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Gene: Bmi1 (Bmi1 polycomb ring finger oncogene) Mus musculus
Symbol: Bmi1
Name: Bmi1 polycomb ring finger oncogene
Description: Exhibits RNA polymerase II proximal promoter sequence-specific DNA binding activity; promoter-specific chromatin binding activity; and ubiquitin-protein transferase activator activity. Involved in several processes, including chordate embryonic development; histone modification; and positive regulation of lymphocyte proliferation. Localizes to the heterochromatin; nucleus; and ubiquitin ligase complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; and hepatocellular carcinoma. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to several human genes including COMMD3-BMI1 (COMMD3-BMI1 readthrough); PARTICIPATES IN histone modification pathway; INTERACTS WITH 1,4-benzoquinone; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
Also known as: AW546694; B lymphoma Mo-MLV insertion region 1; Bmi-1; Pcgf4; polycomb complex protein BMI-1; polycomb group ring finger 4; polycomb group RING finger protein 4
Homo sapiens (human) : BMI1 (BMI1 proto-oncogene, polycomb ring finger)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Bmi1 (BMI1 proto-oncogene, polycomb ring finger)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bmi1 (BMI1 proto-oncogene, polycomb ring finger)
Pan paniscus (bonobo/pygmy chimpanzee) : BMI1 (BMI1 proto-oncogene, polycomb ring finger)
Canis lupus familiaris (dog) : BMI1 (BMI1 proto-oncogene, polycomb ring finger)
Sus scrofa (pig) : BMI1 (BMI1 proto-oncogene, polycomb ring finger)
Chlorocebus sabaeus (green monkey) : BMI1 (BMI1 proto-oncogene, polycomb ring finger)
Heterocephalus glaber (naked mole-rat) : Bmi1 (BMI1 proto-oncogene, polycomb ring finger)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl218,677,018 - 18,686,629 (+)Ensembl
GRCm38218,677,018 - 18,686,629 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37218,598,645 - 18,608,256 (+)NCBIGRCm37mm9NCBIm37
MGSCv36218,594,772 - 18,604,383 (+)NCBImm8
Celera218,564,450 - 18,578,495 (+)NCBICelera
Cytogenetic Map2 A3NCBI
cM Map212.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Bmi1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316582
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.