Pfkfb3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3) - Rat Genome Database

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Gene: Pfkfb3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3) Rattus norvegicus
Analyze
Symbol: Pfkfb3
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
RGD ID: 619776
Description: Predicted to have 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Involved in brain development and fructose 2,6-bisphosphate metabolic process. Predicted to localize to cytosol and nucleoplasm. Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3); PARTICIPATES IN hypoxia inducible factor pathway; fructose and mannose metabolic pathway; glycolysis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme; PFK/FBPase 3; RB2K
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21766,983,629 - 67,064,702 (+)NCBI
Rnor_6.0 Ensembl1770,684,134 - 70,713,726 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01770,632,778 - 70,713,736 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01772,334,950 - 72,416,018 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41778,241,182 - 78,268,272 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11778,252,014 - 78,279,105 (+)NCBI
Celera1766,539,556 - 66,566,619 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,4-benzoquinone  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
ampicillin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chrysene  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dioxygen  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
folic acid  (ISO)
genistein  (ISO)
hexadecanoic acid  (ISO)
hydrazines  (ISO)
indinavir  (ISO)
lactacystin  (EXP)
lamivudine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
motexafin gadolinium  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resorcinol  (ISO)
Salinomycin  (ISO)
saquinavir  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)
nucleoplasm  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:2837207   PMID:9464277   PMID:10095107   PMID:14623077   PMID:15896703   PMID:15983194   PMID:18191036   PMID:19448625   PMID:19595670   PMID:22421967   PMID:23703029   PMID:26498254  
PMID:28235572   PMID:30132885  


Genomics

Comparative Map Data
Pfkfb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21766,983,629 - 67,064,702 (+)NCBI
Rnor_6.0 Ensembl1770,684,134 - 70,713,726 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01770,632,778 - 70,713,736 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01772,334,950 - 72,416,018 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41778,241,182 - 78,268,272 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11778,252,014 - 78,279,105 (+)NCBI
Celera1766,539,556 - 66,566,619 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
PFKFB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl106,144,934 - 6,254,644 (+)EnsemblGRCh38hg38GRCh38
GRCh38106,144,918 - 6,254,648 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37106,186,884 - 6,296,611 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36106,284,901 - 6,317,501 (+)NCBINCBI36hg18NCBI36
Build 34106,284,900 - 6,317,500NCBI
Celera106,116,166 - 6,206,226 (+)NCBI
Cytogenetic Map10p15.1NCBI
HuRef106,113,180 - 6,203,192 (+)NCBIHuRef
CHM1_1106,186,884 - 6,276,773 (+)NCBICHM1_1
Pfkfb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39211,476,241 - 11,558,882 (-)NCBIGRCm39mm39
GRCm39 Ensembl211,476,244 - 11,558,888 (-)Ensembl
GRCm38211,471,430 - 11,554,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl211,471,433 - 11,554,077 (-)EnsemblGRCm38mm10GRCm38
MGSCv37211,393,057 - 11,475,556 (-)NCBIGRCm37mm9NCBIm37
MGSCv36211,389,288 - 11,419,920 (-)NCBImm8
Celera211,389,848 - 11,473,089 (-)NCBICelera
Cytogenetic Map2A1NCBI
Pfkfb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542122,848,548 - 22,866,035 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542122,762,290 - 22,868,677 (+)NCBIChiLan1.0ChiLan1.0
PFKFB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1106,167,841 - 6,257,263 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl106,167,841 - 6,275,940 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0106,185,415 - 6,294,641 (+)NCBIMhudiblu_PPA_v0panPan3
PFKFB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1229,716,866 - 29,785,643 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl229,716,752 - 29,801,936 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha226,748,126 - 26,834,516 (-)NCBI
ROS_Cfam_1.0230,098,553 - 30,184,947 (-)NCBI
UMICH_Zoey_3.1227,195,708 - 27,282,045 (-)NCBI
UNSW_CanFamBas_1.0228,031,490 - 28,118,114 (-)NCBI
UU_Cfam_GSD_1.0228,751,303 - 28,837,993 (-)NCBI
Pfkfb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934432,191,332 - 32,278,311 (-)NCBI
SpeTri2.0NW_0049364848,356,523 - 8,434,529 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKFB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1064,776,315 - 64,859,051 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11064,776,315 - 64,859,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21070,831,486 - 70,857,739 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PFKFB3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.196,267,766 - 6,354,775 (+)NCBI
ChlSab1.1 Ensembl96,332,570 - 6,354,932 (+)Ensembl
Vero_WHO_p1.0NW_02366605111,571,686 - 11,658,469 (+)NCBI
Pfkfb3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247751,092,018 - 1,173,848 (+)NCBI

Position Markers
D17Rat96  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21767,047,777 - 67,047,980 (+)MAPPER
Rnor_6.01770,696,817 - 70,697,019NCBIRnor6.0
Rnor_5.01772,399,108 - 72,399,310UniSTSRnor5.0
RGSC_v3.41778,253,719 - 78,254,071RGDRGSC3.4
RGSC_v3.41778,253,865 - 78,254,067UniSTSRGSC3.4
RGSC_v3.11778,264,552 - 78,264,904RGD
Celera1766,552,212 - 66,552,414UniSTS
RH 3.4 Map17637.4RGD
RH 3.4 Map17637.4UniSTS
RH 2.0 Map17570.7RGD
SHRSP x BN Map1737.1399RGD
Cytogenetic Map17q12.3UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17173413148Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17173413148Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17333697273413148Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17333697273413148Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17333697273413148Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172149095074823273Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172841314873413148Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173097522875975228Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173097522875975228Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173205588277922655Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173330362778303627Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173330362785321557Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173628324577922655Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173779030673413148Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)174117605786176057Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)174117605786176057Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174173108086731080Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174254187285446768Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174435615789356157Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174866025273413148Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174866025273413148Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)175241095790843779Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)175241095790843779Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175347518090690466Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175387148890843779Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175399194790843779Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175622429686731080Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)176219570373981731Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)176219570374702206Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176219582286194199Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176549735982019219Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176700421277922655Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176751265790843779Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176933327285183543Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:305
Count of miRNA genes:158
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000025700, ENSRNOT00000025731, ENSRNOT00000051067, ENSRNOT00000068354
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 14 22 6 19 6 6 9 74 35 31 11 6
Low 1 29 35 35 35 2 2 10 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_057135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB006710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC141172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU034674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000025700   ⟹   ENSRNOP00000025700
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1770,684,539 - 70,711,216 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000025731   ⟹   ENSRNOP00000025731
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1770,684,134 - 70,707,555 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000051067   ⟹   ENSRNOP00000040928
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1770,684,340 - 70,713,726 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000068354   ⟹   ENSRNOP00000062965
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1770,684,134 - 70,711,224 (+)Ensembl
RefSeq Acc Id: NM_057135   ⟹   NP_476476
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21767,035,095 - 67,062,190 (+)NCBI
Rnor_6.01770,684,134 - 70,711,224 (+)NCBI
Rnor_5.01772,334,950 - 72,416,018 (+)NCBI
RGSC_v3.41778,241,182 - 78,268,272 (+)RGD
Celera1766,539,556 - 66,566,619 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254192   ⟹   XP_006254254
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21767,035,100 - 67,064,702 (+)NCBI
Rnor_6.01770,684,139 - 70,713,736 (+)NCBI
Rnor_5.01772,334,950 - 72,416,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254193   ⟹   XP_006254255
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21767,035,100 - 67,064,702 (+)NCBI
Rnor_6.01770,684,139 - 70,713,736 (+)NCBI
Rnor_5.01772,334,950 - 72,416,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254196   ⟹   XP_006254258
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21767,035,100 - 67,064,702 (+)NCBI
Rnor_6.01770,684,139 - 70,713,736 (+)NCBI
Rnor_5.01772,334,950 - 72,416,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254197   ⟹   XP_006254259
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21767,035,100 - 67,064,702 (+)NCBI
Rnor_6.01770,684,139 - 70,713,736 (+)NCBI
Rnor_5.01772,334,950 - 72,416,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254198   ⟹   XP_006254260
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21767,035,100 - 67,064,702 (+)NCBI
Rnor_6.01770,684,139 - 70,713,736 (+)NCBI
Rnor_5.01772,334,950 - 72,416,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600444   ⟹   XP_017455933
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21766,983,629 - 67,064,702 (+)NCBI
Rnor_6.01770,632,778 - 70,711,151 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_476476   ⟸   NM_057135
- UniProtKB: O35552 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006254255   ⟸   XM_006254193
- Peptide Label: isoform X2
- UniProtKB: O35552 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006254254   ⟸   XM_006254192
- Peptide Label: isoform X1
- UniProtKB: O35552 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006254258   ⟸   XM_006254196
- Peptide Label: isoform X4
- UniProtKB: O35552 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006254260   ⟸   XM_006254198
- Peptide Label: isoform X6
- UniProtKB: O35552 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006254259   ⟸   XM_006254197
- Peptide Label: isoform X5
- UniProtKB: O35552 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017455933   ⟸   XM_017600444
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000040928   ⟸   ENSRNOT00000051067
RefSeq Acc Id: ENSRNOP00000062965   ⟸   ENSRNOT00000068354
RefSeq Acc Id: ENSRNOP00000025700   ⟸   ENSRNOT00000025700
RefSeq Acc Id: ENSRNOP00000025731   ⟸   ENSRNOT00000025731
Protein Domains
6PF2K

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700558
Promoter ID:EPDNEW_R11081
Type:multiple initiation site
Name:Pfkfb3_1
Description:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01770,684,196 - 70,684,256EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619776 AgrOrtholog
Ensembl Genes ENSRNOG00000018911 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025700 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000025731 UniProtKB/Swiss-Prot
  ENSRNOP00000040928 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000062965 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025700 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000025731 UniProtKB/Swiss-Prot
  ENSRNOT00000051067 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000068354 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6Pfruct_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6Phosfructo_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_Pase_superF_clade-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_PPase_superfam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG/BPGM_mutase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117276 UniProtKB/Swiss-Prot
NCBI Gene 117276 ENTREZGENE
PANTHER PTHR10606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 6PF2K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_Phos_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pfkfb3 PhenoGen
PRINTS 6PFRUCTKNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PG_MUTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PGAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53254 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A7UAK3_RAT UniProtKB/TrEMBL
  F263_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O35096 UniProtKB/Swiss-Prot
  O35553 UniProtKB/Swiss-Prot
  O35554 UniProtKB/Swiss-Prot
  O35555 UniProtKB/Swiss-Prot
  O35556 UniProtKB/Swiss-Prot
  O35557 UniProtKB/Swiss-Prot
  Q9QWQ5 UniProtKB/Swiss-Prot
  Q9QWQ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Pfkfb3  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Pfkfb3  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression isozyme expressed specifically in brain 729510