METHIONINE CYCLE/METABOLIC PATHWAY (PW:0000048)

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Description

Methionine is an essential amino acid derived from diet and necessary for normal mammalian growth and development. As an amino acid methionine is used for the synthesis of proteins while its metabolic cycle provides a number of metabolites important for a range of other metabolic pathways and processes. Methionine adenosyltransferases (Mat) catalyze the formation of S-adenosylmethionine (known as AdoMet or SAM) using ATP in two consecutive reactions of which the second is rate-limiting. Mammals

Pathway Diagram:

Ariadne Genomics Inc. S-adenosylmethioninamine ---> methylthioadenosine dimethylglycine ---| Bhmt Srm Sms polyamine metabolic pathway S-adenosylmethionine ---> S-adenosylhomocysteine AdoMet-dependent methyltransferases betaine 5-methyl-THF THF dimethylglycine homocysteine methylthioadenosine spermine metabolic pathway methyl group transfer  to carbon, nitrogen, oxygen or sulfur atoms on proteins, nucleic acids, carbohydrates, lipids, small molecules Cbl ATP ---> S-adenosylmethionine methylthioadenosine ---> 1-phosphomethylthioribose AdoMet radical reactions involved in co-factor and other natural products biosynthesis in anaerobic organisms S-adenosylmethionine ---> S-adenosylmethioninamine spermidine metabolic pathway Mtap S-adenosylmethioninamine 1-phosphomethylthioribose ATP methionine adenosine Mtrr ---> Mtr Mtrr Mat2b ---> Mat2a Mat2b folate cycle metabolic pathway Amd1 S-adenosylhomocysteine ---| AdoMet-dependent methyltransferases homocysteine metabolic pathway diet ---> methionine diet 5-methyl-THF ---> THF adenosine <--> S-adenosylhomocysteine Ahcy Mat2a Mat1a 1-phosphomethylthioribose ---> methionine methionine ---> protein biosynthesis protein biosynthesis methionine ---> S-adenosylmethionine S-adenosylmethionine ---> AdoMet radical reactions involved in co-factor and other natural products biosynthesis in anaerobic organisms Mtr homocysteine <--> S-adenosylhomocysteine folate mediated one-carbon metabolic pathway homocysteine ---> methionine Bhmt betaine ---> dimethylglycine S-adenosylhomocysteine S-adenosylmethionine
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Genes in Pathway:

