Calml3 (calmodulin-like 3) - Rat Genome Database

Name: Calml3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Calml3 (calmodulin-like 3) Rattus norvegicus

Analyze

Symbol:

Calml3

Name:

calmodulin-like 3

RGD ID:

1305499

Description:

Predicted to enable calcium ion binding activity. Orthologous to human CALML3 (calmodulin like 3); PARTICIPATES IN Alzheimer's disease pathway; calcium/calcium-mediated signaling pathway; glioma pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

calmodulin-like protein 3; LOC307100

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CALML3 (calmodulin like 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Calml3 (calmodulin-like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CALML3 (calmodulin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC102153034 (calmodulin-like protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101976513 (calmodulin-like protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CALML3 (calmodulin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Calml3 (calmodulin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CALM2 (calmodulin 2)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	CALML3 (calmodulin like 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Calml3 (calmodulin-like 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CMD1	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cal-1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	cal-3	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	pat-10	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	66,419,844 - 66,423,083 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	66,419,882 - 66,423,175 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	69,902,584 - 69,903,956 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	73,731,395 - 73,732,767 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	67,774,410 - 67,775,782 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	70,070,458 - 70,073,697 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	70,072,156 - 70,073,530 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	71,774,029 - 71,777,255 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	77,594,514 - 77,595,889 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	77,605,346 - 77,606,721 (+)	NCBI
Celera	17	65,927,353 - 65,928,728 (+)	NCBI		Celera
Cytogenetic Map	17	q12.2	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hepatocellular carcinoma (ISO)

hypoparathyroidism-deafness-renal disease syndrome (ISO)

Lung Neoplasms (ISO)

Neoplasm Metastasis (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,3-dinitrobenzene (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

acetamide (EXP)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bleomycin A2 (EXP)

bromobenzene (EXP)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

diclofenac (EXP)

diuron (EXP)

gentamycin (EXP)

hydroquinone (ISO)

isotretinoin (ISO)

lead diacetate (EXP)

Monobutylphthalate (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

simvastatin (ISO)

sodium arsenate (ISO)

sodium fluoride (ISO)

sulforaphane (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

Molecular Function

calcium ion binding (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Alzheimer's disease pathway (IEA)

calcium/calcium-mediated signaling pathway (IEA)

glioma pathway (IEA)

gonadotropin-releasing hormone signaling pathway (IEA)

insulin signaling pathway (IEA)

long term potentiation (IEA)

neurotrophic factor signaling pathway (IEA)

phosphatidylinositol 3-kinase signaling pathway (IEA)

tuberculosis pathway (IEA)

visual phototransduction pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation
8.	Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma.	Yang B, etal., Nat Commun. 2018 Feb 14;9(1):678. doi: 10.1038/s41467-018-03024-2.

Additional References at PubMed

PMID:12477932	PMID:19056867

Genomics

Comparative Map Data

Calml3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	66,419,844 - 66,423,083 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	66,419,882 - 66,423,175 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	69,902,584 - 69,903,956 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	73,731,395 - 73,732,767 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	67,774,410 - 67,775,782 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	70,070,458 - 70,073,697 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	70,072,156 - 70,073,530 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	71,774,029 - 71,777,255 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	77,594,514 - 77,595,889 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	77,605,346 - 77,606,721 (+)	NCBI
Celera	17	65,927,353 - 65,928,728 (+)	NCBI		Celera
Cytogenetic Map	17	q12.2	NCBI

CALML3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	5,524,961 - 5,526,771 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	5,524,961 - 5,526,771 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	5,566,924 - 5,568,734 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	5,556,924 - 5,558,225 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	5,556,923 - 5,558,225	NCBI
Celera	10	5,498,075 - 5,499,376 (+)	NCBI		Celera
Cytogenetic Map	10	p15.1	NCBI
HuRef	10	5,496,886 - 5,498,187 (+)	NCBI		HuRef
CHM1_1	10	5,566,804 - 5,568,105 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	5,528,229 - 5,530,040 (+)	NCBI		T2T-CHM13v2.0

