Ryr2 (ryanodine receptor 2) - Rat Genome Database

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Gene: Ryr2 (ryanodine receptor 2) Rattus norvegicus
Analyze
Symbol: Ryr2
Name: ryanodine receptor 2
RGD ID: 620314
Description: Enables ryanodine-sensitive calcium-release channel activity and scaffold protein binding activity. Involved in several processes, including metal ion transport; regulation of cytosolic calcium ion concentration; and response to magnesium ion. Located in several cellular components, including sarcolemma; sarcomere; and sarcoplasmic reticulum membrane. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Used to study congestive heart failure. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cardiac muscle ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel; cardiac-type ryaodine receptor; LOC689560; ryanodine receptor 2, cardiac; ryanodine receptor type 2; ryanodine receptor type II; RyR; RYR-2; similar to ryanodine receptor 2, cardiac; type 2 ryanodine receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Cm15
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81763,081,527 - 63,667,141 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1763,081,527 - 63,666,705 (+)EnsemblGRCr8
mRatBN7.21758,389,925 - 58,975,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1758,389,925 - 58,975,142 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1761,577,482 - 62,170,893 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01765,580,613 - 66,173,955 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01759,734,794 - 60,328,300 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01765,533,998 - 65,955,606 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1765,535,403 - 65,955,606 (-)Ensemblrn6Rnor6.0
Rnor_5.01767,285,205 - 67,704,766 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41768,959,042 - 69,544,816 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1761,573,393 - 61,976,022 (-)NCBICelera
RGSC_v3.11769,519,966 - 69,552,036 (+)NCBI
Cytogenetic Map17q12.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 1  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
autism spectrum disorder  (ISO)
Brugada syndrome  (ISO)
cardiac arrest  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Conduction Defect  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO,ISS)
catecholaminergic polymorphic ventricular tachycardia 2  (ISO)
Childhood Schizophrenia  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (IDA,ISO)
coronary artery disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diastolic Dysfunction  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1AA  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1C  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
Experimental Diabetes Mellitus  (IDA)
familial hypertrophic cardiomyopathy  (ISO)
Familial Sudden Death  (ISO)
Familial Ventricular Tachycardia  (ISO)
gastrointestinal stromal tumor  (ISO)
gestational diabetes  (ISO)
Heart Block  (ISO)
heart disease  (ISO,ISS)
Hereditary Leiomyomatosis and Renal Cell Cancer  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 4  (ISO)
Infant Death  (ISO)
left ventricular noncompaction  (ISO)
long QT syndrome  (ISO)
long QT syndrome 1  (ISO)
malignant mesothelioma  (ISO)
microcephalic osteodysplastic primordial dwarfism type I  (ISO)
Microcephalic Osteodysplastic Primordial Dwarfism, Type III  (ISO)
Myocardial Ischemia  (ISO)
parathyroid carcinoma  (ISO)
Paroxysmal Ventricular Fibrillation  (ISO)
pre-eclampsia  (ISO)
pulmonary hypertension  (IEP)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
Syncope  (ISO)
Tachycardia  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Fibrillation, Paroxysmal Familial, 1  (ISO)
Ventricular Tachycardia  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
17beta-estradiol  (EXP)
2,2',3,3',6,6'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-Zearalanol  (EXP)
antimony trichloride  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atenolol  (ISO)
baclofen  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bicuculline  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (EXP)
cantharidin  (ISO)
capsaicin  (ISO)
carvedilol  (EXP,ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cocaine  (EXP,ISO)
Cuprizon  (EXP)
cyclic ADP-beta-D-ribose  (EXP)
dantrolene  (EXP)
daunorubicin  (EXP,ISO)
diarsenic trioxide  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
etoposide  (ISO)
fenvalerate  (EXP)
flutamide  (ISO)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
isoprenaline  (EXP,ISO)
L-methionine  (ISO)
linsidomine  (EXP)
maraviroc  (ISO)
