit alpha1 H)
CACNA1I  (calcium voltage-gated channel subunit alpha1 I)
CACNA1S  (calcium voltage-gated channel subunit alpha1 S)
CACNB1  (calcium voltage-gated channel auxiliary subunit beta 1)
CACNB2  (calcium voltage-gated channel auxiliary subunit beta 2)
CACNB3  (calcium voltage-gated channel auxiliary subunit beta 3)
CACNB4  (calcium voltage-gated channel auxiliary subunit beta 4)


Additional Information