Calml3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	3,852,893 - 3,854,318 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	3,852,896 - 3,854,316 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	3,802,893 - 3,804,318 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	3,802,896 - 3,804,316 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	3,802,139 - 3,803,564 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	3,802,141 - 3,803,562 (-)	NCBI		MGSCv36	mm8
Celera	13	3,786,628 - 3,788,053 (-)	NCBI		Celera
Cytogenetic Map	13	A1	NCBI
cM Map	13	2.13	NCBI

CALML3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	10	18,082,644 - 18,084,751 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	5,565,223 - 5,567,471 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	5,550,835 - 5,553,087 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	5,551,906 - 5,552,355 (+)	Ensembl	panpan1.1		panPan2

LOC102153034
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	30,410,830 - 30,411,981 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	27,440,705 - 27,441,958 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	30,791,914 - 30,793,167 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	30,792,586 - 30,793,035 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	27,888,217 - 27,889,574 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	28,725,362 - 28,726,615 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	29,443,053 - 29,444,306 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101976513
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	32,811,313 - 32,812,782 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	8,977,252 - 8,977,701 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936484	8,976,512 - 8,977,792 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CALML3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	5,634,739 - 5,636,634 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	5,635,456 - 5,635,905 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	10,890,285 - 10,892,540 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Calml3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624775	337,054 - 337,503 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624775	335,860 - 338,267 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Calml3
21 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	216
Count of miRNA genes:	126
Interacting mature miRNAs:	142
Transcripts:	ENSRNOT00000046667
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	31368391	73951021	Rat
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	31990784	76990784	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	31990784	81292925	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	34550843	73951021	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	35837085	69599340	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	37479847	82479847	Rat
2317054	Aia12	Adjuvant induced arthritis QTL 12	4.24		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	38281509	83281509	Rat
2317060	Aia26	Adjuvant induced arthritis QTL 26	3.22		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	38281509	83281509	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40540041	80387013	Rat
1358295	Aocep1	Aortic cell protein QTL 1	6.1	0.00000071	thoracic aorta cellular protein amount (VT:0010598)	aortic cell percentage	17	40990005	85990005	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	17	42073160	69599340	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	42073160	69599340	Rat
7411575	Bw140	Body weight QTL 140	30.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
8694181	Bw151	Body weight QTL 151	4.36	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	49920154	86533673	Rat
2303580	Gluco49	Glucose level QTL 49	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	50040271	86533673	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	50909099	86022412	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	53498828	82479847	Rat
70210	Cm15	Cardiac mass QTL 15	6.5		heart right ventricle mass (VT:0007033)	heart right ventricle wet weight (CMO:0000072)	17	57246723	70156904	Rat
1600398	Edcs5	Endometrial carcinoma susceptibility QTL 5	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	17	57246723	70852846	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	57246843	82046127	Rat
7488963	Bp369	Blood pressure QTL 369		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	59005649	77910000	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	60781426	86533673	Rat
7411577	Bw141	Body weight QTL 141		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	62619516	86533673	Rat
1300131	Bp193	Blood pressure QTL 193	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	63640009	73951021	Rat
631502	Cm26	Cardiac mass QTL 26	3.71		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	65703580	81153923	Rat

Markers in Region

RH130616

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	66,422,774 - 66,422,988 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	70,073,298 - 70,073,510	NCBI	Rnor6.0
Rnor_5.0	17	71,776,856 - 71,777,068	UniSTS	Rnor5.0
RGSC_v3.4	17	77,595,656 - 77,595,868	UniSTS	RGSC3.4
Celera	17	65,928,495 - 65,928,707	UniSTS
RH 3.4 Map	17	635.5	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			8		8						27	10
Low		6	26	18	10	18	3	4	2	17	9	1	3
Below cutoff	3	22	22	22	1	22	5	7	21	18	5		5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC086350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000046667 ⟹ ENSRNOP00000043121

