Mak (male germ cell-associated kinase)

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Gene: Mak (male germ cell-associated kinase) Rattus norvegicus

Analyze

Symbol:

Mak

Name:

male germ cell-associated kinase

RGD ID:

3036

Description:

Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Predicted to be involved in several processes, including cilium organization; photoreceptor cell maintenance; and protein autophosphorylation. Predicted to act upstream of or within negative regulation of non-motile cilium assembly. Predicted to be located in several cellular components, including ciliary tip; cytoskeleton; and photoreceptor cell cilium. Predicted to be active in cilium; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 62. Orthologous to human MAK (male germ cell associated kinase); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; amphetamine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC93585; serine/threonine-protein kinase MAK

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MAK (male germ cell associated kinase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Mak (male germ cell-associated kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mak (male germ cell associated kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MAK (male germ cell associated kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MAK (male germ cell associated kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mak (male germ cell associated kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MAK (male germ cell associated kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MAK (male germ cell associated kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mak (male germ cell associated kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MAK (male germ cell associated kinase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mak (male germ cell-associated kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mak (male germ cell-associated kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IME2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG42366	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dyf-5	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	23,683,674 - 23,731,125 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	23,693,878 - 23,730,001 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	23,563,079 - 23,599,721 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	17	25,166,550 - 25,203,190 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	17	23,504,042 - 23,540,690 (+)	NCBI	Rnor_WKY
Rnor_6.0	17	21,531,651 - 21,567,742 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	21,521,505 - 21,568,440 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	23,514,576 - 23,550,277 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	29,644,795 - 29,698,155 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	29,647,635 - 29,700,996 (+)	NCBI
Celera	17	23,364,931 - 23,400,211 (+)	NCBI		Celera
RH 3.4 Map	17	278.3	RGD
Cytogenetic Map	17	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cataract 13 with adult i phenotype (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

retinitis pigmentosa (ISO)

retinitis pigmentosa 62 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

cisplatin (ISO)

Cuprizon (EXP)

D-glucose (ISO)

dapsone (ISO)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethyl methanesulfonate (ISO)

fenvalerate (EXP)

flavonoids (EXP)

formaldehyde (ISO)

fucoxanthin (ISO)

glucose (ISO)

lead diacetate (EXP)

lipopolysaccharide (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

Monobutylphthalate (ISO)

panobinostat (ISO)

paracetamol (ISO)

paraquat (EXP)

phenylmercury acetate (ISO)

rac-lactic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

streptozocin (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

cilium assembly (IBA)

intracellular signal transduction (IBA)

intraciliary transport (IBA)

negative regulation of non-motile cilium assembly (ISO)

non-motile cilium assembly (ISO)

photoreceptor cell maintenance (ISO,ISS)

positive regulation of DNA-templated transcription (IEA)

protein autophosphorylation (ISO,ISS)

protein phosphorylation (IEA,ISO,ISS)

spermatogenesis (IEA)

Cellular Component

axoneme (ISO)

centrosome (ISO,ISS)

ciliary tip (ISO)

cilium (IBA)

cytoplasm (IBA)

midbody (ISO,ISS)

mitotic spindle (ISO,ISS)

motile cilium (ISO)

nucleus (IBA,ISO,ISS)

photoreceptor connecting cilium (ISO)

photoreceptor inner segment (ISO,ISS)

photoreceptor outer segment (ISO,ISS)

Molecular Function

ATP binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

protein kinase activity (IEA,ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA)

transcription coactivator activity (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4.	A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis.	Matsushime H, etal., Mol Cell Biol 1990 May;10(5):2261-8.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:12084720	PMID:16951154	PMID:21148103	PMID:21825139	PMID:21986944

Genomics

Comparative Map Data

Mak
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	23,683,674 - 23,731,125 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	23,693,878 - 23,730,001 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	23,563,079 - 23,599,721 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	17	25,166,550 - 25,203,190 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	17	23,504,042 - 23,540,690 (+)	NCBI	Rnor_WKY
Rnor_6.0	17	21,531,651 - 21,567,742 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	21,521,505 - 21,568,440 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	23,514,576 - 23,550,277 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	29,644,795 - 29,698,155 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	29,647,635 - 29,700,996 (+)	NCBI
Celera	17	23,364,931 - 23,400,211 (+)	NCBI		Celera
RH 3.4 Map	17	278.3	RGD
Cytogenetic Map	17	p13	NCBI

