Bmp6 (bone morphogenetic protein 6) - Rat Genome Database

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Gene: Bmp6 (bone morphogenetic protein 6) Rattus norvegicus
Symbol: Bmp6
Name: bone morphogenetic protein 6
RGD ID: 2214
Description: Enables growth factor activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of aldosterone secretion; and positive regulation of cell differentiation. Located in extracellular space and vesicle. Biomarker of anemia; brain ischemia; and colitis. Orthologous to human BMP6 (bone morphogenetic protein 6); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; Hedgehog signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,6-dinitrotoluene; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BMP-6; VG-1-related protein; VGR; VGR-1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81726,523,704 - 26,785,558 (-)NCBIGRCr8
mRatBN7.21726,318,121 - 26,469,691 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1726,318,569 - 26,470,365 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1726,176,967 - 26,326,912 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01727,780,553 - 27,930,507 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01726,125,854 - 26,275,216 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01726,955,142 - 27,112,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1726,955,142 - 27,112,820 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01728,870,345 - 29,029,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41732,380,199 - 32,689,295 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11732,383,039 - 32,692,136 (-)NCBI
Celera1725,955,026 - 26,103,008 (-)NCBICelera
RH 3.4 Map17342.3RGD
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-chloro-2,4-dinitrobenzene  (ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminosalicylic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alatrofloxacin  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpidem  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
apomorphine  (ISO)
arsenite(3-)  (ISO)
atropine  (EXP)
Benzamil  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
biperiden  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromfenac  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGS 15943  (ISO)
chlorpyrifos  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diphenhydramine  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
esculetin  (EXP)
esmolol  (ISO)
ethambutol  (ISO)
ethanol  (ISO)
etodolac  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenvalerate  (EXP)
ferric ammonium citrate  (ISO)
fludrocortisone  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
Fulvic acid  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
heparin  (ISO)
indometacin  (ISO)
Iproniazid  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
kenpaullone  (ISO)
ketoconazole  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (ISO)
lumiracoxib  (ISO)
mebendazole  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methylisothiazolinone  (ISO)
nefazodone  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
octreotide  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
pasireotide  (ISO)
penbutolol  (ISO)
pentacarbonyliron  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
phosphane  (EXP)
pioglitazone  (ISO)
pirprofen  (ISO)
procyclidine  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
protriptyline  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
streptozocin  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tienilic acid  (ISO)
tipifarnib  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trazodone  (ISO)
trichostatin A  (ISO)
triclosan  (EXP,ISO)
Trihexyphenidyl  (ISO)
triprolidine  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zafirlukast  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (IBA,ISO)
bone development  (ISO)
cartilage development  (IEA)
cellular response to BMP stimulus  (ISO)
cellular response to iron ion  (ISO)
cellular response to mechanical stimulus  (IEP)
endochondral ossification  (ISO)
eye development  (ISO)
immune response  (ISO)
inflammatory response  (ISO)
intracellular iron ion homeostasis  (ISO)
kidney development  (ISO)
male genitalia development  (ISO)
multicellular organismal-level iron ion homeostasis  (ISO,ISS)
negative regulation of adherens junction organization  (ISO)
negative regulation of cell-cell adhesion mediated by cadherin  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron differentiation  (ISO)
ossification  (IDA)
osteoblast differentiation  (IEP,ISO)
positive regulation of aldosterone biosynthetic process  (ISO)
positive regulation of aldosterone secretion  (IDA)
positive regulation of bone mineralization  (ISO)
positive regulation of chondrocyte differentiation  (IDA)
positive regulation of endothelial cell differentiation  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of lipopolysaccharide-mediated signaling pathway  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of osteoblast differentiation  (IMP,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular permeability  (ISO)
regulation of cell differentiation  (TAS)
response to activity  (IEP)
response to glucocorticoid  (IEP)
response to iron ion  (IEP)
response to magnesium ion  (IEP)
response to retinoic acid  (IEP)
type B pancreatic cell development  (ISO)

Cellular Component
extracellular space  (IBA,IDA,ISO)
vesicle  (IDA)

Molecular Function


References - curated
# Reference Title Reference Citation
1. A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7. Alarmo EL, etal., Breast Cancer Res Treat. 2007 Jun;103(2):239-46. Epub 2006 Sep 21.
2. Immunolocalization and mRNA expression of bone morphogenetic protein-6 in human clear cell renal carcinoma. Basic-Jukic N, etal., Kidney Blood Press Res. 2009;32(6):445-50. doi: 10.1159/000266479. Epub 2009 Dec 17.
