MAP3K8 (mitogen-activated protein kinase kinase kinase 8) - Rat Genome Database

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Gene: MAP3K8 (mitogen-activated protein kinase kinase kinase 8) Sus scrofa
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Symbol: MAP3K8
Name: mitogen-activated protein kinase kinase kinase 8
RGD ID: 14287041
Description: ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); protein kinase activity (ortholog); INVOLVED IN cardiac ventricle development (ortholog); gap junction-mediated intercellular transport (ortholog); PARTICIPATES IN p38 MAPK signaling pathway; ASSOCIATED WITH background diabetic retinopathy (ortholog); breast cancer (ortholog); Carcinogenesis (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1040,713,847 - 40,742,462 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11040,714,004 - 40,746,390 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21045,065,121 - 45,078,892 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IEA)
membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:15265077   PMID:17145712   PMID:22301074   PMID:31039922  


Genomics

Comparative Map Data
MAP3K8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1040,713,847 - 40,742,462 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11040,714,004 - 40,746,390 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21045,065,121 - 45,078,892 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381030,434,021 - 30,461,833 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1030,434,021 - 30,461,833 (+)EnsemblGRCh38hg38GRCh38
GRCh371030,722,950 - 30,750,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361030,762,872 - 30,790,767 (+)NCBINCBI36Build 36hg18NCBI36
Build 341030,762,871 - 30,790,767NCBI
Celera1030,487,787 - 30,515,686 (+)NCBICelera
Cytogenetic Map10p11.23NCBI
HuRef1030,441,888 - 30,469,569 (+)NCBIHuRef
CHM1_11030,722,912 - 30,750,718 (+)NCBICHM1_1
T2T-CHM13v2.01030,465,061 - 30,492,876 (+)NCBIT2T-CHM13v2.0
Map3k8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39184,331,325 - 4,352,978 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl184,331,327 - 4,353,015 (-)EnsemblGRCm39 Ensembl
GRCm38184,331,325 - 4,352,953 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl184,331,327 - 4,353,015 (-)EnsemblGRCm38mm10GRCm38
MGSCv37184,331,325 - 4,352,951 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36184,331,325 - 4,352,951 (-)NCBIMGSCv36mm8
Celera184,376,104 - 4,394,119 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map182.73NCBI
Map3k8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81758,078,175 - 58,098,455 (+)NCBIGRCr8
mRatBN7.21753,382,908 - 53,403,216 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1753,383,131 - 53,403,216 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1756,551,207 - 56,571,466 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01760,554,141 - 60,574,400 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01754,712,378 - 54,732,666 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01756,109,403 - 56,129,925 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1756,109,549 - 56,129,919 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01754,146,364 - 54,166,886 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41761,910,179 - 61,930,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11761,921,011 - 61,941,292 (+)NCBI
Celera1749,376,490 - 49,396,770 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
Map3k8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542921,716,958 - 21,741,585 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542921,717,153 - 21,739,349 (-)NCBIChiLan1.0ChiLan1.0
MAP3K8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2843,099,092 - 43,126,986 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11043,104,467 - 43,132,408 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01030,579,220 - 30,607,249 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11030,933,449 - 30,960,824 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1030,933,483 - 30,960,824 (+)Ensemblpanpan1.1panPan2
MAP3K8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,717,845 - 16,740,816 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,720,596 - 16,740,515 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha214,213,953 - 14,236,910 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0214,958,609 - 14,981,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl214,961,553 - 14,981,545 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1214,403,368 - 14,426,326 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0214,289,689 - 14,313,028 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0214,562,884 - 14,585,927 (+)NCBIUU_Cfam_GSD_1.0
Map3k8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093449,241,108 - 9,263,359 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366133,791,681 - 3,813,892 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366133,791,684 - 3,813,857 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605638,717,813 - 38,744,742 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248052,611,038 - 2,633,943 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248052,611,297 - 2,633,650 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAP3K8
1150 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000033089   ⟹   ENSSSCP00000028391
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1040,714,012 - 40,742,462 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000034425   ⟹   ENSSSCP00000028719
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1040,713,847 - 40,746,630 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000058548   ⟹   ENSSSCP00000040859
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1040,713,847 - 40,740,821 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000079510   ⟹   ENSSSCP00000064885
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1040,732,731 - 40,741,789 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000085015   ⟹   ENSSSCP00000073268
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1040,713,852 - 40,741,789 (-)Ensembl
RefSeq Acc Id: XM_013980209   ⟹   XP_013835663
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11040,714,004 - 40,742,057 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064737   ⟹   XP_020920396
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11040,714,004 - 40,743,350 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064738   ⟹   XP_020920397
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11040,714,004 - 40,746,390 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064739   ⟹   XP_020920398
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11040,714,004 - 40,742,307 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064740   ⟹   XP_020920399
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11040,714,004 - 40,745,265 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064742   ⟹   XP_020920401
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11040,714,004 - 40,746,177 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020920397   ⟸   XM_021064738
- Peptide Label: isoform X2
- UniProtKB: A0A8D1KXL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020920401   ⟸   XM_021064742
- Peptide Label: isoform X3
- UniProtKB: A0A287AAP3 (UniProtKB/TrEMBL),   A0A4X1UIT6 (UniProtKB/TrEMBL),   A0A0B8RVQ5 (UniProtKB/TrEMBL),   A0A8D1KXL8 (UniProtKB/TrEMBL),   A0A8D0LGC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020920399   ⟸   XM_021064740
- Peptide Label: isoform X3
- UniProtKB: A0A287AAP3 (UniProtKB/TrEMBL),   A0A4X1UIT6 (UniProtKB/TrEMBL),   A0A0B8RVQ5 (UniProtKB/TrEMBL),   A0A8D1KXL8 (UniProtKB/TrEMBL),   A0A8D0LGC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020920396   ⟸   XM_021064737
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UL44 (UniProtKB/TrEMBL),   K7GKL4 (UniProtKB/TrEMBL),   A0A8D1KXL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020920398   ⟸   XM_021064739
- Peptide Label: isoform X3
- UniProtKB: A0A287AAP3 (UniProtKB/TrEMBL),   A0A4X1UIT6 (UniProtKB/TrEMBL),   A0A0B8RVQ5 (UniProtKB/TrEMBL),   A0A8D1KXL8 (UniProtKB/TrEMBL),   A0A8D0LGC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013835663   ⟸   XM_013980209
- Peptide Label: isoform X3
- UniProtKB: A0A287AAP3 (UniProtKB/TrEMBL),   A0A4X1UIT6 (UniProtKB/TrEMBL),   A0A0B8RVQ5 (UniProtKB/TrEMBL),   A0A8D1KXL8 (UniProtKB/TrEMBL),   A0A8D0LGC9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000028719   ⟸   ENSSSCT00000034425
Ensembl Acc Id: ENSSSCP00000040859   ⟸   ENSSSCT00000058548
Ensembl Acc Id: ENSSSCP00000073268   ⟸   ENSSSCT00000085015
Ensembl Acc Id: ENSSSCP00000064885   ⟸   ENSSSCT00000079510
Ensembl Acc Id: ENSSSCP00000028391   ⟸   ENSSSCT00000033089
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000020705 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015059535 UniProtKB/TrEMBL
  ENSSSCG00025049959 UniProtKB/TrEMBL
  ENSSSCG00030014710 UniProtKB/TrEMBL
  ENSSSCG00035030027 UniProtKB/TrEMBL
  ENSSSCG00040022143 UniProtKB/TrEMBL
  ENSSSCG00045016302 UniProtKB/TrEMBL
  ENSSSCG00050027563 UniProtKB/TrEMBL
  ENSSSCG00055024578 UniProtKB/TrEMBL
  ENSSSCG00060056202 UniProtKB/TrEMBL
  ENSSSCG00065038657 UniProtKB/TrEMBL
  ENSSSCG00070017632 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000033089 ENTREZGENE
  ENSSSCT00000033089.4 UniProtKB/TrEMBL
  ENSSSCT00000058548 ENTREZGENE
  ENSSSCT00000058548.2 UniProtKB/TrEMBL
  ENSSSCT00000079510.1 UniProtKB/TrEMBL
  ENSSSCT00015079511.1 UniProtKB/TrEMBL
  ENSSSCT00015079560.1 UniProtKB/TrEMBL
  ENSSSCT00015079698.1 UniProtKB/TrEMBL
  ENSSSCT00025068123.1 UniProtKB/TrEMBL
  ENSSSCT00025068232.1 UniProtKB/TrEMBL
  ENSSSCT00025068326.1 UniProtKB/TrEMBL
  ENSSSCT00030020270.1 UniProtKB/TrEMBL
  ENSSSCT00035039773.1 UniProtKB/TrEMBL
  ENSSSCT00035039782.1 UniProtKB/TrEMBL
  ENSSSCT00035039784.1 UniProtKB/TrEMBL
  ENSSSCT00035039787.1 UniProtKB/TrEMBL
  ENSSSCT00040029679.1 UniProtKB/TrEMBL
  ENSSSCT00040029727.1 UniProtKB/TrEMBL
  ENSSSCT00040029756.1 UniProtKB/TrEMBL
  ENSSSCT00045027746.1 UniProtKB/TrEMBL
  ENSSSCT00045027805.1 UniProtKB/TrEMBL
  ENSSSCT00045027877.1 UniProtKB/TrEMBL
  ENSSSCT00050037078.1 UniProtKB/TrEMBL
  ENSSSCT00055048397.1 UniProtKB/TrEMBL
  ENSSSCT00055048471.1 UniProtKB/TrEMBL
  ENSSSCT00055048518.1 UniProtKB/TrEMBL
  ENSSSCT00060076540.1 UniProtKB/TrEMBL
  ENSSSCT00060076572.1 UniProtKB/TrEMBL
  ENSSSCT00060076575.1 UniProtKB/TrEMBL
  ENSSSCT00065052839.1 UniProtKB/TrEMBL
  ENSSSCT00065052843.1 UniProtKB/TrEMBL
  ENSSSCT00065052848.1 UniProtKB/TrEMBL
  ENSSSCT00070034831.1 UniProtKB/TrEMBL
  ENSSSCT00070034844.1 UniProtKB/TrEMBL
  ENSSSCT00070034847.1 UniProtKB/TrEMBL
  ENSSSCT00070034852.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase_kinase_kinase UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:100622217 UniProtKB/TrEMBL
NCBI Gene MAP3K8 ENTREZGENE
PANTHER MAP KINASE KINASE KINASE SSK2-RELATED-RELATED UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0B8RVQ5 ENTREZGENE
  A0A287AAP3 ENTREZGENE
  A0A4X1UIT6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UL44 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0I8P2_PIG UniProtKB/TrEMBL
  A0A8D0LGC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0SJ07_PIG UniProtKB/TrEMBL
  A0A8D0ZC76_PIG UniProtKB/TrEMBL
  A0A8D1KWZ0_PIG UniProtKB/TrEMBL
  A0A8D1KXL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1RVA6_PIG UniProtKB/TrEMBL
  K7GKL4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287AAP3 UniProtKB/TrEMBL
  A0A5G2QLH5 UniProtKB/TrEMBL
VGNC ID VGNC:98110 ENTREZGENE