mercury dichloride  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP,ISO)
metoprolol  (ISO)
mifepristone  (ISO)
mitoxantrone  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
nicotine  (EXP,ISO)
O-methyleugenol  (ISO)
ouabain  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (EXP)
phenytoin  (EXP)
picrotoxin  (EXP)
progesterone  (EXP,ISO)
propofol  (EXP)
razoxane  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
ryanodine  (EXP,ISO)
SCH 23390  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
terbufos  (ISO)
thalidomide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transmembrane import into cytosol  (ISO)
calcium ion transmembrane transport  (IEA,IMP,ISO)
calcium ion transport  (IEA,ISO,ISS)
calcium ion transport into cytosol  (ISO)
calcium-mediated signaling  (IEA,ISO,ISS)
cardiac muscle contraction  (ISO)
cardiac muscle hypertrophy  (ISO)
cellular response to caffeine  (ISO,ISS)
cellular response to epinephrine stimulus  (ISO)
detection of calcium ion  (ISO)
embryonic heart tube morphogenesis  (ISO,ISS)
establishment of localization in cell  (ISO)
establishment of protein localization to endoplasmic reticulum  (ISO)
intracellular calcium ion homeostasis  (IEA,ISO,ISS)
left ventricular cardiac muscle tissue morphogenesis  (ISO)
manganese ion transmembrane transport  (IMP)
monoatomic ion transmembrane transport  (IEA,IMP)
monoatomic ion transport  (IEA)
negative regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of heart rate  (ISO)
positive regulation of sequestering of calcium ion  (ISO)
positive regulation of the force of heart contraction  (ISO)
Purkinje myocyte to ventricular cardiac muscle cell signaling  (ISO)
regulation of atrial cardiac muscle cell action potential  (ISO)
regulation of AV node cell action potential  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of cardiac muscle contraction by calcium ion signaling  (ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (ISO)
regulation of cytosolic calcium ion concentration  (IEA,IMP)
regulation of heart rate  (ISO)
regulation of SA node cell action potential  (ISO)
regulation of ventricular cardiac muscle cell action potential  (ISO)
release of sequestered calcium ion into cytosol  (ISO)
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IBA,ISO,ISS)
response to caffeine  (ISO)
response to calcium ion  (IDA)
response to hypoxia  (IEA,IEP,ISO)
response to magnesium ion  (IDA)
response to muscle activity  (ISO)
response to muscle stretch  (ISO)
response to nutrient  (IEP)
response to redox state  (ISO)
response to xenobiotic stimulus  (IEP)
sarcoplasmic reticulum calcium ion transport  (IEA,IMP)
striated muscle contraction  (IBA)
transmembrane transport  (IEA)
type B pancreatic cell apoptotic process  (ISO)
ventricular cardiac muscle cell action potential  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
arrhythmogenic right ventricular cardiomyopathy pathway  (IEA)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium transport pathway   (ISO)
calcium/calcium-mediated signaling pathway   (IEA,ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
hypertrophic cardiomyopathy pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Ryanodine receptor dysfunction in hearts of streptozotocin-induced diabetic rats. Bidasee KR, etal., Mol Pharmacol 2001 Dec;60(6):1356-64.
2. Ischemia enhances activation by Ca2+ and redox modification of ryanodine receptor channels from rat brain cortex. Bull R, etal., J Neurosci. 2008 Sep 17;28(38):9463-72.
3. Late memory-related genes in the hippocampus revealed by RNA fingerprinting. Cavallaro S, etal., Proc Natl Acad Sci U S A 1997 Sep 2;94(18):9669-73.
4. Mg2+ activates the ryanodine receptor type 2 (RyR2) at intermediate Ca2+ concentrations. Chugun A, etal., Am J Physiol Cell Physiol. 2007 Jan;292(1):C535-44. Epub 2006 Sep 13.
5. Identification of functionally segregated sarcoplasmic reticulum calcium stores in pulmonary arterial smooth muscle. Clark JH, etal., J Biol Chem. 2010 Apr 30;285(18):13542-9. doi: 10.1074/jbc.M110.101485. Epub 2010 Feb 21.
6. Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats. Dahan D, etal., Am J Physiol Lung Cell Mol Physiol. 2012 Nov 1;303(9):L824-33. doi: 10.1152/ajplung.00244.2011. Epub 2012 Sep 7.
7. Ryanodine receptor subtype 2 encodes Ca2+ oscillations activated by acetylcholine via the M2 muscarinic receptor/cADP-ribose signalling pathway in duodenum myocytes. Fritz N, etal., J Cell Sci. 2005 May 15;118(Pt 10):2261-70. Epub 2005 May 3.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors. Ho HT, etal., J Physiol. 2011 Oct 1;589(Pt 19):4697-708. Epub 2011 Aug 1.
10. mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. Kapiloff MS, etal., J Cell Sci. 2001 Sep;114(Pt 17):3167-76.
11. Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy. Kraner SD, etal., Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1384-91. Epub 2011 Apr 6.
12. Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Lanner JT, etal., Cold Spring Harb Perspect Biol. 2010 Nov;2(11):a003996. doi: 10.1101/cshperspect.a003996. Epub 2010 Oct 20.
13. Functional groups of ryanodine receptors in rat ventricular cells. Lukyanenko V, etal., J Physiol. 2007 Aug 15;583(Pt 1):251-69. Epub 2007 Jul 12.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding. Oda T, etal., Circ Res. 2013 Feb 1;112(3):487-97. doi: 10.1161/CIRCRESAHA.111.300290. Epub 2012 Dec 11.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. Pare GC, etal., J Cell Sci. 2005 Dec 1;118(Pt 23):5637-46.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII). Rokita AG and Anderson ME, Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990.
24. Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells. Rosker C, etal., J Biol Chem. 2009 Feb 20;284(8):5186-94. doi: 10.1074/jbc.M805587200. Epub 2008 Dec 30.
25. Distribution of proteins implicated in excitation-contraction coupling in rat ventricular myocytes. Scriven DR, etal., Biophys J. 2000 Nov;79(5):2682-91.
26. Caveolin-3 is adjacent to a group of extradyadic ryanodine receptors. Scriven DR, etal., Biophys J. 2005 Sep;89(3):1893-901. Epub 2005 Jun 24.
27. Formation of molecular complexes by N-methyl-D-aspartate receptor subunit NR2B and ryanodine receptor 2 in neonatal rat myocard. Seeber S, etal., J Biol Chem. 2004 May 14;279(20):21062-8. Epub 2004 Mar 9.
28. Dyssynchronous (non-uniform) Ca(2+) release in myocytes from streptozotocin-induced diabetic rats. Shao CH, etal., J Mol Cell Cardiol. 2007 Jan;42(1):234-46. Epub 2006 Oct 6.
29. Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). Tiso N, etal., Hum Mol Genet. 2001 Feb 1;10(3):189-94.
30. Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients. Varshney S, etal., Endocrine. 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9. Epub 2022 Dec 8.
31. Down-regulation of the cardiac sarcoplasmic reticulum ryanodine channel in severely food-restricted rats. Vizotto VA, etal., Braz J Med Biol Res. 2007 Jan;40(1):27-31.
32. Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts. Xiao B, etal., Biochem J. 2006 May 15;396(1):7-16.
33. Effects of simvastatin on cardiac performance and expression of sarcoplasmic reticular calcium regulatory proteins in rat heart. Zheng X and Hu SJ, Acta Pharmacol Sin. 2005 Jun;26(6):696-704.
34. Ryanodine receptor interaction with the SNARE-associated protein snapin. Zissimopoulos S, etal., J Cell Sci. 2006 Jun 1;119(Pt 11):2386-97.
Additional References at PubMed
PMID:9287354   PMID:9628868   PMID:10444400   PMID:10473538   PMID:10830164   PMID:11576544   PMID:11934703   PMID:12089338   PMID:12324472   PMID:12401811   PMID:12443530   PMID:12477932  
PMID:12606683   PMID:12676814   PMID:12829653   PMID:12837242   PMID:12919952   PMID:14592808   PMID:14593104   PMID:15041652   PMID:15044459   PMID:15105296   PMID:15197150   PMID:15626694  
PMID:15731460   PMID:16204356   PMID:16213210   PMID:16249429   PMID:16481613   PMID:16931553   PMID:17234969   PMID:17237229   PMID:17267548   PMID:17313373   PMID:17360443   PMID:17431507  
PMID:17516033   PMID:17569730   PMID:17630346   PMID:17652368   PMID:17693412   PMID:17823125   PMID:17872467   PMID:17875969   PMID:17921453   PMID:18468998   PMID:18718444   PMID:18755143  
PMID:18979913   PMID:19120137   PMID:19131648   PMID:19220289   PMID:19226252   PMID:19284993   PMID:19383796   PMID:20008518   PMID:20018773   PMID:20080623   PMID:20226167   PMID:20336285  
PMID:20427316   PMID:20431056   PMID:20445169   PMID:20471962   PMID:21156134   PMID:21282625   PMID:21372126   PMID:21421556   PMID:21612318   PMID:21649588   PMID:21673970   PMID:21788490  
PMID:22067155   PMID:22073362   PMID:22363773   PMID:22404946   PMID:22406107   PMID:22867515   PMID:22890710   PMID:23040497   PMID:23177664   PMID:23354458   PMID:23376485   PMID:23454728  
PMID:23499836   PMID:23943510   PMID:24186966   PMID:24417961   PMID:24631538   PMID:24693334   PMID:24786399   PMID:25263335   PMID:26046640   PMID:26071359   PMID:26092277   PMID:26164367  
PMID:26316108   PMID:26963898   PMID:27013634   PMID:27422983   PMID:27516456   PMID:28630041   PMID:29162778   PMID:29357673   PMID:30123252   PMID:30885011   PMID:31505169   PMID:31916935  
PMID:33689540   PMID:33753579   PMID:33812310   PMID:35134547   PMID:35562179   PMID:36344175   PMID:38266577   PMID:38652413  


Genomics

Comparative Map Data
Ryr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81763,081,527 - 63,667,141 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1763,081,527 - 63,666,705 (+)EnsemblGRCr8
mRatBN7.21758,389,925 - 58,975,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1758,389,925 - 58,975,142 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1761,577,482 - 62,170,893 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01765,580,613 - 66,173,955 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01759,734,794 - 60,328,300 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01765,533,998 - 65,955,606 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1765,535,403 - 65,955,606 (-)Ensemblrn6Rnor6.0
Rnor_5.01767,285,205 - 67,704,766 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41768,959,042 - 69,544,816 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1761,573,393 - 61,976,022 (-)NCBICelera
RGSC_v3.11769,519,966 - 69,552,036 (+)NCBI
Cytogenetic Map17q12.1NCBI
RYR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381237,042,184 - 237,833,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1237,042,184 - 237,833,988 (+)Ensemblhg38GRCh38
GRCh371237,205,484 - 237,997,288 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361235,272,325 - 236,063,911 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341233,531,742 - 234,322,694NCBI
Celera1210,455,038 - 211,246,790 (+)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1207,662,133 - 208,453,675 (+)NCBIHuRef
CHM1_11238,478,098 - 239,269,604 (+)NCBICHM1_1
T2T-CHM13v2.01236,453,199 - 237,245,297 (+)NCBIT2T-CHM13v2.0
Ryr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391311,567,985 - 12,121,831 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1311,567,988 - 12,121,831 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381311,553,099 - 12,106,945 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1311,553,102 - 12,106,945 (-)Ensemblmm10GRCm38
MGSCv371311,645,370 - 12,199,212 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361311,608,677 - 12,160,499 (-)NCBIMGSCv36mm8
Celera1311,467,020 - 12,025,871 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.38NCBI
Ryr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554922,648,956 - 3,076,509 (-)Ensembl
ChiLan1.0NW_0049554922,647,597 - 3,275,512 (-)NCBIChiLan1.0ChiLan1.0
RYR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2111,327,556 - 12,116,058 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1111,544,360 - 12,334,567 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01212,600,198 - 213,387,312 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11217,598,069 - 218,384,849 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1217,815,676 - 218,383,509 (+)EnsemblpanPan2panpan1.1
RYR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.142,371,868 - 2,908,132 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl42,373,114 - 2,907,875 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha42,419,733 - 3,146,551 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.042,390,864 - 3,118,926 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl42,391,241 - 3,118,902 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.142,386,589 - 3,119,270 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.042,522,518 - 3,249,453 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.042,743,722 - 3,470,663 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ryr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934439,237,258 - 39,734,210 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648415,403,819 - 15,824,441 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648415,402,488 - 15,825,410 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RYR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1453,652,485 - 54,192,063 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11453,652,140 - 54,406,691 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21457,571,491 - 58,014,914 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q22-q23NCBI
RYR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12574,169,024 - 74,951,371 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2574,389,122 - 74,953,451 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605576,267,928 - 77,050,853 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ryr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477512,956,042 - 13,419,381 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477512,954,653 - 13,650,449 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ryr2
4505 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:14
Count of miRNA genes:5
Interacting mature miRNAs:6
Transcripts:ENSRNOT00000023601, ENSRNOT00000067949
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174949693265155015Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)176109144668550213Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat

Markers in Region
D17Rat123  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81763,460,310 - 63,460,481 (+)Marker Load Pipeline
mRatBN7.21758,768,794 - 58,768,965 (-)MAPPERmRatBN7.2
Rnor_6.01765,739,231 - 65,739,401NCBIRnor6.0
Rnor_5.01767,489,835 - 67,490,005UniSTSRnor5.0
RGSC_v3.41769,337,501 - 69,337,672RGDRGSC3.4
RGSC_v3.41769,337,502 - 69,337,672UniSTSRGSC3.4
Celera1761,772,098 - 61,772,268UniSTS
RGSC_v3.11769,348,334 - 69,348,505RGD
SHRSP x BN Map1732.6999UniSTS
SHRSP x BN Map1732.6999RGD
Cytogenetic Map17q12.1UniSTS
D17Arb5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,691,835 - 58,691,962 (-)MAPPERmRatBN7.2
Rnor_6.01765,830,897 - 65,831,023NCBIRnor6.0
Rnor_5.01767,580,807 - 67,580,933UniSTSRnor5.0
RGSC_v3.41769,257,316 - 69,257,442UniSTSRGSC3.4
RGSC_v3.41769,257,315 - 69,257,442RGDRGSC3.4
Celera1761,848,039 - 61,848,165UniSTS
RGSC_v3.11769,268,149 - 69,268,275RGD
RH 3.4 Map17617.3UniSTS
RH 3.4 Map17617.3RGD
SHRSP x BN Map1732.6999UniSTS
SHRSP x BN Map1732.6999RGD
FHH x ACI Map1742.1599RGD
Cytogenetic Map17q12.1UniSTS
D17Rat68  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,632,929 - 58,633,100 (-)MAPPERmRatBN7.2
Rnor_6.01765,888,732 - 65,888,902NCBIRnor6.0
Rnor_5.01767,638,898 - 67,639,068UniSTSRnor5.0
RGSC_v3.41769,196,750 - 69,196,921RGDRGSC3.4
RGSC_v3.41769,196,751 - 69,196,921UniSTSRGSC3.4
Celera1761,906,744 - 61,906,915UniSTS
FHH x ACI Map1742.19UniSTS
FHH x ACI Map1742.19RGD
Cytogenetic Map17q12.1UniSTS
D17Got79  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,816,258 - 58,816,366 (-)MAPPERmRatBN7.2
Rnor_6.01765,691,658 - 65,691,765NCBIRnor6.0
Rnor_5.01767,442,262 - 67,442,369UniSTSRnor5.0
RGSC_v3.41769,384,960 - 69,385,068RGDRGSC3.4
RGSC_v3.41769,384,961 - 69,385,068UniSTSRGSC3.4
Celera1761,725,590 - 61,725,697UniSTS
RGSC_v3.11769,395,794 - 69,395,901RGD
RH 3.4 Map17619.1UniSTS
RH 3.4 Map17619.1RGD
RH 2.0 Map17479.8RGD
Cytogenetic Map17q12.1UniSTS
D17Got77  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,541,482 - 58,541,590 (-)MAPPERmRatBN7.2
Rnor_6.01765,977,518 - 65,977,625NCBIRnor6.0
Rnor_5.01767,726,678 - 67,726,785UniSTSRnor5.0