MAK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	10,762,723 - 10,838,539 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	10,762,723 - 10,838,553 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	10,762,956 - 10,838,772 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	10,870,942 - 10,939,096 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	10,870,941 - 10,939,096	NCBI
Celera	6	11,991,430 - 12,059,559 (-)	NCBI		Celera
Cytogenetic Map	6	p24.2	NCBI
HuRef	6	10,638,967 - 10,714,575 (-)	NCBI		HuRef
CHM1_1	6	10,765,069 - 10,840,891 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	10,630,425 - 10,706,179 (-)	NCBI		T2T-CHM13v2.0

Mak
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	41,178,483 - 41,233,182 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	41,178,484 - 41,233,182 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	41,025,007 - 41,079,706 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	41,025,008 - 41,079,706 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	41,120,489 - 41,175,075 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	41,037,287 - 41,081,433 (-)	NCBI		MGSCv36	mm8
Celera	13	42,106,965 - 42,161,961 (-)	NCBI		Celera
Cytogenetic Map	13	A3.3	NCBI
cM Map	13	20.25	NCBI

Mak
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955465	3,556,490 - 3,616,203 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955465	3,556,733 - 3,615,126 (+)	NCBI	ChiLan1.0	ChiLan1.0

MAK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	10,882,745 - 10,956,579 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	10,882,745 - 10,956,579 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	10,604,723 - 10,679,712 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

MAK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	10,474,081 - 10,530,951 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	10,475,179 - 10,525,089 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	10,422,956 - 10,479,688 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	10,578,458 - 10,635,393 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	10,579,556 - 10,629,471 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	10,407,466 - 10,464,334 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	10,454,716 - 10,511,409 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	11,775,254 - 11,832,119 (-)	NCBI		UU_Cfam_GSD_1.0

Mak
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	13,901,835 - 13,951,238 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936534	2,170,794 - 2,224,065 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936534	2,170,853 - 2,239,647 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	7,482,097 - 7,538,282 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	7,482,089 - 7,538,373 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	7,793,737 - 7,850,117 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	61,301,634 - 61,376,885 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666044	10,798,618 - 10,873,770 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mak
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	15,119,788 - 15,168,680 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624756	15,119,788 - 15,167,815 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mak
310 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	192
Count of miRNA genes:	131
Interacting mature miRNAs:	141
Transcripts:	ENSRNOT00000020672, ENSRNOT00000040707
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31701463	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	1	31990913	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	37830672	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2115149	34551001	Rat
631499	Stl1	Serum triglyceride level QTL 1	3.6		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	3271398	27389946	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	4299130	35837242	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4354487	27028127	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4354487	27028127	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9991286	40540197	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15330613	55836425	Rat
1354640	Scl32	Serum cholesterol level QTL 32	5.4		blood HDL cholesterol amount (VT:0000184)	blood high density lipoprotein cholesterol level (CMO:0000052)	17	15781592	60781592	Rat
1354659	Scl68	Serum cholesterol level QTL 68	3.9		blood VLDL cholesterol amount (VT:0005144)	blood very low density lipoprotein cholesterol level (CMO:0000648)	17	15781592	60781592	Rat
7394837	Memor18	Memory QTL 18			exploratory behavior trait (VT:0010471)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	17	18640182	63640182	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21293039	60781592	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22454924	50909196	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23080567	59555013	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	57246843	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat

Markers in Region

D17Got30

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	23,725,829 - 23,726,005 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	21,563,571 - 21,563,746	NCBI	Rnor6.0
Rnor_5.0	17	23,546,106 - 23,546,281	UniSTS	Rnor5.0
RGSC_v3.4	17	29,693,983 - 29,694,159	RGD	RGSC3.4
RGSC_v3.4	17	29,693,984 - 29,694,159	UniSTS	RGSC3.4
RGSC_v3.1	17	29,696,825 - 29,697,000	RGD
Celera	17	23,396,040 - 23,396,215	UniSTS
RH 3.4 Map	17	278.6	UniSTS
RH 3.4 Map	17	278.6	RGD
RH 2.0 Map	17	198.4	RGD
Cytogenetic Map	17	p12	UniSTS

