Idi1 (isopentenyl-diphosphate delta isomerase 1) - Rat Genome Database

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Gene: Idi1 (isopentenyl-diphosphate delta isomerase 1) Rattus norvegicus
Analyze
Symbol: Idi1
Name: isopentenyl-diphosphate delta isomerase 1
RGD ID: 621835
Description: Predicted to enable isopentenyl-diphosphate delta-isomerase activity; magnesium ion binding activity; and manganese ion binding activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process and response to stilbenoid. Located in peroxisome. Orthologous to human IDI1 (isopentenyl-diphosphate delta isomerase 1); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-benzylpiperazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IPP isomerase 1; IPPI1; isopentenyl pyrophosphate isomerase 1; isopentenyl-diphosphate delta isomerase; isopentenyl-diphosphate Delta-isomerase 1; MGC108635
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21761,629,592 - 61,637,357 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1761,629,594 - 61,637,357 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1765,150,543 - 65,158,198 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01768,979,347 - 68,987,006 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01763,000,917 - 63,008,598 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01757,976,266 - 57,984,036 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1757,976,268 - 57,984,036 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01759,781,714 - 59,789,305 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41772,557,196 - 72,563,149 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11772,568,028 - 72,573,982 (-)NCBI
Celera1754,413,799 - 54,421,561 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-benzylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
Actein  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
benzalkonium chloride  (ISO)
benzatropine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
caffeine  (EXP)
calciol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
corn oil  (EXP)
coumestrol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
DDE  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
dicrotophos  (ISO)
difenoconazole  (EXP)
diquat  (ISO)
diuron  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
fingolimod hydrochloride  (ISO)
fluoranthene  (ISO)
flusilazole  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
HC toxin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoflavones  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
ketamine  (EXP)
ketoconazole  (EXP,ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
loperamide  (ISO)
lucanthone  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
mevastatin  (ISO)
miconazole  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nicotine  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenylpropanolamine  (ISO)
phosgene  (ISO)
picoxystrobin  (ISO)
picrotoxin  (EXP)
pinosylvin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
progesterone  (ISO)
propanil  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
ritodrine  (ISO)
rotenone  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tacedinaline  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topiramate  (EXP)
topotecan  (EXP)
trans-pinosylvin  (ISO)
triacsin C  (ISO)
triadimefon  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
peroxisome  (IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl diphosphate isomerase. A PTS1 motif targets the enzyme to peroxisomes. Paton VG, etal., J Biol Chem 1997 Jul 25;272(30):18945-50.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
Additional References at PubMed
PMID:8806705   PMID:8889548   PMID:12477932   PMID:17086191   PMID:17180682   PMID:17202134   PMID:17250851   PMID:18614015  


Genomics

Comparative Map Data
Idi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21761,629,592 - 61,637,357 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1761,629,594 - 61,637,357 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1765,150,543 - 65,158,198 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01768,979,347 - 68,987,006 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01763,000,917 - 63,008,598 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01757,976,266 - 57,984,036 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1757,976,268 - 57,984,036 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01759,781,714 - 59,789,305 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41772,557,196 - 72,563,149 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11772,568,028 - 72,573,982 (-)NCBI
Celera1754,413,799 - 54,421,561 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
IDI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38101,039,152 - 1,056,704 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl101,039,152 - 1,049,119 (-)EnsemblGRCh38hg38GRCh38
GRCh37101,085,092 - 1,102,644 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36101,075,963 - 1,085,061 (-)NCBINCBI36Build 36hg18NCBI36
Build 34101,075,965 - 1,085,061NCBI
Celera101,036,251 - 1,044,473 (-)NCBICelera
Cytogenetic Map10p15.3NCBI
HuRef101,025,257 - 1,033,604 (-)NCBIHuRef
CHM1_1101,085,060 - 1,093,181 (-)NCBICHM1_1
T2T-CHM13v2.0101,036,296 - 1,053,319 (-)NCBIT2T-CHM13v2.0
Idi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39138,935,642 - 8,942,432 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl138,935,537 - 8,942,487 (+)EnsemblGRCm39 Ensembl
GRCm38138,885,606 - 8,892,396 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl138,885,501 - 8,892,451 (+)EnsemblGRCm38mm10GRCm38
MGSCv37138,884,852 - 8,891,642 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36138,885,220 - 8,891,616 (+)NCBIMGSCv36mm8
Celera138,829,584 - 8,836,913 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map133.62NCBI
IDI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11013,571,367 - 13,580,999 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0101,078,107 - 1,087,054 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1101,124,920 - 1,134,028 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl101,124,920 - 1,133,234 (-)Ensemblpanpan1.1panPan2
IDI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1233,927,759 - 33,930,651 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha230,960,125 - 30,967,067 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0234,309,281 - 34,316,208 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl234,310,839 - 34,316,208 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1231,392,540 - 31,399,466 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0232,232,275 - 32,239,172 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0232,979,655 - 32,986,260 (+)NCBIUU_Cfam_GSD_1.0
Idi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934436,889,129 - 36,896,165 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648413,054,155 - 13,061,935 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100625049
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1068,534,796 - 68,539,280 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11068,534,520 - 68,539,279 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21075,367,606 - 75,370,798 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IDI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19995,608 - 1,011,226 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9996,909 - 1,003,963 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660516,050,014 - 6,065,635 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Idi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247759,806,482 - 9,879,265 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Idi1
48 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:102
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000022389
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat

Markers in Region
RH130561  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21761,629,661 - 61,629,869 (+)MAPPERmRatBN7.2
Rnor_6.01757,976,336 - 57,976,543NCBIRnor6.0
Rnor_5.01759,781,784 - 59,781,991UniSTSRnor5.0
RGSC_v3.41772,555,654 - 72,555,861UniSTSRGSC3.4
Celera1754,413,869 - 54,414,076UniSTS
RH 3.4 Map17610.9UniSTS
Cytogenetic Map17q12.1UniSTS
RH143310  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21761,631,017 - 61,631,258 (+)MAPPERmRatBN7.2
Rnor_6.01757,977,692 - 57,977,932NCBIRnor6.0
Rnor_5.01759,783,140 - 59,783,380UniSTSRnor5.0
RGSC_v3.41772,557,010 - 72,557,250UniSTSRGSC3.4
Celera1754,415,225 - 54,415,465UniSTS
RH 3.4 Map17587.1UniSTS
Cytogenetic Map17q12.1UniSTS
RH139889  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21761,637,480 - 61,637,678 (+)MAPPERmRatBN7.2
Rnor_6.01757,984,160 - 57,984,357NCBIRnor6.0
Rnor_5.01759,789,429 - 59,789,626UniSTSRnor5.0
RGSC_v3.41772,563,292 - 72,563,489UniSTSRGSC3.4
Celera1754,421,685 - 54,421,882UniSTS
RH 3.4 Map17611.4UniSTS
Cytogenetic Map17q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 24 48 35 19 35 1 1 74 33 39 11 1
Low 19 9 6 6 7 10 2 2 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF003835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF389837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP491941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP500454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM059509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000022389   ⟹   ENSRNOP00000022389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1761,629,594 - 61,637,357 (-)Ensembl
Rnor_6.0 Ensembl1757,976,268 - 57,984,036 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093832   ⟹   ENSRNOP00000078971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1761,629,594 - 61,637,121 (-)Ensembl
RefSeq Acc Id: NM_053539   ⟹   NP_445991
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21761,629,592 - 61,637,357 (-)NCBI
Rnor_6.01757,976,266 - 57,984,036 (-)NCBI
Rnor_5.01759,781,714 - 59,789,305 (-)NCBI
RGSC_v3.41772,557,196 - 72,563,149 (-)RGD
Celera1754,413,799 - 54,421,561 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096128   ⟹   XP_038952056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21761,629,603 - 61,636,622 (-)NCBI
RefSeq Acc Id: XM_039096129   ⟹   XP_038952057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21761,629,603 - 61,636,609 (-)NCBI
RefSeq Acc Id: XM_039096130   ⟹   XP_038952058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21761,629,603 - 61,636,626 (-)NCBI
RefSeq Acc Id: XM_039096131   ⟹   XP_038952059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21761,629,603 - 61,636,634 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_445991   ⟸   NM_053539
- UniProtKB: O35760 (UniProtKB/Swiss-Prot),   A0A0H2UHN2 (UniProtKB/TrEMBL),   A6KRN6 (UniProtKB/TrEMBL),   A0A8I5ZLV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022389   ⟸   ENSRNOT00000022389
RefSeq Acc Id: XP_038952059   ⟸   XM_039096131
- Peptide Label: isoform X1
- UniProtKB: O35760 (UniProtKB/Swiss-Prot),   Q5FVT3 (UniProtKB/Swiss-Prot),   A0A8I5ZLV9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952058   ⟸   XM_039096130
- Peptide Label: isoform X1
- UniProtKB: O35760 (UniProtKB/Swiss-Prot),   Q5FVT3 (UniProtKB/Swiss-Prot),   A0A8I5ZLV9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952056   ⟸   XM_039096128
- Peptide Label: isoform X1
- UniProtKB: O35760 (UniProtKB/Swiss-Prot),   Q5FVT3 (UniProtKB/Swiss-Prot),   A0A8I5ZLV9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952057   ⟸   XM_039096129
- Peptide Label: isoform X1
- UniProtKB: O35760 (UniProtKB/Swiss-Prot),   Q5FVT3 (UniProtKB/Swiss-Prot),   A0A8I5ZLV9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078971   ⟸   ENSRNOT00000093832
Protein Domains
Nudix hydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35760-F1-model_v2 AlphaFold O35760 1-227 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621835 AgrOrtholog
BioCyc Gene G2FUF-8882 BioCyc
BioCyc Pathway PWY-922 [mevalonate pathway I (eukaryotes and bacteria)] BioCyc
Ensembl Genes ENSRNOG00000016690 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022389 ENTREZGENE
  ENSRNOP00000022389.5 UniProtKB/TrEMBL
  ENSRNOP00000078971.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022389 ENTREZGENE
  ENSRNOT00000022389.7 UniProtKB/TrEMBL
  ENSRNOT00000093832.1 UniProtKB/TrEMBL
Gene3D-CATH Nucleoside Triphosphate Pyrophosphohydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7322086 IMAGE-MGC_LOAD
InterPro IsopentenylPP_isomerase_typ1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUDIX_hydrolase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUDIX_hydrolase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:89784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108635 IMAGE-MGC_LOAD
NCBI Gene 89784 ENTREZGENE
PANTHER ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NUDIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Idi1 PhenoGen
PIRSF Isopntndiph_ism UniProtKB/Swiss-Prot
PROSITE NUDIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55811 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHN2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZLV9 ENTREZGENE, UniProtKB/TrEMBL
  A6KRN6 ENTREZGENE, UniProtKB/TrEMBL
  IDI1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FVT3 ENTREZGENE
UniProt Secondary Q5FVT3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Idi1  isopentenyl-diphosphate delta isomerase 1  Idi1  isopentenyl-diphosphate delta isomerase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Idi1  isopentenyl-diphosphate delta isomerase      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Idi1  isopentenyl-diphosphate delta isomerase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the peroxisome 729078
gene_regulation expression is upregulated by a diet supplemented with 5% cholestyramine + 0.1% mevinolin 729078