RGSC_v3.41769,105,678 - 69,105,786RGDRGSC3.4
RGSC_v3.41769,105,679 - 69,105,786UniSTSRGSC3.4
Celera1761,997,939 - 61,998,046UniSTS
RGSC_v3.11769,116,512 - 69,116,619RGD
RH 3.4 Map17614.8UniSTS
RH 3.4 Map17614.8RGD
RH 2.0 Map17488.8RGD
Cytogenetic Map17q12.1UniSTS
RH131486  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,975,330 - 58,975,547 (-)MAPPERmRatBN7.2
Rnor_6.01765,534,089 - 65,534,305NCBIRnor6.0
Rnor_5.01767,285,296 - 67,285,512UniSTSRnor5.0
RGSC_v3.41769,545,842 - 69,546,058UniSTSRGSC3.4
Celera1761,573,484 - 61,573,700UniSTS
RH 3.4 Map17615.9UniSTS
Cytogenetic Map17q12.1UniSTS
AU049096  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,116,089 - 85,117,213 (+)MAPPERmRatBN7.2
Rnor_6.01088,096,096 - 88,097,217NCBIRnor6.0
Rnor_5.01087,888,771 - 87,889,892UniSTSRnor5.0
RGSC_v3.41769,029,828 - 69,030,313UniSTSRGSC3.4
RGSC_v3.41089,121,733 - 89,122,854UniSTSRGSC3.4
Celera1762,083,834 - 62,084,319UniSTS
Celera1083,835,564 - 83,836,678UniSTS
Cytogenetic Map17q12.1UniSTS
Cytogenetic Map10q32.1UniSTS
AU049552  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,768,778 - 58,769,026 (-)MAPPERmRatBN7.2
Rnor_6.01765,739,170 - 65,739,417NCBIRnor6.0
Rnor_5.01767,489,774 - 67,490,021UniSTSRnor5.0
RGSC_v3.41769,337,486 - 69,337,733UniSTSRGSC3.4
Celera1761,772,037 - 61,772,284UniSTS
Cytogenetic Map17q12.1UniSTS
PMC21940P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,975,120 - 58,975,366 (-)MAPPERmRatBN7.2
Rnor_6.01765,534,270 - 65,534,515NCBIRnor6.0
Rnor_5.01767,285,477 - 67,285,722UniSTSRnor5.0
RGSC_v3.41769,545,632 - 69,545,877UniSTSRGSC3.4
Celera1761,573,665 - 61,573,910UniSTS
Cytogenetic Map17q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 67 151 68 67 36 38 36 6 258 137 10 128 62 92 31 14 14

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005495333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB204523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF011789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF112257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF130880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF363960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC167757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU346200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023601   ⟹   ENSRNOP00000023601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1763,081,527 - 63,666,705 (+)Ensembl
mRatBN7.2 Ensembl1758,389,925 - 58,975,142 (+)Ensembl
Rnor_6.0 Ensembl1765,535,403 - 65,955,606 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000067949   ⟹   ENSRNOP00000059019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1763,081,527 - 63,666,705 (+)Ensembl
mRatBN7.2 Ensembl1758,389,925 - 58,975,142 (+)Ensembl
Rnor_6.0 Ensembl1765,535,403 - 65,955,606 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111439   ⟹   ENSRNOP00000087428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1763,254,126 - 63,666,705 (+)Ensembl
mRatBN7.2 Ensembl1758,562,590 - 58,975,142 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158171   ⟹   ENSRNOP00000108473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1763,081,527 - 63,666,705 (+)Ensembl
RefSeq Acc Id: NM_001191043   ⟹   NP_001177972
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,527 - 63,667,138 (+)NCBI
mRatBN7.21758,389,925 - 58,975,638 (+)NCBI
Rnor_6.01765,533,998 - 65,955,606 (-)NCBI
Rnor_5.01767,285,205 - 67,704,766 (-)NCBI
Celera1761,573,393 - 61,976,022 (-)NCBI
Sequence:
RefSeq Acc Id: NM_032078   ⟹   NP_114467
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,527 - 63,667,138 (+)NCBI
mRatBN7.21758,389,925 - 58,975,638 (+)NCBI
Rnor_6.01765,535,403 - 65,955,606 (-)NCBI
Rnor_5.01767,285,205 - 67,704,766 (-)NCBI
RGSC_v3.41768,959,042 - 69,544,816 (+)RGD
Celera1761,574,873 - 61,976,022 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063276749   ⟹   XP_063132819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276750   ⟹   XP_063132820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276751   ⟹   XP_063132821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276752   ⟹   XP_063132822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276753   ⟹   XP_063132823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276754   ⟹   XP_063132824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276755   ⟹   XP_063132825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276756   ⟹   XP_063132826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276757   ⟹   XP_063132827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276758   ⟹   XP_063132828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276759   ⟹   XP_063132829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276760   ⟹   XP_063132830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276761   ⟹   XP_063132831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,514,922 (+)NCBI
RefSeq Acc Id: XM_063276762   ⟹   XP_063132832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276763   ⟹   XP_063132833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276764   ⟹   XP_063132834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XR_005495333
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,549,913 (+)NCBI
mRatBN7.21758,390,217 - 58,858,418 (+)NCBI
RefSeq Acc Id: XR_010058952
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,523,042 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001177972 (Get FASTA)   NCBI Sequence Viewer  
  NP_114467 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132819 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132820 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132821 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132822 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132823 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132824 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132825 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132826 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132827 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132828 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132829 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132830 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132831 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132832 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132833 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132834 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB65757 (Get FASTA)   NCBI Sequence Viewer  
  AAB70011 (Get FASTA)   NCBI Sequence Viewer  
  AAB70013 (Get FASTA)   NCBI Sequence Viewer  
  AAD31271 (Get FASTA)   NCBI Sequence Viewer  
  AAD48900 (Get FASTA)   NCBI Sequence Viewer  
  AAI67757 (Get FASTA)   NCBI Sequence Viewer  
  AAK37569 (Get FASTA)   NCBI Sequence Viewer  
  ABY79796 (Get FASTA)   NCBI Sequence Viewer  
  B0LPN4 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10276 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10277 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10278 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10279 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10280 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10281 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10282 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10283 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10284 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023601
  ENSRNOP00000023601.7
  ENSRNOP00000059019.4
  ENSRNOP00000087428
  ENSRNOP00000108473
  ENSRNOP00060023022
  ENSRNOP00060023073
  ENSRNOP00065027978
  ENSRNOP00065027995
RefSeq Acc Id: NP_114467   ⟸   NM_032078
- Peptide Label: isoform 1
- UniProtKB: F1LRZ1 (UniProtKB/Swiss-Prot),   D7UNT3 (UniProtKB/Swiss-Prot),   B0LPN4 (UniProtKB/Swiss-Prot),   F1LS89 (UniProtKB/TrEMBL),   A0A8I6A7R2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177972   ⟸   NM_001191043
- Peptide Label: isoform 2
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023601   ⟸   ENSRNOT00000023601
Ensembl Acc Id: ENSRNOP00000059019   ⟸   ENSRNOT00000067949
Ensembl Acc Id: ENSRNOP00000087428   ⟸   ENSRNOT00000111439
RefSeq Acc Id: XP_063132819   ⟸   XM_063276749
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132821   ⟸   XM_063276751
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132826   ⟸   XM_063276756
- Peptide Label: isoform X8
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132822   ⟸   XM_063276752
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132827   ⟸   XM_063276757
- Peptide Label: isoform X9
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132824   ⟸   XM_063276754
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132828   ⟸   XM_063276758
- Peptide Label: isoform X10
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132823   ⟸   XM_063276753
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132832   ⟸   XM_063276762
- Peptide Label: isoform X14
