Lgals8 (galectin 8) - Rat Genome Database

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Gene: Lgals8 (galectin 8) Rattus norvegicus
Analyze
Symbol: Lgals8
Name: galectin 8
RGD ID: 621272
Description: Predicted to enable carbohydrate binding activity and integrin binding activity. Predicted to be involved in cellular response to virus; lymphatic endothelial cell migration; and xenophagy. Predicted to act upstream of or within T cell costimulation and plasma cell differentiation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human LGALS8 (galectin 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 30 kDa S-type lectin; gal-8; galectin-8; lectin, galactose binding, soluble 8; lectin, galactoside-binding, soluble 8; lectin, galactoside-binding, soluble, 8; RL-30
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Lgals8-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81762,716,368 - 62,744,272 (+)NCBIGRCr8
mRatBN7.21758,024,652 - 58,052,764 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1758,028,105 - 58,052,764 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1761,217,535 - 61,242,070 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01765,220,645 - 65,245,181 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01759,374,848 - 59,399,383 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01766,487,451 - 66,515,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1766,487,457 - 66,511,870 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01768,232,995 - 68,261,071 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,589,595 - 68,614,014 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11768,600,427 - 68,624,843 (+)NCBI
Celera1762,481,132 - 62,505,453 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinic acid  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
finasteride  (EXP)
flutamide  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
inulin  (ISO)
irinotecan  (ISO)
leflunomide  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nefazodone  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytoplasmic vesicle  (IEA)
cytosol  (ISO,ISS)
membrane raft  (IEA)
plasma membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Galectin-8. A new rat lectin, related to galectin-4. Hadari YR, etal., J Biol Chem 1995 Feb 17;270(7):3447-53.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:19268462   PMID:19946888   PMID:21753146   PMID:22246324   PMID:22357632   PMID:23376485   PMID:28077878  


Genomics

Comparative Map Data
Lgals8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81762,716,368 - 62,744,272 (+)NCBIGRCr8
mRatBN7.21758,024,652 - 58,052,764 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1758,028,105 - 58,052,764 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1761,217,535 - 61,242,070 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01765,220,645 - 65,245,181 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01759,374,848 - 59,399,383 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01766,487,451 - 66,515,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1766,487,457 - 66,511,870 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01768,232,995 - 68,261,071 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,589,595 - 68,614,014 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11768,600,427 - 68,624,843 (+)NCBI
Celera1762,481,132 - 62,505,453 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
LGALS8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381236,518,214 - 236,552,981 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1236,518,000 - 236,552,981 (+)EnsemblGRCh38hg38GRCh38
GRCh371236,681,514 - 236,716,281 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361234,748,188 - 234,779,619 (+)NCBINCBI36Build 36hg18NCBI36
Build 341233,007,605 - 233,039,037NCBI
Celera1209,929,863 - 209,961,279 (+)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1207,138,181 - 207,173,297 (+)NCBIHuRef
CHM1_11237,954,415 - 237,989,174 (+)NCBICHM1_1
T2T-CHM13v2.01235,919,116 - 235,953,936 (+)NCBIT2T-CHM13v2.0
Lgals8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391312,454,283 - 12,479,857 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1312,454,296 - 12,479,825 (-)EnsemblGRCm39 Ensembl
GRCm381312,439,402 - 12,464,977 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1312,439,415 - 12,464,944 (-)EnsemblGRCm38mm10GRCm38
MGSCv371312,531,686 - 12,553,757 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361312,493,757 - 12,515,752 (-)NCBIMGSCv36mm8
Celera1312,355,672 - 12,377,742 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.64NCBI
Lgals8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554923,673,233 - 3,693,776 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554923,673,233 - 3,693,777 (-)NCBIChiLan1.0ChiLan1.0
