METHIONINE CYCLE/METABOLIC PATHWAY (PW:0000048)

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Description

Methionine is an essential amino acid derived from diet and necessary for normal mammalian growth and development. As an amino acid methionine is used for the synthesis of proteins while its metabolic cycle provides a number of metabolites important for a range of other metabolic pathways and processes. Methionine adenosyltransferases (Mat) catalyze the formation of S-adenosylmethionine (known as AdoMet or SAM) using ATP in two consecutive reactions of which the second is rate-limiting. Mammals

Pathway Diagram:

Ariadne Genomics Inc. S-adenosylmethioninamine ---> methylthioadenosine dimethylglycine ---| Bhmt Srm Sms polyamine metabolic pathway S-adenosylmethionine ---> S-adenosylhomocysteine AdoMet-dependent methyltransferases betaine 5-methyl-THF THF dimethylglycine homocysteine methylthioadenosine spermine metabolic pathway methyl group transfer  to carbon, nitrogen, oxygen or sulfur atoms on proteins, nucleic acids, carbohydrates, lipids, small molecules Cbl ATP ---> S-adenosylmethionine methylthioadenosine ---> 1-phosphomethylthioribose AdoMet radical reactions involved in co-factor and other natural products biosynthesis in anaerobic organisms S-adenosylmethionine ---> S-adenosylmethioninamine spermidine metabolic pathway Mtap S-adenosylmethioninamine 1-phosphomethylthioribose ATP methionine adenosine Mtrr ---> Mtr Mtrr Mat2b ---> Mat2a Mat2b folate cycle metabolic pathway Amd1 S-adenosylhomocysteine ---| AdoMet-dependent methyltransferases homocysteine metabolic pathway diet ---> methionine diet 5-methyl-THF ---> THF adenosine <--> S-adenosylhomocysteine Ahcy Mat2a Mat1a 1-phosphomethylthioribose ---> methionine methionine ---> protein biosynthesis protein biosynthesis methionine ---> S-adenosylmethionine S-adenosylmethionine ---> AdoMet radical reactions involved in co-factor and other natural products biosynthesis in anaerobic organisms Mtr homocysteine <--> S-adenosylhomocysteine folate mediated one-carbon metabolic pathway homocysteine ---> methionine Bhmt betaine ---> dimethylglycine S-adenosylhomocysteine S-adenosylmethionine
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Genes in Pathway:

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methionine cycle/metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahcy adenosylhomocysteinase JBrowse link 3 150,587,833 150,603,057 RGD:730275
RGD:10402751
RGD:7242932
RGD:7242425
G Amd1 adenosylmethionine decarboxylase 1 JBrowse link 20 45,384,000 45,399,694 RGD:7242425
RGD:10402751
RGD:7242932
G As3mt arsenite methyltransferase JBrowse link 1 266,482,787 266,514,570 RGD:625365
G Asmt acetylserotonin O-methyltransferase JBrowse link 12 18,521,383 18,527,036 RGD:1359073
G Bhmt betaine-homocysteine S-methyltransferase JBrowse link 2 23,236,573 23,256,158 RGD:1359026
RGD:10402751
RGD:7242425
G Carm1 coactivator-associated arginine methyltransferase 1 JBrowse link 8 22,577,723 22,622,555 RGD:1359044
RGD:7242552
G Cbs cystathionine beta synthase JBrowse link 20 10,361,987 10,386,663 RGD:10402751
G Chdh choline dehydrogenase JBrowse link 16 6,078,083 6,109,386 RGD:10402751
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:1359089
G Cth cystathionine gamma-lyase JBrowse link 2 264,266,959 264,293,040 RGD:10402751
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:1359078
RGD:10402751
RGD:7242551
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:7242551
G Dnmt3b DNA methyltransferase 3 beta JBrowse link 3 149,131,541 149,170,061 RGD:7242551
G Dot1l DOT1 like histone lysine methyltransferase JBrowse link 7 11,786,105 11,824,742 RGD:1359080
RGD:7242554
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:7242554
G Gamt guanidinoacetate N-methyltransferase JBrowse link 7 12,314,848 12,317,998 RGD:1359081
G Gnmt glycine N-methyltransferase JBrowse link 9 16,565,274 16,568,626 RGD:1359070
RGD:7242551
RGD:7242425
G Hnmt histamine N-methyltransferase JBrowse link 3 905,111 937,038 RGD:1359041
G Icmt isoprenylcysteine carboxyl methyltransferase JBrowse link 5 169,475,270 169,482,031 RGD:1359083
G Il4i1 interleukin 4 induced 1 JBrowse link 1 100,811,727 100,836,901 RGD:10402751
G Kmt5a lysine methyltransferase 5A JBrowse link 12 37,558,150 37,581,183 RGD:7242554
G Mars methionyl-tRNA synthetase JBrowse link 7 70,585,011 70,602,425 RGD:10402751
G Mat1a methionine adenosyltransferase 1A JBrowse link 16 18,690,649 18,709,135 RGD:1359039
RGD:7242932
RGD:7242425
G Mat2a methionine adenosyltransferase 2A JBrowse link 4 100,297,478 100,303,047 RGD:1359040
RGD:10402751
RGD:7242425
G Mat2b methionine adenosyltransferase 2B JBrowse link 10 25,832,096 25,848,045 RGD:7242425
RGD:10402751
G Mrm2 mitochondrial rRNA methyltransferase 2 JBrowse link 12 16,398,749 16,403,656 RGD:1359074
G Msrb2 methionine sulfoxide reductase B2 JBrowse link 17 86,066,841 86,148,131 RGD:10402751
G Msrb3 methionine sulfoxide reductase B3 JBrowse link 7 62,850,506 62,972,487 RGD:10402751
G Mtap methylthioadenosine phosphorylase JBrowse link 5 107,711,077 107,777,530 RGD:7242425
RGD:10402751
RGD:7242932
G Mtfmt mitochondrial methionyl-tRNA formyltransferase JBrowse link 8 70,952,209 70,986,393 RGD:10402751
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:1535021
RGD:10402751
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 17 66,210,444 66,295,014 RGD:1359026
RGD:10402751
RGD:7242426
RGD:7242425
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase JBrowse link 1 37,743,089 37,774,485 RGD:1359037
RGD:7242426
G Nnmt nicotinamide N-methyltransferase JBrowse link 8 52,918,437 52,938,172 RGD:1359084
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 JBrowse link 1 1,734,863 1,767,759 RGD:729481
G Pemt phosphatidylethanolamine N-methyltransferase JBrowse link 10 46,339,821 46,404,640 RGD:729486
G Pnmt phenylethanolamine-N-methyltransferase JBrowse link 10 86,340,893 86,342,501 RGD:1359087
G Prmt1 protein arginine methyltransferase 1 JBrowse link 1 100,971,132 100,980,411 RGD:1359044
RGD:7242552
G Prmt2 protein arginine methyltransferase 2 JBrowse link 20 13,154,513 13,212,613 RGD:7242552
G Prmt3 protein arginine methyltransferase 3 JBrowse link 1 105,113,595 105,200,253 RGD:1359044
RGD:7242552
G Prmt5 protein arginine methyltransferase 5 JBrowse link 15 33,156,508 33,165,893 RGD:1359044
RGD:7242552