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	66,419,882 - 66,423,175 (+)	Ensembl
Rnor_6.0 Ensembl	17	70,072,156 - 70,073,530 (+)	Ensembl

RefSeq Acc Id:

NM_001012054 ⟹ NP_001012054

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	66,421,633 - 66,423,009 (+)	NCBI
Rnor_6.0	17	70,072,156 - 70,073,531 (+)	NCBI
Rnor_5.0	17	71,774,029 - 71,777,255 (+)	NCBI
RGSC_v3.4	17	77,594,514 - 77,595,889 (+)	RGD
Celera	17	65,927,353 - 65,928,728 (+)	RGD

Sequence:

show sequence

CAGAGCTGGGGAGAGGAGCCCAGCCCACAGTTAGTGCTTGGAAGCATAGACCAGACTGACCACA
TCTGCCACATCACCCGAGATCTGCTAGCATGGCCAACCAGCTGACTGAGGAGCAAATCGCCGAG
TTCAAGGAGGCTTTCTCTCTGTTTGACAAGGATGGGGATGGCTGCATCACCACCCAAGAACTGG
GCACTGTCATGAGGTCCCTGGGTCAGAACCCCACAGAGGCTGAGCTCCAAGACATGGTGAACGA
AATCGACAAGGATGGAAACGGCACCGTGGACTTCCCCGAGTTCCTGACCATGATGTCCAGGAAG
ATGAAAGACACCGACAGCGAGGAGGAGATCCGGGAGGCCTTCCGGGTGTTTGACAAGGACGGCA
ACGGCTTCGTCAGCGCAGCTGAGCTGAGGCACGTGATGACCAGGCTTGGGGAGAAGCTGAGCGA
CGAGGAGGTAGATGAAATGATACAGGCGGCGGATACAGACGGCGACGGGCAAGTGAACTATGAG
GAATTTGTTCACATGCTAGTGTCCAAGTGAGGCTGCGCCAGAAACTGGTACAGCCAGGTGCCCA
CGAGGCTCCTGGGCTCCAAGCTTAGCTGGGTAATAGCTACCCTCACTGTGGCGGGAATCTTACC
CAGGCCTTAGATGTCTTTCCCTGTTTCCCAGCTTCCCCTGGGCTCTATGGACTGCACCCACAAG
TCTGCCTTTCACTTTCTGCATCTTATTCTGCCAACTTCCTACCAGCTCGTTCCCCTTGACTGAG
AAGGCCTCCGGCTGAGACAGGCATCAACTCCTCCTAGCCGGCAAGAGCTGAAGCAGAAAGTCCC
ATCTCTGTATGGATAATGAGCCGAAGGACCCACACTCCTATTTGTTTGCTTGCTTGTTTGTTTT
TTCCTTTTCTTCTTTTTCCCCGTTTCCAACAGAAATGATCTGTCACCACCACCCAACGCATCAA
GGTGGCCTGTGGCCATCAGTTCACACGTCATAGTTCTTGTACATCTTTGGCTGAAGACTGCATC
TGTTGAATTTGGAAAGGATCTGAGGATTGGGACGAAGGGCAATGGTGGAGGTTTTAATGACTGA
GGTTAGACTGTGTGGAAAATATCCCTTCCCTTCTGTGCAGACTTGCTTGCTCCTTCCTGTCTCA
ATCAAATCCTGGTTTGTTTGTTTTTTGGTTTTTTTTTTTTTTTGTATGTTTGTTTTTGGGTTGG
TTTTTGTTTGCTTGCTCTTGTTTTTGTTTTTCTTTGTTTGGCTTTTGAGCTGAGAGTAAAGCTG
GGGGGGTCATTGTAGCATGTTTGTATCCATCTAGAAGGAAAGAAATTTAAATACAAGAGAGAGG
GAAGCTTCAGGGGAATAAATGAGTAAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006254208 ⟹ XP_006254270

