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Gene: Bmi1 (Bmi1 polycomb ring finger oncogene) Mus musculus
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Symbol: Bmi1
Name: Bmi1 polycomb ring finger oncogene
Description: Exhibits RNA polymerase II proximal promoter sequence-specific DNA binding activity; promoter-specific chromatin binding activity; and ubiquitin-protein transferase activator activity. Involved in several processes, including chordate embryonic development; histone modification; and positive regulation of lymphocyte proliferation. Localizes to the heterochromatin; nucleus; and ubiquitin ligase complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; and hepatocellular carcinoma. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to several human genes including COMMD3-BMI1 (COMMD3-BMI1 readthrough); PARTICIPATES IN histone modification pathway; INTERACTS WITH 1,4-benzoquinone; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AW546694; B lymphoma Mo-MLV insertion region 1; Bmi-1; Pcgf4; polycomb complex protein BMI-1; polycomb group ring finger 4; polycomb group RING finger protein 4
Orthologs:
Homo sapiens (human) : BMI1 (BMI1 proto-oncogene, polycomb ring finger)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Bmi1 (BMI1 proto-oncogene, polycomb ring finger)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bmi1 (BMI1 proto-oncogene, polycomb ring finger)
Pan paniscus (bonobo/pygmy chimpanzee) : BMI1 (BMI1 proto-oncogene, polycomb ring finger)
Canis lupus familiaris (dog) : BMI1 (BMI1 proto-oncogene, polycomb ring finger)
Sus scrofa (pig) : BMI1 (BMI1 proto-oncogene, polycomb ring finger)
Chlorocebus sabaeus (green monkey) : BMI1 (BMI1 proto-oncogene, polycomb ring finger)
Heterocephalus glaber (naked mole-rat) : Bmi1 (BMI1 proto-oncogene, polycomb ring finger)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl218,677,018 - 18,686,629 (+)Ensembl
GRCm38218,677,018 - 18,686,629 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37218,598,645 - 18,608,256 (+)NCBIGRCm37mm9NCBIm37
MGSCv36218,594,772 - 18,604,383 (+)NCBImm8
Celera218,564,450 - 18,578,495 (+)NCBICelera
Cytogenetic Map2 A3NCBI
cM Map212.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Bmi1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316582
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.