LGALS8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,636,843 - 12,669,351 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,849,686 - 12,881,558 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01212,083,584 - 212,112,182 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11217,078,628 - 217,112,773 (+)NCBIpanpan1.1PanPan1.1panPan2
LGALS8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.143,548,066 - 3,581,382 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl43,533,200 - 3,567,311 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha43,596,286 - 3,613,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.043,568,616 - 3,602,071 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl43,566,334 - 3,598,155 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.143,583,330 - 3,600,748 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.043,700,220 - 3,717,655 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.043,920,489 - 3,937,943 (-)NCBIUU_Cfam_GSD_1.0
Lgals8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934440,192,204 - 40,209,528 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648416,357,816 - 16,374,689 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648416,357,433 - 16,374,675 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGALS8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1454,867,021 - 54,892,049 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11454,867,014 - 54,892,188 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21458,845,312 - 58,865,899 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LGALS8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12573,661,941 - 73,682,949 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2573,661,556 - 73,687,534 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605575,752,168 - 75,773,227 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgals8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477514,097,181 - 14,110,929 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477514,096,463 - 14,112,701 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lgals8
143 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:122
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000044662
Prediction methods:Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)175089090860781592Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)175089090860781592Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)175090919660781426Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)175402992960463637Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat

Markers in Region
D17Rat150  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,012,452 - 58,012,678 (-)MAPPERmRatBN7.2
Rnor_6.01766,527,909 - 66,528,134NCBIRnor6.0
Rnor_5.01768,273,665 - 68,273,890UniSTSRnor5.0
RGSC_v3.41768,573,312 - 68,573,538RGDRGSC3.4
RGSC_v3.41768,573,313 - 68,573,538UniSTSRGSC3.4
RGSC_v3.11768,584,145 - 68,584,371RGD
Celera1762,520,907 - 62,521,132UniSTS
RH 3.4 Map17604.4UniSTS
RH 3.4 Map17604.4RGD
SHRSP x BN Map1732.6999UniSTS
SHRSP x BN Map1732.6999RGD
Cytogenetic Map17q12.1UniSTS
D17Rat148  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,038,006 - 58,038,147 (-)MAPPERmRatBN7.2
Rnor_6.01766,501,856 - 66,501,996NCBIRnor6.0
Rnor_5.01768,247,612 - 68,247,752UniSTSRnor5.0
RGSC_v3.41768,599,468 - 68,599,609RGDRGSC3.4
RGSC_v3.41768,599,469 - 68,599,609UniSTSRGSC3.4
RGSC_v3.11768,610,168 - 68,610,609RGD
Celera1762,495,525 - 62,495,665UniSTS
SHRSP x BN Map1732.6999RGD
SHRSP x BN Map1732.6999UniSTS
Cytogenetic Map17q12.1UniSTS
RH133085  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0X77,848,602 - 77,848,801NCBIRnor5.0
Rnor_5.01768,233,390 - 68,233,588NCBIRnor5.0
RGSC_v3.41768,613,633 - 68,613,830UniSTSRGSC3.4
RGSC_v3.4X94,781,342 - 94,781,540UniSTSRGSC3.4
Celera1762,481,316 - 62,481,513UniSTS
CeleraX72,954,475 - 72,954,673UniSTS
RH 3.4 Map17610.79UniSTS
Cytogenetic MapXq31UniSTS
Cytogenetic Map17q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 41 11 8
Low 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000044662   ⟹   ENSRNOP00000040412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1758,028,107 - 58,052,552 (+)Ensembl
Rnor_6.0 Ensembl1766,487,457 - 66,511,870 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107534   ⟹   ENSRNOP00000093738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1758,028,105 - 58,052,764 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111447   ⟹   ENSRNOP00000092313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1758,032,628 - 58,052,552 (+)Ensembl
RefSeq Acc Id: NM_053862   ⟹   NP_446314
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81762,719,853 - 62,744,272 (+)NCBI
mRatBN7.21758,028,133 - 58,052,552 (+)NCBI
Rnor_6.01766,487,451 - 66,511,870 (-)NCBI
Rnor_5.01768,232,995 - 68,261,071 (-)NCBI
RGSC_v3.41768,589,595 - 68,614,014 (+)RGD
Celera1762,481,132 - 62,505,453 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006254166   ⟹   XP_006254228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81762,719,808 - 62,744,272 (+)NCBI
mRatBN7.21758,028,137 - 58,052,764 (+)NCBI
Rnor_6.01766,487,451 - 66,511,949 (-)NCBI
Rnor_5.01768,232,995 - 68,261,071 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006254167   ⟹   XP_006254229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81762,716,368 - 62,744,272 (+)NCBI
mRatBN7.21758,024,652 - 58,052,764 (+)NCBI
Rnor_6.01766,487,451 - 66,515,316 (-)NCBI
Rnor_5.01768,232,995 - 68,261,071 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006254168   ⟹   XP_006254230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81762,719,808 - 62,744,272 (+)NCBI
mRatBN7.21758,028,179 - 58,052,764 (+)NCBI
Rnor_6.01766,487,451 - 66,511,637 (-)NCBI
Rnor_5.01768,232,995 - 68,261,071 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600439   ⟹   XP_017455928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81762,718,585 - 62,744,272 (+)NCBI
mRatBN7.21758,028,016 - 58,052,764 (+)NCBI
Rnor_6.01766,487,451 - 66,511,950 (-)NCBI
Sequence:
RefSeq Acc Id: NP_446314   ⟸   NM_053862
- UniProtKB: Q62665 (UniProtKB/Swiss-Prot),   Q6IN24 (UniProtKB/TrEMBL),   F1M9Q4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254229   ⟸   XM_006254167
- Peptide Label: isoform X1
- UniProtKB: Q62665 (UniProtKB/Swiss-Prot),   Q6IN24 (UniProtKB/TrEMBL),   F1M9Q4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254228   ⟸   XM_006254166
- Peptide Label: isoform X1
- UniProtKB: Q62665 (UniProtKB/Swiss-Prot),   Q6IN24 (UniProtKB/TrEMBL),   F1M9Q4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254230   ⟸   XM_006254168
- Peptide Label: isoform X1
- UniProtKB: Q62665 (UniProtKB/Swiss-Prot),   Q6IN24 (UniProtKB/TrEMBL),   F1M9Q4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455928   ⟸   XM_017600439
- Peptide Label: isoform X2
- UniProtKB: Q62665 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000040412   ⟸   ENSRNOT00000044662
RefSeq Acc Id: ENSRNOP00000092313   ⟸   ENSRNOT00000111447
RefSeq Acc Id: ENSRNOP00000093738   ⟸   ENSRNOT00000107534
Protein Domains
Galectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62665-F1-model_v2 AlphaFold Q62665 1-316 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700538
Promoter ID:EPDNEW_R11062
Type:initiation region
Name:Lgals8_1
Description:galectin 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01766,511,869 - 66,511,929EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621272 AgrOrtholog
BioCyc Gene G2FUF-8939 BioCyc
Ensembl Genes ENSRNOG00000018046 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044662 ENTREZGENE
  ENSRNOT00000044662.5 UniProtKB/TrEMBL
  ENSRNOT00000107534.1 UniProtKB/TrEMBL
  ENSRNOT00000111447.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7104910 IMAGE-MGC_LOAD
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galectin_CRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116641 UniProtKB/TrEMBL
MGC_CLONE MGC:91554 IMAGE-MGC_LOAD
NCBI Gene 116641 ENTREZGENE
PANTHER PTHR11346 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11346:SF22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gal-bind_lectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lgals8 PhenoGen
PROSITE GALECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018046 RatGTEx
SMART Gal-bind_lectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AHL3_RAT UniProtKB/TrEMBL
  A0A8I6AMD3_RAT UniProtKB/TrEMBL
  A6KN35_RAT UniProtKB/TrEMBL
  F1M9Q4 ENTREZGENE
  LEG8_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IN24 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1M9Q4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-18 Lgals8  galectin 8  Lgals8  lectin, galactoside-binding, soluble, 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-30 Lgals8  lectin, galactoside-binding, soluble, 8  Lgals8  lectin, galactose binding, soluble 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-19 Lgals8  lectin, galactose binding, soluble 8  Lgals8  lectin, galactoside-binding, soluble 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Lgals8  lectin, galactoside-binding, soluble 8    lectin, galactose binding, soluble 8  Name updated 1299863 APPROVED
2005-01-20 Lgals8  lectin, galactose binding, soluble 8      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Lgals8  lectin, galactose binding, soluble 8      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver, kidney, cardiac muscle, lung, and brain 729012