Bmi1 (BMI1 proto-oncogene, polycomb ring finger) - Rat Genome Database

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Gene: Bmi1 (BMI1 proto-oncogene, polycomb ring finger) Rattus norvegicus
Analyze
Symbol: Bmi1
Name: BMI1 proto-oncogene, polycomb ring finger
RGD ID: 1307403
Description: Predicted to enable several functions, including RING-like zinc finger domain binding activity; promoter-specific chromatin binding activity; and zinc ion binding activity. Involved in cellular response to dexamethasone stimulus; cellular response to interleukin-1; and regulation of kidney development. Predicted to be located in cytosol; heterochromatin; and nuclear body. Predicted to be part of PRC1 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to several human genes including BMI1 (BMI1 proto-oncogene, polycomb ring finger); PARTICIPATES IN histone modification pathway; INTERACTS WITH amphetamine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B lymphoma Mo-MLV insertion region 1; Bmi1 polycomb ring finger oncogene; LOC307151; Pcgf4; polycomb complex protein BMI-1; polycomb group ring finger 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81786,240,683 - 86,250,044 (+)NCBIGRCr8
mRatBN7.21781,332,175 - 81,341,625 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1781,332,214 - 81,388,690 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1784,809,066 - 84,812,740 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01788,644,466 - 88,648,140 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01782,661,208 - 82,664,882 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01785,360,439 - 85,370,283 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1785,364,483 - 85,368,208 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01787,087,687 - 87,091,418 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41792,784,216 - 92,787,947 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11792,795,131 - 92,798,710 (+)NCBI
Celera1780,616,376 - 80,620,118 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
betulinic acid  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butyric acid  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
casticin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
genistein  (ISO)
glucaric acid  (ISO)
glutathione  (ISO)
glycidol  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydroxyurea  (ISO)
ibrutinib  (ISO)
indometacin  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
malathion  (ISO)
melatonin  (ISO)
monosodium L-glutamate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
ozone  (EXP)
p-anisidine  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pyrogallol  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Glucocorticoids induce long-lasting effects in neural stem cells resulting in senescence-related alterations. Bose R, etal., Cell Death Dis. 2010 Nov 4;1:e92.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. PRC1 complex diversity: where is it taking us? Gil J and O'Loghlen A, Trends Cell Biol. 2014 Jul 22. pii: S0962-8924(14)00102-0. doi: 10.1016/j.tcb.2014.06.005.
4. The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins. Kim JH, etal., Cancer Lett. 2004 Jan 20;203(2):217-24.
5. The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma. Martinez-Romero C, etal., J Pathol. 2009 Oct;219(2):205-13. doi: 10.1002/path.2585.
6. Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Metsuyanim S, etal., Stem Cells. 2008 Jul;26(7):1808-17. doi: 10.1634/stemcells.2007-0322. Epub 2008 May 8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. BMI-1 is highly expressed in M0-subtype acute myeloid leukemia. Sawa M, etal., Int J Hematol. 2005 Jul;82(1):42-7.
12. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
13. Pro-inflammatory cytokine interleukin-1beta promotes the development of intestinal stem cells. Wang L, etal., Inflamm Res. 2012 Oct;61(10):1085-92. doi: 10.1007/s00011-012-0501-3. Epub 2012 Jun 16.
14. Methylation-associated silencing of miR-200b facilitates human hepatocellular carcinoma progression by directly targeting BMI1. Wu WR, etal., Oncotarget. 2016 Apr 5;7(14):18684-93. doi: 10.18632/oncotarget.7629.
15. Aberrant expression of EZH2 is associated with a poor outcome and P53 alteration in squamous cell carcinoma of the esophagus. Yamada A, etal., Int J Oncol. 2011 Feb;38(2):345-53. doi: 10.3892/ijo.2010.868. Epub 2010 Dec 9.
Additional References at PubMed
PMID:7926765   PMID:8887324   PMID:9312051   PMID:9367786   PMID:10445843   PMID:11290297   PMID:12167701   PMID:12183370   PMID:12477932   PMID:12714971   PMID:15334543   PMID:15964995  
PMID:16359901   PMID:16624538   PMID:16687444   PMID:16714294   PMID:17107999   PMID:17420273   PMID:18311137   PMID:19636380   PMID:20956546   PMID:21282530   PMID:21544870   PMID:22770845  
PMID:24105743   PMID:24352954   PMID:24623306   PMID:26151332   PMID:27716060   PMID:29479858   PMID:34101367  


Genomics

Comparative Map Data
Bmi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81786,240,683 - 86,250,044 (+)NCBIGRCr8
mRatBN7.21781,332,175 - 81,341,625 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1781,332,214 - 81,388,690 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1784,809,066 - 84,812,740 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01788,644,466 - 88,648,140 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01782,661,208 - 82,664,882 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01785,360,439 - 85,370,283 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1785,364,483 - 85,368,208 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01787,087,687 - 87,091,418 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41792,784,216 - 92,787,947 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11792,795,131 - 92,798,710 (+)NCBI
Celera1780,616,376 - 80,620,118 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
BMI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381022,321,099 - 22,331,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1022,321,099 - 22,331,484 (+)EnsemblGRCh38hg38GRCh38
GRCh371022,610,028 - 22,620,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361022,650,146 - 22,660,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 341022,650,145 - 22,660,190NCBI
Celera1022,297,715 - 22,308,139 (+)NCBICelera
Cytogenetic Map10p12.2NCBI
HuRef1022,276,563 - 22,281,617 (+)NCBIHuRef
CHM1_11022,610,777 - 22,620,864 (+)NCBICHM1_1
T2T-CHM13v2.01022,340,133 - 22,350,740 (+)NCBIT2T-CHM13v2.0
Bmi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39218,681,953 - 18,691,440 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl218,681,829 - 18,691,440 (+)EnsemblGRCm39 Ensembl
GRCm38218,677,018 - 18,686,629 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl218,677,018 - 18,686,629 (+)EnsemblGRCm38mm10GRCm38
MGSCv37218,598,645 - 18,608,256 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36218,594,772 - 18,604,383 (+)NCBIMGSCv36mm8
Celera218,564,450 - 18,578,495 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map212.9NCBI
Bmi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554296,547,731 - 6,558,105 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554296,548,586 - 6,553,730 (-)NCBIChiLan1.0ChiLan1.0
BMI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2835,001,734 - 35,011,206 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11035,006,599 - 35,016,531 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01022,477,755 - 22,487,894 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11022,854,230 - 22,863,482 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1022,857,776 - 22,863,479 (+)Ensemblpanpan1.1panPan2
BMI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1210,818,232 - 10,828,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl210,818,232 - 10,833,613 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha29,511,530 - 9,521,768 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.029,018,100 - 9,028,340 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl29,018,100 - 9,033,607 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.128,381,805 - 8,392,033 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.028,465,970 - 8,476,210 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.028,633,839 - 8,644,069 (-)NCBIUU_Cfam_GSD_1.0
Bmi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934422,243,467 - 22,253,222 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365205,707,778 - 5,717,024 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365205,707,542 - 5,716,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1052,586,509 - 52,596,564 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11052,586,089 - 52,596,154 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21058,240,742 - 58,245,839 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BMI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1922,095,592 - 22,104,894 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605127,837,839 - 27,848,269 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247966,274,561 - 6,282,984 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247966,277,201 - 6,282,830 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bmi1
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:37
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000064257
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)177177462182479847Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat

Markers in Region
