(S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of RYR2 mRNA, Nicotine results in increased expression of RYR2 protein CTD PMID:21113126 (S)-nicotine increases expression ISO RGD:1557868 6480464 Nicotine results in increased expression of RYR2 mRNA CTD PMID:21113126 (S)-nicotine multiple interactions ISO RGD:1557868 6480464 CHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA] CTD PMID:21113126 (S)-nicotine multiple interactions EXP 6480464 CREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA], Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter] CTD PMID:21113126 1,2-dimethylhydrazine increases expression ISO RGD:1557868 6480464 1, 2-Dimethylhydrazine results in increased expression of RYR2 mRNA CTD PMID:22206623 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine multiple interactions EXP 6480464 Trimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of RYR2 mRNA] CTD PMID:25937560 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of RYR2 mRNA CTD PMID:20068009 2,2',3,3',6,6'-hexachlorobiphenyl multiple interactions EXP 6480464 2 more ... CTD PMID:18954145 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of RYR2 mRNA CTD PMID:32109520 2,3-bis(4-hydroxyphenyl)propionitrile increases phosphorylation EXP 6480464 2, 3-bis(4-hydroxyphenyl)-propionitrile results in increased phosphorylation of RYR2 protein CTD PMID:25723814 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 4-(2-phenyl-5 more ... CTD PMID:25723814 4,4'-sulfonyldiphenol affects methylation ISO RGD:1557868 6480464 bis(4-hydroxyphenyl)sulfone affects the methylation of RYR2 gene CTD PMID:31683443 4,4'-sulfonyldiphenol increases expression ISO RGD:1557868 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of RYR2 mRNA CTD PMID:30951980 4,4'-sulfonyldiphenol increases phosphorylation EXP 6480464 bis(4-hydroxyphenyl)sulfone results in increased phosphorylation of RYR2 protein CTD PMID:25723814 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of RYR2 mRNA CTD PMID:24780913 aflatoxin B1 decreases methylation ISO RGD:1317019 6480464 Aflatoxin B1 results in decreased methylation of RYR2 gene CTD PMID:27153756 aflatoxin B1 increases methylation ISO RGD:1317019 6480464 Aflatoxin B1 results in increased methylation of RYR2 intron CTD PMID:30157460 Aflatoxin B2 alpha increases methylation ISO RGD:1317019 6480464 aflatoxin B2 results in increased methylation of RYR2 intron CTD PMID:30157460 Aroclor 1254 increases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of RYR2 protein CTD PMID:16309888 more ... arsane affects methylation ISO RGD:1317019 6480464 Arsenic affects the methylation of RYR2 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1317019 6480464 Arsenic affects the methylation of RYR2 gene CTD PMID:25304211 atenolol increases activity ISO RGD:1317019 6480464 Atenolol results in increased activity of RYR2 protein CTD PMID:12743001 atenolol multiple interactions ISO RGD:1317019 6480464 Atenolol promotes the reaction [FKBP1B protein binds to RYR2 protein] CTD PMID:12743001 baclofen multiple interactions ISO RGD:1557868 6480464 Baclofen inhibits the reaction [A 68930 results in increased expression of RYR2 protein], Baclofen inhibits the reaction [SK&F 82958 results in increased expression of RYR2 protein] CTD PMID:22504960 benzo[a]pyrene increases mutagenesis ISO RGD:1317019 6480464 Benzo(a)pyrene results in increased mutagenesis of RYR2 gene CTD PMID:25435355 benzo[a]pyrene affects methylation ISO RGD:1317019 6480464 Benzo(a)pyrene affects the methylation of RYR2 3' UTR more ... CTD PMID:27901495 , PMID:30157460 benzo[a]pyrene decreases expression ISO RGD:1317019 6480464 Benzo(a)pyrene results in decreased expression of RYR2 mRNA CTD PMID:22316170 benzo[e]pyrene increases methylation ISO RGD:1317019 6480464 benzo(e)pyrene results in increased methylation of RYR2 intron CTD PMID:30157460 bicuculline increases response to substance EXP 6480464 RYR2 results in increased susceptibility to Bicuculline CTD PMID:22534176 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of RYR2 mRNA CTD PMID:20920545 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1317019 6480464 Diethylhexyl Phthalate results in increased expression of RYR2 mRNA CTD PMID:31163220 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of RYR2 mRNA CTD PMID:25181051 bisphenol A multiple interactions ISO RGD:1557868 6480464 Mifepristone inhibits the reaction [bisphenol A results in decreased expression of RYR2 mRNA] CTD PMID:31566189 bisphenol A multiple interactions ISO RGD:1317019 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of RYR2 gene CTD PMID:31601247 bisphenol A decreases expression ISO RGD:1557868 6480464 bisphenol A results in decreased expression of RYR2 mRNA CTD PMID:31566189 , PMID:32156529 bisphenol A decreases methylation ISO RGD:1317019 6480464 bisphenol A results in decreased methylation of RYR2 gene CTD PMID:31601247 bisphenol A increases expression ISO RGD:1557868 6480464 bisphenol A results in increased expression of RYR2 mRNA CTD PMID:30245210 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of RYR2 mRNA CTD PMID:30816183 bisphenol A increases phosphorylation EXP 6480464 bisphenol A results in increased phosphorylation of RYR2 protein CTD PMID:28324061 bisphenol F increases expression ISO RGD:1557868 6480464 bisphenol F results in increased expression of RYR2 mRNA CTD PMID:30951980 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of RYR2 mRNA CTD PMID:33453195 caffeine multiple interactions EXP 6480464 Dantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]], HOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 calcium atom multiple interactions ISO RGD:1317019 6480464 FKBP1A protein inhibits the reaction [Calcium results in increased activity of RYR2 protein] CTD PMID:17872463 calcium atom multiple interactions EXP 6480464 Dantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] more ... CTD PMID:12887973 calcium(0) multiple interactions ISO RGD:1317019 6480464 FKBP1A protein inhibits the reaction [Calcium results in increased activity of RYR2 protein] CTD PMID:17872463 calcium(0) multiple interactions EXP 6480464 Dantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] more ... CTD PMID:12887973 candesartan multiple interactions EXP 6480464 candesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein] CTD PMID:16723803 cantharidin decreases expression ISO RGD:1557868 6480464 Cantharidin results in decreased expression of RYR2 mRNA CTD PMID:36907384 carvedilol affects activity ISO RGD:1317019 6480464 carvedilol affects the activity of RYR2 protein, carvedilol analog affects the activity of RYR2 protein CTD PMID:21743453 carvedilol increases expression EXP 6480464 carvedilol results in increased expression of RYR2 protein CTD PMID:19620082 carvedilol multiple interactions ISO RGD:1557868 6480464 [Huang Qi co-treated with carvedilol] results in increased expression of RYR2 mRNA CTD PMID:21924056 carvedilol multiple interactions EXP 6480464 carvedilol promotes the reaction [Perindopril results in increased expression of RYR2 protein], Perindopril promotes the reaction [carvedilol results in increased expression of RYR2 protein] CTD PMID:19620082 carvedilol increases expression ISO RGD:1557868 6480464 carvedilol results in increased expression of RYR2 mRNA CTD PMID:21924056 carvedilol increases activity ISO RGD:1317019 6480464 carvedilol results in increased activity of RYR2 protein CTD PMID:12743001 carvedilol multiple interactions ISO RGD:1317019 6480464 carvedilol inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein], carvedilol promotes the reaction [FKBP1B protein binds to RYR2 protein] CTD PMID:12743001 , PMID:21743453 CGP 52608 multiple interactions ISO RGD:1317019 6480464 CGP 52608 promotes the reaction [RORA