Msrb2 (methionine sulfoxide reductase B2) - Rat Genome Database

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Gene: Msrb2 (methionine sulfoxide reductase B2) Rattus norvegicus
Analyze
Symbol: Msrb2
Name: methionine sulfoxide reductase B2
RGD ID: 1306026
Description: Predicted to enable actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Predicted to be involved in actin filament polymerization. Predicted to act upstream of or within protein repair. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Orthologous to human MSRB2 (methionine sulfoxide reductase B2); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystinuria pathway; hypermethioninemia pathway; INTERACTS WITH 1,3-dinitrobenzene; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361286; methionine sulfoxide reductase B; methionine-R-sulfoxide reductase B2, mitochondrial; MGC114588; Mrsb
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21781,974,378 - 82,000,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1781,974,196 - 82,000,043 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1785,439,480 - 85,465,090 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01789,274,912 - 89,300,521 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01783,291,676 - 83,317,287 (+)NCBIRnor_WKY
Rnor_6.01786,066,841 - 86,148,131 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1786,066,833 - 86,148,130 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01787,781,867 - 87,860,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41793,416,941 - 93,442,773 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11793,427,774 - 93,453,606 (+)NCBI
Celera1781,244,664 - 81,270,209 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrion  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14699060   PMID:18614015   PMID:23911929  


Genomics

Comparative Map Data
Msrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21781,974,378 - 82,000,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1781,974,196 - 82,000,043 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1785,439,480 - 85,465,090 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01789,274,912 - 89,300,521 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01783,291,676 - 83,317,287 (+)NCBIRnor_WKY
Rnor_6.01786,066,841 - 86,148,131 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1786,066,833 - 86,148,130 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01787,781,867 - 87,860,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41793,416,941 - 93,442,773 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11793,427,774 - 93,453,606 (+)NCBI
Celera1781,244,664 - 81,270,209 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
MSRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381023,095,579 - 23,122,013 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1023,095,579 - 23,122,013 (+)EnsemblGRCh38hg38GRCh38
GRCh371023,384,508 - 23,410,942 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361023,424,433 - 23,450,948 (+)NCBINCBI36Build 36hg18NCBI36
Build 341023,424,480 - 23,450,093NCBI
Celera1023,072,080 - 23,098,540 (+)NCBICelera
Cytogenetic Map10p12.2NCBI
HuRef1023,053,143 - 23,070,958 (+)NCBIHuRef
CHM1_11023,384,967 - 23,411,480 (+)NCBICHM1_1
T2T-CHM13v2.01023,114,573 - 23,140,973 (+)NCBIT2T-CHM13v2.0
Msrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39219,376,247 - 19,399,787 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl219,376,251 - 19,399,787 (+)EnsemblGRCm39 Ensembl
GRCm38219,371,436 - 19,394,976 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl219,371,440 - 19,394,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv37219,293,263 - 19,316,597 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36219,289,390 - 19,312,724 (+)NCBIMGSCv36mm8
Celera219,270,456 - 19,293,738 (+)NCBICelera
Cytogenetic Map2A3NCBI
Msrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554295,867,091 - 5,887,587 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554295,867,091 - 5,887,460 (-)NCBIChiLan1.0ChiLan1.0
MSRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11023,642,999 - 23,659,724 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01023,259,791 - 23,285,261 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MSRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1210,134,747 - 10,152,830 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl210,135,112 - 10,152,836 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha28,827,503 - 8,845,635 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.028,331,743 - 8,349,875 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl28,332,108 - 8,349,841 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.127,697,248 - 7,715,376 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.027,780,144 - 7,798,265 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.027,948,592 - 7,966,708 (-)NCBIUU_Cfam_GSD_1.0
Msrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934422,909,705 - 22,925,035 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365205,035,442 - 5,052,736 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1051,889,208 - 51,910,392 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11051,888,828 - 51,910,725 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21057,544,134 - 57,565,963 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1922,863,029 - 22,890,765 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl922,863,184 - 22,889,644 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605128,626,417 - 28,654,450 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msrb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247965,604,411 - 5,623,567 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247965,603,682 - 5,623,582 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Msrb2
93 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:73
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000022661
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)177177462182479847Rat

Markers in Region
RH132163  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21781,999,750 - 81,999,955 (+)MAPPERmRatBN7.2
Rnor_6.01786,147,838 - 86,148,042NCBIRnor6.0
Rnor_5.01787,859,828 - 87,860,032UniSTSRnor5.0
RGSC_v3.41793,442,480 - 93,442,684UniSTSRGSC3.4
Celera1781,269,916 - 81,270,120UniSTS
RH 3.4 Map17833.6UniSTS
Cytogenetic Map17q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 57 41 12 41 1 39 35 39 7
Low 9 7 8 10 35 2 4 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022661   ⟹   ENSRNOP00000022661
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1781,974,389 - 82,000,040 (+)Ensembl
Rnor_6.0 Ensembl1786,066,833 - 86,148,130 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095828   ⟹   ENSRNOP00000086902
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1781,974,196 - 82,000,043 (+)Ensembl
RefSeq Acc Id: NM_001031660   ⟹   NP_001026830
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21781,974,398 - 82,000,044 (+)NCBI
Rnor_6.01786,066,841 - 86,148,131 (+)NCBI
Rnor_5.01787,781,867 - 87,860,121 (+)NCBI
RGSC_v3.41793,416,941 - 93,442,773 (+)RGD
Celera1781,244,664 - 81,270,209 (+)RGD
Sequence:
RefSeq Acc Id: XM_039095963   ⟹   XP_038951891
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21781,980,882 - 82,000,044 (+)NCBI
RefSeq Acc Id: XM_039095964   ⟹   XP_038951892
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21781,974,378 - 81,994,044 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001026830 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951891 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951892 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98953 (Get FASTA)   NCBI Sequence Viewer  
  EDL78778 (Get FASTA)   NCBI Sequence Viewer  
  Q4FZX5 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001026830   ⟸   NM_001031660
- Peptide Label: precursor
- UniProtKB: Q4FZX5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022661   ⟸   ENSRNOT00000022661
RefSeq Acc Id: XP_038951892   ⟸   XM_039095964
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038951891   ⟸   XM_039095963
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000086902   ⟸   ENSRNOT00000095828
Protein Domains
MsrB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4FZX5-F1-model_v2 AlphaFold Q4FZX5 1-174 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700607
Promoter ID:EPDNEW_R11130
Type:initiation region
Name:Msrb2_1
Description:methionine sulfoxide reductase B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01786,066,844 - 86,066,904EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306026 AgrOrtholog
BioCyc Gene G2FUF-8529 BioCyc
Ensembl Genes ENSRNOG00000016873 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022661 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000086902.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022661 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000095828.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7374871 IMAGE-MGC_LOAD
InterPro Met_Sox_Rdtase UniProtKB/Swiss-Prot
  Met_Sox_Rdtase_MsrB UniProtKB/Swiss-Prot
  Met_Sox_Rdtase_MsrB UniProtKB/TrEMBL
  Met_Sox_Rdtase_MsrB_dom UniProtKB/TrEMBL
  Mss4-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361286 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114588 IMAGE-MGC_LOAD
NCBI Gene 361286 ENTREZGENE
PANTHER PTHR10173 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SelR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Msrb2 PhenoGen
PROSITE MSRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51316 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs TIGR00357 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A270_RAT UniProtKB/TrEMBL
  MSRB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Msrb2  methionine sulfoxide reductase B2  Mrsb  methionine sulfoxide reductase B  Symbol and Name updated 1299863 APPROVED
2005-12-06 Mrsb  methionine sulfoxide reductase B  Mrsb_predicted  methionine sulfoxide reductase B (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mrsb_predicted  methionine sulfoxide reductase B (predicted)      Symbol and Name status set to approved 70820 APPROVED