Mak (male germ cell-associated kinase) - Rat Genome Database

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Gene: Mak (male germ cell-associated kinase) Rattus norvegicus
Analyze
Symbol: Mak
Name: male germ cell-associated kinase
RGD ID: 3036
Description: Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Predicted to be involved in cilium organization; intracellular signal transduction; and photoreceptor cell maintenance. Predicted to act upstream of or within negative regulation of non-motile cilium assembly. Predicted to be located in several cellular components, including cytoskeleton; midbody; and photoreceptor cell cilium. Predicted to be active in cilium; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 62. Orthologous to human MAK (male germ cell associated kinase); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC93585; serine/threonine-protein kinase MAK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81723,889,417 - 23,936,857 (+)NCBIGRCr8
mRatBN7.21723,683,753 - 23,731,125 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1723,693,878 - 23,730,001 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1723,563,079 - 23,599,721 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01725,166,550 - 25,203,190 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01723,504,042 - 23,540,690 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01721,531,651 - 21,567,742 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1721,521,505 - 21,568,440 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01723,514,576 - 23,550,277 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41729,644,795 - 29,698,155 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11729,647,635 - 29,700,996 (+)NCBI
Celera1723,364,931 - 23,400,211 (+)NCBICelera
RH 3.4 Map17278.3RGD
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axoneme  (IEA,ISO)
centrosome  (IEA,ISO,ISS)
cilium  (IBA)
cytoplasm  (IBA)
midbody  (IEA,ISO,ISS)
mitotic spindle  (IEA,ISO,ISS)
motile cilium  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
photoreceptor connecting cilium  (IEA,ISO)
photoreceptor inner segment  (IEA,ISO,ISS)
photoreceptor outer segment  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis. Matsushime H, etal., Mol Cell Biol 1990 May;10(5):2261-8.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12084720   PMID:16951154   PMID:21148103   PMID:21825139   PMID:21986944  


Genomics

Comparative Map Data
Mak
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81723,889,417 - 23,936,857 (+)NCBIGRCr8
mRatBN7.21723,683,753 - 23,731,125 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1723,693,878 - 23,730,001 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1723,563,079 - 23,599,721 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01725,166,550 - 25,203,190 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01723,504,042 - 23,540,690 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01721,531,651 - 21,567,742 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1721,521,505 - 21,568,440 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01723,514,576 - 23,550,277 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41729,644,795 - 29,698,155 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11729,647,635 - 29,700,996 (+)NCBI
Celera1723,364,931 - 23,400,211 (+)NCBICelera
RH 3.4 Map17278.3RGD
Cytogenetic Map17p12NCBI
MAK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38610,762,723 - 10,838,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl610,762,723 - 10,838,553 (-)EnsemblGRCh38hg38GRCh38
GRCh37610,762,956 - 10,838,772 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36610,870,942 - 10,939,096 (-)NCBINCBI36Build 36hg18NCBI36
Build 34610,870,941 - 10,939,096NCBI
Celera611,991,430 - 12,059,559 (-)NCBICelera
Cytogenetic Map6p24.2NCBI
HuRef610,638,967 - 10,714,575 (-)NCBIHuRef
CHM1_1610,765,069 - 10,840,891 (-)NCBICHM1_1
T2T-CHM13v2.0610,630,425 - 10,706,179 (-)NCBIT2T-CHM13v2.0
Mak
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391341,178,483 - 41,233,182 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1341,178,484 - 41,233,182 (-)EnsemblGRCm39 Ensembl
GRCm381341,025,007 - 41,079,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1341,025,008 - 41,079,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv371341,120,489 - 41,175,075 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361341,037,287 - 41,081,433 (-)NCBIMGSCv36mm8
Celera1342,106,965 - 42,161,961 (-)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1320.25NCBI
Mak
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554653,556,490 - 3,616,203 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554653,556,733 - 3,615,126 (+)NCBIChiLan1.0ChiLan1.0
MAK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2525,406,102 - 25,494,896 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1621,399,155 - 21,485,073 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0610,604,723 - 10,679,712 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1610,882,745 - 10,956,579 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl610,882,745 - 10,956,579 (-)Ensemblpanpan1.1panPan2
MAK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13510,474,081 - 10,530,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3510,475,179 - 10,525,089 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3510,422,956 - 10,479,688 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03510,578,458 - 10,635,393 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3510,579,556 - 10,629,471 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13510,407,466 - 10,464,334 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03510,454,716 - 10,511,409 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03511,775,254 - 11,832,119 (-)NCBIUU_Cfam_GSD_1.0
Mak
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494613,901,835 - 13,951,238 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365342,170,794 - 2,224,065 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365342,170,853 - 2,239,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl77,482,097 - 7,538,282 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.177,482,089 - 7,538,373 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.277,793,737 - 7,850,117 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11761,301,634 - 61,376,885 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604410,798,618 - 10,873,770 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mak
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475615,119,788 - 15,168,680 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475615,119,788 - 15,167,815 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mak
358 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:131
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000020672, ENSRNOT00000040707
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat

Markers in Region
D17Got30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21723,725,829 - 23,726,005 (+)MAPPERmRatBN7.2
Rnor_6.01721,563,571 - 21,563,746NCBIRnor6.0
Rnor_5.01723,546,106 - 23,546,281UniSTSRnor5.0
RGSC_v3.41729,693,983 - 29,694,159RGDRGSC3.4
RGSC_v3.41729,693,984 - 29,694,159UniSTSRGSC3.4
RGSC_v3.11729,696,825 - 29,697,000RGD
Celera1723,396,040 - 23,396,215UniSTS
RH 3.4 Map17278.6UniSTS
RH 3.4 Map17278.6RGD
RH 2.0 Map17198.4RGD
Cytogenetic Map17p12UniSTS
RH94552  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21723,729,812 - 23,729,978 (+)MAPPERmRatBN7.2
Rnor_6.01721,567,554 - 21,567,719NCBIRnor6.0
Rnor_5.01723,550,089 - 23,550,254UniSTSRnor5.0
RGSC_v3.41729,697,967 - 29,698,132UniSTSRGSC3.4
Celera1723,400,023 - 23,400,188UniSTS
RH 3.4 Map17278.3UniSTS
Cytogenetic Map17p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 12 8 8 2 8 62 20 32 11
Below cutoff 2 15 31 19 17 19 3 5 12 12 2 3