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132833   ⟸   XM_063276763
- Peptide Label: isoform X15
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132829   ⟸   XM_063276759
- Peptide Label: isoform X11
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132830   ⟸   XM_063276760
- Peptide Label: isoform X12
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132820   ⟸   XM_063276750
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132825   ⟸   XM_063276755
- Peptide Label: isoform X7
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132834   ⟸   XM_063276764
- Peptide Label: isoform X16
- UniProtKB: A0A8I6A7R2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132831   ⟸   XM_063276761
- Peptide Label: isoform X13
- UniProtKB: A6KN28 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108473   ⟸   ENSRNOT00000158171
Protein Domains
B30.2/SPRY   EF-hand   Ion transport   MIR

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620314 AgrOrtholog
BioCyc Gene G2FUF-8929 BioCyc
Ensembl Genes ENSRNOG00000017060 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00060015609 UniProtKB/Swiss-Prot
  ENSRNOG00065020109 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023601 ENTREZGENE
  ENSRNOT00000023601.8 UniProtKB/Swiss-Prot
  ENSRNOT00000067949.4 UniProtKB/Swiss-Prot
  ENSRNOT00000111439 ENTREZGENE
  ENSRNOT00000158171 ENTREZGENE
  ENSRNOT00060028627 UniProtKB/Swiss-Prot
  ENSRNOT00060028685 UniProtKB/Swiss-Prot
  ENSRNOT00065034837 UniProtKB/Swiss-Prot
  ENSRNOT00065034855 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.10.490.160 UniProtKB/Swiss-Prot
  2.60.120.920 UniProtKB/Swiss-Prot
  2.80.10.50 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
  IP3 receptor type 1 binding core, RIH domain UniProtKB/Swiss-Prot
InterPro B30.2/SPRY UniProtKB/Swiss-Prot
  B30.2/SPRY_sf UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  Ins145_P3_rcpt UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  MIR_dom_sf UniProtKB/Swiss-Prot
  MIR_motif UniProtKB/Swiss-Prot
  RIH_assoc-dom UniProtKB/Swiss-Prot
  RIH_dom UniProtKB/Swiss-Prot
  Ryan_recept UniProtKB/Swiss-Prot
  Ryanodine_IP3_receptor UniProtKB/Swiss-Prot
  Ryanodine_rcpt UniProtKB/Swiss-Prot
  Ryanrecept_TM4-6 UniProtKB/Swiss-Prot
  RYDR_Jsol UniProtKB/Swiss-Prot
  RyR/IP3R_RIH_dom_sf UniProtKB/Swiss-Prot
  SPRY1_RyR UniProtKB/Swiss-Prot
  SPRY2_RyR UniProtKB/Swiss-Prot
  SPRY3_RyR UniProtKB/Swiss-Prot
  SPRY_dom UniProtKB/Swiss-Prot
KEGG Report rno:689560 UniProtKB/Swiss-Prot
NCBI Gene Ryr2 ENTREZGENE
PANTHER B30.2/SPRY DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  RYANODINE RECEPTOR 2 UniProtKB/Swiss-Prot
Pfam EF-hand_7 UniProtKB/Swiss-Prot
  Ins145_P3_rec UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
  MIR UniProtKB/Swiss-Prot
  RIH_assoc UniProtKB/Swiss-Prot
  RR_TM4-6 UniProtKB/Swiss-Prot
  RYDR_ITPR UniProtKB/Swiss-Prot
  RYDR_Jsol UniProtKB/Swiss-Prot
  RyR UniProtKB/Swiss-Prot
  SPRY UniProtKB/Swiss-Prot
PhenoGen Ryr2 PhenoGen
PRINTS RYANODINER UniProtKB/Swiss-Prot
PROSITE B302_SPRY UniProtKB/Swiss-Prot
  MIR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017060 RatGTEx
  ENSRNOG00060015609 RatGTEx
  ENSRNOG00065020109 RatGTEx
SMART MIR UniProtKB/Swiss-Prot
  SPRY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100909 UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
  SSF49899 UniProtKB/Swiss-Prot
  SSF82109 UniProtKB/Swiss-Prot
UniProt A0A8I6A7R2 ENTREZGENE, UniProtKB/TrEMBL
  A6KN28 ENTREZGENE, UniProtKB/TrEMBL
  B0LPN4 ENTREZGENE
  B3DM99_RAT UniProtKB/TrEMBL
  D7UNT3 ENTREZGENE
  F1LRZ1 ENTREZGENE
  F1LS89 ENTREZGENE
  O08660_RAT UniProtKB/TrEMBL
  Q9WUE2_RAT UniProtKB/TrEMBL
  RYR2_RAT UniProtKB/Swiss-Prot
UniProt Secondary D7UNT3 UniProtKB/Swiss-Prot
  F1LRZ1 UniProtKB/Swiss-Prot
  F1LS89 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Ryr2  ryanodine receptor 2  Ryr2  ryanodine receptor 2, cardiac  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-12 Ryr2  ryanodine receptor 2, cardiac  LOC689560  similar to ryanodine receptor 2, cardiac  Data merged from RGD:1591067 737654 APPROVED
2006-11-20 LOC689560  similar to ryanodine receptor 2, cardiac      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Ryr2  ryanodine receptor 2, cardiac    ryanodine receptor type II  Name updated 1299863 APPROVED
2002-08-07 Ryr2  ryanodine receptor type II      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process ryanodine binding to receptor is decreased in diabetic rats 634031