G Prmt6 protein arginine methyltransferase 6 JBrowse link 2 213,173,403 213,180,721 RGD:1359044
RGD:7242552
G Prmt7 protein arginine methyltransferase 7 JBrowse link 19 38,189,605 38,237,155 RGD:7242552
G Rnmt RNA (guanine-7-) methyltransferase JBrowse link 18 64,084,746 64,108,246 RGD:1359071
G Setd7 SET domain containing (lysine methyltransferase) 7 JBrowse link 2 140,576,188 140,618,405 RGD:7242554
G Setdb1 SET domain, bifurcated 1 JBrowse link 2 196,495,867 196,527,412 RGD:1359072
G Shmt1 serine hydroxymethyltransferase 1 JBrowse link 10 47,030,813 47,059,216 RGD:10402751
G Sms spermine synthase JBrowse link X 40,363,646 40,415,110 RGD:7242425
G Smyd2 SET and MYND domain containing 2 JBrowse link 13 108,642,156 108,686,293 RGD:7242554
G Srm spermidine synthase JBrowse link 5 165,405,168 165,408,325 RGD:7242425
RGD:10402751
G Suv39h1l1 suppressor of variegation 3-9 homolog 1 (Drosophila)-like 1 JBrowse link X 15,171,280 15,185,191 RGD:7242554
G Suv39h2 suppressor of variegation 3-9 homolog 2 JBrowse link 17 78,762,897 78,782,016 RGD:1359810
RGD:7242554
G Trdmt1 tRNA aspartic acid methyltransferase 1 JBrowse link 17 80,824,652 80,859,585 RGD:1359088

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassAdoMet-dependent methyltransferases

Pathway Gene Annotations

Disease Annotations Associated with Genes in the methionine cycle/metabolic pathway
Disease TermsGene Symbols
abdominal aortic aneurysmMthfr
abetalipoproteinemiaDnmt1
Abortion, HabitualMthfr
ACANTHOCYTOSISDnmt1
acanthosis nigricansPrmt7
acute kidney failureMthfr
acute lymphocytic leukemiaEzh2
acute monocytic leukemiaDnmt3a
acute myeloid leukemiaDnmt1 , Dnmt3a , Dnmt3b , Ezh2 , Mthfr , Mtrr
Acute PainComt
acute promyelocytic leukemiaDnmt3a
adenocarcinomaDnmt1
adenomaMtrr
AlbuminuriaMthfr
alcohol use disorderComt
Alcoholic Fatty LiverDnmt1 , Pemt
allergic hypersensitivity diseaseMthfr
alopeciaMthfr
alopecia areataDnmt1
Alzheimer's diseaseMthfr , Pcmt1 , Pnmt
amino acid metabolic disorderAhcy , Cth , Gamt , Mat1a
amphetamine abuseComt
amyotrophic lateral sclerosisDnmt3a , Mthfr
anemiaMthfr
anencephalyMtrr
angle-closure glaucomaMthfr
Animal Disease ModelsAhcy , Shmt1 , Srm
anxiety disorderDnmt1 , Dnmt3b
Aortic CoarctationMthfr
Aortic InjuriesPcmt1
aphthous stomatitisMthfr
Arakawa Syndrome 2Mtr
Arsenic PoisoningAs3mt , Mthfr
Arterial Occlusive DiseasesMthfr
asthmaCarm1 , Dnmt1 , Hnmt , Mthfr , Prmt1 , Prmt2 , Prmt3 , Prmt5
astrocytomaPcmt1
AtaxiaDnmt1
atherosclerosisMthfr
atopic dermatitisHnmt
attention deficit hyperactivity disorderAs3mt , Comt , Mthfr
autism spectrum disorderComt , Dnmt3a , Dnmt3b
autistic disorderAsmt , Comt , Mthfr , Mtr , Setdb1
Autoimmune DiseasesDnmt1
autoimmune thrombocytopenic purpuraDnmt3a , Dnmt3b
autosomal dominant cerebellar ataxia, deafness and narcolepsyDnmt1
autosomal recessive nonsyndromic deafness 74Msrb3
B- and T-cell mixed leukemiaDot1l
B-cell lymphomaEzh2
Beckwith-Wiedemann syndromeDnmt1
biliary tract neoplasmMtap
Binge DrinkingDnmt1
bipolar disorderComt , Mthfr
Birth WeightAs3mt
bone marrow diseaseDnmt3a
brain diseaseMat1a
brain infarctionHnmt
Brain InjuriesComt , Dnmt1
brain ischemiaMthfr
Breast NeoplasmsCarm1 , Comt , Dnmt1 , Dnmt3a , Dnmt3b , Ezh2 , Mthfr , Mtr , Shmt1
Bronchial HyperreactivityHnmt
bronchiolo-alveolar adenocarcinomaDnmt1
Budd-Chiari syndromeMthfr
bulimia nervosaComt
CarcinogenesisDnmt1 , Dnmt3a
carcinomaDnmt1 , Dnmt3b
Cardiomyopathy, Hypertrophic, FamilialComt
cardiovascular system diseaseCbs , Mthfr
carotid stenosisMthfr
CatalepsyComt
cataractCth , Mthfr
catecholaminergic polymorphic ventricular tachycardiaMtr
central core myopathyCbs
cerebellar ataxiaDnmt1
cerebral creatine deficiency syndromeGamt
cerebral infarctionMthfr
cervix uteri carcinoma in situMthfr
Charcot-Marie-Tooth diseaseMars
Charcot-Marie-Tooth disease axonal type 2UMars
Chemical and Drug Induced Liver InjuryMat1a , Mthfr
Child Behavior DisordersComt
cholangiocarcinomaMthfr
choline deficiency diseaseDnmt1
choreatic diseaseDnmt1
Chromosome 17, Trisomy 17p11 2Pemt , Shmt1
chronic kidney diseaseMthfr
Chronic Lymphocytic Leukemia, B-CellDnmt3b , Mthfr
chronic myeloid leukemiaDnmt1 , Dnmt3a , Dnmt3b , Mthfr
chronic myelomonocytic leukemiaEzh2
Ciliary Motility DisordersCbs
clear cell renal cell carcinomaDnmt1 , Dnmt3a , Mthfr
cleft lipMthfr , Mtr
cleft palateMtr
clubfootMthfr
Cocaine-Related DisordersComt , Prmt6
Cognition DisordersComt
Colonic NeoplasmsDnmt1 , Mthfr
colorectal adenocarcinomaDnmt3b
Colorectal NeoplasmsDnmt1 , Dnmt3b , Mthfr , Mtrr
combined oxidative phosphorylation deficiencyMtfmt
Combined Oxidative Phosphorylation Deficiency 15Mtfmt
common bile duct neoplasmMtap
congenital heart diseaseDnmt1 , Dnmt3a , Dnmt3b , Mthfr
congestive heart failureDnmt1 , Pcmt1
Conotruncal Cardiac DefectsMthfr
ContusionsPnmt
coronary artery diseaseCbs , Mthfr
Coronary DiseaseMthfr
coronary restenosisMthfr
Craniofacial AbnormalitiesDnmt3a , Dnmt3b
craniosynostosisEzh2
Crohn's diseaseDnmt3a , Mthfr
Cutaneous Malignant Melanoma, Susceptibility To, 1Ezh2
cutaneous T cell lymphomaDnmt3a
cystathioninuriaCth
Deglutition DisordersDnmt1
dementiaDnmt1
demyelinating diseaseMat1a
Developmental DisabilitiesAs3mt
dextro-looped transposition of the great arteriesMthfr
diabetic angiopathyMthfr
Diabetic NephropathiesMthfr , Mtrr , Prmt1
diabetic retinopathyMthfr
Diaphyseal Medullary Stenosis with Malignant Fibrous HistiocytomaMtap
diffuse large B-cell lymphomaEzh2 , Mthfr
DiGeorge syndromeComt
dilated cardiomyopathyComt
dilated cardiomyopathy 1ADot1l
dilated cardiomyopathy 1AAMtr
disease of mental healthComt
Down syndromeHnmt , Mthfr , Mtrr
drug allergyHnmt
Drug EruptionsMthfr
Drug-Induced DyskinesiaComt
Drug-Related Side Effects and Adverse ReactionsMthfr , Mtr , Mtrr , Shmt1
DysarthriaDnmt1
DysmenorrheaDnmt3b
end stage renal failureMthfr
Endometrial NeoplasmsComt , Dnmt1 , Dnmt3b , Ezh2 , Mthfr
Endometrioid CarcinomasDnmt1 , Dnmt3b
endometriosisDnmt1 , Dnmt3a , Dnmt3b
endometriosis of uterusDnmt1 , Dnmt3a , Dnmt3b
epilepsyMtr
Esophageal NeoplasmsSmyd2
esophagus squamous cell carcinomaDnmt3b
essential hypertensionPnmt
essential tremorHnmt
eumycotic mycetomaComt
Experimental ArthritisAhcy , Dnmt1
Experimental Autoimmune EncephalomyelitisComt
Experimental Diabetes MellitusComt , Ezh2 , Mthfr , Mtr , Pemt , Pnmt
extrahepatic cholestasisSetd7
eye diseaseMthfr
FaciesDnmt3a
factor VIII deficiencyMthfr
FatigueComt
fatty liver diseaseMat1a , Mthfr
Female InfertilityMthfr