Sequence


RefSeq Acc Id: ENSRNOT00000020672   ⟹   ENSRNOP00000020672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1723,693,890 - 23,730,001 (+)Ensembl
Rnor_6.0 Ensembl1721,521,505 - 21,568,440 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103805   ⟹   ENSRNOP00000090127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1723,693,878 - 23,730,001 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105813   ⟹   ENSRNOP00000084056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1723,693,890 - 23,730,001 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107200   ⟹   ENSRNOP00000079083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1723,693,878 - 23,730,001 (+)Ensembl
RefSeq Acc Id: NM_013136   ⟹   NP_037268
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,889,491 - 23,935,734 (+)NCBI
mRatBN7.21723,683,753 - 23,730,002 (+)NCBI
Rnor_6.01721,531,651 - 21,567,742 (+)NCBI
Rnor_5.01723,514,576 - 23,550,277 (+)NCBI
RGSC_v3.41729,644,795 - 29,698,155 (+)RGD
Celera1723,364,931 - 23,400,211 (+)RGD
Sequence:
RefSeq Acc Id: XM_039095389   ⟹   XP_038951317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,889,501 - 23,936,857 (+)NCBI
mRatBN7.21723,683,794 - 23,731,125 (+)NCBI
RefSeq Acc Id: XM_039095391   ⟹   XP_038951319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,890,571 - 23,936,857 (+)NCBI
mRatBN7.21723,684,828 - 23,731,125 (+)NCBI
RefSeq Acc Id: XM_039095393   ⟹   XP_038951321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,889,532 - 23,936,857 (+)NCBI
mRatBN7.21723,683,794 - 23,731,125 (+)NCBI
RefSeq Acc Id: XM_039095394   ⟹   XP_038951322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,900,001 - 23,936,857 (+)NCBI
mRatBN7.21723,694,263 - 23,731,125 (+)NCBI
RefSeq Acc Id: XM_039095395   ⟹   XP_038951323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,889,501 - 23,936,857 (+)NCBI
mRatBN7.21723,683,794 - 23,731,125 (+)NCBI
RefSeq Acc Id: XM_039095396   ⟹   XP_038951324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,889,532 - 23,936,857 (+)NCBI
mRatBN7.21723,683,794 - 23,731,125 (+)NCBI
RefSeq Acc Id: XM_063276111   ⟹   XP_063132181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,889,417 - 23,936,857 (+)NCBI
RefSeq Acc Id: XM_063276112   ⟹   XP_063132182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,889,417 - 23,936,857 (+)NCBI
RefSeq Acc Id: NP_037268   ⟸   NM_013136
- UniProtKB: P20793 (UniProtKB/Swiss-Prot),   G3V7Y4 (UniProtKB/Swiss-Prot),   Q6AYW0 (UniProtKB/Swiss-Prot),   A0A8I6G9U0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020672   ⟸   ENSRNOT00000020672
RefSeq Acc Id: XP_038951324   ⟸   XM_039095396
- Peptide Label: isoform X5
- UniProtKB: A0A8I6G9U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951317   ⟸   XM_039095389
- Peptide Label: isoform X1
- UniProtKB: P20793 (UniProtKB/Swiss-Prot),   G3V7Y4 (UniProtKB/Swiss-Prot),   Q6AYW0 (UniProtKB/Swiss-Prot),   A0A8I6G9U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951321   ⟸   XM_039095393
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G9U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951323   ⟸   XM_039095395
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AB71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951319   ⟸   XM_039095391
- Peptide Label: isoform X1
- UniProtKB: P20793 (UniProtKB/Swiss-Prot),   G3V7Y4 (UniProtKB/Swiss-Prot),   Q6AYW0 (UniProtKB/Swiss-Prot),   A0A8I6G9U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951322   ⟸   XM_039095394
- Peptide Label: isoform X3
- UniProtKB: A0A8I6G9U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000090127   ⟸   ENSRNOT00000103805
RefSeq Acc Id: ENSRNOP00000079083   ⟸   ENSRNOT00000107200
RefSeq Acc Id: ENSRNOP00000084056   ⟸   ENSRNOT00000105813
RefSeq Acc Id: XP_063132181   ⟸   XM_063276111
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G9U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132182   ⟸   XM_063276112
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AB71 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20793-F1-model_v2 AlphaFold P20793 1-622 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3036 AgrOrtholog
BioCyc Gene G2FUF-9730 BioCyc
Ensembl Genes ENSRNOG00000015101 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020672 ENTREZGENE
  ENSRNOT00000020672.8 UniProtKB/Swiss-Prot
  ENSRNOT00000103805.1 UniProtKB/TrEMBL
  ENSRNOT00000105813.1 UniProtKB/TrEMBL
  ENSRNOT00000107200.1 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111717 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25677 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93585 IMAGE-MGC_LOAD
NCBI Gene 25677 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE MAK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mak PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015101 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC202258
UniProt A0A8I6AB71 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G9U0 ENTREZGENE, UniProtKB/TrEMBL
  G3V7Y4 ENTREZGENE
  MAK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6AYW0 ENTREZGENE
UniProt Secondary G3V7Y4 UniProtKB/Swiss-Prot
  Q6AYW0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mak  Male germ cell-associated kinase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in testicular cells entering and after meiosis 728938
gene_homology 40% identical to the cdc2-CDC28 gene family in Schizosaccharomyces pombe, Saccharomyces cerevisiae, and humans 728938