Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Lgals8 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of LGALS8 mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | decreases expression | ISO | Lgals8 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of LGALS8 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LGALS8 mRNA and EGF protein inhibits the reaction [Estradiol results in decreased expression of LGALS8 mRNA] | CTD | PMID:19619570 and PMID:24758408 | 17beta-estradiol | decreases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of LGALS8 mRNA | CTD | PMID:19167446 and PMID:24758408 | 17beta-estradiol | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Estradiol results in increased expression of LGALS8 mRNA | CTD | PMID:19619570 | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Metribolone results in increased expression of LGALS8 mRNA | CTD | PMID:17010196 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LGALS8 mRNA and [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of LGALS8 mRNA | CTD | PMID:19619570 and PMID:29704546 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of LGALS8 mRNA | CTD | PMID:20106945 and PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Lgals8 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of LGALS8 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of LGALS8 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Lgals8 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LGALS8 mRNA | CTD | PMID:16960034 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LGALS8 mRNA | CTD | PMID:16960034 and PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LGALS8 mRNA | CTD | PMID:19619570 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of LGALS8 mRNA | CTD | PMID:21346803 | 3-methylcholanthrene | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to LGALS8 promoter] | CTD | PMID:20348232 | 4,4'-diaminodiphenylmethane | increases expression | ISO | Lgals8 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of LGALS8 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | LGALS8 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of LGALS8 gene | CTD | PMID:31601247 | 5-fluorouracil | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | LGALS8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] | CTD | PMID:17327601 | 5-formyltetrahydrofolic acid | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | LGALS8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] | CTD | PMID:17327601 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of LGALS8 mRNA | CTD | PMID:30047161 | acrolein | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of LGALS8 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of LGALS8 mRNA | CTD | PMID:32699268 | aflatoxin B1 | decreases methylation | ISO | LGALS8 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of LGALS8 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of LGALS8 mRNA | CTD | PMID:21934132 and PMID:33167477 | alpha-pinene | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of LGALS8 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of LGALS8 mRNA | CTD | PMID:32699268 | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of LGALS8 mRNA | CTD | PMID:30047161 | antirheumatic drug | decreases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of LGALS8 mRNA | CTD | PMID:24449571 | Aroclor 1254 | decreases expression | ISO | Lgals8 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of LGALS8 mRNA | CTD | PMID:23650126 | arsenous acid | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of LGALS8 mRNA | CTD | PMID:20458559 | arsenous acid | affects expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Arsenic Trioxide affects the expression of LGALS8 mRNA | CTD | PMID:25873331 | benzene | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Benzene results in increased expression of LGALS8 mRNA | CTD | PMID:15929907 and PMID:19162166 | benzo[a]pyrene | increases expression | ISO | Lgals8 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of LGALS8 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | affects methylation | ISO | LGALS8 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of LGALS8 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | LGALS8 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of LGALS8 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | Lgals8 (Mus musculus) | 6480464 | [Tetradecanoylphorbol Acetate co-treated with Benzo(a)pyrene co-treated with Particulate Matter] results in increased expression of LGALS8 mRNA and [Tetradecanoylphorbol Acetate co-treated with Benzo(a)pyrene co-treated with Vehicle Emissions] results in increased expression of LGALS8 mRNA | CTD | PMID:18353537 | benzo[a]pyrene | decreases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of LGALS8 mRNA | CTD | PMID:20106945 and PMID:21632981 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of LGALS8 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of LGALS8 mRNA | CTD | PMID:30816183 and PMID:34947998 | bisphenol A | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of LGALS8 mRNA | CTD | PMID:29275510 | bortezomib | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Bortezomib results in increased expression of LGALS8 mRNA | CTD | PMID:20977926 | calcitriol | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of LGALS8 mRNA | CTD | PMID:16002434 | CGP 52608 | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to LGALS8 gene] | CTD | PMID:28238834 | cisplatin | increases expression | ISO | Lgals8 (Mus musculus) | 6480464 | Cisplatin results in increased expression of LGALS8 mRNA | CTD | PMID:21151649 | clofibrate | decreases expression | ISO | Lgals8 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of LGALS8 mRNA | CTD | PMID:23811191 | clozapine | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Clozapine results in increased expression of LGALS8 protein | CTD | PMID:36482696 | cobalt dichloride | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of LGALS8 mRNA | CTD | PMID:19320972 and PMID:19376846 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of LGALS8 mRNA | CTD | PMID:24386269 | copper atom | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of LGALS8 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of LGALS8 mRNA | CTD | PMID:20971185 | copper(II) sulfate | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of LGALS8 mRNA | CTD | PMID:19549813 | coumestrol | decreases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of LGALS8 mRNA | CTD | PMID:19167446 | cyclosporin A | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of LGALS8 mRNA | CTD | PMID:20106945 | diarsenic trioxide | affects expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Arsenic Trioxide affects the expression of LGALS8 mRNA | CTD | PMID:25873331 | diarsenic trioxide | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of LGALS8 mRNA | CTD | PMID:20458559 | dimethylarsinic acid | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of LGALS8 mRNA | CTD | PMID:23192986 | diquat | decreases expression | ISO | Lgals8 (Mus musculus) | 6480464 | Diquat results in decreased expression of LGALS8 protein | CTD | PMID:36851058 | dorsomorphin | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of LGALS8 mRNA | CTD | PMID:29803840 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of LGALS8 mRNA | CTD | PMID:24136188 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of LGALS8 mRNA | CTD | PMID:24136188 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of LGALS8 mRNA | CTD | PMID:22061828 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of LGALS8 mRNA | CTD | PMID:33387578 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of LGALS8 mRNA | CTD | PMID:24136188 | inulin | multiple interactions | ISO | Lgals8 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of LGALS8 mRNA | CTD | PMID:36331819 | irinotecan | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | LGALS8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] | CTD | PMID:17327601 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of LGALS8 mRNA | CTD | PMID:24136188 | menadione | affects expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of LGALS8 mRNA | CTD | PMID:20044591 | mercury dibromide | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of LGALS8 mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS8 mRNA | CTD | PMID:27188386 | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of LGALS8 mRNA | CTD | PMID:30047161 | methylarsonic acid | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of LGALS8 mRNA | CTD | PMID:23192986 | methylmercury chloride | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of LGALS8 mRNA | CTD | PMID:28001369 | N-methyl-N'-nitro-N-nitrosoguanidine | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Methylnitronitrosoguanidine results in increased expression of LGALS8 mRNA | CTD | PMID:12634122 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of LGALS8 mRNA | CTD | PMID:24136188 | nickel sulfate | decreases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | nickel sulfate results in decreased expression of LGALS8 mRNA | CTD | PMID:16780908 | niclosamide | decreases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Niclosamide results in decreased expression of LGALS8 mRNA | CTD | PMID:36318118 | ozone | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of LGALS8 mRNA more ... | CTD | PMID:32699268 and PMID:35430440 | paracetamol | decreases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of LGALS8 mRNA | CTD | PMID:21420995 and PMID:22230336 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of LGALS8 mRNA | CTD | PMID:33387578 | PCB138 | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:23829299 | perfluorohexanesulfonic acid | increases expression | ISO | Lgals8 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of LGALS8 mRNA | CTD | PMID:37995155 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Lgals8 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of LGALS8 mRNA more ... | CTD | PMID:36331819 | perfluorooctanoic acid | decreases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of LGALS8 protein | CTD | PMID:26879310 | phenylmercury acetate | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of LGALS8 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS8 mRNA | CTD | PMID:27188386 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | Lgals8 (Mus musculus) | 6480464 | [Tetradecanoylphorbol Acetate co-treated with Benzo(a)pyrene co-treated with Particulate Matter] results in increased expression of LGALS8 mRNA and [Tetradecanoylphorbol Acetate co-treated with Benzo(a)pyrene co-treated with Vehicle Emissions] results in increased expression of LGALS8 mRNA | CTD | PMID:18353537 | pirinixic acid | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LGALS8 mRNA | CTD | PMID:19710929 | pirinixic acid | decreases expression | ISO | Lgals8 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of LGALS8 mRNA | CTD | PMID:23811191 | progesterone | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Progesterone results in increased expression of LGALS8 mRNA | CTD | PMID:18070364 | propiconazole | increases expression | EXP | | 6480464 | propiconazole results in increased expression of LGALS8 mRNA | CTD | PMID:30047161 | quercetin | decreases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of LGALS8 mRNA | CTD | PMID:21632981 | resveratrol | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of LGALS8 mRNA | CTD | PMID:23557933 | SB 431542 | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silver atom | decreases expression | ISO | Lgals8 (Mus musculus) | 6480464 | Silver results in decreased expression of LGALS8 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | ISO | Lgals8 (Mus musculus) | 6480464 | Silver results in decreased expression of LGALS8 mRNA | CTD | PMID:27131904 | sodium arsenite | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of LGALS8 mRNA and [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of LGALS8 mRNA | CTD | PMID:23192986 and PMID:25873331 | sodium arsenite | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of LGALS8 mRNA | CTD | PMID:29301061 | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of LGALS8 mRNA | CTD | PMID:30047161 | tamoxifen | decreases expression | ISO | Lgals8 (Mus musculus) | 6480464 | Tamoxifen results in decreased expression of LGALS8 mRNA | CTD | PMID:17555576 | tert-butyl hydroperoxide | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in increased expression of LGALS8 mRNA | CTD | PMID:15336504 | tetrachloromethane | affects expression | ISO | Lgals8 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of LGALS8 mRNA | CTD | PMID:17484886 | tetrachloromethane | decreases expression | ISO | Lgals8 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of LGALS8 mRNA | CTD | PMID:25270620 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of LGALS8 mRNA | CTD | PMID:34492290 | trichostatin A | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of LGALS8 mRNA | CTD | PMID:24935251 | valdecoxib | increases expression | EXP | | 6480464 | valdecoxib results in increased expression of LGALS8 mRNA | CTD | PMID:24136188 | valproic acid | affects expression | ISO | Lgals8 (Mus musculus) | 6480464 | Valproic Acid affects the expression of LGALS8 mRNA | CTD | PMID:17292431 | valproic acid | multiple interactions | ISO | LGALS8 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LGALS8 mRNA | CTD | PMID:27188386 | valproic acid | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of LGALS8 mRNA | CTD | PMID:19101580 more ... | valproic acid | affects expression | ISO | LGALS8 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of LGALS8 mRNA | CTD | PMID:25979313 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of LGALS8 mRNA | CTD | PMID:23034163 and PMID:23869203 | vinclozolin | decreases methylation | EXP | | 6480464 | vinclozolin results in decreased methylation of LGALS8 gene | CTD | PMID:31682807 | vorinostat | increases expression | ISO | LGALS8 (Homo sapiens) | 6480464 | vorinostat results in increased expression of LGALS8 mRNA | CTD | PMID:27188386 | |