Apc (APC, WNT signaling pathway regulator) - Rat Genome Database

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Gene: Apc (APC, WNT signaling pathway regulator) Mus musculus
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Symbol: Apc
Name: APC, WNT signaling pathway regulator
RGD ID: 10166
MGI Page MGI
Description: Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and enzyme binding activity. Involved in insulin receptor signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of protein localization to centrosome. Acts upstream of or within several processes, including canonical Wnt signaling pathway; regionalization; and regulation of microtubule polymerization or depolymerization. Located in several cellular components, including axonal growth cone; cell projection membrane; and microtubule cytoskeleton. Part of Scrib-APC-beta-catenin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and retina. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial adenomatous polyposis 1; gastrointestinal system cancer (multiple); hereditary desmoid disease; and reproductive organ cancer (multiple). Orthologous to human APC (APC regulator of WNT signaling pathway).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenomatosis polyposis coli; adenomatous polyposis coli protein; AI047805; AU020952; AW124434; CC1; M; mAPC; Min; multiple intestinal neoplasia
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Apc-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,353,350 - 34,455,243 (+)NCBIGRCm39mm39
GRCm39 Ensembl1834,353,977 - 34,455,605 (+)Ensembl
GRCm381834,220,297 - 34,322,190 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,220,924 - 34,322,552 (+)EnsemblGRCm38mm10GRCm38
MGSCv371834,380,638 - 34,481,844 (+)NCBIGRCm37mm9NCBIm37
MGSCv361834,385,824 - 34,443,409 (+)NCBImm8
Celera1834,670,234 - 34,773,431 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
acinar cell carcinoma  (ISO)
adenocarcinoma  (ISO)
adenoma  (ISO)
Adenomatous Polyps  (ISO)
adult respiratory distress syndrome  (ISO)
Aggressive Fibromatosis  (ISO)
Alzheimer's disease  (ISO)
amenorrhea  (ISO)
anemia  (ISO)
Animal Mammary Neoplasms  (ISO)
ascending colon cancer  (ISO)
Attenuated Adenomatous Polyposis Coli  (ISO)
autistic disorder  (ISO)
breast cancer  (IEA,ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
cholangiocarcinoma  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
Colonic Polyps  (ISO)
colorectal adenoma  (ISO)
colorectal cancer  (IEA,ISO)
Colorectal Neoplasms  (ISO)
craniopharyngioma  (ISO)
Digestive System Neoplasms  (ISO)
disease of cellular proliferation  (ISO)
duodenum adenocarcinoma  (ISO)
endometrial cancer  (IMP,ISO)
endometrial carcinoma  (IMP,ISO)
Endometrial Neoplasms  (IMP)
Endometrioid Carcinomas  (ISO)
Eye Abnormalities  (ISO)
familial adenomatous polyposis  (IEA,ISO)
familial adenomatous polyposis 1  (ISO)
familial hyperlipidemia  (ISO)
Fibromatosis, Abdominal  (ISO)
gallbladder cancer  (ISO)
Gallbladder Neoplasms  (ISO)
Gardner Syndrome  (ISO)
Gastric Adenocarcinoma and Proximal Polyposis of the Stomach  (ISO)
Gastrointestinal Hemorrhage  (ISO)
Gastrointestinal Neoplasms  (ISO)
gastrointestinal stromal tumor  (ISO)
glioblastoma  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (IEA,ISO)
hereditary desmoid disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hyperplasia  (IMP)
inflammatory bowel disease  (ISO)
intellectual disability  (ISO)
Intestinal Neoplasms  (IMP,ISO)
Intestinal Polyps  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
Jaw Neoplasms  (ISO)
Klatskin's tumor  (ISO)
Leukocytosis  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lynch syndrome  (ISO)
macrocytic anemia  (ISO)
medulloblastoma  (ISO)
Mesothelioma  (ISO)
mismatch repair cancer syndrome  (ISO)
Monoclonal B-Cell Lymphocytosis  (ISO)
Neoplastic Cell Transformation  (ISO)
Neurodevelopmental Disorders  (ISO)
ovarian cancer  (IEA)
pancreatic cancer  (IAGP,ISO)
prostate cancer  (IEA,ISO)
Prostatic Neoplasms  (ISO)
rectal benign neoplasm  (ISO)
rectum adenocarcinoma  (ISO)
renal cell carcinoma  (IMP,ISO)
sigmoid colon cancer  (ISO)
sigmoid neoplasm  (ISO)
Splenomegaly  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
transitional cell carcinoma  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (ISO)
bromobenzene  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carmustine  (ISO)
celastrol  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (EXP)
clorgyline  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
curcumin  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
dextran sulfate  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dioxygen  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP)
ethosuximide  (ISO)
etodolac  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
