Msrb2 (methionine sulfoxide reductase B2)

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Gene: Msrb2 (methionine sulfoxide reductase B2) Rattus norvegicus

Analyze

Symbol:

Msrb2

Name:

methionine sulfoxide reductase B2

RGD ID:

1306026

Description:

Predicted to have actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Predicted to be involved in actin filament polymerization and protein repair. Predicted to localize to mitochondrion. Orthologous to human MSRB2 (methionine sulfoxide reductase B2); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystinuria pathway; hypermethioninemia pathway; INTERACTS WITH 1,3-dinitrobenzene; acetamide; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

LOC361286; methionine sulfoxide reductase B; methionine-R-sulfoxide reductase B2, mitochondrial; MGC114588; Mrsb

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MSRB2 (methionine sulfoxide reductase B2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Msrb2 (methionine sulfoxide reductase B2)	HGNC	Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Msrb2 (methionine sulfoxide reductase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MSRB2 (methionine sulfoxide reductase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MSRB2 (methionine sulfoxide reductase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Msrb2 (methionine sulfoxide reductase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MSRB2 (methionine sulfoxide reductase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	MSRB2 (methionine sulfoxide reductase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Msrb2 (methionine sulfoxide reductase B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MSRB2 (methionine sulfoxide reductase B2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Msrb2 (methionine sulfoxide reductase B2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	msrb2 (methionine sulfoxide reductase B2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	F44E2.6	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	MXR2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	SelR	Alliance	DIOPT (OMA\|OrthoFinder\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	81,974,378 - 82,000,044 (+)	NCBI
Rnor_6.0 Ensembl	17	86,066,833 - 86,148,130 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	17	86,066,841 - 86,148,131 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	17	87,781,867 - 87,860,121 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	93,416,941 - 93,442,773 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	17	93,427,774 - 93,453,606 (+)	NCBI
Celera	17	81,244,664 - 81,270,209 (+)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

1,4-dithiothreitol (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-azacytidine (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

carbon nanotube (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dioxygen (EXP,ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

indometacin (ISO)

L-1,4-dithiothreitol (ISO)

menadione (ISO)

methylmercury chloride (ISO)

nefazodone (EXP)

nickel atom (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium dodecyl sulfate (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament polymerization (ISO,ISS)

protein repair (ISO)

response to oxidative stress (IEA)

Cellular Component

cytoplasm (IBA)

mitochondrion (ISO)

Molecular Function

actin binding (ISO,ISS)

L-methionine-(R)-S-oxide reductase activity (IEA)

peptide-methionine (R)-S-oxide reductase activity (IBA,ISO,ISS)

protein binding (ISO)

zinc ion binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

glycine N-methyltransferase deficiency pathway (ISO)

homocystinuria pathway (ISO)

hypermethioninemia pathway (ISO)

methionine cycle/metabolic pathway (ISO)

methylenetetrahydrofolate reductase deficiency pathway (ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA data from the GO Consortium
3.	MGD data from the GO Consortium
4.	Pipeline to import SMPDB annotations from SMPDB into RGD
5.	RGD automated data pipeline
6.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:14699060	PMID:18614015	PMID:23911929

Genomics

Comparative Map Data

Msrb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	81,974,378 - 82,000,044 (+)	NCBI
Rnor_6.0 Ensembl	17	86,066,833 - 86,148,130 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	17	86,066,841 - 86,148,131 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	17	87,781,867 - 87,860,121 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	93,416,941 - 93,442,773 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	17	93,427,774 - 93,453,606 (+)	NCBI
Celera	17	81,244,664 - 81,270,209 (+)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

MSRB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	10	23,095,579 - 23,122,013 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	10	23,095,564 - 23,122,013 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	10	23,384,508 - 23,410,942 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	23,424,433 - 23,450,948 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	10	23,424,480 - 23,450,093	NCBI
Celera	10	23,072,080 - 23,098,540 (+)	NCBI
Cytogenetic Map	10	p12.2	NCBI
HuRef	10	23,053,143 - 23,070,958 (+)	NCBI		HuRef
CHM1_1	10	23,384,967 - 23,411,480 (+)	NCBI		CHM1_1

Msrb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	19,376,247 - 19,399,787 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	2	19,376,251 - 19,399,787 (+)	Ensembl
GRCm38	2	19,371,436 - 19,394,976 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	19,371,440 - 19,394,976 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	19,293,263 - 19,316,597 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	2	19,289,390 - 19,312,724 (+)	NCBI			mm8
Celera	2	19,270,456 - 19,293,738 (+)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI

Msrb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	5,867,091 - 5,887,587 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955429	5,867,091 - 5,887,460 (-)	NCBI	ChiLan1.0	ChiLan1.0

MSRB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	10	23,642,999 - 23,659,724 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	10	23,259,791 - 23,285,261 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

MSRB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	10,134,747 - 10,152,830 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	10,135,112 - 10,152,836 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	8,827,503 - 8,845,635 (-)	NCBI
ROS_Cfam_1.0	2	8,331,743 - 8,349,875 (-)	NCBI
UMICH_Zoey_3.1	2	7,697,248 - 7,715,376 (-)	NCBI
UNSW_CanFamBas_1.0	2	7,780,144 - 7,798,265 (-)	NCBI
UU_Cfam_GSD_1.0	2	7,948,592 - 7,966,708 (-)	NCBI

Msrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	22,909,705 - 22,925,035 (+)	NCBI
SpeTri2.0	NW_004936520	5,035,442 - 5,052,736 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MSRB2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	51,888,817 - 51,910,392 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	51,888,828 - 51,910,725 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	57,544,134 - 57,565,963 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MSRB2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	22,863,029 - 22,890,765 (+)	NCBI
ChlSab1.1 Ensembl	9	22,863,184 - 22,889,644 (+)	Ensembl

Msrb2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624796	5,603,682 - 5,623,582 (-)	NCBI

Position Markers

RH132163

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	17	86,147,838 - 86,148,042	NCBI	Rnor6.0
Rnor_5.0	17	87,859,828 - 87,860,032	UniSTS	Rnor5.0
RGSC_v3.4	17	93,442,480 - 93,442,684	UniSTS	RGSC3.4
Celera	17	81,269,916 - 81,270,120	UniSTS
RH 3.4 Map	17	833.6	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317054	Aia12	Adjuvant induced arthritis QTL 12	4.24		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	41176057	86176057	Rat
2317060	Aia26	Adjuvant induced arthritis QTL 26	3.22		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	41176057	86176057	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	41731080	86731080	Rat
1358295	Aocep1	Aortic cell protein QTL 1	6.1	0.00000071	thoracic aorta cellular protein amount (VT:0010598)	aortic cell percentage	17	44356157	89356157	Rat
7411575	Bw140	Body weight QTL 140	30.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	52410957	90843779	Rat
8694181	Bw151	Body weight QTL 151	4.36	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	52410957	90843779	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	53475180	90690466	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	53871488	90843779	Rat
2303580	Gluco49	Glucose level QTL 49	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	53991947	90843779	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	56224296	86731080	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	62195822	86194199	Rat
7411577	Bw141	Body weight QTL 141		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	67512657	90843779	Rat
12904736	Cm121	Cardiac mass QTL 121		0.043	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	75705427	86731080	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	87
Count of miRNA genes:	73
Interacting mature miRNAs:	85
Transcripts:	ENSRNOT00000022661
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	57	41	12	41		1	39	35	39	7
Low		9			7		8	10	35		2	4	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001031660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000022661 ⟹ ENSRNOP00000022661

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	17	86,066,833 - 86,148,130 (+)	Ensembl

RefSeq Acc Id:

NM_001031660 ⟹ NP_001026830

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	81,974,398 - 82,000,044 (+)	NCBI
Rnor_6.0	17	86,066,841 - 86,148,131 (+)	NCBI
Rnor_5.0	17	87,781,867 - 87,860,121 (+)	NCBI
RGSC_v3.4	17	93,416,941 - 93,442,773 (+)	RGD
Celera	17	81,244,664 - 81,270,209 (+)	RGD

Sequence:

show sequence

CCCGTTGGTGGCAGAGTCATGGCGCGTCTGCTGCGAGCGCTGCGGGGTCTGCCTTGGCTGGAGG
CGCCTGGGCGAGCTCGGGGTTGCGCGGGATCGGGACGCGGGGACACAGGGTCTCTTATCAAGTC
CAAGCTCTCTCTAAGCAAGGCAGACTGGCAGAAGAAACTGACCCCTGAGCAATTCTACGTCACC
AGAGAGAAAGGAACTGAAGCGCCTTTCAGTGGAATGTATTTGAAAAACAAGGAGACAGGGATGT
ACCATTGCGTGTGCTGTGATAGCCCACTCTTCAGTTCTGAGAAGAAGTACTGTTCTGGCACCGG
TTGGCCTTCGTTTTCTGAGGCTCACGGCACCAAAGGCTCAGATGAAAGTCACACAGGGATCCTG
AGGCGCCTGGACACTTCCTTAGGATGTCCTCGCATGGAGGTGGTCTGCAAACAGTGTGAAGCTC
ACCTTGGCCATGTGTTTCCTGATGGACCCGATCCCACTGGACAAAGGTTTTGCATCAACAGCGT
GGCCCTGAAGTTCAAACCAAGCAAGCCCTGACTGTCTGCAGGGGGCCTGTGCTTTGCCCCTGCT
TGTGGAGCCACGGTTCTGTAATTCTGTTGAATCCCTTGCTTTAGTTGCTGAAAGTTTAGGTGAA
GGTTGTTCCTGGCCAACAGGGGAGTCAGAGCTTCTTAGTCACCTGACTTCCACTTGGGCTGTGG
GATTTCAACTGGCTGCCCAGACTCTGGGTGAGACCACAGGGTGGGACCCAGGCAGGATTTCCAC
GGGTTCATGGGCTGATGAGGGTTCCCAAAGCTCCTGAAGGGAACCTGAGTTGGCCATCTCGGTT
CATTCCTTCATGGGCGTATACAGATGAGGGCCCAAGGGGGAGAGAAAGGAACAGATGGGCTGGA
CCAGATGAGAGATCCCAGTGTTGGAGAGGAGGATGGGAGTGGCCGAGCATGGGAACACATTCAG
GGATGGATGAGTCTGTGGTTTCTTATCCAAAACTCCACTGACTCAACCTTAAAACTCACAAGTG
GGATCCATGCGGACTGAGTCAATCTGAGTGACTGTGAATAATGAATGCTCTCCCTCAACTCTTT
GTCACAACACTAAACTTCAAAATACTCAAATAAAATATTGAGGTCAATGTTTAAAAAAAAAAAA
AAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039095963 ⟹ XP_038951891

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	81,980,882 - 82,000,044 (+)	NCBI

RefSeq Acc Id:

XM_039095964 ⟹ XP_038951892

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	81,974,378 - 81,994,044 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001026830	(Get FASTA)	NCBI Sequence Viewer
	XP_038951891	(Get FASTA)	NCBI Sequence Viewer
	XP_038951892	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98953	(Get FASTA)	NCBI Sequence Viewer
	EDL78778	(Get FASTA)	NCBI Sequence Viewer
	Q4FZX5	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001026830 ⟸ NM_001031660
- Peptide Label:	precursor
- UniProtKB:	Q4FZX5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MARLLRALRGLPWLEAPGRARGCAGSGRGDTGSLIKSKLSLSKADWQKKLTPEQFYVTREKGTE APFSGMYLKNKETGMYHCVCCDSPLFSSEKKYCSGTGWPSFSEAHGTKGSDESHTGILRRLDTS LGCPRMEVVCKQCEAHLGHVFPDGPDPTGQRFCINSVALKFKPSKP hide sequence

RefSeq Acc Id:

ENSRNOP00000022661 ⟸ ENSRNOT00000022661

RefSeq Acc Id:	XP_038951892 ⟸ XM_039095964
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038951891 ⟸ XM_039095963
- Peptide Label:	isoform X1

Protein Domains

MsrB

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700607

Promoter ID:

EPDNEW_R11130

Type:

initiation region

Name:

Msrb2_1

Description:

methionine sulfoxide reductase B2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	86,066,844 - 86,066,904	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306026	AgrOrtholog
Ensembl Genes	ENSRNOG00000016873	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000022661	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000022661	ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7374871	IMAGE-MGC_LOAD
InterPro	Met_Sox_Rdtase	UniProtKB/Swiss-Prot
	Met_Sox_Rdtase_MsrB	UniProtKB/Swiss-Prot
	Mss4-like_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:361286	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:114588	IMAGE-MGC_LOAD
NCBI Gene	361286	ENTREZGENE
PANTHER	PTHR10173	UniProtKB/Swiss-Prot
Pfam	SelR	UniProtKB/Swiss-Prot
PhenoGen	Msrb2	PhenoGen
PROSITE	MSRB	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF51316	UniProtKB/Swiss-Prot
TIGRFAMs	TIGR00357	UniProtKB/Swiss-Prot
UniProt	MSRB2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Msrb2	methionine sulfoxide reductase B2	Mrsb	methionine sulfoxide reductase B	Symbol and Name updated	1299863	APPROVED
2005-12-06	Mrsb	methionine sulfoxide reductase B	Mrsb_predicted	methionine sulfoxide reductase B (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Mrsb_predicted	methionine sulfoxide reductase B (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - SMPDB