RH94552

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	23,729,812 - 23,729,978 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	21,567,554 - 21,567,719	NCBI	Rnor6.0
Rnor_5.0	17	23,550,089 - 23,550,254	UniSTS	Rnor5.0
RGSC_v3.4	17	29,697,967 - 29,698,132	UniSTS	RGSC3.4
Celera	17	23,400,023 - 23,400,188	UniSTS
RH 3.4 Map	17	278.3	UniSTS
Cytogenetic Map	17	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium											7
Low		12	8	8	2	8			62	20	32	11
Below cutoff	2	15	31	19	17	19	3	5	12	12	2		3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_013136	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095389	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095394	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095395	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC119496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000288	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M35862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000020672 ⟹ ENSRNOP00000020672

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	23,693,890 - 23,730,001 (+)	Ensembl
Rnor_6.0 Ensembl	17	21,521,505 - 21,568,440 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103805 ⟹ ENSRNOP00000090127

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	23,693,878 - 23,730,001 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000105813 ⟹ ENSRNOP00000084056

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	23,693,890 - 23,730,001 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107200 ⟹ ENSRNOP00000079083

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	23,693,878 - 23,730,001 (+)	Ensembl

RefSeq Acc Id:

NM_013136 ⟹ NP_037268

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	23,693,892 - 23,730,001 (+)	NCBI
Rnor_6.0	17	21,531,651 - 21,567,742 (+)	NCBI
Rnor_5.0	17	23,514,576 - 23,550,277 (+)	NCBI
RGSC_v3.4	17	29,644,795 - 29,698,155 (+)	RGD
Celera	17	23,364,931 - 23,400,211 (+)	RGD

Sequence:

show sequence

TCTGAATATGTGGAGACTATTATAGCAAAATGGACTCAGTGTCTCTTTGCCAGATTCCTTATTG
CTGTATCCCATGAGCCTACCTGACCTTGAGGAAGAGCCGTGTTTAATGATGACAAGCCTGTCTC
CCGTGTAGTGACAAAAAGGAGGAGGACCACAAGGAAAGACGGATTTAGATTTCTACTCAGCAAG
GAAGCGAGCTCTGTCAGCAACCTCTCTGGATTACCCTTCCCAAGATGAACCGATATACAACCAT
GAGGCAGCTGGGGGACGGCACGTACGGGAGTGTGCTTATGGGCAAGAGCAATGAGTCTGGGGAG
CTGGTGGCAATCAAGAGGATGAAGAGAAAGTTCTATTCTTGGGATGAGTGTATGAACTTGCGAG
AAGTTAAGTCCCTGAAGAAACTCAATCATGCCAATGTGATTAAACTAAAAGAAGTTATCAGAGA
AAATGACCATCTTTATTTTATATTTGAATATATGAAAGAAAACCTCTATCAGCTAATGAAAGAC
AGAAACAAACTGTTCCCTGAGTCAGTCATCAGAAATATTATGTATCAAATACTACAGGGGCTGG
CATTTATCCACAAACATGGCTTTTTTCACAGGGACATGAAACCTGAGAATTTGCTTTGCATGGG
TCCAGAGCTGGTGAAGATTGCTGATTTTGGACTTGCGAGAGAATTAAGATCACAGCCACCATAT
ACTGACTATGTGTCTACCAGATGGTACCGTGCTCCTGAAGTTTTGCTAAGGTCTTCAGTGTACA
GCTCTCCCATTGACGTGTGGGCCGTGGGAAGTATAATGGCCGAGCTATATACGTTTAGACCGCT
TTTCCCAGGGACCAGTGAAGTTGATGAGATCTTTAAAATTTGCCAAGTGTTAGGGACTCCCAAG
AAAAGTGACTGGCCGGAGGGGTACCAGCTGGCATCCTCCATGAACTTCCGCTTTCCCCAGTGCA
TTCCTATAAACCTGAAAACTCTCATTCCCAATGCCAGTAGTGAGGCTATTCAGCTTATGACAGA
AATGCTTAACTGGGATCCAAAGAAACGGCCAACTGCAAGCCAGGCACTGAAGCACCCATATTTT
CAAGTCGGTCAGGTATTGGGCCCTTCTGCACACCATCTGGATGCAAAACAGACTTTGCACAAGC
AGCTGCAGCCTCCAGAGCCAAAGCCATCTTCCTCTGAACGGGATCCTAAGCCTTTGCCAAACAT
CCTTGATCAGCCTGCCGGGCAGCCCCAGCCAAAACAGGGCCACCAACCACTGCAGGCCATTCAG
CCACCACAGAACACAGTGGTTCAGCCACCTCCAAAGCAGCAGGGTCACCATAAGCAACCACAAA
CGATGTTTCCAAGTATCGTCAAAACCATACCAACGAATCCAGTCAGCACAGTAGGCCATAAGGG
GGCCCGGAGACGGTGGGGTCAGACAGTCTTCAAGTCTGGAGACAGCTGTGACAACATCGAGGAC
TGCGACTTGGGAGCCTCCCACTCCAAGAAGCCGAGCATGGATGCCTTCAAGGAAAAAAAGAAGA
AGGAGTCTCCATTTCGGTTTCCAGAAGCAGGACTCCCAGTCTCCAACCACTTGAAGGGGGAAAA
TAGAAATTTACATGCATCCTTAAAATCTGACACAAACTTGTCAACTGCTTCAACCGCTAAGCAG
TACTATTTGAAACAATCAAGATACCTTCCGGGTGTGAACCCCAAGAACGTGTCTTTGGTAGCTG
GCGGCAAGGATATAAATTCACACTCTTGGAATAATCAGCTATTTCCTAAGTCTCTGGGATCCAT
GGGGGCGGACCTCGCTTTCAAGAGGAGTAACGCAGCAGGGAACCTTGGGAGCTACAGCGCTTAC
AGCCAGACGGGATGCGTGCCTTCCTTTCTCAAGAAAGAAGTGGGATCAGCTGGCCAGAGGATCC
ACTTGGCGCCTCTGGGTGCGTCGGCTGCCGACTATACCTGGAGCACAAAAACTGGCCGAGGCCA
GTTTTCAGGACGAACTTACAATCCCACAGCCAAAAATCTCAATATTGTGAACCGCACACAGCCA
GTCCCCTCGGTGCACGGGAGGACAGACTGGGTGGCTAAGTACGGAGGCCACCGGTAGGAGAAGT
GGAAGCCTGAAGCATTGCTCCGTAGAGGACAATCACGCCCCTTGATCCTGGGAGACGTCTACAG
AGTCTATTTCTACCGAGTTCCACAGGACGCACACAACCGTGGGCGCCTCAGAGACCGGAAGTCA
GCTCCCGATTTCTTCCTTTTCCGGAAATGCAATGCATTTTCTTAACTTGTGGCCAGCAGTGCTG
ATGCAGCACCGTGCTGAAACTTTTGAGCGGGACTTTTAAAGAGTATTGAATAAATTATTTGCCA
AAGT

hide sequence

RefSeq Acc Id:

XM_039095389 ⟹ XP_038951317

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	23,683,794 - 23,731,125 (+)	NCBI

RefSeq Acc Id:

XM_039095390 ⟹ XP_038951318

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	23,683,674 - 23,731,125 (+)	NCBI

RefSeq Acc Id:

XM_039095391 ⟹ XP_038951319

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	23,684,828 - 23,731,125 (+)	NCBI

RefSeq Acc Id:

XM_039095392 ⟹ XP_038951320

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	23,686,336 - 23,731,125 (+)	NCBI

RefSeq Acc Id:

XM_039095393 ⟹ XP_038951321

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	23,683,794 - 23,731,125 (+)	NCBI

RefSeq Acc Id:

XM_039095394 ⟹ XP_038951322

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	23,694,263 - 23,731,125 (+)	NCBI

RefSeq Acc Id:

XM_039095395 ⟹ XP_038951323

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	23,683,794 - 23,731,125 (+)	NCBI

RefSeq Acc Id:

XM_039095396 ⟹ XP_038951324

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	23,683,794 - 23,731,125 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_037268	(Get FASTA)	NCBI Sequence Viewer
	XP_038951317	(Get FASTA)	NCBI Sequence Viewer
	XP_038951318	(Get FASTA)	NCBI Sequence Viewer
	XP_038951319	(Get FASTA)	NCBI Sequence Viewer
	XP_038951320	(Get FASTA)	NCBI Sequence Viewer
	XP_038951321	(Get FASTA)	NCBI Sequence Viewer
	XP_038951322	(Get FASTA)	NCBI Sequence Viewer
	XP_038951323	(Get FASTA)	NCBI Sequence Viewer
	XP_038951324	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41562	(Get FASTA)	NCBI Sequence Viewer
	AAH78887	(Get FASTA)	NCBI Sequence Viewer
	EDL98222	(Get FASTA)	NCBI Sequence Viewer
	P20793	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_037268 ⟸ NM_013136

- UniProtKB:

Q6AYW0 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIK
LKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKP
ENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAE
LYTFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSE
AIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSAHHLDAKQTLHKQLQPPEPKPSSSERD
PKPLPNILDQPAGQPQPKQGHQPLQAIQPPQNTVVQPPPKQQGHHKQPQTMFPSIVKTIPTNPV
STVGHKGARRRWGQTVFKSGDSCDNIEDCDLGASHSKKPSMDAFKEKKKKESPFRFPEAGLPVS
NHLKGENRNLHASLKSDTNLSTASTAKQYYLKQSRYLPGVNPKNVSLVAGGKDINSHSWNNQLF
PKSLGSMGADLAFKRSNAAGNLGSYSAYSQTGCVPSFLKKEVGSAGQRIHLAPLGASAADYTWS
TKTGRGQFSGRTYNPTAKNLNIVNRTQPVPSVHGRTDWVAKYGGHR

hide sequence

RefSeq Acc Id:

ENSRNOP00000020672 ⟸ ENSRNOT00000020672

RefSeq Acc Id:	XP_038951318 ⟸ XM_039095390
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038951324 ⟸ XM_039095396
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038951317 ⟸ XM_039095389
- Peptide Label:	isoform X1
- UniProtKB:	Q6AYW0 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038951321 ⟸ XM_039095393
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038951323 ⟸ XM_039095395
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038951319 ⟸ XM_039095391
- Peptide Label:	isoform X1
- UniProtKB:	Q6AYW0 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038951320 ⟸ XM_039095392
- Peptide Label:	isoform X1
- UniProtKB:	Q6AYW0 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038951322 ⟸ XM_039095394
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000090127 ⟸ ENSRNOT00000103805

RefSeq Acc Id:

ENSRNOP00000079083 ⟸ ENSRNOT00000107200

RefSeq Acc Id:

ENSRNOP00000084056 ⟸ ENSRNOT00000105813

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P20793-F1-model_v2	AlphaFold	P20793	1-622	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3036	AgrOrtholog
BioCyc Gene	G2FUF-9730	BioCyc
Ensembl Genes	ENSRNOG00000015101	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000020672	ENTREZGENE
	ENSRNOP00000020672.4	UniProtKB/Swiss-Prot
	ENSRNOP00000079083	ENTREZGENE
	ENSRNOP00000079083.1	UniProtKB/Swiss-Prot
	ENSRNOP00000084056.1	UniProtKB/TrEMBL
	ENSRNOP00000090127.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000020672	ENTREZGENE
	ENSRNOT00000020672.8	UniProtKB/Swiss-Prot
	ENSRNOT00000103805.1	UniProtKB/TrEMBL
	ENSRNOT00000105813.1	UniProtKB/TrEMBL
	ENSRNOT00000107200	ENTREZGENE
	ENSRNOT00000107200.1	UniProtKB/Swiss-Prot
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7111717	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25677	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93585	IMAGE-MGC_LOAD
NCBI Gene	25677	ENTREZGENE
PANTHER	MITOGEN-ACTIVATED PROTEIN KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE MAK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mak	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC202258
UniProt	A0A8I6AB71_RAT	UniProtKB/TrEMBL
	A0A8I6G9U0_RAT	UniProtKB/TrEMBL
	MAK_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6AYW0	ENTREZGENE
UniProt Secondary	G3V7Y4	UniProtKB/Swiss-Prot
	Q6AYW0	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Mak	Male germ cell-associated kinase			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	highly expressed in testicular cells entering and after meiosis	728938
gene_homology	40% identical to the cdc2-CDC28 gene family in Schizosaccharomyces pombe, Saccharomyces cerevisiae, and humans	728938

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM