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Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel.

Authors: Perez-Reyes, E  Castellano, A  Kim, HS  Bertrand, P  Baggstrom, E  Lacerda, AE  Wei, XY  Birnbaumer, L 
Citation: Perez-Reyes E, etal., J Biol Chem 1992 Jan 25;267(3):1792-7.
Pubmed: (View Article at PubMed) PMID:1370480

The skeletal muscle dihydropyridine receptor/Ca2+ channel is composed of five protein components (alpha 1, alpha 2 delta, beta, and gamma). Only two such components, alpha 1 and alpha 2, have been identified in heart. The present study reports the cloning and expression of a novel beta gene that is expressed in heart, lung, and brain. Coexpression of this beta with a cardiac alpha 1 in Xenopus oocytes causes the following changes in Ca2+ channel activity: it increases peak currents, accelerates activation kinetics, and shifts the current-voltage relationship toward more hyperpolarized potentials. It also increases dihydropyridine binding to alpha 1 in COS cells. These results indicate that the cardiac L-type Ca2+ channel has a similar subunit structure as in skeletal muscle, and provides evidence for the modulatory role of the beta subunit.

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RGD ID: 632405
Created: 2003-08-29
Species: All species
Last Modified: 2004-05-25
Status: ACTIVE



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