Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pak1ip1 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PAK1IP1 mRNA] | CTD | PMID:31150632 | Pak1ip1 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Pak1ip1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PAK1IP1 mRNA | CTD | PMID:36331819 | Pak1ip1 | Rat | 1,2-dimethylhydrazine | affects expression | ISO | Pak1ip1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine affects the expression of PAK1IP1 mRNA | CTD | PMID:22206623 | Pak1ip1 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Pak1ip1 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of PAK1IP1 mRNA | CTD | PMID:17555576 | Pak1ip1 | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Pak1ip1 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of PAK1IP1 mRNA | CTD | PMID:17942748 | Pak1ip1 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of PAK1IP1 mRNA | CTD | PMID:26496021 | Pak1ip1 | Rat | 17beta-estradiol | increases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Estradiol results in increased expression of PAK1IP1 mRNA | CTD | PMID:31614463 | Pak1ip1 | Rat | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of PAK1IP1 mRNA | CTD | PMID:29581250 | Pak1ip1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Pak1ip1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PAK1IP1 mRNA | CTD | PMID:16611356 | Pak1ip1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PAK1IP1 mRNA | CTD | PMID:33387578 | Pak1ip1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PAK1IP1 mRNA | CTD | PMID:21632981 | Pak1ip1 | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of PAK1IP1 mRNA | CTD | PMID:30851411 | Pak1ip1 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PAK1IP1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PAK1IP1 mRNA | CTD | PMID:28628672 | Pak1ip1 | Rat | 4,4'-sulfonyldiphenol | affects expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | bisphenol S affects the expression of PAK1IP1 protein | CTD | PMID:31945527 | Pak1ip1 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of PAK1IP1 mRNA | CTD | PMID:30047161 | Pak1ip1 | Rat | all-trans-retinoic acid | decreases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PAK1IP1 mRNA | CTD | PMID:33167477 | Pak1ip1 | Rat | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of PAK1IP1 mRNA | CTD | PMID:30047161 | Pak1ip1 | Rat | Aroclor 1254 | decreases expression | ISO | Pak1ip1 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of PAK1IP1 mRNA | CTD | PMID:23650126 | Pak1ip1 | Rat | atrazine | decreases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of PAK1IP1 mRNA | CTD | PMID:22378314 | Pak1ip1 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of PAK1IP1 mRNA | CTD | PMID:26496021 | Pak1ip1 | Rat | bisphenol A | decreases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PAK1IP1 mRNA | CTD | PMID:29275510 | Pak1ip1 | Rat | bisphenol A | affects expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | bisphenol A affects the expression of PAK1IP1 mRNA | CTD | PMID:30903817 | Pak1ip1 | Rat | bisphenol A | multiple interactions | ISO | PAK1IP1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PAK1IP1 mRNA | CTD | PMID:28628672 | Pak1ip1 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PAK1IP1 gene | CTD | PMID:28505145 | Pak1ip1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PAK1IP1 mRNA | CTD | PMID:25181051 | Pak1ip1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PAK1IP1 mRNA | CTD | PMID:26982218 | Pak1ip1 | Rat | butanal | increases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of PAK1IP1 mRNA | CTD | PMID:26079696 | Pak1ip1 | Rat | caffeine | decreases phosphorylation | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of PAK1IP1 protein | CTD | PMID:35688186 | Pak1ip1 | Rat | calcitriol | increases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of PAK1IP1 mRNA | CTD | PMID:21592394 | Pak1ip1 | Rat | calcitriol | multiple interactions | ISO | PAK1IP1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of PAK1IP1 mRNA | CTD | PMID:21592394 | Pak1ip1 | Rat | CGP 52608 | multiple interactions | ISO | PAK1IP1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PAK1IP1 gene] | CTD | PMID:28238834 | Pak1ip1 | Rat | cisplatin | multiple interactions | ISO | PAK1IP1 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of PAK1IP1 mRNA | CTD | PMID:27392435 | Pak1ip1 | Rat | cobalt dichloride | decreases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of PAK1IP1 mRNA | CTD | PMID:19320972 | Pak1ip1 | Rat | copper(II) sulfate | increases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of PAK1IP1 mRNA | CTD | PMID:19549813 | Pak1ip1 | Rat | crocidolite asbestos | decreases expression | ISO | Pak1ip1 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of PAK1IP1 mRNA | CTD | PMID:29279043 | Pak1ip1 | Rat | cyclosporin A | increases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PAK1IP1 mRNA | CTD | PMID:20106945 and PMID:25562108 | Pak1ip1 | Rat | cylindrospermopsin | increases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | cylindrospermopsin results in increased expression of PAK1IP1 mRNA | CTD | PMID:24921660 | Pak1ip1 | Rat | DDE | increases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in increased expression of PAK1IP1 mRNA | CTD | PMID:38568856 | Pak1ip1 | Rat | dexamethasone | multiple interactions | ISO | PAK1IP1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PAK1IP1 mRNA | CTD | PMID:28628672 | Pak1ip1 | Rat | dibenzo[a,l]pyrene | decreases expression | ISO | Pak1ip1 (Mus musculus) | 6480464 | dibenzo(a and l)pyrene results in decreased expression of PAK1IP1 mRNA | CTD | PMID:25908611 | Pak1ip1 | Rat | Dibutyl phosphate | affects expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PAK1IP1 mRNA | CTD | PMID:37042841 | Pak1ip1 | Rat | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of PAK1IP1 mRNA | CTD | PMID:21266533 | Pak1ip1 | Rat | dicrotophos | decreases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of PAK1IP1 mRNA | CTD | PMID:28302478 | Pak1ip1 | Rat | dioxygen | multiple interactions | EXP | | 6480464 | [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression of PAK1IP1 mRNA | CTD | PMID:33729688 | Pak1ip1 | Rat | doxorubicin | increases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of PAK1IP1 mRNA | CTD | PMID:29803840 | Pak1ip1 | Rat | ethanol | increases expression | ISO | Pak1ip1 (Mus musculus) | 6480464 | Ethanol results in increased expression of PAK1IP1 mRNA | CTD | PMID:30319688 | Pak1ip1 | Rat | ethyl methanesulfonate | decreases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of PAK1IP1 mRNA | CTD | PMID:23649840 | Pak1ip1 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of PAK1IP1 mRNA | CTD | PMID:24136188 | Pak1ip1 | Rat | FR900359 | decreases phosphorylation | ISO | PAK1IP1 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of PAK1IP1 protein | CTD | PMID:37730182 | Pak1ip1 | Rat | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of PAK1IP1 mRNA | CTD | PMID:24136188 | Pak1ip1 | Rat | hydrogen peroxide | affects expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of PAK1IP1 mRNA | CTD | PMID:20044591 | Pak1ip1 | Rat | hypochlorous acid | increases expression | ISO | Pak1ip1 (Mus musculus) | 6480464 | Hypochlorous Acid results in increased expression of PAK1IP1 mRNA | CTD | PMID:19376150 | Pak1ip1 | Rat | indometacin | multiple interactions | ISO | PAK1IP1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PAK1IP1 mRNA | CTD | PMID:28628672 | Pak1ip1 | Rat | isobutanol | multiple interactions | ISO | PAK1IP1 (Homo sapiens) | 6480464 | [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of PAK1IP1 mRNA | CTD | PMID:29432896 | Pak1ip1 | Rat | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of PAK1IP1 mRNA | CTD | PMID:30047161 | Pak1ip1 | Rat | methyl methanesulfonate | decreases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of PAK1IP1 mRNA | CTD | PMID:23649840 | Pak1ip1 | Rat | N-methyl-4-phenylpyridinium | decreases expression | ISO | Pak1ip1 (Mus musculus) | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of PAK1IP1 protein | CTD | PMID:26558463 | Pak1ip1 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PAK1IP1 mRNA | CTD | PMID:25729387 | Pak1ip1 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of PAK1IP1 mRNA | CTD | PMID:33387578 | Pak1ip1 | Rat | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of PAK1IP1 mRNA | CTD | PMID:32680482 | Pak1ip1 | Rat | pentachlorophenol | increases expression | ISO | Pak1ip1 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of PAK1IP1 mRNA | CTD | PMID:23892564 | Pak1ip1 | Rat | perfluorononanoic acid | increases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in increased expression of PAK1IP1 mRNA | CTD | PMID:32588087 | Pak1ip1 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Pak1ip1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PAK1IP1 mRNA | CTD | PMID:36331819 | Pak1ip1 | Rat | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of PAK1IP1 mRNA | CTD | PMID:35163327 | Pak1ip1 | Rat | permethrin | increases expression | EXP | | 6480464 | Permethrin results in increased expression of PAK1IP1 mRNA | CTD | PMID:19017407 | Pak1ip1 | Rat | phenobarbital | affects expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of PAK1IP1 mRNA | CTD | PMID:19159669 | Pak1ip1 | Rat | pirinixic acid | multiple interactions | ISO | PAK1IP1 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PAK1IP1 mRNA | CTD | PMID:19710929 | Pak1ip1 | Rat | progesterone | decreases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Progesterone results in decreased expression of PAK1IP1 mRNA | CTD | PMID:18037150 | Pak1ip1 | Rat | rac-lactic acid | decreases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of PAK1IP1 mRNA | CTD | PMID:30851411 | Pak1ip1 | Rat | resveratrol | multiple interactions | ISO | PAK1IP1 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of PAK1IP1 mRNA | CTD | PMID:23557933 | Pak1ip1 | Rat | sodium arsenite | decreases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of PAK1IP1 mRNA | CTD | PMID:38568856 | Pak1ip1 | Rat | sodium dichromate | increases expression | EXP | | 6480464 | sodium bichromate results in increased expression of PAK1IP1 mRNA | CTD | PMID:25993096 | Pak1ip1 | Rat | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of PAK1IP1 mRNA | CTD | PMID:30047161 | Pak1ip1 | Rat | sunitinib | increases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PAK1IP1 mRNA | CTD | PMID:31533062 | Pak1ip1 | Rat | tamoxifen | affects expression | ISO | Pak1ip1 (Mus musculus) | 6480464 | Tamoxifen affects the expression of PAK1IP1 mRNA | CTD | PMID:17555576 | Pak1ip1 | Rat | testosterone | multiple interactions | ISO | PAK1IP1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of PAK1IP1 mRNA | CTD | PMID:21592394 | Pak1ip1 | Rat | testosterone | increases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Testosterone results in increased expression of PAK1IP1 mRNA | CTD | PMID:21592394 | Pak1ip1 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of PAK1IP1 mRNA | CTD | PMID:31150632 | Pak1ip1 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PAK1IP1 mRNA] | CTD | PMID:31150632 | Pak1ip1 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PAK1IP1 mRNA | CTD | PMID:23411599 and PMID:34492290 | Pak1ip1 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PAK1IP1 mRNA | CTD | PMID:25729387 | Pak1ip1 | Rat | trichostatin A | affects expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | trichostatin A affects the expression of PAK1IP1 mRNA | CTD | PMID:28542535 | Pak1ip1 | Rat | triphenyl phosphate | affects expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of PAK1IP1 mRNA | CTD | PMID:37042841 | Pak1ip1 | Rat | urethane | decreases expression | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Urethane results in decreased expression of PAK1IP1 mRNA | CTD | PMID:28818685 | Pak1ip1 | Rat | valproic acid | decreases methylation | ISO | PAK1IP1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of PAK1IP1 gene | CTD | PMID:29154799 | Pak1ip1 | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of PAK1IP1 mRNA | CTD | PMID:19015723 | |