Map3k8 (mitogen-activated protein kinase kinase kinase 8) - Rat Genome Database

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Gene: Map3k8 (mitogen-activated protein kinase kinase kinase 8) Rattus norvegicus
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Symbol: Map3k8
Name: mitogen-activated protein kinase kinase kinase 8
RGD ID: 620969
Description: Enables MAP kinase kinase kinase activity. Involved in cardiac ventricle development and gap junction-mediated intercellular transport. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma; lung cancer; and stomach cancer. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: D17TPL2; serine/threonine kinase (Tpl-2); Tpl-2; Tpl2; tumor progression locus 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81758,078,175 - 58,098,455 (+)NCBIGRCr8
mRatBN7.21753,382,908 - 53,403,216 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1753,383,131 - 53,403,216 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1756,551,207 - 56,571,466 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01760,554,141 - 60,574,400 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01754,712,378 - 54,732,666 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01756,109,403 - 56,129,925 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1756,109,549 - 56,129,919 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01754,146,364 - 54,166,886 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41761,910,179 - 61,930,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11761,921,011 - 61,941,292 (+)NCBI
Celera1749,376,490 - 49,396,770 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
adefovir pivoxil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
C.I. Natural Red 20  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (EXP)
Genipin  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-nitrosodimethylamine  (EXP)
nickel dichloride  (EXP,ISO)
o-xylene  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procyanidin B3  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
Shikonin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sulindac  (EXP)
tamoxifen  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO,TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Prognostic role of TPL2 in early‑stage non‑small cell lung cancer. Boldrini L, etal., Mol Med Rep. 2017 Jun;15(6):3451-3458. doi: 10.3892/mmr.2017.6430. Epub 2017 Apr 3.
2. Mutational activation of the MAP3K8 protooncogene in lung cancer. Clark AM, etal., Genes Chromosomes Cancer. 2004 Oct;41(2):99-108. doi: 10.1002/gcc.20069.
3. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. TPL2 kinase is a suppressor of lung carcinogenesis. Gkirtzimanaki K, etal., Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):E1470-9. doi: 10.1073/pnas.1215938110. Epub 2013 Mar 26.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control TH2-Mediated Immunopathology. Kannan Y, etal., PLoS Pathog. 2016 Aug 3;12(8):e1005783. doi: 10.1371/journal.ppat.1005783. eCollection 2016 Aug.
8. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
9. Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. Koliaraki V, etal., J Clin Invest. 2012 Nov;122(11):4231-42. doi: 10.1172/JCI63917. Epub 2012 Oct 15.
10. Tumor Progression Locus 2 Promotes Induction of IFNlambda, Interferon Stimulated Genes and Antigen-Specific CD8+ T Cell Responses and Protects against Influenza Virus. Kuriakose T, etal., PLoS Pathog. 2015 Aug 4;11(8):e1005038. doi: 10.1371/journal.ppat.1005038. eCollection 2015 Aug.
11. TPL2 (Therapeutic Targeting Tumor Progression Locus-2)/ATF4 (Activating Transcription Factor-4)/SDF1α (Chemokine Stromal Cell-Derived Factor-α) Axis Suppresses Diabetic Retinopathy. Lai DW, etal., Circ Res. 2017 Sep 1;121(6):e37-e52. doi: 10.1161/CIRCRESAHA.117.311066. Epub 2017 Jul 19.
12. Benzo[a]pyrene-7,8-diol-9,10-epoxide inhibits gap junction intercellular communication via phosphorylation of tumor progression locus 2 in WB-F344 rat liver epithelial cells. Lee BK, etal., Mol Carcinog. 2015 May;54(5):351-8. doi: 10.1002/mc.22103. Epub 2013 Nov 19.
13. Tpl2 kinase impacts tumor growth and metastasis of clear cell renal cell carcinoma. Lee HW, etal., Mol Cancer Res. 2013 Nov;11(11):1375-86. doi: 10.1158/1541-7786.MCR-13-0101-T. Epub 2013 Aug 27.
14. Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice. Li X, etal., J Exp Clin Cancer Res. 2015 Nov 11;34:138. doi: 10.1186/s13046-015-0254-2.
15. Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: activation by provirus insertion. Makris A, etal., J Virol. 1993 Jul;67(7):4283-9. doi: 10.1128/JVI.67.7.4283-4289.1993.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Honokiol thwarts gastric tumor growth and peritoneal dissemination by inhibiting Tpl2 in an orthotopic model. Pan HC, etal., Carcinogenesis. 2013 Nov;34(11):2568-79. doi: 10.1093/carcin/bgt243. Epub 2013 Jul 4.
20. Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Patriotis C, etal., Proc Natl Acad Sci U S A 1993 Mar 15;90(6):2251-5.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. TPL2 expression is correlated with distant metastasis and poor prognosis in colorectal cancer. Pyo JS, etal., Hum Pathol. 2018 Sep;79:50-56. doi: 10.1016/j.humpath.2018.05.003. Epub 2018 May 12.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase. Salmeron A, etal., EMBO J. 1996 Feb 15;15(4):817-26.
26. Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation. Serebrennikova OB, etal., Proc Natl Acad Sci U S A. 2012 May 1;109(18):E1082-91. doi: 10.1073/pnas.1115098109. Epub 2012 Mar 26.
27. Overexpression of the Tpl-2/Cot oncogene in human breast cancer. Sourvinos G, etal., Oncogene. 1999 Sep 2;18(35):4968-73. doi: 10.1038/sj.onc.1202891.
28. NF-kappaB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-kappaB function. Sun F, etal., Oncogene. 2016 May 5;35(18):2299-310. doi: 10.1038/onc.2015.299. Epub 2015 Aug 24.
29. Overexpression of CK20, MAP3K8 and EIF5A correlates with poor prognosis in early-onset colorectal cancer patients. Tunca B, etal., J Cancer Res Clin Oncol. 2013 Apr;139(4):691-702. doi: 10.1007/s00432-013-1372-x. Epub 2013 Jan 16.
Additional References at PubMed
PMID:9950430   PMID:17049604  


Genomics

Comparative Map Data
Map3k8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81758,078,175 - 58,098,455 (+)NCBIGRCr8
mRatBN7.21753,382,908 - 53,403,216 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1753,383,131 - 53,403,216 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1756,551,207 - 56,571,466 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01760,554,141 - 60,574,400 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01754,712,378 - 54,732,666 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01756,109,403 - 56,129,925 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1756,109,549 - 56,129,919 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01754,146,364 - 54,166,886 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41761,910,179 - 61,930,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11761,921,011 - 61,941,292 (+)NCBI
Celera1749,376,490 - 49,396,770 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
MAP3K8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381030,434,021 - 30,461,833 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1030,434,021 - 30,461,833 (+)EnsemblGRCh38hg38GRCh38
GRCh371030,722,950 - 30,750,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361030,762,872 - 30,790,767 (+)NCBINCBI36Build 36hg18NCBI36
Build 341030,762,871 - 30,790,767NCBI
Celera1030,487,787 - 30,515,686 (+)NCBICelera
Cytogenetic Map10p11.23NCBI
HuRef1030,441,888 - 30,469,569 (+)NCBIHuRef
CHM1_11030,722,912 - 30,750,718 (+)NCBICHM1_1
T2T-CHM13v2.01030,465,061 - 30,492,876 (+)NCBIT2T-CHM13v2.0
Map3k8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39184,331,325 - 4,352,978 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl184,331,327 - 4,353,015 (-)EnsemblGRCm39 Ensembl
GRCm38184,331,325 - 4,352,953 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl184,331,327 - 4,353,015 (-)EnsemblGRCm38mm10GRCm38
MGSCv37184,331,325 - 4,352,951 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36184,331,325 - 4,352,951 (-)NCBIMGSCv36mm8
Celera184,376,104 - 4,394,119 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map182.73NCBI
Map3k8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542921,716,958 - 21,741,585 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542921,717,153 - 21,739,349 (-)NCBIChiLan1.0ChiLan1.0
MAP3K8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2843,099,092 - 43,126,986 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11043,104,467 - 43,132,408 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01030,579,220 - 30,607,249 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11030,933,449 - 30,960,824 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1030,933,483 - 30,960,824 (+)Ensemblpanpan1.1panPan2
MAP3K8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,717,845 - 16,740,816 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,720,596 - 16,740,515 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha214,213,953 - 14,236,910 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0214,958,609 - 14,981,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl214,961,553 - 14,981,545 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1214,403,368 - 14,426,326 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0214,289,689 - 14,313,028 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0214,562,884 - 14,585,927 (+)NCBIUU_Cfam_GSD_1.0
Map3k8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093449,241,108 - 9,263,359 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366133,791,681 - 3,813,892 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366133,791,684 - 3,813,857 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1040,713,847 - 40,742,462 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11040,714,004 - 40,746,390 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21045,065,121 - 45,078,892 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605638,717,813 - 38,744,742 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248052,611,038 - 2,633,943 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248052,611,297 - 2,633,650 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map3k8
158 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:112
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000022190
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)175089090860781592Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)175089090860781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)175090919660781426Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 58 31

Sequence


Ensembl Acc Id: ENSRNOT00000022190   ⟹   ENSRNOP00000022190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1753,383,131 - 53,403,216 (+)Ensembl
Rnor_6.0 Ensembl1756,109,549 - 56,129,919 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119501   ⟹   ENSRNOP00000091878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1753,383,131 - 53,403,216 (+)Ensembl
RefSeq Acc Id: NM_053847   ⟹   NP_446299
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81758,078,175 - 58,098,455 (+)NCBI
mRatBN7.21753,382,936 - 53,403,216 (+)NCBI
Rnor_6.01756,109,403 - 56,129,925 (+)NCBI
Rnor_5.01754,146,364 - 54,166,886 (+)NCBI
RGSC_v3.41761,910,179 - 61,930,459 (+)RGD
Celera1749,376,490 - 49,396,770 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254048   ⟹   XP_006254110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81758,078,534 - 58,098,455 (+)NCBI
mRatBN7.21753,383,295 - 53,403,216 (+)NCBI
Rnor_6.01756,109,704 - 56,129,925 (+)NCBI
Rnor_5.01754,146,364 - 54,166,886 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095291   ⟹   XP_038951219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81758,082,632 - 58,098,455 (+)NCBI
mRatBN7.21753,382,908 - 53,403,216 (+)NCBI
RefSeq Acc Id: XM_039095293   ⟹   XP_038951221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81758,078,726 - 58,098,455 (+)NCBI
mRatBN7.21753,383,476 - 53,403,216 (+)NCBI
RefSeq Acc Id: XM_039095294   ⟹   XP_038951222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81758,088,309 - 58,098,455 (+)NCBI
mRatBN7.21753,393,071 - 53,403,216 (+)NCBI
RefSeq Acc Id: XM_063276022   ⟹   XP_063132092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81758,078,504 - 58,088,253 (+)NCBI
RefSeq Acc Id: NP_446299   ⟸   NM_053847
- UniProtKB: Q63562 (UniProtKB/Swiss-Prot),   A6K9G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254110   ⟸   XM_006254048
- Peptide Label: isoform X1
- UniProtKB: Q63562 (UniProtKB/Swiss-Prot),   A6K9G3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022190   ⟸   ENSRNOT00000022190
RefSeq Acc Id: XP_038951219   ⟸   XM_039095291
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038951221   ⟸   XM_039095293
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038951222   ⟸   XM_039095294
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000091878   ⟸   ENSRNOT00000119501
RefSeq Acc Id: XP_063132092   ⟸   XM_063276022
- Peptide Label: isoform X4
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63562-F1-model_v2 AlphaFold Q63562 1-467 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700526
Promoter ID:EPDNEW_R11049
Type:single initiation site
Name:Map3k8_1
Description:mitogen-activated protein kinase kinase kinase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01756,109,533 - 56,109,593EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620969 AgrOrtholog
BioCyc Gene G2FUF-9002 BioCyc
Ensembl Genes ENSRNOG00000016378 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000022190 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP_kinase_kinase_kinase UniProtKB/Swiss-Prot
  MAPKKK8 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:116596 UniProtKB/Swiss-Prot
NCBI Gene 116596 ENTREZGENE
PANTHER MAP KINASE KINASE KINASE SSK2-RELATED-RELATED UniProtKB/Swiss-Prot
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Map3k8 PhenoGen
PIRSF MAPKKK8 UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016378 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6AGZ3_RAT UniProtKB/TrEMBL
  A6K9G3 ENTREZGENE, UniProtKB/TrEMBL
  G3V840_RAT UniProtKB/TrEMBL
  M3K8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Map3k8  mitogen-activated protein kinase kinase kinase 8      Symbol and Name updated 629477 APPROVED
2003-03-12 Map3k8  mitogen-activated protein kinase kinase kinase 8  Tpl2  tumor progression locus 2  Data merged from RGD:3897 628472 PROVISIONAL
2002-08-07 Map3k8  itogen-activated protein kinase kinase kinase 8      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Tpl2  tumor progression locus 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in most tissues 70317
gene_expression expression increases after birth 70317
gene_protein expression is up-regulated during postnatal development 70317