3. Glucocorticoid-induced differentiation of fetal rat calvarial osteoblasts is mediated by bone morphogenetic protein-6. Boden SD, etal., Endocrinology. 1997 Jul;138(7):2820-8.
4. Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism. Dai J, etal., Cancer Res. 2005 Sep 15;65(18):8274-85.
5. BMP-6 over-expression in prostate cancer is associated with increased Id-1 protein and a more invasive phenotype. Darby S, etal., J Pathol. 2007 Dec 10;214(3):394-404.
6. Loss of endogenous bone morphogenetic protein-6 aggravates renal fibrosis. Dendooven A, etal., Am J Pathol. 2011 Mar;178(3):1069-79. doi: 10.1016/j.ajpath.2010.12.005.
7. BMP-6 and BMPR-1a are up-regulated in the growth plate of the fractured tibia. Fischerauer EE, etal., J Orthop Res. 2013 Mar;31(3):357-63. doi: 10.1002/jor.22238. Epub 2012 Oct 23.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. Gazit D, etal., Mol Endocrinol. 1993 Feb;7(2):189-98.
10. Hepcidin expression in the liver of rats fed a magnesium-deficient diet. Ishizaki N, etal., Br J Nutr. 2011 Oct;106(8):1169-72. doi: 10.1017/S0007114511001553. Epub 2011 May 18.
11. In vitro chondrogenesis by BMP6 gene therapy. Kayabasi GK, etal., J Biomed Mater Res A. 2013 May;101(5):1353-61. doi: 10.1002/jbm.a.34430. Epub 2012 Oct 18.
12. Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1. Knittel T, etal., Exp Cell Res 1997 May 1;232(2):263-9.
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Comparison of osteogenic potentials of human rat BMP4 and BMP6 gene therapy using [E1-] and [E1-,E2b-] adenoviral vectors. Li H, etal., Int J Med Sci. 2006;3(3):97-105. Epub 2006 Jun 1.
15. BMP signaling in rats with TNBS-induced colitis following BMP7 therapy. Maric I, etal., Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1151-62. doi: 10.1152/ajpgi.00244.2011. Epub 2012 Feb 23.
16. Expression of bone morphogenetic protein-6 and transforming growth factor-beta1 in the rat brain after a mild and reversible ischemic damage. Martinez G, etal., Brain Res. 2001 Mar 9;894(1):1-11.
17. An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland. Matsumoto Y, etal., J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):8-14. doi: 10.1016/j.jsbmb.2012.04.004. Epub 2012 Apr 17.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins. Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30.
20. Dynamic regulation of bone morphogenetic proteins in engineered osteochondral constructs by biomechanical stimulation. Nam J, etal., Tissue Eng Part A. 2013 Mar;19(5-6):783-92. doi: 10.1089/ten.tea.2012.0103. Epub 2012 Nov 30.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines. Sauermann U, etal., J Neurosci Res 1992 Sep;33(1):142-7.
28. Tissue remodeling in the acute otitis media mouse model. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
29. Localization of bone morphogenetic proteins (BMPs)-2, -4, and -6 within megakaryocytes and platelets. Sipe JB, etal., Bone. 2004 Dec;35(6):1316-22.
30. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
31. Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo. Theurl I, etal., Haematologica. 2011 Dec;96(12):1761-9. doi: 10.3324/haematol.2011.048926. Epub 2011 Aug 22.
32. Progressive development of the osteoblast phenotype during differentiation of osteoprogenitor cells derived from fetal rat calvaria: model for in vitro bone formation. Yamamoto N, etal., Biol Pharm Bull. 2002 Apr;25(4):509-15.
33. Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression. Yuen HF, etal., Cancer Sci. 2012 Jun;103(6):1145-54. doi: 10.1111/j.1349-7006.2012.02252.x. Epub 2012 Apr 3.
34. Bone morphogenetic protein-6 is expressed early by activated astrocytes in lesions of rat traumatic brain injury. Zhang Z, etal., Neuroscience. 2006;138(1):47-53. Epub 2006 Jan 4.
Additional References at PubMed
PMID:7811286   PMID:9664685   PMID:9786991   PMID:11865031   PMID:12151307   PMID:14623234   PMID:14623245   PMID:16109715   PMID:16154126   PMID:16527843   PMID:16798745   PMID:16886151  
PMID:17244894   PMID:18326817   PMID:18436533   PMID:18472332   PMID:19252488   PMID:19366699   PMID:19852960   PMID:20406889   PMID:21450970   PMID:21703414   PMID:24006456   PMID:24183201  
PMID:24732882   PMID:25467747   PMID:25551924   PMID:26598555   PMID:28256809   PMID:31121597   PMID:32448307   PMID:36845161  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81726,523,704 - 26,785,558 (-)NCBIGRCr8
mRatBN7.21726,318,121 - 26,469,691 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1726,318,569 - 26,470,365 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1726,176,967 - 26,326,912 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01727,780,553 - 27,930,507 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01726,125,854 - 26,275,216 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01726,955,142 - 27,112,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1726,955,142 - 27,112,820 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01728,870,345 - 29,029,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41732,380,199 - 32,689,295 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11732,383,039 - 32,692,136 (-)NCBI
Celera1725,955,026 - 26,103,008 (-)NCBICelera
RH 3.4 Map17342.3RGD
Cytogenetic Map17p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3867,726,099 - 7,881,728 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl67,726,099 - 7,881,728 (+)EnsemblGRCh38hg38GRCh38
GRCh3767,726,332 - 7,881,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3667,672,010 - 7,826,960 (+)NCBINCBI36Build 36hg18NCBI36
Build 3467,672,008 - 7,826,726NCBI
Celera68,956,438 - 9,111,399 (+)NCBICelera
Cytogenetic Map6p24.3NCBI
HuRef67,604,128 - 7,759,039 (+)NCBIHuRef
CHM1_167,728,829 - 7,884,079 (+)NCBICHM1_1
T2T-CHM13v2.067,594,835 - 7,750,477 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391338,529,098 - 38,684,283 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1338,529,083 - 38,684,278 (+)EnsemblGRCm39 Ensembl
GRCm381338,345,716 - 38,500,314 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1338,345,107 - 38,500,302 (+)EnsemblGRCm38mm10GRCm38
MGSCv371338,437,585 - 38,591,597 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361338,353,182 - 38,507,194 (+)NCBIMGSCv36mm8
Celera1339,464,167 - 39,615,905 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1318.15NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554656,054,931 - 6,200,377 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554656,053,600 - 6,201,254 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2522,365,813 - 22,522,551 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1618,363,471 - 18,519,549 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v067,564,164 - 7,720,341 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.167,848,255 - 8,002,030 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl67,848,249 - 8,000,649 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1357,780,763 - 7,833,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,804,231 - 7,831,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha357,690,267 - 7,840,113 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0357,770,103 - 7,915,608 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl357,770,103 - 7,915,377 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1357,622,630 - 7,772,359 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0357,648,291 - 7,798,326 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,982,152 - 9,131,717 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494616,438,976 - 16,602,907 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365344,709,064 - 4,871,023 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365344,707,658 - 4,871,865 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl75,058,817 - 5,210,270 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.175,058,817 - 5,208,868 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.275,163,209 - 5,313,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11764,279,243 - 64,436,356 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1764,280,609 - 64,435,382 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660447,712,261 - 7,873,910 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475617,743,834 - 17,894,753 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475617,742,822 - 17,894,931 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Bmp6
1179 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:60
Interacting mature miRNAs:72
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21726,318,971 - 26,319,152 (+)MAPPERmRatBN7.2
Rnor_6.01726,954,928 - 26,955,108NCBIRnor6.0
Rnor_5.01728,870,131 - 28,870,311UniSTSRnor5.0
RGSC_v3.41732,379,985 - 32,380,165UniSTSRGSC3.4
Celera1725,954,812 - 25,954,992UniSTS
Cytogenetic Map17p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21726,318,576 - 26,318,761 (+)MAPPERmRatBN7.2
Rnor_6.01726,954,533 - 26,954,717NCBIRnor6.0
Rnor_5.01728,869,736 - 28,869,920UniSTSRnor5.0
RGSC_v3.41732,379,590 - 32,379,774UniSTSRGSC3.4
Celera1725,954,417 - 25,954,601UniSTS
RH 3.4 Map17342.3UniSTS
Cytogenetic Map17p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21726,367,150 - 26,367,311 (+)MAPPERmRatBN7.2
Rnor_6.01727,003,842 - 27,004,002NCBIRnor6.0
Rnor_5.01728,918,885 - 28,919,045UniSTSRnor5.0
Celera1726,002,985 - 26,003,145UniSTS
RH 3.4 Map17344.4UniSTS
Cytogenetic Map17p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21726,468,473 - 26,468,607 (+)MAPPERmRatBN7.2
Rnor_6.01727,112,407 - 27,112,540NCBIRnor6.0
Rnor_5.01729,029,151 - 29,029,284UniSTSRnor5.0
RGSC_v3.41732,688,882 - 32,689,015UniSTSRGSC3.4
Celera1726,102,595 - 26,102,728UniSTS
Cytogenetic Map17p12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 11 1 41 2 10 11
Low 3 32 57 41 18 41 8 11 33 33 31 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000018359   ⟹   ENSRNOP00000018359
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1726,318,569 - 26,470,365 (-)Ensembl
Rnor_6.0 Ensembl1726,955,142 - 27,112,820 (-)Ensembl
RefSeq Acc Id: NM_013107   ⟹   NP_037239
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81726,523,704 - 26,675,261 (-)NCBI
mRatBN7.21726,318,121 - 26,469,691 (-)NCBI
Rnor_6.01726,955,142 - 27,112,820 (-)NCBI
Rnor_5.01728,870,345 - 29,029,564 (-)NCBI
RGSC_v3.41732,380,199 - 32,689,295 (-)RGD
Celera1725,955,026 - 26,103,008 (-)RGD
RefSeq Acc Id: XM_039095387   ⟹   XP_038951315
Rat AssemblyChrPosition (strand)Source
GRCr81726,523,704 - 26,675,303 (-)NCBI
mRatBN7.21726,318,121 - 26,469,034 (-)NCBI
RefSeq Acc Id: XM_063276106   ⟹   XP_063132176
Rat AssemblyChrPosition (strand)Source
GRCr81726,523,704 - 26,675,315 (-)NCBI
RefSeq Acc Id: XM_063276107   ⟹   XP_063132177
Rat AssemblyChrPosition (strand)Source
GRCr81726,523,704 - 26,785,558 (-)NCBI
RefSeq Acc Id: XM_063276108   ⟹   XP_063132178
Rat AssemblyChrPosition (strand)Source
GRCr81726,523,704 - 26,785,558 (-)NCBI
RefSeq Acc Id: XM_063276109   ⟹   XP_063132179
Rat AssemblyChrPosition (strand)Source
GRCr81726,523,704 - 26,635,565 (-)NCBI
RefSeq Acc Id: XM_063276110   ⟹   XP_063132180
Rat AssemblyChrPosition (strand)Source
GRCr81726,523,704 - 26,785,442 (-)NCBI
RefSeq Acc Id: NP_037239   ⟸   NM_013107
- Peptide Label: precursor
- UniProtKB: Q811S4 (UniProtKB/Swiss-Prot),   Q04906 (UniProtKB/Swiss-Prot),   A6J7A4 (UniProtKB/TrEMBL),   A6J7A5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018359   ⟸   ENSRNOT00000018359
RefSeq Acc Id: XP_038951315   ⟸   XM_039095387
- Peptide Label: isoform X1
- UniProtKB: A6J7A5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132178   ⟸   XM_063276108
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132177   ⟸   XM_063276107
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132180   ⟸   XM_063276110
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063132176   ⟸   XM_063276106
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063132179   ⟸   XM_063276109
- Peptide Label: isoform X4
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q04906-F1-model_v2 AlphaFold Q04906 1-506 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700393
Promoter ID:EPDNEW_R10915
Type:single initiation site
Description:bone morphogenetic protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01727,112,908 - 27,112,968EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2214 AgrOrtholog
BioCyc Gene G2FUF-9689 BioCyc
Ensembl Genes ENSRNOG00000013717 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00065008388 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018359 ENTREZGENE
  ENSRNOT00000018359.8 UniProtKB/Swiss-Prot
  ENSRNOT00065013296 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystine-knot cytokines UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25644 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bmp6 PhenoGen
  TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013717 RatGTEx
  ENSRNOG00065008388 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Cystine-knot cytokines UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC218331
UniProt Secondary Q811S4 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Bmp6  bone morphogenetic protein 6    Bone morphogenetic protein 6  Name updated 629478 APPROVED
2002-06-10 Bmp6  Bone morphogenetic protein 6      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed constitutively in the central nervous system 631795
gene_expression expressed in lung and in minor quantities in spleen, kidney, heart, brain, and liver 631742
gene_function growth factor molecule 631742
gene_process involve in induction of osteogenesis, control of growth and differentiation during embryogenesis and liver organogenesis 631742
gene_product member of the transforming growth factor beta superfamily 631742
gene_product member of the transforming growth factor beta superfamily 631795
gene_regulation upregulated by transforming growth factor-beta 1 631742
gene_transcript 3.7 kb 631742
gene_transcript 3.7 kb 631795