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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | increases expression | ISO | RGD:1553608 | 6480464 | ethylene dichloride results in increased expression of RREB1 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:1553608 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of RREB1 mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | RGD:1322078 | 6480464 | Estradiol results in increased expression of RREB1 mRNA | CTD | PMID:23019147, PMID:31614463 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | RGD:1553608 | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1553608 | 6480464 | Tetrachlorodibenzodioxin affects the expression of RREB1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RREB1 mRNA | CTD | PMID:32109520 | 2,4,6-trinitrobenzenesulfonic acid | multiple interactions | ISO | RGD:1553608 | 6480464 | Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNA] | CTD | PMID:18200517 | 2,4,6-trinitrobenzenesulfonic acid | decreases expression | ISO | RGD:1553608 | 6480464 | Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNA | CTD | PMID:18200517 | 2-hydroxypropanoic acid | increases expression | ISO | RGD:1322078 | 6480464 | Lactic Acid results in increased expression of RREB1 mRNA | CTD | PMID:30851411 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | RGD:1553608 | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of RREB1 mRNA | CTD | PMID:20188158 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | RGD:1553608 | 6480464 | bis(4-hydroxyphenyl)sulfone results in decreased methylation of RREB1 exon | CTD | PMID:33297965 | 4-hydroxyphenyl retinamide | increases expression | ISO | RGD:1553608 | 6480464 | Fenretinide results in increased expression of RREB1 mRNA | CTD | PMID:28973697 | arsane | affects methylation | ISO | RGD:1322078 | 6480464 | Arsenic affects the methylation of RREB1 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | RGD:1322078 | 6480464 | Arsenic affects the methylation of RREB1 gene | CTD | PMID:25304211 | arsenite(3-) | multiple interactions | ISO | RGD:1322078 | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to RREB1 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | increases mutagenesis | ISO | RGD:1322078 | 6480464 | Benzo(a)pyrene results in increased mutagenesis of RREB1 gene | CTD | PMID:25435355 | benzo[a]pyrene | affects methylation | ISO | RGD:1322078 | 6480464 | Benzo(a)pyrene affects the methylation of RREB1 5' UTR, Benzo(a)pyrene affects the methylation of RREB1 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RGD:1322078 | 6480464 | 7 more ... | CTD | PMID:19150397 | benzo[e]pyrene | increases methylation | ISO | RGD:1322078 | 6480464 | benzo(e)pyrene results in increased methylation of RREB1 exon | CTD | PMID:30157460 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of RREB1 mRNA | CTD | PMID:25181051 | bisphenol A | decreases methylation | ISO | RGD:1322078 | 6480464 | bisphenol A results in decreased methylation of RREB1 gene | CTD | PMID:31601247 | bisphenol A | multiple interactions | ISO | RGD:1322078 | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of RREB1 gene | CTD | PMID:31601247 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of RREB1 gene | CTD | PMID:28505145 | cadmium atom | increases expression | ISO | RGD:1322078 | 6480464 | Cadmium results in increased expression of RREB1 mRNA | CTD | PMID:24376830 | cisplatin | decreases expression | ISO | RGD:1322078 | 6480464 | Cisplatin results in decreased expression of RREB1 mRNA | CTD | PMID:27392435, PMID:27594783 | clofibrate | increases expression | ISO | RGD:1553608 | 6480464 | Clofibrate results in increased expression of RREB1 mRNA | CTD | PMID:23811191 | crocidolite asbestos | affects expression | ISO | RGD:1322078 | 6480464 | Asbestos, Crocidolite affects the expression of RREB1 mRNA | CTD | PMID:17331233 | curcumin | multiple interactions | ISO | RGD:1553608 | 6480464 | Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNA] | CTD | PMID:18200517 | dexamethasone | increases expression | ISO | RGD:1322078 | 6480464 | Dexamethasone results in increased expression of RREB1 mRNA | CTD | PMID:16144937 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of RREB1 mRNA | CTD | PMID:21266533 | dichloroacetic acid | increases expression | ISO | RGD:1553608 | 6480464 | Dichloroacetic Acid results in increased expression of RREB1 mRNA | CTD | PMID:28962523 | dichloromethane | decreases expression | ISO | RGD:1553608 | 6480464 | Methylene Chloride results in decreased expression of RREB1 mRNA | CTD | PMID:28392392 | dicrotophos | increases expression | ISO | RGD:1322078 | 6480464 | dicrotophos results in increased expression of RREB1 mRNA | CTD | PMID:28302478 | dorsomorphin | multiple interactions | ISO | RGD:1322078 | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | ethanol | increases expression | ISO | RGD:1553608 | 6480464 | Ethanol results in increased expression of RREB1 mRNA | CTD | PMID:30319688 | fenthion | decreases expression | ISO | RGD:1553608 | 6480464 | Fenthion results in decreased expression of RREB1 mRNA | CTD | PMID:34813904 | folic acid | decreases expression | ISO | RGD:1553608 | 6480464 | Folic Acid results in decreased expression of RREB1 mRNA | CTD | PMID:25629700 | formaldehyde | decreases expression | ISO | RGD:1322078 | 6480464 | Formaldehyde