Eci3 (enoyl-Coenzyme A delta isomerase 3) - Rat Genome Database

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Gene: Eci3 (enoyl-Coenzyme A delta isomerase 3) Rattus norvegicus
No known orthologs.
Symbol: Eci3
Name: enoyl-Coenzyme A delta isomerase 3
RGD ID: 1310224
Description: Predicted to enable catalytic activity and fatty-acyl-CoA binding activity.
Type: protein-coding
Previously known as: hypothetical protein LOC291076; LOC291076; MGC108813; RGD1310224; similar to RIKEN cDNA 1810022C23
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21729,921,962 - 29,943,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1729,921,977 - 29,943,862 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1729,742,730 - 29,764,519 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01731,346,474 - 31,368,263 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01729,738,453 - 29,760,242 (+)NCBIRnor_WKY
Rnor_6.01730,617,382 - 30,639,068 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1730,556,884 - 30,639,040 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01732,517,301 - 32,539,061 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41736,253,004 - 36,274,899 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11736,255,844 - 36,277,739 (+)NCBI
Celera1729,492,074 - 29,513,890 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:24344334  



Variants in Eci3
75 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21729,942,533 - 29,943,712 (+)MAPPERmRatBN7.2
Rnor_6.01730,637,739 - 30,638,917NCBIRnor6.0
Rnor_5.01732,537,732 - 32,538,910UniSTSRnor5.0
RGSC_v3.41736,273,570 - 36,274,748UniSTSRGSC3.4
Celera1729,512,561 - 29,513,739UniSTS
RH 3.4 Map17372.4UniSTS
Cytogenetic Map17p12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 36 11 8
Low 5
Below cutoff


Reference Sequences
RefSeq Acc Id: NM_001009275   ⟹   NP_001009275
Rat AssemblyChrPosition (strand)Source
mRatBN7.21729,922,037 - 29,943,863 (+)NCBI
Rnor_6.01730,617,382 - 30,639,068 (+)NCBI
Rnor_5.01732,517,301 - 32,539,061 (+)NCBI
RGSC_v3.41736,253,004 - 36,274,899 (+)RGD
Celera1729,492,074 - 29,513,890 (+)RGD
RefSeq Acc Id: XM_039095485   ⟹   XP_038951413
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21729,921,966 - 29,943,863 (+)NCBI
RefSeq Acc Id: XM_039095486   ⟹   XP_038951414
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21729,921,962 - 29,943,864 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001009275 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951413 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951414 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88178 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001009275   ⟸   NM_001009275
- UniProtKB: Q5M884 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038951414   ⟸   XM_039095486
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038951413   ⟸   XM_039095485
- Peptide Label: isoform X1


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700406
Promoter ID:EPDNEW_R10929
Type:initiation region
Description:enoyl-CoA delta isomerase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_R10928  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01730,617,376 - 30,617,436EPDNEW

Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-9620 BioCyc
Ensembl Genes ENSRNOG00000029549 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000050206 ENTREZGENE
  ENSRNOP00000050206.2 UniProtKB/TrEMBL
  ENSRNOP00000072135.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048923 ENTREZGENE
  ENSRNOT00000048923.5 UniProtKB/TrEMBL
  ENSRNOT00000080929.2 UniProtKB/TrEMBL
InterPro Acyl-CoA-binding_sf UniProtKB/TrEMBL
  ClpP/crotonase-like_dom UniProtKB/TrEMBL
  Crontonase_C UniProtKB/TrEMBL
  Crotonase_core UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_3-hlx UniProtKB/TrEMBL
KEGG Report rno:291076 UniProtKB/TrEMBL
PhenoGen Eci3 PhenoGen
Superfamily-SCOP SSF47027 UniProtKB/TrEMBL
  SSF52096 UniProtKB/TrEMBL
UniProt A0A0G2K277_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-03-17 Eci3  enoyl-Coenzyme A delta isomerase 3  RGD1310224  similar to RIKEN cDNA 1810022C23  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1310224  similar to RIKEN cDNA 1810022C23  RGD1310224_predicted  similar to RIKEN cDNA 1810022C23 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310224_predicted  similar to RIKEN cDNA 1810022C23 (predicted)  LOC291076_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC291076_predicted  similar to RIKEN cDNA 1810022C23 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL