Mak (male germ cell associated kinase) - Rat Genome Database

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Gene: Mak (male germ cell associated kinase) Heterocephalus glaber
Analyze
Symbol: Mak
Name: male germ cell associated kinase
RGD ID: 18920054
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); protein kinase activity (inferred); INVOLVED IN negative regulation of non-motile cilium assembly (ortholog); non-motile cilium assembly (ortholog); photoreceptor cell maintenance (ortholog); ASSOCIATED WITH cataract 13 with adult i phenotype (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN axoneme (inferred); centrosome (inferred); cilium (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase MAK
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475615,119,788 - 15,168,680 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475615,119,788 - 15,167,815 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mak
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475615,119,788 - 15,168,680 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475615,119,788 - 15,167,815 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MAK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38610,762,723 - 10,838,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl610,762,723 - 10,838,553 (-)EnsemblGRCh38hg38GRCh38
GRCh37610,762,956 - 10,838,772 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36610,870,942 - 10,939,096 (-)NCBINCBI36Build 36hg18NCBI36
Build 34610,870,941 - 10,939,096NCBI
Celera611,991,430 - 12,059,559 (-)NCBICelera
Cytogenetic Map6p24.2NCBI
HuRef610,638,967 - 10,714,575 (-)NCBIHuRef
CHM1_1610,765,069 - 10,840,891 (-)NCBICHM1_1
T2T-CHM13v2.0610,630,425 - 10,706,179 (-)NCBIT2T-CHM13v2.0
Mak
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391341,178,483 - 41,233,182 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1341,178,484 - 41,233,182 (-)EnsemblGRCm39 Ensembl
GRCm381341,025,007 - 41,079,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1341,025,008 - 41,079,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv371341,120,489 - 41,175,075 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361341,037,287 - 41,081,433 (-)NCBIMGSCv36mm8
Celera1342,106,965 - 42,161,961 (-)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1320.25NCBI
Mak
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81723,889,417 - 23,936,857 (+)NCBIGRCr8
mRatBN7.21723,683,753 - 23,731,125 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1723,693,878 - 23,730,001 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1723,563,079 - 23,599,721 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01725,166,550 - 25,203,190 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01723,504,042 - 23,540,690 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01721,531,651 - 21,567,742 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1721,521,505 - 21,568,440 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01723,514,576 - 23,550,277 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41729,644,795 - 29,698,155 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11729,647,635 - 29,700,996 (+)NCBI
Celera1723,364,931 - 23,400,211 (+)NCBICelera
RH 3.4 Map17278.3RGD
Cytogenetic Map17p12NCBI
Mak
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554653,556,490 - 3,616,203 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554653,556,733 - 3,615,126 (+)NCBIChiLan1.0ChiLan1.0
MAK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2525,406,102 - 25,494,896 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1621,399,155 - 21,485,073 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0610,604,723 - 10,679,712 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1610,882,745 - 10,956,579 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl610,882,745 - 10,956,579 (-)Ensemblpanpan1.1panPan2
MAK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13510,474,081 - 10,530,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3510,475,179 - 10,525,089 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3510,422,956 - 10,479,688 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03510,578,458 - 10,635,393 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3510,579,556 - 10,629,471 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13510,407,466 - 10,464,334 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03510,454,716 - 10,511,409 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03511,775,254 - 11,832,119 (-)NCBIUU_Cfam_GSD_1.0
Mak
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494613,901,835 - 13,951,238 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365342,170,794 - 2,224,065 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365342,170,853 - 2,239,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl77,482,097 - 7,538,282 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.177,482,089 - 7,538,373 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.277,793,737 - 7,850,117 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11761,301,634 - 61,376,885 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604410,798,618 - 10,873,770 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000012269   ⟹   ENSHGLP00000012135
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475615,119,788 - 15,168,680 (+)Ensembl
RefSeq Acc Id: XM_004847699   ⟹   XP_004847756
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475615,119,847 - 15,167,815 (+)NCBI
RefSeq Acc Id: XM_021260661   ⟹   XP_021116320
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475615,119,788 - 15,167,815 (+)NCBI
RefSeq Acc Id: XM_021260662   ⟹   XP_021116321
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475615,126,400 - 15,167,815 (+)NCBI
RefSeq Acc Id: XM_021260663   ⟹   XP_021116322
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475615,119,788 - 15,167,815 (+)NCBI
RefSeq Acc Id: XM_021260664   ⟹   XP_021116323
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475615,119,788 - 15,162,737 (+)NCBI
RefSeq Acc Id: XM_021260665   ⟹   XP_021116324
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475615,133,539 - 15,167,815 (+)NCBI
RefSeq Acc Id: XM_021260666   ⟹   XP_021116325
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475615,119,788 - 15,162,734 (+)NCBI
RefSeq Acc Id: XM_021260667   ⟹   XP_021116326
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475615,119,788 - 15,154,258 (+)NCBI
RefSeq Acc Id: XM_021260668   ⟹   XP_021116327
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475615,138,086 - 15,167,815 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021116320   ⟸   XM_021260661
- Peptide Label: isoform X1
- UniProtKB: G5BN60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116322   ⟸   XM_021260663
- Peptide Label: isoform X2
- UniProtKB: A0A0P6J3Z1 (UniProtKB/TrEMBL),   G5BN60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116323   ⟸   XM_021260664
- Peptide Label: isoform X3
- UniProtKB: G5BN60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116325   ⟸   XM_021260666
- Peptide Label: isoform X5
- UniProtKB: G5BN60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116326   ⟸   XM_021260667
- Peptide Label: isoform X6
RefSeq Acc Id: XP_004847756   ⟸   XM_004847699
- Peptide Label: isoform X1
- UniProtKB: G5BN60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116321   ⟸   XM_021260662
- Peptide Label: isoform X1
- UniProtKB: G5BN60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116324   ⟸   XM_021260665
- Peptide Label: isoform X4
- UniProtKB: G5BN60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116327   ⟸   XM_021260668
- Peptide Label: isoform X7
- UniProtKB: G5BN60 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000012135   ⟸   ENSHGLT00000012269


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008680 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000012269 ENTREZGENE
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Mak ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE MAK UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0P6J3Z1 ENTREZGENE, UniProtKB/TrEMBL
  G5BN60 ENTREZGENE, UniProtKB/TrEMBL