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Gene: Map3k8 (mitogen-activated protein kinase kinase kinase 8) Mus musculus
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Symbol: Map3k8
Name: mitogen-activated protein kinase kinase kinase 8
Description: Predicted to have MAP kinase kinase kinase activity. Predicted to be involved in several processes, including activation of protein kinase activity; signal transduction by protein phosphorylation; and stress-activated protein kinase signaling cascade. Predicted to localize to cytosol. Is expressed in colon; parotid gland; stomach mucosa; sublingual gland; and submandibular gland. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: c-COT; cancer Osaka thyroid oncogene; cancer Osaka thyroid, oncogene; Cot; COT proto-oncogene serine/threonine-protein kinase; Cot/Tpl2; Est; Estf; mitogen activated protein kinase kinase kinase 8; proto-oncogene c-Cot; serine/threonine-protein kinase cot; Tpl-2; Tpl2; tumor progression locus 2
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl184,331,327 - 4,353,015 (-)EnsemblGRCm38mm10GRCm38
GRCm38184,331,325 - 4,352,953 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37184,331,325 - 4,352,951 (-)NCBIGRCm37mm9NCBIm37
MGSCv36184,331,325 - 4,352,951 (-)NCBImm8
Celera184,376,104 - 4,394,119 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map182.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Map3k8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731489
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.