protein binds to RYR2 gene] CTD PMID:28238834 chlorpyrifos increases expression ISO RGD:1557868 6480464 Chlorpyrifos results in increased expression of RYR2 mRNA CTD PMID:32715474 choline multiple interactions ISO RGD:1557868 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RYR2 gene CTD PMID:20938992 cocaine affects expression EXP 6480464 Cocaine affects the expression of RYR2 mRNA CTD PMID:20187946 cocaine increases expression ISO RGD:1557868 6480464 Cocaine results in increased expression of RYR2 mRNA CTD PMID:21113126 Cuprizon decreases expression EXP 6480464 Cuprizone results in decreased expression of RYR2 mRNA CTD PMID:26577399 cyclic ADP-beta-D-ribose multiple interactions EXP 6480464 HOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 dantrolene multiple interactions EXP 6480464 Dantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 daunorubicin multiple interactions EXP 6480464 Razoxane inhibits the reaction [Daunorubicin results in decreased expression of RYR2 mRNA] CTD PMID:10960060 daunorubicin decreases expression ISO RGD:1317019 6480464 Daunorubicin results in decreased expression of RYR2 mRNA CTD PMID:26537877 , PMID:28940058 daunorubicin increases expression EXP 6480464 Daunorubicin results in increased expression of RYR2 protein CTD PMID:26328012 daunorubicin decreases expression EXP 6480464 Daunorubicin results in decreased expression of RYR2 mRNA CTD PMID:10960060 dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of RYR2 mRNA CTD PMID:25937560 dioxygen multiple interactions ISO RGD:1557868 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of RYR2 mRNA CTD PMID:30529165 dioxygen multiple interactions EXP 6480464 Trimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of RYR2 mRNA] CTD PMID:25937560 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of RYR2 mRNA CTD PMID:19915844 doxorubicin decreases expression ISO RGD:1317019 6480464 Doxorubicin results in decreased expression of RYR2 mRNA CTD PMID:26537877 more ... etoposide decreases expression ISO RGD:1317019 6480464 Etoposide results in decreased expression of RYR2 mRNA CTD PMID:29397400 fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of RYR2 mRNA CTD PMID:30307764 flutamide multiple interactions ISO RGD:1557868 6480464 Flutamide inhibits the reaction [CD38 gene mutant form results in increased expression of RYR2 mRNA] CTD PMID:21840325 folic acid multiple interactions ISO RGD:1557868 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RYR2 gene CTD PMID:20938992 folic acid decreases expression ISO RGD:1557868 6480464 Folic Acid results in decreased expression of RYR2 mRNA CTD PMID:25629700 fonofos increases methylation ISO RGD:1317019 6480464 Fonofos results in increased methylation of RYR2 promoter CTD PMID:22847954 fulvestrant multiple interactions ISO RGD:1317019 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of RYR2 gene CTD PMID:31601247 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of RYR2 mRNA CTD PMID:22061828 isoprenaline multiple interactions EXP 6480464 candesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein] CTD PMID:16723803 isoprenaline increases phosphorylation ISO RGD:1317019 6480464 Isoproterenol results in increased phosphorylation of RYR2 protein CTD PMID:21743453 isoprenaline multiple interactions ISO RGD:1317019 6480464 carvedilol inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein] CTD PMID:21743453 isoprenaline increases phosphorylation EXP 6480464 Isoproterenol results in increased phosphorylation of RYR2 protein CTD PMID:16723803 L-methionine multiple interactions ISO RGD:1557868 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RYR2 gene CTD PMID:20938992 linsidomine increases oxidation EXP 6480464 linsidomine results in increased oxidation of RYR2 protein CTD PMID:28086193 maraviroc multiple interactions ISO RGD:1557868 6480464 [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of RYR2 mRNA CTD PMID:31023824 mercury dichloride decreases expression EXP 6480464 Mercuric Chloride results in decreased expression of RYR2 mRNA CTD PMID:32599119 methamphetamine increases expression ISO RGD:1557868 6480464 Methamphetamine results in increased expression of RYR2 mRNA CTD PMID:36914120 methapyrilene increases methylation ISO RGD:1317019 6480464 Methapyrilene results in increased methylation of RYR2 intron CTD PMID:30157460 methylmercury chloride increases expression ISO RGD:1317019 6480464 methylmercuric chloride results in increased expression of RYR2 mRNA CTD PMID:28001369 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of RYR2 mRNA, methylmercuric chloride results in increased expression of RYR2 protein CTD PMID:35678294 metoprolol multiple interactions ISO RGD:1317019 6480464 Metoprolol promotes the reaction [FKBP1B protein binds to RYR2 protein] CTD PMID:12743001 metoprolol increases activity ISO RGD:1317019 6480464 Metoprolol results in increased activity of RYR2 protein CTD PMID:12743001 mifepristone multiple interactions ISO RGD:1557868 6480464 Mifepristone inhibits the reaction [bisphenol A results in decreased expression of RYR2 mRNA] more ... CTD PMID:27264040 , PMID:31566189 mitoxantrone decreases expression ISO RGD:1317019 6480464 Mitoxantrone results in decreased expression of RYR2 mRNA CTD PMID:26537877 , PMID:28940058 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide decreases phosphorylation EXP 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased phosphorylation of RYR2 protein CTD PMID:27495954 nicotine increases expression EXP 6480464 Nicotine results in increased expression of RYR2 mRNA, Nicotine results in increased expression of RYR2 protein CTD PMID:21113126 nicotine increases expression ISO RGD:1557868 6480464 Nicotine results in increased expression of RYR2 mRNA CTD PMID:21113126 nicotine multiple interactions ISO RGD:1557868 6480464 CHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA] CTD PMID:21113126 nicotine multiple interactions EXP 6480464 CREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA], Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter] CTD PMID:21113126 O-methyleugenol decreases expression ISO RGD:1317019 6480464 methyleugenol results in decreased expression of RYR2 mRNA CTD PMID:32234424 ouabain multiple interactions ISO RGD:1557868 6480464 K201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain] CTD PMID:20080988 ouabain increases response to substance ISO RGD:1557868 6480464 RYR2 mutant form results in increased susceptibility to Ouabain CTD PMID:20080988 ozone multiple interactions ISO RGD:1557868 6480464 [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of RYR2 mRNA CTD PMID:34911549 paracetamol affects expression ISO RGD:1557868 6480464 Acetaminophen affects the expression of RYR2 mRNA CTD PMID:17562736 paraquat increases expression ISO RGD:1557868 6480464 Paraquat results in increased expression of RYR2 mRNA CTD PMID:22563483 parathion increases methylation ISO RGD:1317019 6480464 Parathion results in increased methylation of RYR2 promoter CTD PMID:22847954 perfluorooctanoic acid increases expression ISO RGD:1317019 6480464 perfluorooctanoic acid results in increased expression of RYR2 mRNA CTD PMID:36326898 perindopril multiple interactions EXP 6480464 carvedilol promotes the reaction [Perindopril results in increased expression of RYR2 protein], Perindopril promotes the reaction [carvedilol results in increased expression of RYR2 protein] CTD PMID:19620082 perindopril increases expression EXP 6480464 Perindopril results in increased expression of RYR2 protein CTD PMID:19620082 phenytoin increases expression EXP 6480464 Phenytoin results in increased expression of RYR2 mRNA CTD PMID:20345932 picrotoxin increases expression EXP 6480464 Picrotoxin results in increased expression of RYR2 mRNA CTD PMID:21113126 progesterone increases expression EXP 6480464 Progesterone results in increased expression of RYR2 mRNA CTD PMID:20726854 progesterone decreases expression ISO RGD:1557868 6480464 Progesterone results in decreased expression of RYR2 mRNA CTD PMID:27264040 , PMID:31566189 progesterone multiple interactions ISO RGD:1557868 6480464 Mifepristone inhibits the reaction [Progesterone results in decreased expression of RYR2 mRNA] CTD PMID:27264040 , PMID:31566189 propofol decreases phosphorylation EXP 6480464 Propofol results in decreased phosphorylation of RYR2 protein CTD PMID:27495954 razoxane multiple interactions EXP 6480464 Razoxane inhibits the reaction [Daunorubicin results in decreased expression of RYR2 mRNA] CTD PMID:10960060 resveratrol decreases expression ISO RGD:1557868 6480464 resveratrol results in decreased expression of RYR2 mRNA CTD PMID:22610192 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of RYR2 protein CTD PMID:25425099 rotenone decreases expression ISO RGD:1317019 6480464 Rotenone results in decreased expression of RYR2 mRNA CTD PMID:29955902 ryanodine affects binding ISO RGD:1557868 6480464 Ryanodine binds to RYR2 protein CTD PMID:11278295 ryanodine multiple interactions ISO RGD:1557868 6480464 decamethrin promotes the reaction [Ryanodine binds to RYR2 protein] CTD PMID:31166131 ryanodine multiple interactions EXP 6480464 2 more ... CTD PMID:18954145 SCH 23390 multiple interactions ISO RGD:1557868 6480464 SCH 23390 inhibits the reaction [SK&F 82958 results in increased expression of RYR2 protein] CTD PMID:22504960 simvastatin increases expression EXP 6480464 Simvastatin results in increased expression of RYR2 mRNA, Simvastatin results in increased expression of RYR2 protein CTD PMID:15916736 sodium arsenite multiple interactions ISO RGD:1317019 6480464 sodium arsenite results in increased expression of and affects the splicing of RYR2 mRNA CTD PMID:25879800 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of RYR2 mRNA CTD PMID:35314868 sodium arsenite affects methylation ISO RGD:1317019 6480464 sodium arsenite affects the methylation of RYR2 gene CTD PMID:28589171 streptozocin decreases activity EXP 6480464 Streptozocin results in decreased activity of RYR2 protein CTD PMID:16685413 streptozocin multiple interactions ISO RGD:1557868 6480464 [octylphenol co-treated with Streptozocin] results in increased expression of RYR2 mRNA CTD PMID:29935216 sulforaphane decreases expression ISO RGD:1317019 6480464 sulforaphane results in decreased expression of RYR2 mRNA CTD PMID:31838189 sulforaphane increases expression ISO RGD:1557868 6480464 sulforaphane results in increased expression of RYR2 mRNA CTD PMID:30529165 terbufos increases methylation ISO RGD:1317019 6480464 terbufos results in increased methylation of RYR2 promoter CTD PMID:22847954 thalidomide decreases expression ISO RGD:1557868 6480464 Thalidomide results in decreased expression of RYR2 mRNA CTD PMID:26006729 , PMID:26217789 titanium dioxide affects expression ISO RGD:1557868 6480464 titanium dioxide affects the expression of RYR2 mRNA CTD PMID:23557971 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of RYR2 mRNA CTD PMID:18411232 , PMID:33387578 triclosan decreases expression ISO RGD:1317019 6480464 Triclosan results in decreased expression of RYR2 mRNA CTD PMID:30510588 triptonide increases expression ISO RGD:1557868 6480464 triptonide results in increased expression of RYR2 mRNA CTD PMID:33045310 valproic acid increases methylation ISO RGD:1317019 6480464 Valproic Acid results in increased methylation of RYR2 gene CTD PMID:29154799 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of RYR2 mRNA CTD PMID:29427782 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of RYR2 mRNA CTD PMID:19015723 vorinostat decreases expression ISO RGD:1317019 6480464 vorinostat results in decreased expression of RYR2 mRNA CTD PMID:27188386