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	66,419,844 - 66,423,083 (+)	NCBI
Rnor_6.0	17	70,070,458 - 70,073,697 (+)	NCBI
Rnor_5.0	17	71,774,029 - 71,777,255 (+)	NCBI

Sequence:

show sequence

GGTTCATTTCACGGTGAGTGGAAGAAGTATGTTGTCTCCCTTGCCTCTCCCACAGCGAACTCTT
TCCTTCTCTCTTCTTCCCACACACTCAAGGCCTCGGCTTTGGGGGACCCCTTCGAGCAGGAAGT
AACTCATCTGGCAGATAGGCAGCTCCTAGTCTCTCCTGAACCGGAACTCCCTCTAGACAACAAA
AACAGGCTGTCATCTACTTGAATGAAGAAGGCACTTGTATACTAATATTGTAAAGAGGAACATG
AAGGGAGGTTTTCACGTACACCTGGATAAAAAGTGTTGCCCTGACCGCTGCCGGCCCTGCTGGT
GTTTGGCGAGGAAAGTTGCCTTTCACACACAAGAGCTGGCGTCAGCTCAATTAGCAGGCCAGCC
TGGTTGCTGCTCTTGGACTCTTGTCTAAACAGGACCTGGCCTTCAGGCAACCACAGGGGCGGGG
GCGTCTACGGATGGCAGCCCAATCCTACCAGACCAGCCATGGGGGAGGACTCTGCTCCTTCTTA
AGATCCAGCCTGTCAAGCCAGGGCTAGAAAGCCAGTCAGCCAGCCGCCCCTTGCAGTCTCCACC
TGTCTTTACAGAGCTGGGGAGAGGAGCCCAGCCCACAGTTAGTGCTTGGAAGCATAGACCAGAC
TGACCACATCTGCCACATCACCCGAGATCTGCTAGCATGGCCAACCAGCTGACTGAGGAGCAAA
TCGCCGAGTTCAAGGAGGCTTTCTCTCTGTTTGACAAGGATGGGGATGGCTGCATCACCACCCA
AGAACTGGGCACTGTCATGAGGTCCCTGGGTCAGAACCCCACAGAGGCTGAGCTCCAAGACATG
GTGAACGAAATCGACAAGGATGGAAACGGCACCGTGGACTTCCCCGAGTTCCTGACCATGATGT
CCAGGAAGATGAAAGACACCGACAGCGAGGAGGAGATCCGGGAGGCCTTCCGGGTGTTTGACAA
GGACGGCAACGGCTTCGTCAGCGCAGCTGAGCTGAGGCACGTGATGACCAGGCTTGGGGAGAAG
CTGAGCGACGAGGAGGTAGATGAAATGATACAGGCGGCGGATACAGACGGCGACGGGCAAGTGA
ACTATGAGGAATTTGTTCACATGCTAGTGTCCAAGTGAGGCTGCGCCAGAAACTGGTACAGCCA
GGTGCCCACGAGGCTCCTGGGCTCCAAGCTTAGCTGGGTAATAGCTACCCTCACTGTGGCGGGA
ATCTTACCCAGGCCTTAGATGTCTTTCCCTGTTTCCCAGCTTCCCCTGGGCTCTATGGACTGCA
CCCACAAGTCTGCCTTTCACTTTCTGCATCTTATTCTGCCAACTTCCTACCAGCTCGTTCCCCT
TGACTGAGAAGGCCTCCGGCTGAGACAGGCATCAACTCCTCCTAGCCGGCAAGAGCTGAAGCAG
AAAGTCCCATCTCTGTATGGATAATGAGCCGAAGGACCCACACTCCTATTTGTTTGCTTGCTTG
TTTGTTTTTTCCTTTTCTTCTTTTTCCCCGTTTCCAACAGAAATGATCTGTCACCACCACCCAA
CGCATCAAGGTGGCCTGTGGCCATCAGTTCACACGTCATAGTTCTTGTACATCTTTGGCTGAAG
ACTGCATCTGTTGAATTTGGAAAGGATCTGAGGATTGGGACGAAGGGCAATGGTGGAGGTTTTA
ATGACTGAGGTTAGACTGTGTGGAAAATATCCCTTCCCTTCTGTGCAGACTTGCTTGCTCCTTC
CTGTCTCAATCAAATCCTGGTTTGTTTGTTTTTTGGTTTTTTTTTTTTTTTGTATGTTTGTTTT
TGGGTTGGTTTTTGTTTGCTTGCTCTTGTTTTTGTTTTTCTTTGTTTGGCTTTTGAGCTGAGAG
TAAAGCTGGGGGGGTCATTGTAGCATGTTTGTATCCATCTAGAAGGAAAGAAATTTAAATACAA
GAGAGAGGGAAGCTTCAGGGGAATAAATGAGTAAATGACACCCATGCTCCTACTCCTTCTGCTT
CTAACTAAAACACTGTTTCTTGTCTAGGAGATAAACCAGTCAGCAACTTCCGTTTTGTTTTGTT
TTGTTTTAATGTGTGTGTGTGTGTGTGTGTTTTTTTTTTGTAAATGCAATAAATTCCTAGATTG
GTGTGTATAGAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001012054	(Get FASTA)	NCBI Sequence Viewer
	XP_006254270	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86350	(Get FASTA)	NCBI Sequence Viewer
	EDL78582	(Get FASTA)	NCBI Sequence Viewer
	Q5U206	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001012054 ⟸ NM_001012054
- UniProtKB:	Q5U206 (UniProtKB/Swiss-Prot), A6JLQ5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MANQLTEEQIAEFKEAFSLFDKDGDGCITTQELGTVMRSLGQNPTEAELQDMVNEIDKDGNGTV DFPEFLTMMSRKMKDTDSEEEIREAFRVFDKDGNGFVSAAELRHVMTRLGEKLSDEEVDEMIQA ADTDGDGQVNYEEFVHMLVSK hide sequence