glucose  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
indometacin  (EXP,ISO)
irinotecan  (ISO)
lutein  (EXP)
malonaldehyde  (EXP)
manganese(II) chloride  (ISO)
metacetamol  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
miconazole  (EXP)
Monobutylphthalate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel dichloride  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP)
permethrin  (ISO)
phenobarbital  (EXP)
PhIP  (EXP,ISO)
pirinixic acid  (EXP)
Pyridostigmine bromide  (ISO)
quercetin  (ISO)
resorcinol  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (EXP)
sulindac  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
theaflavin  (EXP)
thimerosal  (ISO)
tipifarnib  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
tungsten  (EXP)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acinar cell proliferation  (IGI,IMP)
anterior/posterior pattern specification  (IMP)
apoptotic process  (IMP)
axis specification  (IMP)
axonogenesis  (IGI,IMP)
canonical Wnt signaling pathway  (IMP)
canonical Wnt signaling pathway involved in negative regulation of apoptotic process  (IGI)
canonical Wnt signaling pathway involved in positive regulation of apoptotic process  (IGI)
cell adhesion  (IMP)
cell division  (IMP)
cell fate specification  (IBA)
cell migration  (IBA,IMP,ISO)
cell population proliferation  (IGI,IMP)
cellular response to DNA damage stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
chromosome organization  (IGI,IMP)
cytoplasmic microtubule organization  (IGI)
dorsal/ventral pattern formation  (IMP)
endothelial cell proliferation  (IGI,IMP)
epithelial cell apoptotic process  (IMP)
epithelial cell proliferation  (IGI,IMP)
epithelial cell proliferation involved in prostate gland development  (IMP)
establishment or maintenance of cell polarity  (ISO)
fibroblast apoptotic process  (IMP)
fibroblast migration  (IMP)
hair follicle development  (IMP)
insulin receptor signaling pathway  (IMP,ISO)
kidney development  (IMP)
MAPK cascade  (IGI,IMP)
metaphase/anaphase transition of mitotic cell cycle  (IGI,IMP)
microtubule depolymerization  (IMP)
microtubule polymerization  (IMP)
mitotic cytokinesis  (IMP,ISO)
mitotic spindle assembly checkpoint signaling  (ISO)
muscle cell cellular homeostasis  (IGI)
negative regulation of acinar cell proliferation  (IGI,IMP)
negative regulation of apoptotic process  (IMP)
negative regulation of canonical Wnt signaling pathway  (IBA,IMP,ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of cell cycle G1/S phase transition  (ISO)
negative regulation of cell population proliferation  (IGI,IMP,ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of endothelial cell proliferation  (IGI,IMP)
negative regulation of epithelial cell apoptotic process  (IMP)
negative regulation of epithelial cell proliferation  (IGI,IMP)
negative regulation of epithelial cell proliferation involved in prostate gland development  (IMP)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of MAPK cascade  (IGI,IMP)
negative regulation of microtubule depolymerization  (IBA,IMP,ISO)
negative regulation of odontogenesis  (IMP)
negative regulation of Wnt signaling pathway  (IGI,IMP)
nervous system development  (IBA)
neuron projection development  (ISO)
odontogenesis  (IMP)
pancreas development  (ISO)
pattern specification process  (IBA,IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of cell adhesion  (IMP)
positive regulation of cell death  (ISO)
positive regulation of cell differentiation  (IMP)
positive regulation of cell division  (IMP)
positive regulation of cell migration  (ISO)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of fibroblast apoptotic process  (IMP)
positive regulation of fibroblast migration  (IMP)
positive regulation of microtubule polymerization  (IMP)
positive regulation of protein catabolic process  (IBA,IMP,ISO)
positive regulation of protein localization to centrosome  (IMP,ISO)
positive regulation of pseudopodium assembly  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IC)
protein catabolic process  (IMP)
protein-containing complex assembly  (ISO)
proximal/distal pattern formation  (IMP)
regulation of attachment of spindle microtubules to kinetochore  (IMP,ISO)
regulation of cell cycle  (IMP)
regulation of cell differentiation  (IBA,IGI)
regulation of cell migration  (IGI)
regulation of epithelial cell differentiation  (IMP)
regulation of epithelial cell migration  (IMP)
regulation of glutamate metabolic process  (ISO)
regulation of microtubule-based process  (ISO)
regulation of nitrogen compound metabolic process  (IMP)
regulation of osteoblast differentiation  (IMP)
regulation of osteoclast differentiation  (IMP)
response to alcohol  (ISO)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (IMP)
skin development  (IMP)
somatic stem cell population maintenance  (IGI,IMP)
stem cell population maintenance  (IMP)
T cell differentiation in thymus  (IMP)
thymus development  (IMP)
Wnt signaling pathway  (IDA,IGI,IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal wall morphology  (IAGP)
abnormal adrenal gland morphology  (IAGP)
abnormal anterior visceral endoderm morphology  (IAGP)
abnormal autophagy  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal brain development  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cell proliferation  (IAGP)
abnormal chemokine level  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal circulating enzyme level  (IAGP)
abnormal colon goblet cell morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal corticosterone level  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal DNA methylation  (IAGP)
abnormal DNA repair  (IAGP)
abnormal ear shape  (IAGP)
abnormal effector T cell morphology  (IAGP)
abnormal egg cylinder morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryo size  (IAGP)
abnormal embryonic epiblast morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endocardial heart tube morphology  (IAGP)
abnormal endochondral bone ossification  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal exocrine pancreas morphology  (IAGP)
abnormal feces composition  (IAGP)
abnormal floor plate morphology  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal gut flora balance  (IAGP)
abnormal hair follicle bulb morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle orientation  (IAGP)
abnormal Hassall's corpuscle morphology  (IAGP)
abnormal head development  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal hindbrain development  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal humerus morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal internal female genitalia morphology  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intestinal epithelium physiology  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal intestine development  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal intestine physiology  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal liver morphology  (IAGP)
abnormal mammary gland development  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mesendoderm development  (IAGP)
abnormal mitochondrial crista morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal NK T cell physiology  (IAGP)
abnormal nursing  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal oviduct morphology  (IAGP)
abnormal pancreas development  (IAGP)
abnormal Paneth cell morphology  (IAGP)
abnormal pregnancy  (IAGP)
abnormal primitive node morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal small intestinal crypt cell physiology  (IAGP)
abnormal small intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal survival  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal telencephalon development  (IAGP)
abnormal thoracic cavity morphology  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal tooth development  (IAGP)
abnormal tumor incidence  (IAGP)
abnormal tumor morphology  (IAGP)
abnormal tumor pathology  (IAGP)
abnormal tumor susceptibility  (IAGP)
abnormal tumor vascularization  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
abnormal vagina epithelium morphology  (IAGP)
absent corpus luteum  (IAGP)
absent forebrain  (IAGP)
absent male preputial gland  (IAGP)
absent mandible  (IAGP)
absent mature ovarian follicles  (IAGP)
absent midbrain  (IAGP)
absent neural folds  (IAGP)
absent nipple  (IAGP)
absent sternum  (IAGP)
absent teeth  (IAGP)
absent upper incisors  (IAGP)
acrania  (IAGP)
adrenal gland hyperplasia  (IAGP)
anemia  (IAGP)
aneuploidy  (IAGP)
arrested T cell differentiation  (IAGP)
blepharoptosis  (IAGP)
blistering  (IAGP)
cachexia  (IAGP)
cardia bifida  (IAGP)
chromosomal instability  (IAGP)
colitis  (IAGP)
colon polyps  (IAGP)
corneal epithelium hyperplasia  (IAGP)
decreased alimentary system tumor incidence  (IAGP)
decreased apoptosis  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased colon tumor incidence  (IAGP)
decreased embryo size  (IAGP)
decreased fetal size  (IAGP)
decreased hematocrit  (IAGP)
decreased incidence of induced tumors  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased intestinal adenoma incidence  (IAGP)
decreased macrophage cell number  (IAGP)
decreased mammary gland tumor incidence  (IAGP)
decreased NK cell number  (IAGP)
decreased NK T cell number  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic islet number  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased prostaglandin level  (IAGP)
decreased sensitivity to induced morbidity/mortality  (IAGP)
decreased splenocyte number  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte number  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor incidence  (IAGP)