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methionine cycle/metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahcy adenosylhomocysteinase JBrowse link 3 150,587,833 150,603,057 RGD:730275
RGD:10402751
RGD:7242932
RGD:7242425
G Amd1 adenosylmethionine decarboxylase 1 JBrowse link 20 45,384,000 45,399,694 RGD:7242425
RGD:10402751
RGD:7242932
G As3mt arsenite methyltransferase JBrowse link 1 266,482,787 266,514,570 RGD:625365
G Asmt acetylserotonin O-methyltransferase JBrowse link 12 18,521,383 18,527,036 RGD:1359073
G Bhmt betaine-homocysteine S-methyltransferase JBrowse link 2 23,236,573 23,256,158 RGD:1359026
RGD:10402751
RGD:7242425
G Carm1 coactivator-associated arginine methyltransferase 1 JBrowse link 8 22,577,723 22,622,555 RGD:1359044
RGD:7242552
G Cbs cystathionine beta synthase JBrowse link 20 10,361,987 10,386,663 RGD:10402751
G Chdh choline dehydrogenase JBrowse link 16 6,078,083 6,109,386 RGD:10402751
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:1359089
G Cth cystathionine gamma-lyase JBrowse link 2 264,266,959 264,293,040 RGD:10402751
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:1359078
RGD:10402751
RGD:7242551
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:7242551
G Dnmt3b DNA methyltransferase 3 beta JBrowse link 3 149,131,541 149,170,061 RGD:7242551
G Dot1l DOT1 like histone lysine methyltransferase JBrowse link 7 11,786,105 11,824,742 RGD:1359080
RGD:7242554
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:7242554
G Gamt guanidinoacetate N-methyltransferase JBrowse link 7 12,314,848 12,317,998 RGD:1359081
G Gnmt glycine N-methyltransferase JBrowse link 9 16,565,274 16,568,626 RGD:1359070
RGD:7242551
RGD:7242425
G Hnmt histamine N-methyltransferase JBrowse link 3 905,111 937,038 RGD:1359041
G Icmt isoprenylcysteine carboxyl methyltransferase JBrowse link 5 169,475,270 169,482,031 RGD:1359083
G Il4i1 interleukin 4 induced 1 JBrowse link 1 100,811,727 100,836,901 RGD:10402751
G Kmt5a lysine methyltransferase 5A JBrowse link 12 37,558,150 37,581,183 RGD:7242554
G Mars methionyl-tRNA synthetase JBrowse link 7 70,585,011 70,602,425 RGD:10402751
G Mat1a methionine adenosyltransferase 1A JBrowse link 16 18,690,649 18,709,135 RGD:1359039
RGD:7242932
RGD:7242425
G Mat2a methionine adenosyltransferase 2A JBrowse link 4 100,297,478 100,303,047 RGD:1359040
RGD:10402751
RGD:7242425
G Mat2b methionine adenosyltransferase 2B JBrowse link 10 25,832,096 25,848,045 RGD:7242425
RGD:10402751
G Mrm2 mitochondrial rRNA methyltransferase 2 JBrowse link 12 16,398,749 16,403,656 RGD:1359074
G Msrb2 methionine sulfoxide reductase B2 JBrowse link 17 86,066,841 86,148,131 RGD:10402751
G Msrb3 methionine sulfoxide reductase B3 JBrowse link 7 62,850,506 62,972,487 RGD:10402751
G Mtap methylthioadenosine phosphorylase JBrowse link 5 107,711,077 107,777,530 RGD:7242425
RGD:10402751
RGD:7242932
G Mtfmt mitochondrial methionyl-tRNA formyltransferase JBrowse link 8 70,952,209 70,986,393 RGD:10402751
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:1535021
RGD:10402751
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 17 66,210,444 66,295,014 RGD:1359026
RGD:10402751
RGD:7242426
RGD:7242425
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase JBrowse link 1 37,743,089 37,774,485 RGD:1359037
RGD:7242426
G Nnmt nicotinamide N-methyltransferase JBrowse link 8 52,918,437 52,938,172 RGD:1359084
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 JBrowse link 1 1,734,863 1,767,759 RGD:729481
G Pemt phosphatidylethanolamine N-methyltransferase JBrowse link 10 46,339,821 46,404,640 RGD:729486
G Pnmt phenylethanolamine-N-methyltransferase JBrowse link 10 86,340,893 86,342,501 RGD:1359087
G Prmt1 protein arginine methyltransferase 1 JBrowse link 1 100,971,132 100,980,411 RGD:1359044
RGD:7242552
G Prmt2 protein arginine methyltransferase 2 JBrowse link 20 13,154,513 13,212,613 RGD:7242552
G Prmt3 protein arginine methyltransferase 3 JBrowse link 1 105,113,595 105,200,253 RGD:1359044
RGD:7242552
G Prmt5 protein arginine methyltransferase 5 JBrowse link 15 33,156,508 33,165,893 RGD:1359044
RGD:7242552
G Prmt6 protein arginine methyltransferase 6 JBrowse link 2 213,173,403 213,180,721 RGD:1359044
RGD:7242552
G Prmt7 protein arginine methyltransferase 7 JBrowse link 19 38,189,605 38,237,155 RGD:7242552
G Rnmt RNA (guanine-7-) methyltransferase JBrowse link 18 64,084,746 64,108,246 RGD:1359071
G Setd7 SET domain containing (lysine methyltransferase) 7 JBrowse link 2 140,576,188 140,618,405 RGD:7242554
G Setdb1 SET domain, bifurcated 1 JBrowse link 2 196,495,867 196,527,412 RGD:1359072
G Shmt1 serine hydroxymethyltransferase 1 JBrowse link 10 47,030,813 47,059,216 RGD:10402751
G Sms spermine synthase JBrowse link X 40,363,646 40,415,110 RGD:7242425
G Smyd2 SET and MYND domain containing 2 JBrowse link 13 108,642,156 108,686,293 RGD:7242554
G Srm spermidine synthase JBrowse link 5 165,405,168 165,408,325 RGD:7242425
RGD:10402751
G Suv39h1l1 suppressor of variegation 3-9 homolog 1 (Drosophila)-like 1 JBrowse link X 15,171,280 15,185,191 RGD:7242554
G Suv39h2 suppressor of variegation 3-9 homolog 2 JBrowse link 17 78,762,897 78,782,016 RGD:1359810
RGD:7242554
G Trdmt1 tRNA aspartic acid methyltransferase 1 JBrowse link 17 80,824,652 80,859,585 RGD:1359088

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassAdoMet-dependent methyltransferases

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the methionine cycle/metabolic pathway
Pathway TermsGene Symbols
5'-end pre-mRNA capping pathwayRnmt
alkaptonuria disease pathwayComt , Pnmt
altered folate cycle metabolic pathwayMthfr , Mtr , Mtrr
altered folate mediated one-carbon metabolic pathwayMthfr , Mtr
aminoacyl-tRNA biosynthetic pathwayMars , Mtfmt
androgen signaling pathwayCarm1 , Prmt1
arginine and proline metabolic pathwayAmd1 , Gamt , Srm
arginine:glycine amidinotransferase deficiency pathwayGamt
aromatic amino acid decarboxylase deficiency pathwayPnmt
beta-alanine metabolic pathwaySrm
Canavan disease pathwayIl4i1
carnitine biosynthetic pathwaySetd7 , Shmt1
catecholamine biosynthetic pathwayPnmt
choline metabolic pathwayAhcy , Bhmt , Chdh , Mat2a , Mat2b , Mtr , Pemt
creatine metabolic pathwayGamt
cyanoamino acid metabolic pathwayShmt1
cysteine and methionine metabolic pathwayAhcy , Amd1 , Bhmt , Cbs , Cth , Dnmt1 , Dnmt3a , Dnmt3b , Mat1a , Mat2a , Mat2b , Mtap , Mtr , Srm , Trdmt1
cysteine metabolic pathwayCbs , Cth
dihydropyrimidine dehydrogenase deficiency pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
dimethylglycine dehydrogenase deficiency pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
disulfiram pharmacodynamics pathwayComt , Pnmt
DNA modification pathwayDnmt1 , Dnmt3a , Dnmt3b
dopamine beta hydroxylase deficiency pathwayComt , Pnmt
epinephrine biosynthetic pathwayPnmt
estrogen signaling pathwayCarm1 , Prmt1
folate cycle metabolic pathwayMthfr , Mtr , Mtrr , Shmt1
folate mediated one-carbon metabolic pathwayGnmt , Mtfmt , Mthfr , Mtr , Mtrr , Shmt1
folate metabolic pathwayGnmt , Mtfmt , Mthfr , Mtr , Mtrr , Shmt1
gamma-cystathionase deficiency pathwayCbs , Cth
glutathione metabolic pathwaySrm
glycerophospholipid metabolic pathwayPemt
glycine metabolic pathwayShmt1
glycine N-methyltransferase deficiency pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
glycine, serine and threonine metabolic pathwayBhmt , Cbs , Chdh , Cth , Gamt , Gnmt , Shmt1
guanidinoacetate methyltransferase deficiency pathwayGamt
gyrate atrophy pathwayGamt
hawkinsinuria disease pathwayComt , Pnmt
hereditary folate malabsorption disease pathwayMtfmt , Mthfr
histidine metabolic pathwayHnmt , Prmt3
histidinemia disease pathwayHnmt , Prmt3
histone modification pathwayCarm1 , Dot1l , Ezh2 , Prmt1 , Prmt2 , Prmt5 , Prmt7 , Setd7 , Smyd2 , Suv39h2
homocysteine metabolic pathwayAhcy , As3mt , Asmt , Carm1 , Comt , Dnmt1 , Dot1l , Gamt , Gnmt , Hnmt , Icmt , Mrm2 , Mthfr , Nnmt , Pcmt1 , Pemt , Pnmt , Prmt1 , Prmt3 , Prmt5 , Prmt6 , Rnmt , Setdb1 , Suv39h2 , Trdmt1
homocystinuria disease pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
hypermethioninemia disease pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
hyperornithinemia-hyperammonemia-homocitrullinemia syndrome pathwayGamt
hyperprolinemia disease pathwayGamt
hyperprolinemia type II disease pathwayGamt
lysine degradation pathwayDot1l , Kmt5a , Setd7 , Setdb1 , Suv39h1l1 , Suv39h2
meracaptolactate cysteine disulfiduria pathwayCth
methionine adenosyltransferase deficiency pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
methionine cycle/metabolic pathwayAhcy , Amd1 , As3mt , Asmt , Bhmt , Carm1 , Cbs , Chdh , Comt , Cth , Dnmt1 , Dnmt3a , Dnmt3b , Dot1l , Ezh2 , Gamt , Gnmt , Hnmt , Icmt , Il4i1 , Kmt5a , Mars , Mat1a , Mat2a , Mat2b , Mrm2 , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Mtrr , Nnmt , Pcmt1 , Pemt , Pnmt , Prmt1 , Prmt2 , Prmt3 , Prmt5 , Prmt6 , Prmt7 , Rnmt , Setd7 , Setdb1 , Shmt1 , Sms , Smyd2 , Srm , Suv39h1l1 , Suv39h2 , Trdmt1
methotrexate pharmacodynamics pathwayMtfmt , Mthfr
methylenetetrahydrofolate reductase deficiency pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
monoterpenoid biosynthetic pathwayNnmt
mRNA decay pathwayRnmt
niacin metabolic pathwayNnmt
nonketotic hyperglycinemia disease pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
Nonketotic hyperglycinemia disease pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
ocular nephropathic cystinosis disease pathwayCth
p53 signaling pathwayPrmt5 , Setd7 , Smyd2
phenylketonuria disease pathwayIl4i1
phenytoin pharmacodynamics pathwayComt
polyamine metabolic pathwayAmd1 , Sms , Srm
prolidase deficiency pathwayGamt
putrescine metabolic pathwayAmd1
remethylation pathway of homocysteine metabolism - cobalamin dependentMthfr , Mtr , Mtrr
remethylation pathway of homocysteine metabolism - cobalamin independent, betaine dependentAhcy , Bhmt , Chdh , Mat2a , Mat2b , Mtr , Pemt
RNA transport pathwayPrmt5
sarcosinemia disease pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
selenoamino acid metabolic pathwayAhcy , Cbs , Cth , Mars , Mat2a , Mat2b , Mtr
spermidine metabolic pathwayAmd1 , Mat2a , Mat2b , Sms , Srm
spermine metabolic pathwayAmd1 , Mat2a , Mat2b , Sms , Srm
steroid hormone biosynthetic pathwayComt
transsulfuration pathway of homocysteine metabolismCbs , Cth
tryptophan metabolic pathwayAsmt
tyrosine metabolic pathwayComt , Pnmt
tyrosinemia type I disease pathwayComt , Pnmt
tyrosinemia type II disease pathwayIl4i1
tyrosinemia type III disease pathwayIl4i1
Wnt signaling, non-canonical pathwaySetdb1
Phenotype Annotations Associated with Genes in the methionine cycle/metabolic pathway

References Associated with the methionine cycle/metabolic pathway:

Ontology Path Diagram:

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