RGD Reference Report - Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats. - Rat Genome Database

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Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats.

Authors: Duong, C  Charron, S  Xiao, C  Hamet, P  Menard, A  Roy, J  Deng, AY 
Citation: Duong C, etal., Mamm Genome. 2006 Dec;17(12):1147-61. Epub 2006 Dec 1.
RGD ID: 1599557
Pubmed: PMID:17143582   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-006-0086-7   (Journal Full-text)

Blood pressure (BP) is largely determined by quantitative trait loci (QTLs) in Dahl salt-sensitive (DSS) rats. Little is known about QTLs controlling kidney (K), cardiac (C), and aortic (A) mass (i.e. Km, Cm, and Am, respectively) of DSS rats independent of BP. Their identification can facilitate our understanding of end organ damage. In this work, 36 congenic strains were employed to define QTLs for Km, Cm, and Am either independent of or associated with BP. Five new QTLs, i.e., KmQTLs, that influence Km independent of Cm, Am, and BP were defined. Four new CakmQTLs were defined for Cm, Am, and Km independent of BP. Among them, the CakmC10QTL1 interval contained 13 genes and undefined loci, and none was known to influence the phenotypes in question, paving the way for a novel gene discovery. Among 17 individual QTLs for BP, 14 also affected Cm, Km, and Am, i.e., they are BpcakmQTLs. In contrast, one BpQTL had no effect on Cm, Am, and Kam. Therefore, BP and Cm, Am, and Km have distinct and shared genetic determinants. The discovery of individual Km and Cakm QTLs will likely facilitate the identification of mechanisms underlying renal, cardiac, and/or aortic hypertrophy independent of hypertension.

Disease Annotations    
hypertension  (IAGP)

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table  |  Show All Strains Clinical Measurement

Strains with Phenominer Data Strains with phenominer data
SS.LEW-(D3Rat61-D3Wox1)/Ayd SS.LEW-(D2Rat199-D2Mco17)/Ayd SS.MNS-(D2Rat183-D2Chm113)/Ayd
SS.MNS-(D2Chm25-D2Rat131)/Ayd SS.MNS-(D2Wox27-Adh1)/Ayd SS.MNS-(D2Chm51-D2Rat341)/Ayd
SS.MNS-(D2Chm25-Fgg)/Ayd SS.LEW-(D3Rat52-D3Rat130)/Ayd SS.LEW-(D3Mco21-D3Rat17)/Ayd
SS.LEW-(D10Rat24-Igfbp4)/Ayd SS.LEW-(D8Chm14-D8Rat16)/Ayd SS.LEW-(D8Rat56-D8Rat51)/Ayd
SS.LEW-(D10Rat27-Igfbp4)/Ayd SS.LEW-(D10Chm128-D10Chm121)/Ayd SS.LEW-(D10Chm128-D10Chm169)/Ayd
SS.LEW-(D16Rat38-D16Chm66)/Ayd SS.LEW-(D16Rat12-D16Chm23)/Ayd SS.LEW-(D16Got3-D16Rat112)/Ayd
SS.LEW-(D17Chm14-D17Rat181)/Ayd SS.LEW-(D17Rat65-D17Chm2)/Ayd SS.LEW-(D18Chm41-D18Rat92)/Ayd
SS.LEW-(D18Chm91-D18Rat67)/Ayd SS.LEW-(D18Chm56-D18Rat55)/Ayd LEW
SS.LEW-(D17Chm9-D17Rat97)/Ayd SS/Jr SS.LEW-(D2Rat18-D2Chm277)/Ayd
SS.LEW-(D3Got33-D3Chm68)/Ayd SS.LEW-(D10Chm10-D10Rat11)/Ayd SS.LEW-(D18Rat61-D18Rat45)/Ayd
SS.LEW-(D10Chm224-D10Chm6)/Ayd SS.LEW-(D18Rat30-D18Chm29)/Ayd

Objects Annotated

Am1  (Aortic mass QTL 1)
Am10  (Aortic mass QTL 10)
Am11  (Aortic mass QTL 11)
Am12  (Aortic mass QTL 12)
Am13  (Aortic mass QTL 13)
Am14  (Aortic mass QTL 14)
Am15  (Aortic mass QTL 15)
Am16  (Aortic mass QTL 16)
Am17  (Aortic mass QTL 17)
Am18  (Aortic mass QTL 18)
Am19  (Aortic mass QTL 19)
Am2  (Aortic mass QTL 2)
Am20  (Aortic mass QTL 20)
Am21  (Aortic mass QTL 21)
Am3  (Aortic mass QTL 3)
Am4  (Aortic mass QTL 4)
Am5  (Aortic mass QTL 5)
Am6  (Aortic mass QTL 6)
Am7  (Aortic mass QTL 7)
Am8  (Aortic mass QTL 8)
Am9  (Aortic mass QTL 9)
Bp256  (Blood pressure QTL 256)
Bp257  (Blood pressure QTL 257)
Bp258  (Blood pressure QTL 258)
Bp270  (Blood pressure QTL 270)
Bp278  (Blood pressure QTL 278)
Bp279  (Blood pressure QTL 279)
Bp280  (Blood pressure QTL 280)
Bp281  (Blood pressure QTL 281)
Bp315  (Blood pressure QTL 315)
Bp316  (Blood pressure QTL 316)
Bp317  (Blood pressure QTL 317)
Bp318  (Blood pressure QTL 318)
Bp319  (Blood pressure QTL 319)
Bp320  (Blood pressure QTL 320)
Bp321  (Blood pressure QTL 321)
Bp402  (Blood pressure QTL 402)
Bw176  (Body weight QTL 176)
Bw177  (Body weight QTL 177)
Bw178  (Body weight QTL 178)
Bw179  (Body weight QTL 179)
Bw180  (Body weight QTL 180)
Bw181  (Body weght QTL 181)
Bw182  (Body weight QTL 182)
Bw183  (Body weight QTL 183)
Bw184  (Body weight QTL 184)
Bw185  (Body weight QTL 185)
Bw186  (Body weight QTL 186)
Bw187  (Body weight QTL 187)
Bw188  (Body weight QTL 188)
Bw189  (Body weight QTL 189)
Cm100  (Cardiac mass QTL 100)
Cm101  (Cardiac mass QTL 101)
Cm102  (Cardiac mass QTL 102)
Cm103  (Cardiac mass QTL 103)
Cm104  (Cardiac mass QTL 104)
Cm105  (Cardiac mass QTL 105)
Cm106  (Cardiac mass QTL 106)
Cm107  (Cardiac mass QTL 107)
Cm108  (Cardiac mass QTL 108)
Cm109  (Cardiac mass QTL 109)
Cm110  (Cardiac mass QTL 110)
Cm111  (Cardiac mass QTL 111)
Cm112  (Cardiac mass QTL 112)
Cm113  (Cardiac mass QTL 113)
Cm114  (Cardiac mass QTL 114)
Cm115  (Cardiac mass QTL 115)
Cm116  (Cardiac mass QTL 116)
Cm117  (Cardiac mass QTL 117)
Cm118  (Cardiac mass QTL 118)
Cm119  (Cardiac mass QTL 119)
Cm120  (Cardiac mass QTL 120)
Cm121  (Cardiac mass QTL 121)
Cm122  (Cardiac mass QTL 122)
Cm123  (Cardiac mass QTL 123)
Cm124  (Cardiac mass QTL 124)
Cm125  (Cardiac mass QTL 125)
Cm126  (Cardiac mass QTL 126)
Cm127  (Cardiac mass QTL 127)
Cm128  (Cardiac mass QTL 128)
Cm129  (Cardiac mass QTL 129)
Cm130  (Cardiac mass QTL 130)
Cm131  (Cardiac mass QTL 131)
Cm132  (Cardiac mass QTL 132)
Cm67  (Cardiac mass QTL 67)
Cm68  (Cardiac mass QTL 68)
Cm69  (Cardiac mass QTL 69)
Cm70  (Cardiac mass QTL 70)
Cm82  (Cardiac mass QTL 82)
Cm83  (Cardiac mass QTL 83)
Cm84  (Cardiac mass QTL 84)
Cm85  (Cardiac mass QTL 85)
Cm86  (Cardiac mass QTL 86)
Cm87  (Cardiac mass QTL 87)
Cm88  (Cardiac mass QTL 88)
Cm89  (Cardiac mass QTL 89)
Cm90  (Cardiac mass QTL 90)
Cm91  (Cardiac mass QTL 91)
Cm92  (Cardiac mass QTL 92)
Cm93  (Cardiac mass QTL 93)
Cm94  (Cardiac mass QTL 94)
Cm95  (Cardiac mass QTL 95)
Cm96  (Cardiac mass QTL 96)
Cm97  (Cardiac mass QTL 97)
Cm98  (Cardiac mass QTL 98)
Cm99  (Cardiac mass QTL 99)
Kidm36  (Kidney mass QTL 36)
Kidm37  (Kidney mass QTL 37)
Kidm38  (Kidney mass QTL 38)
Kidm39  (Kidney mass QTL 39)
Kidm40  (Kidney mass QTL 40)
Kidm56  (Kidney mass QTL 56)
Kidm57  (Kidney mass QTL 57)
Kidm58  (Kidney mass QTL 58)
Kidm59  (Kidney mass QTL 59)
Kidm60  (Kidney mass QTL 60)
Kidm61  (Kidney mass QTL 61)
Kidm62  (Kidney mass QTL 62)
Kidm63  (Kidney mass QTL 63)
Kidm64  (Kidney mass QTL 64)
Kidm65  (Kidney mass QTL 65)
Kidm66  (Kidney mass QTL 66)
Kidm67  (Kidney mass QTL 67)
Kidm68  (Kidney mass QTL 68)
Kidm69  (Kidney mass QTL 69)
Kidm70  (Kidney mass QTL 70)
Kidm71  (Kidney mass QTL 71)
Kidm72  (Kidney mass QTL 72)
Kidm73  (Kidney mass QTL 73)

Objects referenced in this article
Marker D8Chm11 D8Chm11 Rattus norvegicus
Marker D17Chm70 D17Chm70 Rattus norvegicus
QTL Bp151 Blood pressure QTL 151 Rattus norvegicus
QTL Bp282 Blood pressure QTL 282 Rattus norvegicus
Strain SS.LEW-(D18Chm31-D18Rat55)/Ayd null Rattus norvegicus
Strain SS.LEW-(D18Chm41-D18Rat45)/Ayd null Rattus norvegicus
Strain SS.LEW-(D18Chm56-D18Rat55)/Ayd null Rattus norvegicus
Strain SS.LEW-(D18Rat29-D18Rat55)/Ayd null Rattus norvegicus
Strain SS.LEW-(D18Rat67-D18Rat55)/Ayd null Rattus norvegicus
Strain SS.LEW-(D2Rat199-D2Mco17)/Ayd null Rattus norvegicus

Additional Information