delayed hair appearance  (IAGP)
duodenal atresia  (IAGP)
duodenum polyps  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality between implantation and placentation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between implantation and somite formation, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
embryonic-extraembryonic boundary constriction  (IAGP)
endometrium hyperplasia  (IAGP)
enhanced osteoblast differentiation  (IAGP)
enlarged kidney  (IAGP)
enlarged liver  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
enlarged spleen  (IAGP)
epidermal cyst  (IAGP)
extended life span  (IAGP)
gastric polyps  (IAGP)
gastrointestinal hemorrhage  (IAGP)
gastrointestinal tract polyps  (IAGP)
Harderian gland hyperplasia  (IAGP)
hemorrhagic ascites  (IAGP)
hepatic necrosis  (IAGP)
hepatic steatosis  (IAGP)
hunched posture  (IAGP)
hyperlipidemia  (IAGP)
incomplete embryo turning  (IAGP)
increased adenocarcinoma incidence  (IAGP)
increased adenoma incidence  (IAGP)
increased apoptosis  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased carcinoma incidence  (IAGP)
increased CD103-positive CD11b-low dendritic cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased cell proliferation  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased classified tumor incidence  (IAGP)
increased colon adenocarcinoma incidence  (IAGP)
increased colon adenoma incidence  (IAGP)
increased colon tumor incidence  (IAGP)
increased cystadenoma incidence  (IAGP)
increased desmoid tumor incidence  (IAGP)
increased double-negative T cell number  (IAGP)
increased ear pigmentation  (IAGP)
increased enterocyte apoptosis  (IAGP)
increased forehead pigmentation  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased granulosa cell tumor incidence  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased incidence of induced tumors  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased incidence of tumors by ionizing radiation induction  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased large intestine adenocarcinoma incidence  (IAGP)
increased liver tumor incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased malignant tumor incidence  (IAGP)
increased mammary adenoacanthoma incidence  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased mast cell number  (IAGP)
increased metastatic potential  (IAGP)
increased NK T cell number  (IAGP)
increased organ/body region tumor incidence  (IAGP)
increased osteoma incidence  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased ovarian carcinoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pancreas tumor incidence  (IAGP)
increased pancreatic acinar cell carcinoma incidence  (IAGP)
increased pancreatic ductal adenocarcinoma incidence  (IAGP)
increased pilomatricoma incidence  (IAGP)
increased prostaglandin level  (IAGP)
increased prostate gland adenocarcinoma incidence  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
increased regulatory T cell number  (IAGP)
increased renal cystadenoma incidence  (IAGP)
increased reproductive system tumor incidence  (IAGP)
increased salivary gland tumor incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased small intestinal crypt cell apoptosis  (IAGP)
increased small intestine adenocarcinoma incidence  (IAGP)
increased stomach tumor incidence  (IAGP)
increased trichoepithelioma incidence  (IAGP)
increased tumor growth/size  (IAGP)
increased tumor incidence  (IAGP)
increased tumor latency  (IAGP)
intestinal hemorrhage  (IAGP)
intestinal obstruction  (IAGP)
intestine polyps  (IAGP)
jejunum polyps  (IAGP)
kidney cyst  (IAGP)
kinked tail  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lethargy  (IAGP)
liver hyperplasia  (IAGP)
liver inflammation  (IAGP)
lordosis  (IAGP)
lymph node hyperplasia  (IAGP)
mammary gland hyperplasia  (IAGP)
melena  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ovary atrophy  (IAGP)
ovary cyst  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
peritoneal inflammation  (IAGP)
polycystic kidney  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
prostate gland epithelial hyperplasia  (IAGP)
rectal hemorrhage  (IAGP)
rectal prolapse  (IAGP)
rostral body truncation  (IAGP)
rostral-caudal axis duplication  (IAGP)
salivary gland epithelial hyperplasia  (IAGP)
scaly skin  (IAGP)
scapular bone hypoplasia  (IAGP)
short hair  (IAGP)
short ribs  (IAGP)
short tail  (IAGP)
short vibrissae  (IAGP)
skin cyst  (IAGP)
skin ridges  (IAGP)
small stomach  (IAGP)
small thymus  (IAGP)
split notochord  (IAGP)
thymus hypoplasia  (IAGP)
underdeveloped hair follicles  (IAGP)
uterus atrophy  (IAGP)
weight loss  (IAGP)
wrinkled skin  (IAGP)
References

References - curated
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