M64279  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21781,341,181 - 81,341,361 (+)MAPPERmRatBN7.2
Rnor_6.01785,369,840 - 85,370,019NCBIRnor6.0
Rnor_5.01787,093,044 - 87,093,223UniSTSRnor5.0
RGSC_v3.41792,789,573 - 92,789,752UniSTSRGSC3.4
Celera1780,621,744 - 80,621,923UniSTS
Cytogenetic Map17q12.3UniSTS
RH136669  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21781,340,905 - 81,341,065 (+)MAPPERmRatBN7.2
Rnor_6.01785,369,564 - 85,369,723NCBIRnor6.0
Rnor_5.01787,092,768 - 87,092,927UniSTSRnor5.0
RGSC_v3.41792,789,297 - 92,789,456UniSTSRGSC3.4
Celera1780,621,468 - 80,621,627UniSTS
RH 3.4 Map17832.8UniSTS
Cytogenetic Map17q12.3UniSTS
AI172222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21781,341,193 - 81,341,290 (+)MAPPERmRatBN7.2
Rnor_6.01785,369,852 - 85,369,948NCBIRnor6.0
Rnor_5.01787,093,056 - 87,093,152UniSTSRnor5.0
RGSC_v3.41792,789,585 - 92,789,681UniSTSRGSC3.4
Celera1780,621,756 - 80,621,852UniSTS
RH 3.4 Map17833.7UniSTS
Cytogenetic Map17q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000064257   ⟹   ENSRNOP00000059998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1781,332,214 - 81,388,690 (+)Ensembl
Rnor_6.0 Ensembl1785,364,483 - 85,368,208 (+)Ensembl
RefSeq Acc Id: NM_001107368   ⟹   NP_001100838
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,244,244 - 86,247,975 (+)NCBI
mRatBN7.21781,335,825 - 81,339,556 (+)NCBI
Rnor_6.01785,364,483 - 85,368,214 (+)NCBI
Rnor_5.01787,087,687 - 87,091,418 (+)NCBI
RGSC_v3.41792,784,216 - 92,787,947 (+)RGD
Celera1780,616,376 - 80,620,118 (+)RGD
Sequence:
RefSeq Acc Id: XM_039095805   ⟹   XP_038951733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,240,683 - 86,250,044 (+)NCBI
mRatBN7.21781,332,175 - 81,341,625 (+)NCBI
RefSeq Acc Id: XM_039095806   ⟹   XP_038951734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,240,982 - 86,250,044 (+)NCBI
mRatBN7.21781,332,635 - 81,341,625 (+)NCBI
RefSeq Acc Id: XM_039095807   ⟹   XP_038951735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,241,276 - 86,250,044 (+)NCBI
mRatBN7.21781,336,006 - 81,341,625 (+)NCBI
RefSeq Acc Id: XM_039095808   ⟹   XP_038951736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,244,352 - 86,250,044 (+)NCBI
mRatBN7.21781,336,164 - 81,341,625 (+)NCBI
RefSeq Acc Id: XM_063276500   ⟹   XP_063132570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,240,972 - 86,250,044 (+)NCBI
RefSeq Acc Id: XM_063276501   ⟹   XP_063132571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,244,359 - 86,250,044 (+)NCBI
RefSeq Acc Id: NP_001100838   ⟸   NM_001107368
- UniProtKB: B4F7B6 (UniProtKB/TrEMBL),   A6JM95 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059998   ⟸   ENSRNOT00000064257
RefSeq Acc Id: XP_038951733   ⟸   XM_039095805
- Peptide Label: isoform X1
- UniProtKB: B4F7B6 (UniProtKB/TrEMBL),   A6JM95 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951734   ⟸   XM_039095806
- Peptide Label: isoform X1
- UniProtKB: B4F7B6 (UniProtKB/TrEMBL),   A6JM95 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951735   ⟸   XM_039095807
- Peptide Label: isoform X1
- UniProtKB: B4F7B6 (UniProtKB/TrEMBL),   A6JM95 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951736   ⟸   XM_039095808
- Peptide Label: isoform X1
- UniProtKB: B4F7B6 (UniProtKB/TrEMBL),   A6JM95 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132570   ⟸   XM_063276500
- Peptide Label: isoform X1
- UniProtKB: A6JM95 (UniProtKB/TrEMBL),   B4F7B6 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132571   ⟸   XM_063276501
- Peptide Label: isoform X1
- UniProtKB: A6JM95 (UniProtKB/TrEMBL),   B4F7B6 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B4F7B6-F1-model_v2 AlphaFold B4F7B6 1-324 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307403 AgrOrtholog
BioCyc Gene G2FUF-8558 BioCyc
Ensembl Genes ENSRNOG00000016585 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064257.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro RAWUL UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:307151 UniProtKB/TrEMBL
NCBI Gene 307151 ENTREZGENE
PANTHER POLYCOMB COMPLEX PROTEIN BMI-1 UniProtKB/TrEMBL
  RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT UniProtKB/TrEMBL
Pfam RAWUL UniProtKB/TrEMBL
  zf-C3HC4_2 UniProtKB/TrEMBL
PharmGKB BMI1 RGD
PhenoGen Bmi1 PhenoGen
PROSITE ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016585 RatGTEx
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A6JM95 ENTREZGENE, UniProtKB/TrEMBL
  B4F7B6 ENTREZGENE
  F7FA44 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B4F7B6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-09 Bmi1  BMI1 proto-oncogene, polycomb ring finger  Bmi1  Bmi1 polycomb ring finger oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Bmi1  Bmi1 polycomb ring finger oncogene  Pcgf4_predicted  polycomb group ring finger 4 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Pcgf4_predicted  polycomb group ring finger 4 (predicted)  Bmi1_predicted  B lymphoma Mo-MLV insertion region 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Bmi1_predicted  B lymphoma Mo-MLV insertion region 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED