Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | Prpf4b (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PRPF4B mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | Prpf4b (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of PRPF4B mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | Prpf4b (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRPF4B mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | affects expression | ISO | Prpf4b (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of PRPF4B mRNA | CTD | PMID:17555576 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Prpf4b (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRPF4B mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PRPF4B mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PRPF4B mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PRPF4B mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Prpf4b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PRPF4B mRNA | CTD | PMID:21354282 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Prpf4b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PRPF4B mRNA | CTD | PMID:19770486 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of PRPF4B mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of PRPF4B mRNA | CTD | PMID:21346803 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Prpf4b (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PRPF4B mRNA | CTD | PMID:26251327 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of PRPF4B mRNA | CTD | PMID:28959563 | aflatoxin B1 | increases expression | ISO | Prpf4b (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of PRPF4B mRNA | CTD | PMID:19770486 | aristolochic acid A | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PRP4K mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | PRP4K (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PRP4K mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | multiple interactions | ISO | Prpf4b (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PRPF4B mRNA | CTD | PMID:27858113 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20018196 and PMID:26238291 | benzo[b]fluoranthene | multiple interactions | ISO | Prpf4b (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PRPF4B mRNA | CTD | PMID:27858113 | bisphenol A | decreases expression | ISO | Prpf4b (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PRPF4B mRNA and bisphenol A results in decreased expression of PRPF4B protein | CTD | PMID:15215581 more ... | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PRPF4B mRNA | CTD | PMID:30816183 more ... | bisphenol A | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PRP4K mRNA | CTD | PMID:29275510 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PRPF4B mRNA | CTD | PMID:25181051 and PMID:32145629 | cadmium dichloride | multiple interactions | ISO | Prpf4b (Mus musculus) | 6480464 | MT3 affects the reaction [Cadmium Chloride affects the expression of PRPF4B mRNA] | CTD | PMID:20371981 | cadmium dichloride | decreases expression | ISO | Prpf4b (Mus musculus) | 6480464 | Cadmium Chloride results in decreased expression of PRPF4B mRNA | CTD | PMID:24982889 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of PRPF4B mRNA | CTD | PMID:33453195 | caffeine | affects phosphorylation | ISO | PRP4K (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of PRP4K protein | CTD | PMID:35688186 | carbon nanotube | increases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Nanotubes and Carbon results in increased expression of PRP4K mRNA | CTD | PMID:24389112 | CGP 52608 | multiple interactions | ISO | PRP4K (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PRP4K gene] | CTD | PMID:28238834 | chloroprene | increases expression | EXP | | 6480464 | Chloroprene results in increased expression of PRPF4B mRNA | CTD | PMID:23125180 | choline | multiple interactions | ISO | Prpf4b (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRPF4B gene | CTD | PMID:20938992 | chrysene | multiple interactions | ISO | Prpf4b (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PRPF4B mRNA | CTD | PMID:27858113 | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of PRPF4B mRNA | CTD | PMID:30556269 | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of PRPF4B mRNA | CTD | PMID:30556269 | coumarin | decreases phosphorylation | ISO | PRP4K (Homo sapiens) | 6480464 | coumarin results in decreased phosphorylation of PRP4K protein | CTD | PMID:35688186 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of PRPF4B mRNA | CTD | PMID:27523638 | dicrotophos | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of PRP4K mRNA | CTD | PMID:28302478 | diethylstilbestrol | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Diethylstilbestrol results in decreased expression of PRP4K mRNA | CTD | PMID:36621641 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of PRPF4B mRNA | CTD | PMID:25152437 | elemental selenium | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Selenium results in decreased expression of PRP4K mRNA | CTD | PMID:19244175 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of PRPF4B mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Prpf4b (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRPF4B gene | CTD | PMID:20938992 | folic acid | decreases expression | ISO | Prpf4b (Mus musculus) | 6480464 | Folic Acid results in decreased expression of PRPF4B mRNA | CTD | PMID:25629700 | formaldehyde | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PRP4K mRNA | CTD | PMID:20655997 | FR900359 | increases phosphorylation | ISO | PRP4K (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of PRPF4B protein | CTD | PMID:37730182 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PRPF4B mRNA | CTD | PMID:22061828 | glyphosate | increases expression | EXP | | 6480464 | Glyphosate results in increased expression of PRPF4B mRNA | CTD | PMID:26302742 | indometacin | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Indomethacin results in decreased expression of PRP4K mRNA | CTD | PMID:16984733 | ivermectin | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PRP4K protein | CTD | PMID:32959892 | ketamine | decreases expression | EXP | | 6480464 | Ketamine results in decreased expression of PRPF4B mRNA | CTD | PMID:20080153 | L-methionine | multiple interactions | ISO | Prpf4b (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRPF4B gene | CTD | PMID:20938992 | lipopolysaccharide | affects expression | ISO | PRP4K (Homo sapiens) | 6480464 | Lipopolysaccharides affects the expression of PRP4K mRNA | CTD | PMID:28070326 | lipopolysaccharide | multiple interactions | ISO | PRP4K (Homo sapiens) | 6480464 | Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of PRP4K mRNA] | CTD | PMID:28070326 | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of PRPF4B mRNA | CTD | PMID:30467583 | methyl methanesulfonate | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of PRP4K mRNA | CTD | PMID:23649840 | N-methyl-4-phenylpyridinium | increases expression | ISO | Prpf4b (Mus musculus) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of PRPF4B protein | CTD | PMID:26558463 | ochratoxin A | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | ochratoxin A results in decreased expression of PRP4K mRNA | CTD | PMID:22124623 | oxaliplatin | multiple interactions | EXP | | 6480464 | [Oxaliplatin co-treated with Topotecan] results in decreased expression of PRPF4B mRNA | CTD | PMID:25729387 | paracetamol | affects expression | ISO | Prpf4b (Mus musculus) | 6480464 | Acetaminophen affects the expression of PRPF4B mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PRP4K mRNA | CTD | PMID:21420995 | pirinixic acid | decreases expression | ISO | Prpf4b (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of PRPF4B mRNA | CTD | PMID:18445702 | pirinixic acid | increases expression | ISO | Prpf4b (Mus musculus) | 6480464 | pirinixic acid results in increased expression of PRPF4B mRNA | CTD | PMID:23811191 | piroxicam | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Piroxicam results in decreased expression of PRP4K mRNA | CTD | PMID:21858171 | quercetin | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Quercetin results in decreased expression of PRP4K mRNA | CTD | PMID:21632981 | raloxifene | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Raloxifene Hydrochloride results in decreased expression of PRP4K mRNA | CTD | PMID:16497877 | resveratrol | decreases expression | EXP | | 6480464 | Resveratrol results in decreased expression of PRPF4B mRNA | CTD | PMID:25905778 | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of PRPF4B protein | CTD | PMID:35544339 | selenium atom | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Selenium results in decreased expression of PRP4K mRNA | CTD | PMID:19244175 | sodium arsenate | increases expression | ISO | Prpf4b (Mus musculus) | 6480464 | sodium arsenate results in increased expression of PRPF4B mRNA | CTD | PMID:21795629 | sodium arsenite | decreases expression | ISO | Prpf4b (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of PRPF4B mRNA | CTD | PMID:16014739 | sodium arsenite | increases expression | ISO | Prpf4b (Mus musculus) | 6480464 | sodium arsenite results in increased expression of PRPF4B mRNA | CTD | PMID:36209798 | sodium fluoride | decreases expression | ISO | Prpf4b (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of PRPF4B protein | CTD | PMID:28918527 | succimer | multiple interactions | ISO | Prpf4b (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PRPF4B mRNA | CTD | PMID:21641980 | sunitinib | increases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PRP4K mRNA | CTD | PMID:31533062 | tamoxifen | increases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Tamoxifen results in increased expression of PRP4K mRNA | CTD | PMID:15590111 | tamoxifen | affects expression | ISO | Prpf4b (Mus musculus) | 6480464 | Tamoxifen affects the expression of PRPF4B mRNA | CTD | PMID:17555576 | tetraphene | multiple interactions | ISO | Prpf4b (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PRPF4B mRNA | CTD | PMID:27858113 | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of PRPF4B mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | EXP | | 6480464 | [Oxaliplatin co-treated with Topotecan] results in decreased expression of PRPF4B mRNA | CTD | PMID:25729387 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of PRPF4B mRNA | CTD | PMID:33387578 | trichostatin A | affects expression | ISO | PRP4K (Homo sapiens) | 6480464 | trichostatin A affects the expression of PRP4K mRNA | CTD | PMID:28542535 | Triptolide | increases expression | EXP | | 6480464 | triptolide results in increased expression of PRPF4B protein | CTD | PMID:32519852 | troglitazone | decreases expression | ISO | Prpf4b (Mus musculus) | 6480464 | Troglitazone results in decreased expression of PRPF4B mRNA | CTD | PMID:28973697 | uranium atom | affects expression | ISO | PRP4K (Homo sapiens) | 6480464 | Uranium affects the expression of PRP4K mRNA | CTD | PMID:15672453 | urethane | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Urethane results in decreased expression of PRP4K mRNA | CTD | PMID:28818685 | valproic acid | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PRP4K mRNA | CTD | PMID:23179753 | valproic acid | affects expression | ISO | PRP4K (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PRP4K mRNA | CTD | PMID:25979313 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of PRPF4B mRNA | CTD | PMID:20566332 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of PRPF4B mRNA | CTD | PMID:23034163 | vincristine | decreases expression | ISO | PRP4K (Homo sapiens) | 6480464 | Vincristine results in decreased expression of PRP4K mRNA | CTD | PMID:23649840 | |