Gdi2 (GDP dissociation inhibitor 2)

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Gene: Gdi2 (GDP dissociation inhibitor 2) Rattus norvegicus

Analyze

Symbol:

Gdi2

Name:

GDP dissociation inhibitor 2

RGD ID:

61802

Description:

Enables Rab GDP-dissociation inhibitor activity and small GTPase binding activity. Involved in vesicle-mediated transport. Is active in synapse. Orthologous to human GDI2 (GDP dissociation inhibitor 2); PARTICIPATES IN Rab family mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol; 2-methoxyethanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GDI-2; GDI-3; Gdi3; guanosine diphosphate (GDP) dissociation inhibitor 3; guanosine diphosphate dissociation inhibitor 2; guanosine diphosphate dissociation inhibitor 3; rab GDI beta; rab GDP dissociation inhibitor beta

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GDI2 (GDP dissociation inhibitor 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gdi2 (guanosine diphosphate (GDP) dissociation inhibitor 2)	HGNC	Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Gdi2 (GDP dissociation inhibitor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GDI2 (GDP dissociation inhibitor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GDI2 (GDP dissociation inhibitor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gdi2 (GDP dissociation inhibitor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GDI2 (GDP dissociation inhibitor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GDI2 (GDP dissociation inhibitor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gdi2 (GDP dissociation inhibitor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GDI1 (GDP dissociation inhibitor 1)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Gdi2 (guanosine diphosphate (GDP) dissociation inhibitor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GDI2 (GDP dissociation inhibitor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	gdi2 (GDP dissociation inhibitor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GDI1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Gdi	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gdi-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	66,649,616 - 66,676,299 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	17	66,649,619 - 66,676,366 (-)	Ensembl
Rnor_6.0	17	70,299,177 - 70,325,864 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	70,299,183 - 70,325,855 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	72,003,428 - 72,030,115 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	77,843,481 - 77,870,171 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	17	77,854,314 - 77,881,004 (-)	NCBI
Celera	17	66,154,818 - 66,181,499 (-)	NCBI		Celera
Cytogenetic Map	17	q12.2	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Down syndrome (ISO)

esophagus squamous cell carcinoma (ISO)

hypoparathyroidism-deafness-renal disease syndrome (ISO)

immunodeficiency 41 (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-ethoxyethanol (EXP)

2-methoxyethanol (EXP)

acrolein (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

aristolochic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

buspirone (EXP)

carmustine (ISO)

chloropicrin (ISO)

choline (EXP)

cobalt dichloride (EXP,ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

diarsenic trioxide (ISO)

dichlorine (EXP)

dicrotophos (ISO)

dimethylarsinic acid (EXP)

doxorubicin (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

folic acid (EXP,ISO)

fulvestrant (ISO)

gentamycin (EXP)

ivermectin (ISO)

L-methionine (EXP)

lovastatin (ISO)

menadione (ISO)

methidathion (ISO)

N-nitrosomorpholine (EXP)

nickel subsulfide (EXP)

nitric oxide (ISO)

Nonylphenol (EXP)

ozone (EXP,ISO)

paracetamol (EXP,ISO)

PCB138 (EXP)

phenol red (ISO)

propiconazole (ISO)

rotenone (ISO)

S-butyl-DL-homocysteine (S,R)-sulfoximine (ISO)

silicon dioxide (ISO)

simvastatin (EXP)

trichloroethene (EXP)

valproic acid (ISO)

warfarin (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of cilium assembly (ISO,ISS)

negative regulation of protein localization to cilium (ISO,ISS)

protein transport (IEA,TAS)

regulation of catalytic activity (IEA)

small GTPase mediated signal transduction (IEA,ISO)

vesicle-mediated transport (IBA,IEP)

Cellular Component

cytoplasm (IBA,IEA)

cytosol (TAS)

Golgi apparatus (ISO)

membrane (IEA)

synapse (EXP,IDA)

Molecular Function

GTPase activator activity (IEA,ISO)

protein binding (ISO)

Rab GDP-dissociation inhibitor activity (IBA,IDA,IEA)

small GTPase binding (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

Rab family mediated signaling pathway (TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	Molecular cloning and characterization of two rab GDI species from rat brain: brain-specific and ubiquitous types.	Nishimura N, etal., J Biol Chem 1994 May 13;269(19):14191-8.
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
9.	Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain.	Weitzdoerfer R, etal., J Neural Transm Suppl. 2001;(61):347-59.
10.	Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.	Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.

Additional References at PubMed

PMID:7642711	PMID:7779099	PMID:7782346	PMID:15489334	PMID:17634366	PMID:19056867	PMID:19190083	PMID:21423176	PMID:22082260	PMID:22681889	PMID:22871113	PMID:23376485
PMID:23533145	PMID:29476059

Genomics

Comparative Map Data

Gdi2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	66,649,616 - 66,676,299 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	17	66,649,619 - 66,676,366 (-)	Ensembl
Rnor_6.0	17	70,299,177 - 70,325,864 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	70,299,183 - 70,325,855 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	72,003,428 - 72,030,115 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	77,843,481 - 77,870,171 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	17	77,854,314 - 77,881,004 (-)	NCBI
Celera	17	66,154,818 - 66,181,499 (-)	NCBI		Celera
Cytogenetic Map	17	q12.2	NCBI

GDI2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	5,765,223 - 5,813,434 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	10	5,765,223 - 5,842,132 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	5,807,186 - 5,855,397 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	5,847,192 - 5,895,379 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	10	5,847,191 - 5,895,379	NCBI
Celera	10	5,737,566 - 5,785,880 (-)	NCBI
Cytogenetic Map	10	p15.1	NCBI
HuRef	10	5,737,326 - 5,785,616 (-)	NCBI		HuRef
CHM1_1	10	5,807,126 - 5,855,477 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	5,769,012 - 5,817,195 (-)	NCBI

Gdi2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	3,588,075 - 3,616,261 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	13	3,588,063 - 3,617,871 (+)	Ensembl
GRCm38	13	3,538,075 - 3,566,261 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	3,538,063 - 3,567,871 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	3,537,321 - 3,565,507 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	13	3,537,379 - 3,567,117 (+)	NCBI			mm8
Celera	13	3,527,746 - 3,555,904 (+)	NCBI		Celera
Cytogenetic Map	13	A1	NCBI

Gdi2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955421	22,450,402 - 22,480,512 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955421	22,449,620 - 22,480,721 (-)	NCBI	ChiLan1.0	ChiLan1.0

GDI2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	10	5,790,651 - 5,839,003 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	5,789,496 - 5,839,003 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	10	5,806,336 - 5,854,676 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

GDI2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	30,150,769 - 30,168,957 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	30,150,769 - 30,169,110 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	27,170,581 - 27,198,461 (+)	NCBI
ROS_Cfam_1.0	2	30,521,228 - 30,549,903 (+)	NCBI
ROS_Cfam_1.0 Ensembl	2	30,520,947 - 30,549,902 (+)	Ensembl
UMICH_Zoey_3.1	2	27,617,910 - 27,645,820 (+)	NCBI
UNSW_CanFamBas_1.0	2	28,454,277 - 28,482,176 (+)	NCBI
UU_Cfam_GSD_1.0	2	29,172,555 - 29,200,474 (+)	NCBI

Gdi2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	32,582,901 - 32,610,040 (+)	NCBI
SpeTri2.0	NW_004936484	8,748,050 - 8,775,234 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GDI2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	65,160,653 - 65,196,447 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	65,160,700 - 65,196,447 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	71,276,439 - 71,312,186 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GDI2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	5,876,245 - 5,923,011 (-)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	9	5,877,042 - 5,922,968 (-)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666051	11,178,905 - 11,225,679 (-)	NCBI	Vero_WHO_p1.0

Gdi2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624775	594,472 - 622,592 (+)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624775	594,477 - 622,592 (+)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

RH127379

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	66,676,692 - 66,676,912 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	70,326,258 - 70,326,477	NCBI	Rnor6.0
Rnor_5.0	17	72,030,509 - 72,030,728	UniSTS	Rnor5.0
RGSC_v3.4	17	77,870,565 - 77,870,784	UniSTS	RGSC3.4
Celera	17	66,181,893 - 66,182,112	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

RH133700

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	66,675,498 - 66,675,683 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	70,325,064 - 70,325,248	NCBI	Rnor6.0
Rnor_5.0	17	72,029,315 - 72,029,499	UniSTS	Rnor5.0
RGSC_v3.4	17	77,869,371 - 77,869,555	UniSTS	RGSC3.4
Celera	17	66,180,699 - 66,180,883	UniSTS
RH 3.4 Map	17	637.4	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	31368391	73951021	Rat
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	31990784	76990784	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	31990784	81292925	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	34550843	73951021	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	35837085	69599340	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	37479847	82479847	Rat
2317054	Aia12	Adjuvant induced arthritis QTL 12	4.24		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	38281509	83281509	Rat
2317060	Aia26	Adjuvant induced arthritis QTL 26	3.22		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	38281509	83281509	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40540041	80387013	Rat
1358295	Aocep1	Aortic cell protein QTL 1	6.1	0.00000071	thoracic aorta cellular protein amount (VT:0010598)	aortic cell percentage	17	40990005	85990005	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	17	42073160	69599340	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	42073160	69599340	Rat
7411575	Bw140	Body weight QTL 140	30.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
8694181	Bw151	Body weight QTL 151	4.36	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	49920154	86533673	Rat
2303580	Gluco49	Glucose level QTL 49	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	50040271	86533673	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	50909099	86022412	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	53498828	82479847	Rat
70210	Cm15	Cardiac mass QTL 15	6.5		heart right ventricle mass (VT:0007033)	heart right ventricle wet weight (CMO:0000072)	17	57246723	70156904	Rat
1600398	Edcs5	Endometrial carcinoma susceptibility QTL 5	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	17	57246723	70852846	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	57246843	82046127	Rat
7488963	Bp369	Blood pressure QTL 369		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	59005649	77910000	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	60781426	86533673	Rat
7411577	Bw141	Body weight QTL 141		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	62619516	86533673	Rat
1300131	Bp193	Blood pressure QTL 193	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	63640009	73951021	Rat
631502	Cm26	Cardiac mass QTL 26	3.71		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	65703580	81153923	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	131
Count of miRNA genes:	111
Interacting mature miRNAs:	119
Transcripts:	ENSRNOT00000024952
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC061767	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X74401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000024952 ⟹ ENSRNOP00000024952

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	66,649,628 - 66,676,351 (-)	Ensembl
Rnor_6.0 Ensembl	17	70,299,183 - 70,325,855 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104020 ⟹ ENSRNOP00000077443

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	66,649,619 - 66,676,199 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109674 ⟹ ENSRNOP00000082980

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	66,649,619 - 66,676,366 (-)	Ensembl

RefSeq Acc Id:

NM_017276 ⟹ NP_058972

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	66,649,616 - 66,676,299 (-)	NCBI
Rnor_6.0	17	70,299,177 - 70,325,864 (-)	NCBI
Rnor_5.0	17	72,003,428 - 72,030,115 (-)	NCBI
RGSC_v3.4	17	77,843,481 - 77,870,171 (-)	RGD
Celera	17	66,154,818 - 66,181,499 (-)	RGD

Sequence:

show sequence

CGCTTTTTTCCCTCTTCCCCCCGGGGCCCAGAACGGCCGGACTTCTCGCTCCCTTCTCTACGGT
GGCCTCCGAGCCCTTGTGTGCGCTCCTTTCCCCGCCATGAATGAGGAATACGACGTGATCGTGC
TGGGCACCGGCCTGACGGAATGTATCCTGTCGGGGATAATGTCAGTGAATGGAAAGAAGGTTCT
TCATATGGATCAGAACCCATACTATGGAGGAGAAAGTGCATCTATAACACCGCTGGAAGATTTA
TACAAAAGATTTAAATTACCAGGACAACCACCAGCATCGATGGGGAGAGGAAGAGACTGGAATG
TTGACTTAATTCCCAAGTTCCTTATGGCCAATGGTCAGTTGGTGAAGATGCTGCTTTTCACAGA
GGTCACTCGTTATATGGACTTCAAAGTGATCGAAGGGAGCTTTGTCTACAAGGGAGGGAAAATC
TACAAGGTTCCTTCCACTGAAGCAGAAGCCCTGGCGTCTAGCTTAATGGGACTGTTTGAGAAAC
GCCGCTTCAGGAAGTTCCTAGTTTATGTTGCCAACTTTGATGAAAAAGATCCTAGAACTTTTGA
GGGTGTGGATCCTAAGAAGACCTCCATGAGAGATGTGTATAAGAAGTTTGATTTGGGCCAGGAT
GTTATAGACTTTACTGGCCATTCTCTTGCATTGTACAGAACAGATGACTACTTAGACCAGCCAT
GTTGTGAAACGATTAACAGAATTAAACTTTACAGCGAGTCTTTGGCAAGATATGGTAAAAGCCC
ATACCTCTATCCACTTTATGGTCTTGGGGAATTGCCACAAGGATTTGCAAGGTTAAGTGCTATA
TATGGAGGTACCTACATGTTGAATAAGCCAATTGAAGAAATCATTGTGCAAAATGGAAAAGTGG
TTGGCGTGAAATCTGAAGGAGAGATTGCTCGCTGTAAGCAGCTCATCTGTGATCCCAGCTATGT
CAAGGATCGGGTTGAAAAAGTAGGCCAGGTAATCAGAGTGATCTGTATCCTTAGCCACCCCATC
AAGAACACCAACGATGCTAACTCCTGCCAGATCATCATTCCACAGAACCAAGTCAACCGCAAGT
CAGATATCTATGTTTGCATGATCTCCTTTGCACATAATGTGGCAGCACAGGGCAAGTATATTGC
CATTGTAAGTACAACTGTGGAGACTAAGGAACCAGAGAAAGAAATCAGACCAGCTTTGGAGCTC
TTGGAACCAATTGAACAAAAATTTGTCAGCATCAGCGACCTCTTTGTACCTAAAGATTTGGGAA
CAGATAGTCAGATCTTTATTTCCCGTGCCTATGATGCTACCACACACTTTGAGACAACCTGTGA
TGACATCAAAGATATCTATAAGAGGATGACAGGGTCTGAGTTTGACTTTGAAGAAATGAAGCGC
AAGAAGAATGACATTTATGGAGAAGACTAACAGCAGTACATATTATGTAATTAGGACAAACTTA
AAATTTGGCAAATAATGTATATTGTATGAAATCAATATTGTAAGCCCTGCTTTTATGATCGAAG
TGGAGATTGAAGAGTGCTATACCAGTGAATGCTCCCTCACTTTTCTAATATCATGTATTAACTT
GTTTTCATGGAATGGCTAGTCAGAATTGGTTGGTTCTGTTCAGTTTAACCAAACTGCATTTTTT
TTTTTTTGTAGTGAAGGAGCTGTTCTAAACATATATTGATATCGATAGAGAACTTGATACAGTA
CTTGTATCTTTTAATCACTGTAGCCTTTACGATTGTGTGATGTTGCCCAAGAGCTGGATCCATA
CAATTTGTTGCCATCCTGATATTGGGAGTCAAATTGAATATCCTTTGGTTTCTGAAAACGTTCA
GTTTTCGCTATTTTGTTATGTCAAGTATTACAGCAGGGCCCAGATAGGAGAGCCACATGTTTTG
TTTATGTGGGTATAAACTTTAACCAAACTTCAGACTTAGGGAGTTGTTTGGAGAAGCCAATATG
TGGTATTTTAACCTACAATTGCTGAGAAAGGGAAAGCAGGTAAAAATATAGAAGCACCTTTTAT
CCCAGGTATGGCTTCTTCAACGGACCAAGCTGCAATGCAGTATTGATTTGACAGAGCCTCAATT
TCGATGATGTCTGTTCCAAAATGGCTCCAAATGATTTCTGTACTGCAAAATAAAGCCAAACTCT
GGAAACCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_058972	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH61767	(Get FASTA)	NCBI Sequence Viewer
	CAA52412	(Get FASTA)	NCBI Sequence Viewer
	EDL78588	(Get FASTA)	NCBI Sequence Viewer
	P50399	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_058972 ⟸ NM_017276

- UniProtKB:

P50399 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDQNPYYGGESASITPLEDLYKRFKLPGQPPA
SMGRGRDWNVDLIPKFLMANGQLVKMLLFTEVTRYMDFKVIEGSFVYKGGKIYKVPSTEAEALA
SSLMGLFEKRRFRKFLVYVANFDEKDPRTFEGVDPKKTSMRDVYKKFDLGQDVIDFTGHSLALY
RTDDYLDQPCCETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIE
EIIVQNGKVVGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQII
IPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSIS
DLFVPKDLGTDSQIFISRAYDATTHFETTCDDIKDIYKRMTGSEFDFEEMKRKKNDIYGED

hide sequence

RefSeq Acc Id:

ENSRNOP00000024952 ⟸ ENSRNOT00000024952

RefSeq Acc Id:

ENSRNOP00000082980 ⟸ ENSRNOT00000109674

RefSeq Acc Id:

ENSRNOP00000077443 ⟸ ENSRNOT00000104020

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P50399-F1-model_v2	AlphaFold	P50399	1-445	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700553

Promoter ID:

EPDNEW_R11077

Type:

multiple initiation site

Name:

Gdi2_1

Description:

GDP dissociation inhibitor 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	70,325,927 - 70,325,987	EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)

ACI/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Damaging Variants

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
17	70299969	70299970	A	C	snv	CDR, SBH/Ygl (MCW)
17	70299970	70299971	A	T	snv	SBH/Ygl (MCW), CDR
17	70300469	70300470	G	A	snv	SBH/Ygl (MCW), CDR
17	70300489	70300490	A	G	snv	SBH/Ygl (MCW)
17	70303199	70303200	G	A	snv	CDR, SBH/Ygl (MCW)
17	70308614	70308615	C	T	snv	SBH/Ygl (MCW)
17	70310499	70310500	T	C	snv	CDR, SBH/Ygl (RGD), SBH/Ygl (MCW)
17	70310511	70310512	T	C	snv	CDR, SBH/Ygl (MCW), SBH/Ygl (RGD), BBDP/Wor (RGD)

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
17	72004720	72004721	G	A	snv	SBH/Ygl (MCW)
17	72007450	72007451	G	A	snv	DOB/Oda (KyushuU)
17	72012757	72012758	A	T	snv	DOB/Oda (KyushuU)
17	72012865	72012866	C	T	snv	DOB/Oda (KyushuU)
17	72014750	72014751	T	C	snv	DOB/Oda (KyushuU)
17	72014762	72014763	T	C	snv	DOB/Oda (KyushuU), SBH/Ygl (MCW)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61802	AgrOrtholog
BioCyc Gene	G2FUF-8812	BioCyc
Ensembl Genes	ENSRNOG00000018091	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000077443.1	UniProtKB/TrEMBL
	ENSRNOP00000082980	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000104020.1	UniProtKB/TrEMBL
	ENSRNOT00000109674	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	3.50.50.60	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:5621162	IMAGE-MGC_LOAD
InterPro	FAD/NAD-bd_sf	UniProtKB/Swiss-Prot
	GDP_dissociation_inhibitor	UniProtKB/Swiss-Prot
	RabGDI	UniProtKB/Swiss-Prot
KEGG Report	rno:29662	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72501	IMAGE-MGC_LOAD
NCBI Gene	29662	ENTREZGENE
PANTHER	PTHR11787	UniProtKB/Swiss-Prot
Pfam	GDI	UniProtKB/Swiss-Prot
PhenoGen	Gdi2	PhenoGen
PRINTS	RABGDI	UniProtKB/Swiss-Prot
	RABGDIREP	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF51905	UniProtKB/Swiss-Prot
TIGR	TC204503
UniProt	A0A8I5YBU1_RAT	UniProtKB/TrEMBL
	GDIB_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q6P797	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Gdi2	GDP dissociation inhibitor 2	Gdi3	guanosine diphosphate dissociation inhibitor 3	Symbol and Name updated	1299863	APPROVED
2002-06-10	Gdi3	guanosine diphosphate dissociation inhibitor 3			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	ubiquitously expressed	61604

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

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RGD Manual Annotations