RefSeq Acc Id:	XP_006254270 ⟸ XM_006254208
- Peptide Label:	isoform X1
- UniProtKB:	Q5U206 (UniProtKB/Swiss-Prot), A6JLQ5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MANQLTEEQIAEFKEAFSLFDKDGDGCITTQELGTVMRSLGQNPTEAELQDMVNEIDKDGNGTV DFPEFLTMMSRKMKDTDSEEEIREAFRVFDKDGNGFVSAAELRHVMTRLGEKLSDEEVDEMIQA ADTDGDGQVNYEEFVHMLVSK hide sequence

RefSeq Acc Id:

ENSRNOP00000043121 ⟸ ENSRNOT00000046667

Protein Domains

EF-hand

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5U206-F1-model_v2	AlphaFold	Q5U206	1-149	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305499	AgrOrtholog
BioCyc Gene	G2FUF-8819	BioCyc
Ensembl Genes	ENSRNOG00000031955	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000043121	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000046667	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	EF-hand	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7302843	IMAGE-MGC_LOAD
InterPro	EF-hand-dom_pair	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:307100	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105977	IMAGE-MGC_LOAD
NCBI Gene	307100	ENTREZGENE
PANTHER	FI08416P-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MYOSIN LIGHT CHAIN 1, 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	EF-hand_7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Calml3	PhenoGen
PROSITE	EF_HAND_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	EFh	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	EF-hand	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt	A6JLQ5	ENTREZGENE, UniProtKB/TrEMBL
	CALL3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Calml3	calmodulin-like 3	Calml3_predicted	calmodulin-like 3 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Calml3_predicted	calmodulin-like 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)