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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620969
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map3k8
Name: mitogen-activated protein kinase kinase kinase 8
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k8affects methylationISOMAP3K8 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of MAP3K8 5' UTRPMID:27901495
Map3k8decreases methylationISOMAP3K8 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of MAP3K8 promoterPMID:27901495
Map3k8increases expressionISOMAP3K8 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of MAP3K8 mRNAPMID:20106945 PMID:21632981 PMID:22316170
Map3k8increases expressionISOMap3k8 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of MAP3K8 mRNAPMID:22228805
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