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Gene: Map3k8 (mitogen-activated protein kinase kinase kinase 8) Mus musculus
Symbol: Map3k8
Name: mitogen-activated protein kinase kinase kinase 8
Description: Predicted to have MAP kinase kinase kinase activity. Predicted to be involved in several processes, including activation of protein kinase activity; signal transduction by protein phosphorylation; and stress-activated protein kinase signaling cascade. Predicted to localize to cytosol. Is expressed in colon; parotid gland; stomach mucosa; sublingual gland; and submandibular gland. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: c-COT; cancer Osaka thyroid oncogene; cancer Osaka thyroid, oncogene; Cot; COT proto-oncogene serine/threonine-protein kinase; Cot/Tpl2; Est; Estf; mitogen activated protein kinase kinase kinase 8; proto-oncogene c-Cot; serine/threonine-protein kinase cot; Tpl-2; Tpl2; tumor progression locus 2
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl184,331,327 - 4,353,015 (-)EnsemblGRCm38mm10GRCm38
GRCm38184,331,325 - 4,352,953 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37184,331,325 - 4,352,951 (-)NCBIGRCm37mm9NCBIm37
MGSCv36184,331,325 - 4,352,951 (-)NCBImm8
Celera184,376,104 - 4,394,119 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map182.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Map3k8
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731489
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.