Apc (APC, WNT signaling pathway regulator) - Rat Genome Database

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Gene: Apc (APC, WNT signaling pathway regulator) Mus musculus
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Symbol: Apc
Name: APC, WNT signaling pathway regulator
RGD ID: 10166
MGI Page MGI
Description: Exhibits several functions, including beta-catenin binding activity; dynein complex binding activity; and enzyme binding activity. Involved in several processes, including animal organ development; cell surface receptor signaling pathway; and regionalization. Localizes to several cellular components, including Scrib-APC-beta-catenin complex; axonal growth cone; and cell projection membrane. Predicted to colocalize with several cellular components, including adherens junction; cytoplasmic microtubule; and neuron projection. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and retina. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of WNT signaling pathway); PARTICIPATES IN altered Wnt signaling, canonical pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adenomatosis polyposis coli; adenomatous polyposis coli protein; AI047805; AU020952; AW124434; CC1; M; mAPC; Min; multiple intestinal neoplasia
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Apc-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,353,350 - 34,455,243 (+)NCBIGRCm39mm39
GRCm39 Ensembl1834,353,977 - 34,455,605 (+)Ensembl
GRCm381834,220,297 - 34,322,190 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,220,924 - 34,322,552 (+)EnsemblGRCm38mm10GRCm38
MGSCv371834,380,638 - 34,481,844 (+)NCBIGRCm37mm9NCBIm37
MGSCv361834,385,824 - 34,443,409 (+)NCBImm8
Celera1834,670,234 - 34,773,431 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model