results in decreased expression of RREB1 mRNA | CTD | PMID:20655997 | fulvestrant | multiple interactions | ISO | RGD:1322078 | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of RREB1 gene | CTD | PMID:31601247 | glutathione | decreases expression | EXP | | 6480464 | Glutathione deficiency results in decreased expression of RREB1 mRNA | CTD | PMID:20621112 | hydrogen chloride | decreases expression | ISO | RGD:1322078 | 6480464 | Hydrochloric Acid results in decreased expression of RREB1 mRNA | CTD | PMID:15046208 | hydrogen cyanide | decreases expression | ISO | RGD:1553608 | 6480464 | Hydrogen Cyanide results in decreased expression of RREB1 mRNA | CTD | PMID:33914522 | leflunomide | increases expression | ISO | RGD:1322078 | 6480464 | leflunomide results in increased expression of RREB1 mRNA | CTD | PMID:28988120 | methapyrilene | increases methylation | ISO | RGD:1322078 | 6480464 | Methapyrilene results in increased methylation of RREB1 exon | CTD | PMID:30157460 | methyl methanesulfonate | decreases expression | ISO | RGD:1322078 | 6480464 | Methyl Methanesulfonate results in decreased expression of RREB1 mRNA | CTD | PMID:23649840 | N-methyl-4-phenylpyridinium | increases expression | ISO | RGD:1322078 | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of RREB1 mRNA | CTD | PMID:24810058 | nimesulide | decreases expression | EXP | | 6480464 | nimesulide results in decreased expression of RREB1 mRNA | CTD | PMID:24136188 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of RREB1 mRNA | CTD | PMID:25729387 | panobinostat | multiple interactions | ISO | RGD:1322078 | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA | CTD | PMID:27188386 | panobinostat | increases expression | ISO | RGD:1322078 | 6480464 | panobinostat results in increased expression of RREB1 mRNA | CTD | PMID:26272509 | paracetamol | decreases expression | ISO | RGD:1322078 | 6480464 | Acetaminophen results in decreased expression of RREB1 mRNA | CTD | PMID:21420995 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of RREB1 mRNA | CTD | PMID:33387578 | pentachlorophenol | increases expression | ISO | RGD:1553608 | 6480464 | Pentachlorophenol results in increased expression of RREB1 mRNA | CTD | PMID:23892564 | phenobarbital | decreases expression | ISO | RGD:1553608 | 6480464 | Phenobarbital results in decreased expression of RREB1 mRNA | CTD | PMID:23091169 | pirinixic acid | increases expression | ISO | RGD:1553608 | 6480464 | pirinixic acid results in increased expression of RREB1 mRNA | CTD | PMID:18301758, PMID:23811191 | potassium cyanide | decreases expression | ISO | RGD:1553608 | 6480464 | Potassium Cyanide results in decreased expression of RREB1 mRNA | CTD | PMID:33914522 | rac-lactic acid | increases expression | ISO | RGD:1322078 | 6480464 | Lactic Acid results in increased expression of RREB1 mRNA | CTD | PMID:30851411 | SB 431542 | multiple interactions | ISO | RGD:1322078 | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | RGD:1553608 | 6480464 | Silicon Dioxide results in decreased expression of RREB1 mRNA | CTD | PMID:19073995 | sodium arsenate | increases expression | ISO | RGD:1553608 | 6480464 | sodium arsenate results in increased expression of RREB1 mRNA | CTD | PMID:21795629 | sodium arsenate | decreases expression | ISO | RGD:1553608 | 6480464 | sodium arsenate results in decreased expression of RREB1 mRNA | CTD | PMID:30953684 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of RREB1 mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | ISO | RGD:1553608 | 6480464 | titanium dioxide results in decreased expression of RREB1 mRNA | CTD | PMID:29264374 | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of RREB1 mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of RREB1 mRNA | CTD | PMID:25729387 | trichostatin A | increases expression | ISO | RGD:1322078 | 6480464 | trichostatin A results in increased expression of RREB1 mRNA | CTD | PMID:26272509 | trichostatin A | affects expression | ISO | RGD:1322078 | 6480464 | trichostatin A affects the expression of RREB1 mRNA | CTD | PMID:28542535 | trichostatin A | multiple interactions | ISO | RGD:1322078 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA | CTD | PMID:27188386 | troglitazone | increases expression | ISO | RGD:1553608 | 6480464 | troglitazone results in increased expression of RREB1 mRNA | CTD | PMID:28973697 | tungsten | decreases expression | ISO | RGD:1553608 | 6480464 | Tungsten results in decreased expression of RREB1 mRNA | CTD | PMID:30912803 | valproic acid | increases methylation | ISO | RGD:1322078 | 6480464 | Valproic Acid results in increased methylation of RREB1 gene | CTD | PMID:29154799 | valproic acid | multiple interactions | ISO | RGD:1322078 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA | CTD | PMID:27188386 | valproic acid | increases expression | ISO | RGD:1322078 | 6480464 | Valproic Acid results in increased expression of RREB1 mRNA | CTD | PMID:23179753 more ... | vorinostat | multiple interactions | ISO | RGD:1322078 | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA | CTD | PMID:27188386 | zinc atom | affects expression | ISO | RGD:1322078 | 6480464 | Zinc affects the expression of RREB1 mRNA | CTD | PMID:21613827 | zinc(0) | affects expression | ISO | RGD:1322078 | 6480464 | Zinc affects the expression of RREB1 mRNA | CTD | PMID:21613827 | |