Fetal Growth RetardationComt , Cth , Dnmt1 , Dnmt3b
fibromyalgiaComt
follicular lymphomaEzh2 , Mthfr , Mtr
Gastrointestinal DiseasesMthfr , Mtr
gastrointestinal stromal tumorMthfr , Mtr , Mtrr , Shmt1
genetic diseaseAhcy , Dnmt3a , Ezh2 , Mtr , Mtrr , Sms
Glandular and Epithelial NeoplasmsAs3mt
glomerulonephritisMthfr
glycine N-methyltransferase deficiencyGnmt
Graft vs Host DiseaseMthfr
Graves' diseaseDnmt1 , Mthfr
Growth DisordersDnmt3a
guanidinoacetate methyltransferase deficiencyGamt
head and neck squamous cell carcinomaDnmt3b
Hearing LossDnmt1 , Msrb3 , Mthfr , Mtr
Hearing Loss, Cisplatin-Induced, Susceptibility ToComt
Hearing Loss, SuddenMthfr , Mtr
heart diseaseMtr , Mtrr
heart septal defectMtrr
Hematologic NeoplasmsMthfr
hematopoietic system diseaseMthfr , Mtr
HepatitisGnmt
Hepatitis, ChronicGnmt
hepatocellular adenomaCarm1
hepatocellular carcinomaCarm1 , Comt , Dnmt1 , Dnmt3a , Dnmt3b , Ezh2 , Gnmt , Mat1a
hereditary sensory and autonomic neuropathy, type IEDnmt1
hereditary sensory neuropathyDnmt1
hereditary sensory neuropathy type 1EDnmt1
hereditary spastic paraplegiaMars
hereditary spastic paraplegia 35Cbs
homocystinuriaCbs , Mthfr , Mtrr
Homocystinuria, Pyridoxine-ResponsiveCbs
Homocystinuria-Megaloblastic Anemia due to Defect in Cobalamin Metabolism, CblE Complementation TypeMtrr
Huntington's diseaseHnmt , Setdb1
HyperalgesiaComt , Dnmt1
hyperhomocysteinemiaAhcy , Cbs , Cth , Gnmt , Mthfr , Mtr , Mtrr
hypermethioninemiaAhcy , Gnmt , Mat1a
hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolaseAhcy
HyperplasiaMat1a
hypertensionAhcy , Cbs , Comt , Mtr , Pnmt
hyperthyroidismMthfr
Hypertrophy, Left VentricularEzh2
hypoglycemiaPnmt
hypopituitarismMthfr
hypothyroidismMthfr
HypoxiaAhcy
Hypoxia-Ischemia, BrainDnmt3a
IgA glomerulonephritisMtr
Immunoblastic LymphadenopathyDnmt3a
immunodeficiency-centromeric instability-facial anomalies syndromeDnmt3b
immunodeficiency-centromeric instability-facial anomalies syndrome 1Dnmt3b
Infantile Liver Failure Syndrome 2Mars
inflammatory bowel diseaseMthfr
inherited blood coagulation diseaseMthfr
inherited metabolic disorderMtr , Mtrr
intellectual disabilityDnmt3a , Gamt
intracranial sinus thrombosisMthfr
invasive ductal carcinomaEzh2
ischemiaMthfr
juvenile myelomonocytic leukemiaDnmt3a , Ezh2
Kabuki syndromeDnmt3b
kidney diseaseMthfr
kidney failureMthfr
Kuhnt-Junius degenerationMthfr
Leigh diseaseGamt , Mtfmt
Leigh Syndrome Due To Mitochondrial Complex I DeficiencyMtfmt
leiomyomaComt , Ezh2
LeukoencephalopathiesMthfr , Mtr
leukopeniaMthfr
Leydig cell tumorPrmt5
liver cirrhosisDnmt1
liver diseaseMthfr
liver neoplasmGnmt , Mthfr
Liver Neoplasms, ExperimentalPemt
lung adenocarcinomaAhcy , Dnmt3a , Dnmt3b , Dot1l , Shmt1 , Srm
Lung NeoplasmsDnmt1 , Dnmt3a , Dnmt3b , Mthfr , Setdb1
lung small cell carcinomaDnmt3b , Mthfr
Lymphatic MetastasisComt , Dnmt3b
lymphomaEzh2 , Mthfr , Mtr
male infertilityMthfr , Mtr , Mtrr
malignant gliomaPcmt1 , Setdb1
malignant mesotheliomaSetdb1
MalnutritionCbs , Mthfr , Mtr
Mammary Neoplasms, AnimalComt
Mammary Neoplasms, ExperimentalDnmt3b
Maxillofacial AbnormalitiesMthfr
medulloblastomaDnmt1
Megakaryoblastic Leukemia of Down SyndromeEzh2
megakaryocytic leukemiaEzh2
melanomaCbs , Cth , Ezh2 , Mtap , Setdb1
Memory DisordersComt
Meniere's diseaseMthfr
meningiomaMtrr
mental depressionDnmt3a , Mthfr
Mental Retardation, Autosomal Recessive 51Hnmt
Methylenetetrahydrofolate Reductase DeficiencyMthfr
methylmalonic aciduria and homocystinuria type cblGMtr
Microsatellite InstabilityMthfr
Microvascular AnginaMthfr
middle cerebral artery infarctionDnmt1 , Dnmt3a
migraineMthfr
migraine with auraMthfr
mitochondrial complex I deficiencyGamt
Mthfr Deficiency, Thermolabile TypeMthfr
mucoepidermoid carcinomaDnmt1
mucositisMthfr
Multiple AbnormalitiesDnmt3a
multiple myelomaMthfr , Mtr , Mtrr
multiple sclerosisPnmt
Musculoskeletal PainComt
myelodysplastic syndromeDnmt3a , Ezh2 , Mtrr
myelodysplastic/myeloproliferative neoplasmEzh2
myelofibrosisEzh2
myeloid neoplasmEzh2 , Mthfr
myelomeningoceleMthfr
myocardial infarctionMthfr
NecrosisMthfr
Neoplasm InvasivenessDnmt1
Neoplasm MetastasisDnmt3b , Mthfr
Neoplasm Recurrence, LocalDnmt3a
Neoplasms, Multiple PrimaryDnmt3b
nephroblastomaMthfr
nephrosclerosisMthfr
nervous system diseaseMthfr , Mtrr , Shmt1
neural tube defectBhmt , Cbs , Mthfr , Mtr , Mtrr
Neural Tube Defect, Folate-SensitiveMthfr , Mtr , Mtrr
neurodegeneration with brain iron accumulation 2ACbs
neutropeniaMthfr
NevusMtap
non-arteritic anterior ischemic optic neuropathyMthfr
non-Hodgkin lymphomaBhmt , Cbs , Ezh2 , Mthfr , Mtrr , Shmt1
nonalcoholic fatty liver diseaseEzh2
nonsyndromic deafnessMsrb3
obesityComt
obsessive-compulsive disorderComt
open-angle glaucomaMthfr
Oral Lichen PlanusDnmt1 , Dnmt3b
oral squamous cell carcinomaDnmt3b , Mthfr
osteogenesis imperfecta type 4Cbs
osteonecrosisMthfr
osteosarcomaEzh2 , Mthfr
Ovarian NeoplasmsComt , Dnmt1 , Shmt1
PainComt
pancreatic cancerEzh2 , Mtap , Mthfr , Mtr , Mtrr
pancreatic ductal carcinomaDnmt1 , Dnmt3b
Pancreatic Intraepithelial NeoplasiaDnmt1
panic disorderComt
Parkinson's diseaseHnmt , Mtrr
Parkinsonian DisordersComt
peripheral artery diseaseMthfr
peripheral T-cell lymphomaDnmt3a
Peritoneal FibrosisDnmt1
phaeochromocytomaComt
Pick's diseaseHnmt
placental abruptionBhmt
polycystic ovary syndromeComt
pre-eclampsiaComt
precursor lymphoblastic lymphoma/leukemiaDnmt3a , Mthfr , Mtr , Mtrr
precursor T-lymphoblastic lymphoma/leukemiaDnmt3a , Ezh2
primary ciliary dyskinesiaCbs
primary immunodeficiency diseaseDnmt3b
progressive myoclonus epilepsyCbs
prostate adenocarcinomaDnmt1 , Dnmt3a , Dnmt3b
prostate cancerKmt5a , Mthfr
prostate carcinoma in situCarm1 , Dnmt1
Prostatic NeoplasmsCarm1 , Comt , Dnmt1 , Dnmt3b , Ezh2 , Gnmt , Mtap , Mthfr , Setdb1
prostatitisDnmt3a , Dnmt3b
psoriasisCarm1 , Comt
pulmonary alveolar proteinosisMars
pulmonary embolismMthfr
pyridoxine deficiency anemiaAhcy
rectal neoplasmMthfr
renal artery diseaseMthfr
renal cell carcinomaComt , Mthfr , Nnmt
Reperfusion InjuryPnmt
retinal diseaseMthfr
Retinal NeovascularizationCth
retinal vein occlusionMthfr
retinoblastomaMtr
Rett syndromeSetdb1
rheumatoid arthritisDnmt1 , Dnmt3b , Mthfr , Sms
rhinitisHnmt
schizophreniaComt , Dnmt1 , Dnmt3b , Hnmt , Mthfr , Setdb1
Schizophrenia Spectrum and Other Psychotic DisordersComt
sciatic neuropathyDnmt3a
seminomaPrmt5
Sezary's diseaseDnmt3a
SHORT STATURE, BRACHYDACTYLY, INTELLECTUAL DEVELOPMENTAL DISABILITY, AND SEIZURESPrmt7
sickle cell anemiaMthfr
skin diseaseMthfr
skin melanomaDnmt3b
Skin/Hair/Eye Pigmentation, Variation In, 9Ahcy
Smith-Magenis syndromePnmt , Shmt1 , Sms
spina bifidaMthfr , Mtr , Mtrr , Pcmt1
spinal cord diseaseMthfr
squamous cell carcinomaMthfr
Stomach NeoplasmsDnmt1 , Dnmt3a , Dnmt3b , Mthfr
Striatonigral Degeneration InfantileIl4i1
StrokeMthfr
syndromic X-linked intellectual disability Snyder typeSms
systemic lupus erythematosusDnmt1
TATTON-BROWN-RAHMAN SYNDROMEDnmt3a
Temporomandibular Joint DisordersComt , Mtrr
tetralogy of FallotMthfr
thoracic aortic aneurysmCbs , Mat2a
thrombocytopeniaMthfr
thrombophiliaMthfr
thrombosisMthfr
Thrombotic MicroangiopathiesMthfr
thymomaDnmt3b
thyrotoxicosisMthfr
transitional cell carcinomaMthfr
type 1 diabetes mellitusDnmt3b , Mthfr
type 2 diabetes mellitusBhmt , Cbs , Dnmt1 , Mat1a , Mthfr , Mtr
ulcerative colitisHnmt , Mtrr
Upper Extremity Deformities, CongenitalEzh2
uremiaComt
urinary bladder cancerAs3mt , Comt , Dnmt1 , Mthfr , Mtr
urticariaHnmt
Uterine Cervical NeoplasmsDnmt1 , Dnmt3b , Mthfr
Vascular CalcificationMthfr
vascular diseaseMthfr
Venous ThromboembolismMthfr
Venous ThrombosisComt , Mthfr
visual epilepsyGamt
vitamin B12 deficiencyMtr
vitiligoComt
Weaver syndromeEzh2
Wilson diseaseAhcy , Asmt , Bhmt
Pathway Annotations Associated with Genes in the methionine cycle/metabolic pathway
Pathway TermsGene Symbols
5'-end pre-mRNA capping pathwayRnmt
AGAT deficiency pathwayGamt
alkaptonuria pathwayComt , Pnmt
altered folate cycle metabolic pathwayMthfr , Mtr , Mtrr
altered folate mediated one-carbon metabolic pathwayMthfr , Mtr
aminoacyl-tRNA biosynthetic pathwayMars , Mtfmt
androgen signaling pathwayCarm1 , Prmt1
arginine and proline metabolic pathwayAmd1 , Gamt , Srm
aromatic L-amino acid decarboxylase deficiency pathwayPnmt
beta-alanine metabolic pathwaySrm
Canavan disease pathwayIl4i1
carnitine biosynthetic pathwaySetd7 , Shmt1
catecholamine biosynthetic pathwayPnmt
choline metabolic pathwayAhcy , Bhmt , Chdh , Mat2a , Mat2b , Mtr , Pemt
creatine metabolic pathwayGamt
cyanoamino acid metabolic pathwayShmt1
cystathioninuria pathwayCbs , Cth
cysteine and methionine metabolic pathwayAhcy , Amd1 , Bhmt , Cbs , Cth , Dnmt1 , Dnmt3a , Dnmt3b , Mat1a , Mat2a , Mat2b , Mtap , Mtr , Srm , Trdmt1
cysteine metabolic pathwayCbs , Cth
dihydropyrimidine dehydrogenase deficiency pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
dimethylglycine dehydrogenase deficiency pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
disulfiram pharmacodynamics pathwayComt , Pnmt
DNA modification pathwayDnmt1 , Dnmt3a , Dnmt3b
dopamine beta-hydroxylase deficiency pathwayComt , Pnmt
epinephrine biosynthetic pathwayPnmt
estrogen signaling pathwayCarm1 , Prmt1
folate cycle metabolic pathwayMthfr , Mtr , Mtrr , Shmt1
folate mediated one-carbon metabolic pathwayGnmt , Mtfmt , Mthfr , Mtr , Mtrr , Shmt1
folate metabolic pathwayGnmt , Mtfmt , Mthfr , Mtr , Mtrr , Shmt1
glutathione metabolic pathwaySrm
glycerophospholipid metabolic pathwayPemt
glycine metabolic pathwayShmt1
glycine N-methyltransferase deficiency pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
glycine, serine and threonine metabolic pathwayBhmt , Cbs , Chdh , Cth , Gamt , Gnmt , Shmt1
guanidinoacetate methyltransferase deficiency pathwayGamt
gyrate atrophy pathwayGamt
hawkinsinuria pathwayComt , Pnmt
hereditary folate malabsorption pathwayMtfmt , Mthfr
histidine metabolic pathwayHnmt , Prmt3
histidinemia pathwayHnmt , Prmt3
histone modification pathwayCarm1 , Dot1l , Ezh2 , Prmt1 , Prmt2 , Prmt5 , Prmt7 , Setd7 , Smyd2 , Suv39h2
homocysteine metabolic pathwayAhcy , As3mt , Asmt , Carm1 , Comt , Dnmt1 , Dot1l , Gamt , Gnmt , Hnmt , Icmt , Mrm2 , Mthfr , Nnmt , Pcmt1 , Pemt , Pnmt , Prmt1 , Prmt3 , Prmt5 , Prmt6 , Rnmt , Setdb1 , Suv39h2 , Trdmt1
homocystinuria pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
hypermethioninemia pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
hypermethioninemia pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
hyperprolinemia type I pathwayGamt
hyperprolinemia type II pathwayGamt
lysine degradation pathwayDot1l , Kmt5a , Setd7 , Setdb1 , Suv39h1l1 , Suv39h2
mercaptolactate-cysteine disulfiduria pathwayCth
methionine cycle/metabolic pathwayAhcy , Amd1 , As3mt , Asmt , Bhmt , Carm1 , Cbs , Chdh , Comt , Cth , Dnmt1 , Dnmt3a , Dnmt3b , Dot1l , Ezh2 , Gamt , Gnmt , Hnmt , Icmt , Il4i1 , Kmt5a , Mars , Mat1a , Mat2a , Mat2b , Mrm2 , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Mtrr , Nnmt , Pcmt1 , Pemt , Pnmt , Prmt1 , Prmt2 , Prmt3 , Prmt5 , Prmt6 , Prmt7 , Rnmt , Setd7 , Setdb1 , Shmt1 , Sms , Smyd2 , Srm , Suv39h1l1 , Suv39h2 , Trdmt1
methotrexate pharmacodynamics pathwayMtfmt , Mthfr
methylenetetrahydrofolate reductase deficiency pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
monoterpenoid biosynthetic pathwayNnmt
mRNA decay pathwayRnmt
niacin metabolic pathwayNnmt
nonketotic hyperglycinemia pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
ocular nonnephropathic cystinosis pathwayCth
ornithine translocase deficiency pathwayGamt
p53 signaling pathwayPrmt5 , Setd7 , Smyd2
phenylketonuria pathwayIl4i1
phenytoin pharmacodynamics pathwayComt
polyamine metabolic pathwayAmd1 , Sms , Srm
prolidase deficiency pathwayGamt
putrescine metabolic pathwayAmd1
remethylation pathway of homocysteine metabolism - cobalamin dependentMthfr , Mtr , Mtrr
remethylation pathway of homocysteine metabolism - cobalamin independent, betaine dependentAhcy , Bhmt , Chdh , Mat2a , Mat2b , Mtr , Pemt
RNA transport pathwayPrmt5
sarcosinemia pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
selenoamino acid metabolic pathwayAhcy , Cbs , Cth , Mars , Mat2a , Mat2b , Mtr
spermidine metabolic pathwayAmd1 , Mat2a , Mat2b , Sms , Srm
spermine metabolic pathwayAmd1 , Mat2a , Mat2b , Sms , Srm
steroid hormone biosynthetic pathwayComt
transsulfuration pathway of homocysteine metabolismCbs , Cth
tryptophan metabolic pathwayAsmt
tyrosine metabolic pathwayComt , Pnmt
tyrosinemia type I pathwayComt , Pnmt
tyrosinemia type II pathwayIl4i1
tyrosinemia type III pathwayIl4i1
Wnt signaling, non-canonical pathwaySetdb1
Phenotype Annotations Associated with Genes in the methionine cycle/metabolic pathway

References Associated with the methionine cycle/metabolic pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: