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Gene: MAP3K8 (mitogen-activated protein kinase kinase kinase 8) Homo sapiens
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Symbol: MAP3K8
Name: mitogen-activated protein kinase kinase kinase 8
Description: Predicted to have protein serine/threonine kinase activity. Predicted to be involved in activation of protein kinase activity and signal transduction by protein phosphorylation. Localizes to the cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: augmented in rheumatoid arthritis 2; AURA2; c-COT; Cancer Osaka thyroid oncogene; COT; cot (cancer Osaka thyroid) oncogene; EST; ESTF; Ewing sarcoma transformant; FLJ10486; MEKK8; proto-oncogene c-Cot; proto-oncogene serine/threoine protein kinase; serine/threonine-protein kinase cot; Tpl-2; TPL2; tumor progression locus 2; tumor progression locus-2
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1030,434,021 - 30,461,833 (+)Ensembl
GRCh381030,434,021 - 30,461,833 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371030,722,950 - 30,750,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361030,762,872 - 30,790,767 (+)NCBINCBI36hg18NCBI36
Build 341030,762,871 - 30,790,767NCBI
Celera1030,487,787 - 30,515,686 (+)NCBI
Cytogenetic Map10p11.23NCBI
HuRef1030,441,888 - 30,469,569 (+)NCBIHuRef
CHM1_11030,722,912 - 30,750,718 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on MAP3K8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731488
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.