Rreb1 (ras responsive element binding protein 1) - Rat Genome Database

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Gene: Rreb1 (ras responsive element binding protein 1) Rattus norvegicus
Analyze
Symbol: Rreb1
Name: ras responsive element binding protein 1
RGD ID: 1310904
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including positive regulation of cell migration; regulation of cell morphogenesis; and regulation of transcription by RNA polymerase II. Predicted to localize to fibrillar center and nuclear speck. Orthologous to human RREB1 (ras responsive element binding protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; dibutyl phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC306873; ras-responsive element-binding protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21726,876,686 - 27,002,615 (-)NCBI
Rnor_6.0 Ensembl1727,539,133 - 27,665,266 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01727,539,137 - 27,718,878 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01729,453,342 - 29,632,680 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41733,125,272 - 33,251,491 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11733,130,948 - 33,187,331 (-)NCBI
Celera1726,508,633 - 26,634,463 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
amenorrhea  (ISO)
microcephaly  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
fibrillar center  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleus  (IBA)

References

Additional References at PubMed
PMID:8816445   PMID:12477932   PMID:18394891   PMID:19056867   PMID:20133935   PMID:21159816   PMID:27923061  


Genomics

Comparative Map Data
Rreb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21726,876,686 - 27,002,615 (-)NCBI
Rnor_6.0 Ensembl1727,539,133 - 27,665,266 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01727,539,137 - 27,718,878 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01729,453,342 - 29,632,680 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41733,125,272 - 33,251,491 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11733,130,948 - 33,187,331 (-)NCBI
Celera1726,508,633 - 26,634,463 (-)NCBICelera
Cytogenetic Map17p12NCBI
RREB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl67,107,597 - 7,251,980 (+)EnsemblGRCh38hg38GRCh38
GRCh3867,107,743 - 7,251,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3767,107,976 - 7,252,213 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3667,053,263 - 7,196,194 (+)NCBINCBI36hg18NCBI36
Build 3467,084,476 - 7,196,194NCBI
Celera68,337,583 - 8,481,974 (+)NCBI
Cytogenetic Map6p24.3NCBI
HuRef66,984,113 - 7,128,514 (+)NCBIHuRef
CHM1_167,109,932 - 7,254,330 (+)NCBICHM1_1
Rreb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391337,962,362 - 38,135,981 (+)NCBIGRCm39mm39
GRCm39 Ensembl1337,962,376 - 38,135,981 (+)Ensembl
GRCm381337,778,382 - 37,952,005 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1337,778,400 - 37,952,005 (+)EnsemblGRCm38mm10GRCm38
MGSCv371337,917,907 - 38,043,874 (+)NCBIGRCm37mm9NCBIm37
MGSCv361337,833,505 - 37,959,468 (+)NCBImm8
Celera1338,946,939 - 39,073,602 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
Rreb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554656,570,522 - 6,636,934 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554656,572,593 - 6,757,423 (-)NCBIChiLan1.0ChiLan1.0
RREB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.167,160,933 - 7,356,556 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl67,257,875 - 7,356,544 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v066,945,205 - 7,089,757 (+)NCBIMhudiblu_PPA_v0panPan3
RREB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,120,505 - 7,255,290 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,120,472 - 7,255,105 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha357,123,955 - 7,258,737 (+)NCBI
ROS_Cfam_1.0357,202,128 - 7,337,072 (+)NCBI
UMICH_Zoey_3.1357,055,626 - 7,190,320 (+)NCBI
UNSW_CanFamBas_1.0357,082,329 - 7,217,217 (+)NCBI
UU_Cfam_GSD_1.0358,414,770 - 8,549,540 (+)NCBI
Rreb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494617,052,502 - 17,233,119 (-)NCBI
SpeTri2.0NW_0049365345,321,488 - 5,390,612 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RREB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.174,512,286 - 4,639,961 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.274,478,004 - 4,652,467 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RREB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11764,938,831 - 65,084,975 (-)NCBI
ChlSab1.1 Ensembl1764,938,800 - 65,009,057 (-)Ensembl
Rreb1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475618,259,884 - 18,383,344 (-)NCBI

Position Markers
RH133262  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01727,636,466 - 27,636,681NCBIRnor6.0
Rnor_5.01729,550,684 - 29,550,899UniSTSRnor5.0
RGSC_v3.41733,222,933 - 33,223,148UniSTSRGSC3.4
Celera1726,606,022 - 26,606,237UniSTS
RH 3.4 Map17341.4UniSTS
Cytogenetic Map17p12UniSTS
AA859655  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01727,539,262 - 27,539,451NCBIRnor6.0
Rnor_5.01729,453,467 - 29,453,656UniSTSRnor5.0
RGSC_v3.41733,125,397 - 33,125,586UniSTSRGSC3.4
Celera1726,508,758 - 26,508,947UniSTS
RH 3.4 Map17353.3UniSTS
Cytogenetic Map17p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17132230361Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17133303755Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138243814Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17163676140Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17173413148Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17173413148Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1751977036283402Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17333697237790462Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17333697263676140Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17333697273413148Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17333697273413148Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17333697273413148Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17341403928073589Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17471606727691136Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17471606727691136Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17519104750191047Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17519104750191047Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17982730454827304Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)171052970942542027Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171574375561036897Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171867614063676140Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171867614063676140Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172149095062195822Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172149095066490950Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172149095066490950Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172149095066490950Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172149095066490950Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172149095066490950Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172149095074823273Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172213681453475276Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172277506564946194Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172403061863676140Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172769095938110914Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172769095961794615Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172769095963994435Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:309
Count of miRNA genes:205
Interacting mature miRNAs:234
Transcripts:ENSRNOT00000060218
Prediction methods:Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 49 33 19 33 4 35 34 11
Low 16 8 8 8 8 11 70 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000060218   ⟹   ENSRNOP00000056967
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1727,539,148 - 27,665,266 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079298   ⟹   ENSRNOP00000073072
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1727,539,133 - 27,602,934 (-)Ensembl
RefSeq Acc Id: NM_001107348   ⟹   NP_001100818
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21726,876,686 - 27,002,615 (-)NCBI
Rnor_6.01727,539,137 - 27,665,266 (-)NCBI
Rnor_5.01729,453,342 - 29,632,680 (-)NCBI
RGSC_v3.41733,125,272 - 33,251,491 (-)RGD
Celera1726,508,633 - 26,634,463 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253812   ⟹   XP_006253874
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01727,539,138 - 27,665,138 (-)NCBI
Rnor_5.01729,453,342 - 29,632,680 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253813   ⟹   XP_006253875
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01727,539,138 - 27,664,332 (-)NCBI
Rnor_5.01729,453,342 - 29,632,680 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253814   ⟹   XP_006253876
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21726,876,687 - 26,935,597 (-)NCBI
Rnor_6.01727,539,138 - 27,718,878 (-)NCBI
Rnor_5.01729,453,342 - 29,632,680 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253815   ⟹   XP_006253877
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01727,539,138 - 27,666,398 (-)NCBI
Rnor_5.01729,453,342 - 29,632,680 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253816   ⟹   XP_006253878
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21726,876,687 - 27,002,520 (-)NCBI
Rnor_6.01727,539,138 - 27,665,138 (-)NCBI
Rnor_5.01729,453,342 - 29,632,680 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253817   ⟹   XP_006253879
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21726,876,687 - 26,934,850 (-)NCBI
Rnor_6.01727,539,138 - 27,597,802 (-)NCBI
Rnor_5.01729,453,342 - 29,632,680 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771571   ⟹   XP_008769793
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01727,539,138 - 27,664,332 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001100818 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253876 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253878 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253879 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98267 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100818   ⟸   NM_001107348
- UniProtKB: D3ZI11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253876   ⟸   XM_006253814
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4K0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253877   ⟸   XM_006253815
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006253878   ⟸   XM_006253816
- Peptide Label: isoform X2
- UniProtKB: D3ZI11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253874   ⟸   XM_006253812
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006253875   ⟸   XM_006253813
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006253879   ⟸   XM_006253817
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008769793   ⟸   XM_008771571
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000073072   ⟸   ENSRNOT00000079298
RefSeq Acc Id: ENSRNOP00000056967   ⟸   ENSRNOT00000060218
Protein Domains
C2H2-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700398
Promoter ID:EPDNEW_R10921
Type:initiation region
Name:Rreb1_1
Description:ras responsive element binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01727,665,205 - 27,665,265EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
17 29470907 29470908 G T snv BBDP/WorN (KNAW)
17 29471351 29471352 C T snv WKY/NHsd (KNAW), ZF (KyushuU), HTX/Kyo (KyushuU), MR/N (KNAW), BBDP/WorN (KNAW), WKY/N (KNAW), WKY/NCrl (KNAW), ZFDM (KyushuU), GK/Ox (KNAW), LEW/Crl (KNAW), LEW/NCrl (KNAW), MNS/Gib (KNAW), BUF/MNa (KyushuU)
17 29472796 29472797 A G snv ACI/EurMcwi (MCW), SR/JrHsd (MCW), FHH/EurMcwi (MCW)


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
17 27556702 27556703 G T snv BBDP/Wor (RGD)
17 27557146 27557147 C T snv CDR, CDS, MR/N (MCW), WKY/N (MCW), BBDP/Wor (RGD), WKY/NHsd (RGD), GK/Ox (RGD), LEW/Crl (RGD), LEW/NCrlBR (RGD), MNS/Gib (RGD), WKY/NCrl (RGD)
17 27558591 27558592 A G snv SR/JrHsd (MCW)


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
17 33143281 33143282 C T snv MR/N (KNAW), WKY/N (KNAW), GK/Ox (ICL), HCR/1Mco (UMich), WKY/NCrl (ICL), BBDP/WorN (ICL), LCR/1Mco (UMich), LEW/Crl (ICL), LEW/NCrl (ICL), MNS/Gib (ICL), WKY/NHsd (ICL)
17 33144726 33144727 A G snv SR/JrHsd (MCW), FHH/EurMcwi (MCW), ACI/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310904 AgrOrtholog
Ensembl Genes ENSRNOG00000015701 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000056967 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000073072 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060218 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000079298 UniProtKB/TrEMBL
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:306873 UniProtKB/TrEMBL
NCBI Gene 306873 ENTREZGENE
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Rreb1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2K4K0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZI11 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Rreb1  ras responsive element binding protein 1   Rreb1_predicted  ras responsive element binding protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rreb1_predicted  ras responsive element binding protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED